{"id":"https://openalex.org/W2280798535","doi":null,"title":"Cytokine-dependent ex vivo expansion of early subsets of CD34+ cord blood myeloid progenitors is enhanced by cord blood plasma, but expansion of the more mature subsets of progenitors is favored.","display_name":"Cytokine-dependent ex vivo expansion of early subsets of CD34+ cord blood myeloid progenitors is enhanced by cord blood plasma, but expansion of the more mature subsets of progenitors is favored.","publication_year":1994,"publication_date":"1994-01-01","ids":{"openalex":"https://openalex.org/W2280798535","mag":"2280798535","pmid":"https://pubmed.ncbi.nlm.nih.gov/7538350"},"language":"en","primary_location":{"id":"pmid:7538350","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7538350","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood cells","raw_type":"Comparative Study"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112142840","display_name":"Luciana Morellatto Ruggieri","orcid":"https://orcid.org/0009-0002-2542-3643","observed_orcids":["https://orcid.org/0009-0002-2542-3643"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L Ruggieri","raw_affiliation_strings":["Department of Medicine (Hematology/Oncology), Indiana University School of Medicine, Indianapolis 46202-5121, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine (Hematology/Oncology), Indiana University School of Medicine, Indianapolis 46202-5121, USA","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111541245","display_name":"Shelly Heimfeld","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Heimfeld","raw_affiliation_strings":["Indiana University-Purdue"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University-Purdue","institution_ids":["https://openalex.org/I592451"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038161052","display_name":"Hal E. Broxmeyer","orcid":"https://orcid.org/0000-0001-6575-0476","observed_orcids":["https://orcid.org/0000-0001-6575-0476"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H E Broxmeyer","raw_affiliation_strings":["Microbiology & Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology & Immunology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.3703,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.89503301,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"20","issue":"2-3","first_page":"436","last_page":"54"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/umbilical-cord-blood","display_name":"umbilical cord blood","score":0.5839999914169312},{"id":"https://openalex.org/keywords/ex-vivo-expansion","display_name":"ex vivo expansion","score":0.6859999895095825},{"id":"https://openalex.org/keywords/myeloid-progenitor-cells","display_name":"myeloid progenitor cells","score":0.8140000104904175},{"id":"https://openalex.org/keywords/cd34-cells","display_name":"CD34+ cells","score":0.9539999961853027},{"id":"https://openalex.org/keywords/cord-blood-plasma","display_name":"cord plasma","score":0.8669999837875366},{"id":"https://openalex.org/keywords/stem-cell-factor","display_name":"stem cell factor","score":0.6909999847412109},{"id":"https://openalex.org/keywords/cfu-gemm","display_name":"CFU-GEMM","score":0.7620000243186951},{"id":"https://openalex.org/keywords/cfu-gm","display_name":"CFU-GM","score":0.8999999761581421},{"id":"https://openalex.org/keywords/progenitor-cell-differentiation","display_name":"progenitor cell differentiation","score":0.7879999876022339},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.43700000643730164},{"id":"https://openalex.org/keywords/fetal-bovine-serum","display_name":"fetal bovine serum","score":0.7099999785423279},{"id":"https://openalex.org/keywords/hematopoietic-stem-cells","display_name":"hematopoietic stem cells","score":0.6990000009536743},{"id":"https://openalex.org/keywords/transplantation","display_name":"transplantation","score":0.4189999997615814}],"concepts":[{"id":"https://openalex.org/C2780914630","wikidata":"https://www.wikidata.org/wiki/Q914952","display_name":"Cord blood","level":2,"score":0.6743414402008057},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.6491095423698425},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.5858566164970398},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.5220027565956116},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.5142928957939148},{"id":"https://openalex.org/C2022786","wikidata":"https://www.wikidata.org/wiki/Q909331","display_name":"Stem cell factor","level":4,"score":0.5027451515197754},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.4749990701675415},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.45932599902153015},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.45859992504119873},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.45350930094718933},{"id":"https://openalex.org/C2779705218","wikidata":"https://www.wikidata.org/wiki/Q821701","display_name":"Megakaryocyte","level":4,"score":0.4384113550186157},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43744727969169617},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4272412657737732},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4074045419692993},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3810776472091675},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3557242155075073},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2784966826438904},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.21784913539886475},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12947365641593933},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003114","descriptor_name":"Colony-Forming Units Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005312","descriptor_name":"Fetal Blood","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D006098","descriptor_name":"Granulocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007377","descriptor_name":"Interleukin-3","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010949","descriptor_name":"Plasma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015672","descriptor_name":"Erythroid Precursor Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D015672","descriptor_name":"Erythroid Precursor Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016178","descriptor_name":"Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016298","descriptor_name":"Hematopoietic Cell Growth Factors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019089","descriptor_name":"Stem Cell Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046508","descriptor_name":"Culture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:7538350","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7538350","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood cells","raw_type":"Comparative Study"},{"id":"mag:2280798535","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7538350","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5097623640","display_name":"CSF MGF FUSION PROTEINS AND MYELOPOIESIS","funder_award_id":"R37CA036464","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5532857528","display_name":"MYELOID REGULATION BY GROWTH SUPPRESSING CYTOKINES","funder_award_id":"R01HL049202","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8337518668","display_name":"UMBILICAL CORD BLOOD STEM CELLS AND IMMUNOLOGY","funder_award_id":"R01HL046549","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2417542845","https://openalex.org/W2412532071","https://openalex.org/W2037741965","https://openalex.org/W2557413399","https://openalex.org/W2049656250","https://openalex.org/W2405719302","https://openalex.org/W2348688166","https://openalex.org/W1603724795","https://openalex.org/W2435867567","https://openalex.org/W2432137767"],"abstract_inverted_index":{"Expansion":[0],"of":[1,30,41,50,67,82,112,128,152,176,217,222,226,241,247,261,271,316,336],"stem/progenitor":[2],"cells":[3,73,141],"has":[4],"important":[5],"implications":[6],"for":[7,215,267],"transplantation.":[8],"We":[9],"recently":[10],"reported":[11],"that":[12,127,311],"a":[13,39,319],"factor":[14,95],"or":[15,93,103,159,180,325],"factors":[16],"in":[17,53,77,149,173,255,329],"cord":[18],"blood":[19,25],"(CB),":[20],"but":[21,327],"not":[22,107],"adult":[23],"peripheral":[24],"(PB),":[26],"plasma":[27,57,114,130,158,186,194,206,214,265,283,300,313,324],"enhanced":[28],"replating":[29],"granulocyte":[31],"erythroid":[32],"macrophage":[33],"megakaryocyte":[34],"colony-forming":[35],"units":[36],"(CFU-GEMM)":[37],"progenitors,":[38],"measure":[40],"self-renewal":[42],"capacity.":[43],"In":[44],"this":[45],"context,":[46],"we":[47],"evaluated":[48],"effects":[49],"CB":[51,72,99,113,153,185,213,282,299,312],"plasma,":[52,100,102],"comparison":[54],"with":[55,146,156,161,184,192,202,229,235,264,281,286,298,305],"PB":[56,101,129,157,193,205,287,306,323],"and":[58,80,134,219,231,284,301],"fetal":[59],"bovine":[60],"serum":[61],"(FBS),":[62],"on":[63],"ex":[64],"vivo":[65],"expansion":[66,121,148,216,232,270,315,328],"CD34+":[68,140],"column-separated":[69],"(72-98%":[70],"CD34+)":[71],"using":[74],"stroma-free":[75],"cultures":[76,331],"the":[78,150,174,238,245],"absence":[79],"presence":[81,151,175],"either":[83,177],"PIXY321":[84],"(a":[85],"granulocyte-macrophage":[86],"colony-stimulating":[87],"factor/interleukin-3":[88],"[GM-CSF/IL-3]":[89],"fusion":[90],"protein),":[91],"IL-3+IL-6+IL-1,":[92],"steel":[94],"(SLF)":[96],"-/+":[97],"PIXY.":[98],"FBS":[104,135,160],"alone":[105],"did":[106],"sustain":[108],"cell":[109,120],"numbers.":[110],"Combinations":[111],"+SLF+PIXY":[115,266],"induced":[116],"maximal":[117],"cumulative":[118],"nucleated":[119],"(1044-fold),":[122],"which":[123],"was":[124,182,207,233,243,278],"greater":[125,183,200,279,320],"than":[126,191,201,289,322],"plus":[131,136],"cytokines":[132,137,164],"(633-fold)":[133],"(142-fold).":[138],"Total":[139],"peaked":[142],"by":[143],"day":[144,168],"7":[145,268],"7-fold":[147],"plasma+SLF+PIXY":[154],"compared":[155],"these":[162,330],"same":[163],"(threefold":[165],"each).":[166],"By":[167],"7,":[169],"total":[170],"CFU-GEMM":[171,242,248,317],"production":[172],"PIXY,":[178],"SLF+PIXY,":[179],"IL-3+IL-6+IL-1":[181],"(maximum":[187],"11.4-fold":[188],"average":[189],"increases)":[190],"(6.8-fold":[195],"increase).":[196],"These":[197],"increases":[198],"were":[199],"FBS.":[203],"However,":[204],"at":[208],"least":[209],"as":[210,212],"good":[211],"immature":[218,290],"mature":[220,273,334],"subsets":[221,335],"CFU-GM.":[223],"The":[224,308],"frequency":[225],"progenitors":[227],"decreased":[228,252],"time,":[230],"coupled":[234],"differentiation.":[236],"Although":[237],"proliferative":[239],"capacity":[240,246],"maintained,":[244],"to":[249,276,293,296,303,318],"be":[250],"replated":[251],"after":[253],"time":[254],"suspension":[256],"culture,":[257],"suggesting":[258],"age-related":[259],"commitment":[260],"cells.":[262,337],"Moreover,":[263],"days,":[269],"more":[272,333],"CFU-GM":[274,291],"(responsive":[275,292],"GM-CSF)":[277],"(16-146-fold":[280],"31-208-fold":[285],"plasma)":[288],"GM-CSF+SFL)":[294],"(4-":[295],"14-fold":[297],"6-":[302],"17-fold":[304],"plasma).":[307],"results":[309],"suggest":[310],"enhances":[314],"extent":[321],"FBS,":[326],"favors":[332]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
