{"id":"https://openalex.org/W2280655896","doi":null,"title":"The role of p53 in normal development and teratogen-induced apoptosis and birth defects in mouse embryos","display_name":"The role of p53 in normal development and teratogen-induced apoptosis and birth defects in mouse embryos","publication_year":2009,"publication_date":"2009-05-15","ids":{"openalex":"https://openalex.org/W2280655896","mag":"2280655896"},"language":"en","primary_location":{"id":"pmh:oai:oaktrust.library.tamu.edu:1969.1/ETD-TAMU-3251","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1969.1/ETD-TAMU-3251","pdf_url":null,"source":{"id":"https://openalex.org/S4306400291","display_name":"OakTrust (Texas A&M University Libraries)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I91045830","host_organization_name":"Texas A&M University","host_organization_lineage":["https://openalex.org/I91045830"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035815147","display_name":"Hiromi Hosako","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Hiromi Hosako","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5035815147"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.6758000254631042,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.6758000254631042,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.19359999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.028699999675154686,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neural-tube-defects","display_name":"neural tube defects","score":0.9589999914169312},{"id":"https://openalex.org/keywords/neural-tube-closure","display_name":"neural tube closure","score":0.7549999952316284},{"id":"https://openalex.org/keywords/teratogens","display_name":"teratogens","score":0.6890000104904175},{"id":"https://openalex.org/keywords/hyperthermia","display_name":"hyperthermia","score":0.9589999914169312},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.878000020980835},{"id":"https://openalex.org/keywords/pmaip1","display_name":"Noxa","score":0.7630000114440918},{"id":"https://openalex.org/keywords/puma","display_name":"PUMA","score":0.9990000128746033},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9200000166893005},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.7820000052452087},{"id":"https://openalex.org/keywords/exencephaly","display_name":"exencephaly","score":0.9390000104904175},{"id":"https://openalex.org/keywords/spina-bifida","display_name":"spina bifida","score":0.9990000128746033},{"id":"https://openalex.org/keywords/preaxial-polydactyly","display_name":"preaxial polydactyly","score":0.9279999732971191},{"id":"https://openalex.org/keywords/congenital-malformations","display_name":"congenital malformations","score":0.8579999804496765},{"id":"https://openalex.org/keywords/mouse-embryo","display_name":"mouse embryo","score":0.574999988079071},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.8009999990463257}],"concepts":[{"id":"https://openalex.org/C2780594696","wikidata":"https://www.wikidata.org/wiki/Q1127402","display_name":"Neural tube","level":3,"score":0.9262759685516357},{"id":"https://openalex.org/C2781052626","wikidata":"https://www.wikidata.org/wiki/Q1774245","display_name":"Exencephaly","level":5,"score":0.8534685969352722},{"id":"https://openalex.org/C2777417711","wikidata":"https://www.wikidata.org/wiki/Q270748","display_name":"Puma","level":3,"score":0.7793797254562378},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6975374817848206},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.6711376309394836},{"id":"https://openalex.org/C65290608","wikidata":"https://www.wikidata.org/wiki/Q631521","display_name":"Teratology","level":4,"score":0.6238679885864258},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5937891602516174},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.44586363434791565},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4379115402698517},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.43087825179100037},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37657344341278076},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.31173843145370483},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.29754751920700073},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15309348702430725},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.1380748450756073}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:oaktrust.library.tamu.edu:1969.1/ETD-TAMU-3251","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1969.1/ETD-TAMU-3251","pdf_url":null,"source":{"id":"https://openalex.org/S4306400291","display_name":"OakTrust (Texas A&M University Libraries)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I91045830","host_organization_name":"Texas A&M University","host_organization_lineage":["https://openalex.org/I91045830"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2280655896","doi":null,"is_oa":false,"landing_page_url":"https://oaktrust.library.tamu.edu/bitstream/1969.1/ETD-TAMU-3251/1/HOSAKO-DISSERTATION.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9074000120162964,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":552,"referenced_works":["https://openalex.org/W31323867","https://openalex.org/W34204517","https://openalex.org/W48627038","https://openalex.org/W53082289","https://openalex.org/W56975468","https://openalex.org/W105623059","https://openalex.org/W106656123","https://openalex.org/W144423133","https://openalex.org/W153132690","https://openalex.org/W165254100","https://openalex.org/W172584573","https://openalex.org/W192261272","https://openalex.org/W194253603","https://openalex.org/W575605346","https://openalex.org/W593832428","https://openalex.org/W651927394","https://openalex.org/W762442463","https://openalex.org/W953187002","https://openalex.org/W1480948328","https://openalex.org/W1481400971","https://openalex.org/W1492668011","https://openalex.org/W1493846190","https://openalex.org/W1495729285","https://openalex.org/W1496144612","https://openalex.org/W1507319558","https://openalex.org/W1531240647","https://openalex.org/W1534713014","https://openalex.org/W1542115623","https://openalex.org/W1547151861","https://openalex.org/W1547619885","https://openalex.org/W1551890621","https://openalex.org/W1552332385","https://openalex.org/W1556370635","https://openalex.org/W1578880263","https://openalex.org/W1583835226","https://openalex.org/W1598779357","https://openalex.org/W1600706591","https://openalex.org/W1603075051","https://openalex.org/W1607777232","https://openalex.org/W1614077614","https://openalex.org/W1616121322","https://openalex.org/W1634826223","https://openalex.org/W1638458828","https://openalex.org/W1643155728","https://openalex.org/W1650797637","https://openalex.org/W1657827244","https://openalex.org/W1668580308","https://openalex.org/W1673346837","https://openalex.org/W1675096266","https://openalex.org/W1745634660","https://openalex.org/W1782545213","https://openalex.org/W1843503887","https://openalex.org/W1852111329","https://openalex.org/W1878774211","https://openalex.org/W1881393103","https://openalex.org/W1888003329","https://openalex.org/W1892498374","https://openalex.org/W1901623573","https://openalex.org/W1912633131","https://openalex.org/W1912789001","https://openalex.org/W1927684145","https://openalex.org/W1928466038","https://openalex.org/W1935109912","https://openalex.org/W1937263563","https://openalex.org/W1937607074","https://openalex.org/W1939472319","https://openalex.org/W1940372773","https://openalex.org/W1944883370","https://openalex.org/W1948938001","https://openalex.org/W1950488640","https://openalex.org/W1963209155","https://openalex.org/W1964872165","https://openalex.org/W1965719307","https://openalex.org/W1966485551","https://openalex.org/W1966880658","https://openalex.org/W1967795278","https://openalex.org/W1967880683","https://openalex.org/W1967993707","https://openalex.org/W1968269107","https://openalex.org/W1968300632","https://openalex.org/W1968574231","https://openalex.org/W1968878097","https://openalex.org/W1969044026","https://openalex.org/W1969308341","https://openalex.org/W1969331809","https://openalex.org/W1969385456","https://openalex.org/W1969788568","https://openalex.org/W1971215274","https://openalex.org/W1972012868","https://openalex.org/W1972166544","https://openalex.org/W1973254311","https://openalex.org/W1973279018","https://openalex.org/W1975131136","https://openalex.org/W1975644211","https://openalex.org/W1976873804","https://openalex.org/W1978311772","https://openalex.org/W1979490110","https://openalex.org/W1979692171","https://openalex.org/W1980333973","https://openalex.org/W1980467354","https://openalex.org/W1980794648","https://openalex.org/W1980999182","https://openalex.org/W1981166298","https://openalex.org/W1981457253","https://openalex.org/W1982013088","https://openalex.org/W1982581456","https://openalex.org/W1982621844","https://openalex.org/W1983318886","https://openalex.org/W1983419413","https://openalex.org/W1983797897","https://openalex.org/W1984347841","https://openalex.org/W1984944970","https://openalex.org/W1986006829","https://openalex.org/W1986308149","https://openalex.org/W1986916123","https://openalex.org/W1987146715","https://openalex.org/W1987267322","https://openalex.org/W1987315246","https://openalex.org/W1987693880","https://openalex.org/W1988283092","https://openalex.org/W1988671949","https://openalex.org/W1988769766","https://openalex.org/W1989223012","https://openalex.org/W1989454102","https://openalex.org/W1989936068","https://openalex.org/W1989946857","https://openalex.org/W1989952069","https://openalex.org/W1989991277","https://openalex.org/W1990880603","https://openalex.org/W1991494214","https://openalex.org/W1991586667","https://openalex.org/W1991923928","https://openalex.org/W1991982116","https://openalex.org/W1993093872","https://openalex.org/W1993170641","https://openalex.org/W1993864973","https://openalex.org/W1994979780","https://openalex.org/W1995724464","https://openalex.org/W1995741673","https://openalex.org/W1995856480","https://openalex.org/W1996441871","https://openalex.org/W1997054509","https://openalex.org/W1997111377","https://openalex.org/W1997222931","https://openalex.org/W1997849178","https://openalex.org/W1997916347","https://openalex.org/W1998120606","https://openalex.org/W1998594680","https://openalex.org/W1999100418","https://openalex.org/W2000446104","https://openalex.org/W2000466566","https://openalex.org/W2000816728","https://openalex.org/W2001180048","https://openalex.org/W2001314244","https://openalex.org/W2001612262","https://openalex.org/W2001720542","https://openalex.org/W2001824068","https://openalex.org/W2003010571","https://openalex.org/W2003185547","https://openalex.org/W2003456967","https://openalex.org/W2004114805","https://openalex.org/W2004584509","https://openalex.org/W2005236007","https://openalex.org/W2005876727","https://openalex.org/W2006293507","https://openalex.org/W2006313701","https://openalex.org/W2007510875","https://openalex.org/W2007935491","https://openalex.org/W2008031088","https://openalex.org/W2008715871","https://openalex.org/W2008887283","https://openalex.org/W2009845042","https://openalex.org/W2010239662","https://openalex.org/W2010452001","https://openalex.org/W2010478401","https://openalex.org/W2010588923","https://openalex.org/W2011470815","https://openalex.org/W2011658104","https://openalex.org/W2011807665","https://openalex.org/W2011813310","https://openalex.org/W2011994306","https://openalex.org/W2012024423","https://openalex.org/W2012053348","https://openalex.org/W2012083927","https://openalex.org/W2012086083","https://openalex.org/W2012173926","https://openalex.org/W2012753961","https://openalex.org/W2013188833","https://openalex.org/W2013330927","https://openalex.org/W2013583594","https://openalex.org/W2013952708","https://openalex.org/W2014104304","https://openalex.org/W2014323289","https://openalex.org/W2014938226","https://openalex.org/W2014939913","https://openalex.org/W2014946489","https://openalex.org/W2015423358","https://openalex.org/W2015871305","https://openalex.org/W2016112105","https://openalex.org/W2016175877","https://openalex.org/W2016350172","https://openalex.org/W2017348361","https://openalex.org/W2017488005","https://openalex.org/W2017945657","https://openalex.org/W2018385269","https://openalex.org/W2018884388","https://openalex.org/W2019405732","https://openalex.org/W2019501042","https://openalex.org/W2020621201","https://openalex.org/W2021326683","https://openalex.org/W2021491682","https://openalex.org/W2021505095","https://openalex.org/W2021682675","https://openalex.org/W2021920476","https://openalex.org/W2022537145","https://openalex.org/W2022868231","https://openalex.org/W2023131959","https://openalex.org/W2023429295","https://openalex.org/W2023789655","https://openalex.org/W2023800438","https://openalex.org/W2024749378","https://openalex.org/W2024996523","https://openalex.org/W2025128734","https://openalex.org/W2025876695","https://openalex.org/W2026057304","https://openalex.org/W2026060163","https://openalex.org/W2026637815","https://openalex.org/W2026873116","https://openalex.org/W2026993409","https://openalex.org/W2027686496","https://openalex.org/W2029080338","https://openalex.org/W2029146706","https://openalex.org/W2029493234","https://openalex.org/W2029678404","https://openalex.org/W2029715841","https://openalex.org/W2032076692","https://openalex.org/W2032446466","https://openalex.org/W2033017868","https://openalex.org/W2033418096","https://openalex.org/W2033527927","https://openalex.org/W2033875628","https://openalex.org/W2034059961","https://openalex.org/W2034915619","https://openalex.org/W2034992001","https://openalex.org/W2035815331","https://openalex.org/W2035992337","https://openalex.org/W2037610573","https://openalex.org/W2038167014","https://openalex.org/W2038303173","https://openalex.org/W2039158609","https://openalex.org/W2039355845","https://openalex.org/W2039463309","https://openalex.org/W2040068538","https://openalex.org/W2040169548","https://openalex.org/W2040851473","https://openalex.org/W2041968244","https://openalex.org/W2042253251","https://openalex.org/W2042813080","https://openalex.org/W2043136696","https://openalex.org/W2044057392","https://openalex.org/W2044079387","https://openalex.org/W2044189886","https://openalex.org/W2045086385","https://openalex.org/W2045497152","https://openalex.org/W2045872949","https://openalex.org/W2046563782","https://openalex.org/W2046609088","https://openalex.org/W2046937605","https://openalex.org/W2047160541","https://openalex.org/W2047165320","https://openalex.org/W2048818640","https://openalex.org/W2048994040","https://openalex.org/W2049562411","https://openalex.org/W2049873418","https://openalex.org/W2050684573","https://openalex.org/W2050686338","https://openalex.org/W2050745715","https://openalex.org/W2050869737","https://openalex.org/W2051692882","https://openalex.org/W2051970069","https://openalex.org/W2052389457","https://openalex.org/W2052853635","https://openalex.org/W2053959241","https://openalex.org/W2054706055","https://openalex.org/W2054847530","https://openalex.org/W2056079046","https://openalex.org/W2056418403","https://openalex.org/W2056613252","https://openalex.org/W2057129148","https://openalex.org/W2057293429","https://openalex.org/W2057551676","https://openalex.org/W2057776005","https://openalex.org/W2058377017","https://openalex.org/W2058711543","https://openalex.org/W2059766157","https://openalex.org/W2059848983","https://openalex.org/W2060112916","https://openalex.org/W2060446375","https://openalex.org/W2061362539","https://openalex.org/W2061816941","https://openalex.org/W2062674518","https://openalex.org/W2062853648","https://openalex.org/W2063060712","https://openalex.org/W2063459576","https://openalex.org/W2063611876","https://openalex.org/W2063669247","https://openalex.org/W2064579441","https://openalex.org/W2065955521","https://openalex.org/W2066741869","https://openalex.org/W2067336793","https://openalex.org/W2067434554","https://openalex.org/W2067438814","https://openalex.org/W2068884609","https://openalex.org/W2069009920","https://openalex.org/W2069323056","https://openalex.org/W2069778851","https://openalex.org/W2070438262","https://openalex.org/W2070685557","https://openalex.org/W2070692423","https://openalex.org/W2070781700","https://openalex.org/W2071542986","https://openalex.org/W2072225623","https://openalex.org/W2072319696","https://openalex.org/W2072809813","https://openalex.org/W2073055560","https://openalex.org/W2073090986","https://openalex.org/W2073795308","https://openalex.org/W2073860278","https://openalex.org/W2073936529","https://openalex.org/W2074129004","https://openalex.org/W2074210527","https://openalex.org/W2074222004","https://openalex.org/W2074451679","https://openalex.org/W2075230059","https://openalex.org/W2075403926","https://openalex.org/W2075477970","https://openalex.org/W2076008643","https://openalex.org/W2076256233","https://openalex.org/W2076278676","https://openalex.org/W2077243611","https://openalex.org/W2077522929","https://openalex.org/W2077861623","https://openalex.org/W2078091557","https://openalex.org/W2079472722","https://openalex.org/W2080462115","https://openalex.org/W2080758856","https://openalex.org/W2080865728","https://openalex.org/W2080873598","https://openalex.org/W2080993588","https://openalex.org/W2081266818","https://openalex.org/W2081560586","https://openalex.org/W2081667575","https://openalex.org/W2082399676","https://openalex.org/W2082541302","https://openalex.org/W2082624222","https://openalex.org/W2083040613","https://openalex.org/W2083158631","https://openalex.org/W2083485306","https://openalex.org/W2083856576","https://openalex.org/W2084457045","https://openalex.org/W2084609653","https://openalex.org/W2084733813","https://openalex.org/W2085195718","https://openalex.org/W2085601531","https://openalex.org/W2085815287","https://openalex.org/W2087628698","https://openalex.org/W2087877138","https://openalex.org/W2088381214","https://openalex.org/W2088647008","https://openalex.org/W2089024209","https://openalex.org/W2089082314","https://openalex.org/W2089623038","https://openalex.org/W2090492363","https://openalex.org/W2091689368","https://openalex.org/W2092409818","https://openalex.org/W2092462528","https://openalex.org/W2092603433","https://openalex.org/W2092713508","https://openalex.org/W2092722802","https://openalex.org/W2093041087","https://openalex.org/W2093242085","https://openalex.org/W2093422134","https://openalex.org/W2093598492","https://openalex.org/W2093628776","https://openalex.org/W2095916340","https://openalex.org/W2096078685","https://openalex.org/W2096276671","https://openalex.org/W2096713885","https://openalex.org/W2096765959","https://openalex.org/W2097005995","https://openalex.org/W2097644162","https://openalex.org/W2098940478","https://openalex.org/W2099113454","https://openalex.org/W2099985607","https://openalex.org/W2100089767","https://openalex.org/W2100324800","https://openalex.org/W2100837269","https://openalex.org/W2101099407","https://openalex.org/W2102082802","https://openalex.org/W2102459218","https://openalex.org/W2102597691","https://openalex.org/W2104521784","https://openalex.org/W2105072114","https://openalex.org/W2105444747","https://openalex.org/W2105592350","https://openalex.org/W2106647194","https://openalex.org/W2107038650","https://openalex.org/W2108547322","https://openalex.org/W2108667455","https://openalex.org/W2110899227","https://openalex.org/W2111420633","https://openalex.org/W2111522573","https://openalex.org/W2112192177","https://openalex.org/W2112287022","https://openalex.org/W2112381649","https://openalex.org/W2112968535","https://openalex.org/W2113869362","https://openalex.org/W2114822907","https://openalex.org/W2115124693","https://openalex.org/W2116635868","https://openalex.org/W2116755440","https://openalex.org/W2117200137","https://openalex.org/W2117391818","https://openalex.org/W2117911291","https://openalex.org/W2118001641","https://openalex.org/W2118440516","https://openalex.org/W2119337308","https://openalex.org/W2119363024","https://openalex.org/W2119502291","https://openalex.org/W2119683782","https://openalex.org/W2120009233","https://openalex.org/W2120140512","https://openalex.org/W2120473562","https://openalex.org/W2121099849","https://openalex.org/W2122387572","https://openalex.org/W2122748292","https://openalex.org/W2122877713","https://openalex.org/W2123159256","https://openalex.org/W2123363472","https://openalex.org/W2124139409","https://openalex.org/W2124595934","https://openalex.org/W2124637558","https://openalex.org/W2125068279","https://openalex.org/W2125124408","https://openalex.org/W2125984118","https://openalex.org/W2126418991","https://openalex.org/W2126426563","https://openalex.org/W2126679757","https://openalex.org/W2127793385","https://openalex.org/W2127891491","https://openalex.org/W2128252882","https://openalex.org/W2129905922","https://openalex.org/W2130446433","https://openalex.org/W2130826341","https://openalex.org/W2131321236","https://openalex.org/W2132172164","https://openalex.org/W2132175411","https://openalex.org/W2133760596","https://openalex.org/W2134230163","https://openalex.org/W2137993938","https://openalex.org/W2138443476","https://openalex.org/W2140483277","https://openalex.org/W2141288070","https://openalex.org/W2141568746","https://openalex.org/W2142026383","https://openalex.org/W2142089847","https://openalex.org/W2143022663","https://openalex.org/W2143537925","https://openalex.org/W2144062723","https://openalex.org/W2144154026","https://openalex.org/W2144312885","https://openalex.org/W2145274822","https://openalex.org/W2145727462","https://openalex.org/W2146350496","https://openalex.org/W2147769421","https://openalex.org/W2147777354","https://openalex.org/W2148200419","https://openalex.org/W2148849694","https://openalex.org/W2149572906","https://openalex.org/W2149967205","https://openalex.org/W2150965482","https://openalex.org/W2151291389","https://openalex.org/W2152139403","https://openalex.org/W2152247516","https://openalex.org/W2152277071","https://openalex.org/W2153197888","https://openalex.org/W2153997486","https://openalex.org/W2154381385","https://openalex.org/W2154745705","https://openalex.org/W2154986076","https://openalex.org/W2155103945","https://openalex.org/W2155414543","https://openalex.org/W2155808288","https://openalex.org/W2156257249","https://openalex.org/W2157793073","https://openalex.org/W2159199900","https://openalex.org/W2159650080","https://openalex.org/W2159881501","https://openalex.org/W2160059463","https://openalex.org/W2160153640","https://openalex.org/W2160165018","https://openalex.org/W2160345685","https://openalex.org/W2160444453","https://openalex.org/W2161298791","https://openalex.org/W2161529502","https://openalex.org/W2162471699","https://openalex.org/W2162487261","https://openalex.org/W2164017119","https://openalex.org/W2164018922","https://openalex.org/W2164400934","https://openalex.org/W2164599679","https://openalex.org/W2164984188","https://openalex.org/W2165179185","https://openalex.org/W2165204791","https://openalex.org/W2165260158","https://openalex.org/W2165764599","https://openalex.org/W2165997736","https://openalex.org/W2166601968","https://openalex.org/W2166972682","https://openalex.org/W2167184679","https://openalex.org/W2168979257","https://openalex.org/W2169756921","https://openalex.org/W2169963343","https://openalex.org/W2171352413","https://openalex.org/W2171407623","https://openalex.org/W2176072857","https://openalex.org/W2177493225","https://openalex.org/W2185410203","https://openalex.org/W2186079830","https://openalex.org/W2294341179","https://openalex.org/W2313281565","https://openalex.org/W2314477394","https://openalex.org/W2316940481","https://openalex.org/W2322037963","https://openalex.org/W2325417132","https://openalex.org/W2327096119","https://openalex.org/W2335695853","https://openalex.org/W2336704086","https://openalex.org/W2356484699","https://openalex.org/W2404597399","https://openalex.org/W2408829284","https://openalex.org/W2433571176","https://openalex.org/W2475714656","https://openalex.org/W2481122189","https://openalex.org/W2488053420","https://openalex.org/W2502780592","https://openalex.org/W2503456313","https://openalex.org/W2747160572","https://openalex.org/W2972632131","https://openalex.org/W3140738769","https://openalex.org/W4243914857","https://openalex.org/W7095701206"],"related_works":["https://openalex.org/W1998841485","https://openalex.org/W2164018922","https://openalex.org/W2967981572","https://openalex.org/W2003185547","https://openalex.org/W2159199900","https://openalex.org/W2056079046","https://openalex.org/W2023419617","https://openalex.org/W2106647194","https://openalex.org/W2082094973","https://openalex.org/W6983553384"],"abstract_inverted_index":{"In":[0,20,57,76,155],"the":[1,9,21,58,66,77,96,109,117,133,156,162,203,285],"studies":[2],"described":[3],"in":[4,40,85,100,123,172,209,215,260],"this":[5],"dissertation,":[6],"we":[7,64,94,159,180],"investigated":[8,84],"roles":[10],"of":[11,25,81,98,111,135,153,164,184,205,213,239,272,287],"p53":[12,26,112,173,177,185,247],"in\\nnormal":[13],"development,":[14],"teratogen-induced":[15,288],"apoptosis,":[16],"and":[17,27,33,69,87,106,115,126,137,144,274,284],"birth":[18],"defects.":[19],"first":[22],"study,\\nthe":[23],"activation":[24,110],"its":[28],"target":[29],"genes,":[30],"p21,":[31],"NOXA,":[32],"PUMA,":[34],"were":[35,147,169,197],"examined\\nduring":[36],"neural":[37,54,73,281],"tube":[38,55,74,282],"closure":[39],"mouse":[41,89,102],"embryos":[42,90,244,261],"exposed":[43,262],"to":[44,52,104,120,176,257,263],"hyperthermia":[45],"(HS)":[46],"or":[47],"4-\\nperoxycyclophosphamide":[48],"(4CP),":[49],"teratogens":[50],"known":[51],"induce":[53],"defects\\n(NTDs).":[56],"second":[59,157],"study,":[60,79,158],"using":[61],"p53-deficient":[62,101],"mice,":[63],"examined":[65,95],"expression":[67,134,163],"of\\nmRNAs":[68],"microRNAs":[70],"(miRNAs)":[71],"during":[72],"closure.":[75],"third":[78],"the\\nincidence":[80],"NTDs":[82,258],"was":[83,241],"p53-":[86],"p21-deficient":[88],"exposed\\nto":[91],"HS.":[92,206,264],"Finally,":[93],"induction":[97],"apoptosis":[99,240,253,273],"embryos\\nexposed":[103],"HS.\\nHS":[105],"4CP":[107],"induced":[108,132],"by":[113],"phosphorylation":[114],"accumulation\\nof":[116],"protein,":[118],"leading":[119],"an":[121,210],"increase":[122],"p21":[124,200,218],"proteins":[125,146,225],"mRNAs.":[127],"Although":[128],"HS":[129,207],"and\\n4CP":[130],"also":[131],"Noxa":[136],"Puma":[138],"mRNAs,":[139],"no":[140,195],"significant":[141],"increases":[142],"in\\nNOXA":[143],"PUMA":[145],"observed,":[148],"suggesting":[149,249],"a":[150,236,246],"possible":[151],"role":[152],"transcriptionindependent\\napoptosis.":[154],"showed":[160,181,234],"that":[161,182,222,235,250,269],"388":[165],"genes\\nand":[166],"5":[167],"miRNAs":[168],"significantly":[170],"altered":[171],"-/-":[174,186,201],"compared":[175],"+/+":[178],"embryos.\\nFinally,":[179],"10%":[183],"pups":[187],"exhibit":[188],"exencephaly,":[189],"spina":[190],"bifida,":[191],"and/or\\npreaxial":[192],"polydactyly,":[193],"whereas":[194],"malformations":[196],"observed":[198,242,259],"among":[199],"offspring\\nin":[202],"absence":[204],"resulted":[208],"increased":[211],"incidence":[212],"exencephaly":[214],"both":[216],"p53\\nand":[217],"null":[219],"mice":[220],"indicating":[221],"these":[223],"two":[224],"act":[226],"as":[227],"teratogen":[228],"suppressors.":[229],"Our":[230],"preliminary":[231],"data":[232],"additionally":[233],"decreased":[237],"level":[238],"in\\nHS-treated":[243],"lacking":[245],"allele,":[248],"too":[251],"little":[252],"may":[254],"be\\ncausally":[255],"linked":[256],"Taken":[265],"together,":[266],"these\\nstudies":[267],"suggest":[268],"precise":[270],"control":[271],"cell":[275],"cycle":[276],"arrest":[277],"pathways":[278],"are\\ncritical":[279],"for":[280],"development":[283],"prevention":[286],"NTDs.":[289]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
