{"id":"https://openalex.org/W2280484307","doi":"https://doi.org/10.1007/s00439-016-1638-x","title":"Gene co-expression analysis identifies brain regions and cell types involved in migraine pathophysiology: a GWAS-based study using the Allen Human Brain Atlas","display_name":"Gene co-expression analysis identifies brain regions and cell types involved in migraine pathophysiology: a GWAS-based study using the Allen Human Brain Atlas","publication_year":2016,"publication_date":"2016-02-22","ids":{"openalex":"https://openalex.org/W2280484307","doi":"https://doi.org/10.1007/s00439-016-1638-x","mag":"2280484307","pmid":"https://pubmed.ncbi.nlm.nih.gov/26899160","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4796339"},"language":"en","primary_location":{"id":"doi:10.1007/s00439-016-1638-x","doi":"https://doi.org/10.1007/s00439-016-1638-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00439-016-1638-x","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00439-016-1638-x.pdf","source":{"id":"https://openalex.org/S199832308","display_name":"Human Genetics","issn_l":"0018-7348","issn":["0018-7348","0340-6717","1432-1203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s00439-016-1638-x.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001447660","display_name":"Else Eising","orcid":"https://orcid.org/0000-0001-9819-1260","observed_orcids":["https://orcid.org/0000-0001-9819-1260"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Else Eising","raw_affiliation_strings":["Department of Human Genetics, Leiden University Medical Center, 2333 ZC, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, Leiden University Medical Center, 2333 ZC, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054898871","display_name":"Sjoerd M. H. Huisman","orcid":"https://orcid.org/0000-0002-4322-8289","observed_orcids":["https://orcid.org/0000-0002-4322-8289"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]},{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Sjoerd M. H. Huisman","raw_affiliation_strings":["Delft Bioinformatics Lab, Department of Intelligent Systems, Delft University of Technology, 2628 CD, Delft, The Netherlands","Division of Image Processing, Department of Radiology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Delft Bioinformatics Lab, Department of Intelligent Systems, Delft University of Technology, 2628 CD, Delft, The Netherlands","institution_ids":["https://openalex.org/I98358874"]},{"raw_affiliation_string":"Division of Image Processing, Department of Radiology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006562407","display_name":"Ahmed Essam Mahfouz","orcid":"https://orcid.org/0000-0001-8601-2149","observed_orcids":["https://orcid.org/0000-0001-8601-2149"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]},{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ahmed Mahfouz","raw_affiliation_strings":["Delft Bioinformatics Lab, Department of Intelligent Systems, Delft University of Technology, 2628 CD, Delft, The Netherlands","Division of Image Processing, Department of Radiology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Delft Bioinformatics Lab, Department of Intelligent Systems, Delft University of Technology, 2628 CD, Delft, The Netherlands","institution_ids":["https://openalex.org/I98358874"]},{"raw_affiliation_string":"Division of Image Processing, Department of Radiology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027776168","display_name":"Lisanne S. Vijfhuizen","orcid":"https://orcid.org/0000-0003-1614-4589","observed_orcids":["https://orcid.org/0000-0003-1614-4589"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Lisanne S. Vijfhuizen","raw_affiliation_strings":["Department of Human Genetics, Leiden University Medical Center, 2333 ZC, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, Leiden University Medical Center, 2333 ZC, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003550354","display_name":"Verneri Anttila","orcid":"https://orcid.org/0000-0002-0073-4675","observed_orcids":["https://orcid.org/0000-0002-0073-4675"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4392738323","display_name":"Stanley Center for Psychiatric Research","ror":"https://ror.org/01tm9b530","country_code":"US","type":"facility","lineage":["https://openalex.org/I107606265","https://openalex.org/I4392738323"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Verneri Anttila","raw_affiliation_strings":["Analytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA","Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA","Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Analytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I4392738323"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028361855","display_name":"Bendik Slagsvold Winsvold","orcid":"https://orcid.org/0000-0003-4171-8919","observed_orcids":["https://orcid.org/0000-0003-4171-8919"]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]},{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Bendik S. Winsvold","raw_affiliation_strings":["FORMI and Department of Neurology, Oslo University Hospital and University of Oslo, 0424, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FORMI and Department of Neurology, Oslo University Hospital and University of Oslo, 0424, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175","https://openalex.org/I184942183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044562854","display_name":"Tobias Kurth","orcid":"https://orcid.org/0000-0001-7169-2620","observed_orcids":["https://orcid.org/0000-0001-7169-2620","https://orcid.org/0000-0002-8994-7860"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Tobias Kurth","raw_affiliation_strings":["Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02215-1204, USA","Institute of Public Health, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, 10117, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02215-1204, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Institute of Public Health, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, 10117, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036303967","display_name":"M. Arfan Ikram","orcid":"https://orcid.org/0000-0003-0372-8585","observed_orcids":["https://orcid.org/0000-0003-0372-8585"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"M. Arfan Ikram","raw_affiliation_strings":["Department of Epidemiology, Erasmus University Medical Centre, 3015 CE, Rotterdam, The Netherlands","Department of Neurology, Erasmus University Medical Centre, 3015 CE, Rotterdam, The Netherlands","Department of Radiology, Erasmus University Medical Centre, 3015 CE, Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Erasmus University Medical Centre, 3015 CE, Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I2801952686"]},{"raw_affiliation_string":"Department of Neurology, Erasmus University Medical Centre, 3015 CE, Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I2801952686"]},{"raw_affiliation_string":"Department of Radiology, Erasmus University Medical Centre, 3015 CE, Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026012400","display_name":"Tobias M. Freilinger","orcid":"https://orcid.org/0009-0007-8071-1521","observed_orcids":["https://orcid.org/0009-0007-8071-1521"]},"institutions":[{"id":"https://openalex.org/I3018771216","display_name":"LMU Klinikum","ror":"https://ror.org/02jet3w32","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I4210141865","display_name":"Hertie Institute for Clinical Brain Research","ror":"https://ror.org/04zzwzx41","country_code":"DE","type":"other","lineage":["https://openalex.org/I4210094118","https://openalex.org/I4210141865","https://openalex.org/I8087733"]},{"id":"https://openalex.org/I4405259612","display_name":"Institut f\u00fcr Schlaganfall- und Demenzforschung","ror":"https://ror.org/02fa5cb34","country_code":"DE","type":"education","lineage":["https://openalex.org/I3018771216","https://openalex.org/I4405259612","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tobias Freilinger","raw_affiliation_strings":["Department of Neurology and Epileptology and Hertie-Institute for Clinical Brain Research, University of T\u00fcbingen, 72076, T\u00fcbingen, Germany","Institute for Stroke and Dementia Research, Klinikum der Universit\u00e4t M\u00fcnchen, Ludwig-Maximillians-Universit\u00e4t, 81377, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology and Epileptology and Hertie-Institute for Clinical Brain Research, University of T\u00fcbingen, 72076, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210141865","https://openalex.org/I8087733"]},{"raw_affiliation_string":"Institute for Stroke and Dementia Research, Klinikum der Universit\u00e4t M\u00fcnchen, Ludwig-Maximillians-Universit\u00e4t, 81377, Munich, Germany","institution_ids":["https://openalex.org/I3018771216","https://openalex.org/I4405259612","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002275174","display_name":"Jaakko A. Kaprio","orcid":"https://orcid.org/0000-0002-3716-2455","observed_orcids":["https://orcid.org/0000-0002-3716-2455"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Jaakko Kaprio","raw_affiliation_strings":["Department of Public Health, University of Helsinki, 00014, Helsinki, Finland","Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00290, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health, University of Helsinki, 00014, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00290, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079752137","display_name":"Dorret Irene Boomsma","orcid":"https://orcid.org/0000-0002-7099-7972","observed_orcids":["https://orcid.org/0000-0002-7099-7972"]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Dorret I. Boomsma","raw_affiliation_strings":["Department of Biological Psychology, VU University, 1081 HV, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Psychology, VU University, 1081 HV, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I865915315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017009749","display_name":"Cornelia M. van Duijn","orcid":"https://orcid.org/0000-0002-2374-9204","observed_orcids":["https://orcid.org/0000-0002-2374-9204","https://orcid.org/0000-0001-8766-6224"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Cornelia M. van Duijn","raw_affiliation_strings":["Department of Epidemiology, Erasmus University Medical Centre, 3015 CE, Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Erasmus University Medical Centre, 3015 CE, Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068508022","display_name":"Marjo\u2010Riitta J\u00e4rvelin","orcid":"https://orcid.org/0000-0002-2149-0630","observed_orcids":["https://orcid.org/0000-0002-2149-0630","https://orcid.org/0000-0003-0271-9732"]},"institutions":[{"id":"https://openalex.org/I2799272722","display_name":"Oulu University Hospital","ror":"https://ror.org/045ney286","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2799272722"]},{"id":"https://openalex.org/I4392738229","display_name":"MRC Centre for Environment and Health","ror":"https://ror.org/01vw4c203","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4392738229","https://openalex.org/I47508984","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]},{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]}],"countries":["FI","GB"],"is_corresponding":false,"raw_author_name":"Marjo-Riitta R. J\u00e4rvelin","raw_affiliation_strings":["Biocenter Oulu, University of Oulu, Aapistie 5A, P.O. Box 5000, 90014, Oulu, Finland","Center for Life-Course Health Research and Northern Finland Cohort Center, Faculty of Medicine, University of Oulu, P.O. Box 5000, 90014, Oulu, Finland","Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, W2 1PG, UK","Unit of Primary Care, Oulu University Hospital, Kajaanintie 50, 90029 OYS, P.O. Box 20, 90220, Oulu, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biocenter Oulu, University of Oulu, Aapistie 5A, P.O. Box 5000, 90014, Oulu, Finland","institution_ids":["https://openalex.org/I98381234"]},{"raw_affiliation_string":"Center for Life-Course Health Research and Northern Finland Cohort Center, Faculty of Medicine, University of Oulu, P.O. Box 5000, 90014, Oulu, Finland","institution_ids":["https://openalex.org/I98381234"]},{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, W2 1PG, UK","institution_ids":["https://openalex.org/I4392738229","https://openalex.org/I47508984"]},{"raw_affiliation_string":"Unit of Primary Care, Oulu University Hospital, Kajaanintie 50, 90029 OYS, P.O. Box 20, 90220, Oulu, Finland","institution_ids":["https://openalex.org/I2799272722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017788181","display_name":"John\u2010Anker Zwart","orcid":"https://orcid.org/0000-0001-5721-0154","observed_orcids":["https://orcid.org/0000-0001-5721-0154"]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]},{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"John-Anker Zwart","raw_affiliation_strings":["FORMI and Department of Neurology, Oslo University Hospital and University of Oslo, 0424, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FORMI and Department of Neurology, Oslo University Hospital and University of Oslo, 0424, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175","https://openalex.org/I184942183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107458942","display_name":"Lydia Quaye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lydia Quaye","raw_affiliation_strings":["Department of Twin Research and Genetic Epidemiology, King's College London, London, SE1 7EH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Twin Research and Genetic Epidemiology, King's College London, London, SE1 7EH, UK","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023211986","display_name":"David Peter Strachan","orcid":"https://orcid.org/0000-0001-7854-1366","observed_orcids":["https://orcid.org/0000-0001-7854-1366"]},"institutions":[{"id":"https://openalex.org/I165862685","display_name":"St George's, University of London","ror":"https://ror.org/040f08y74","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I165862685","https://openalex.org/I4401726869"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David P. Strachan","raw_affiliation_strings":["Population Health Research Institute, St George's, University of London, London, SW17 0RE, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Population Health Research Institute, St George's, University of London, London, SW17 0RE, UK","institution_ids":["https://openalex.org/I165862685"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013481773","display_name":"Christian Kubisch","orcid":"https://orcid.org/0000-0003-4220-0978","observed_orcids":["https://orcid.org/0000-0003-4220-0978"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Kubisch","raw_affiliation_strings":["Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061123357","display_name":"Martin Dichgans","orcid":"https://orcid.org/0000-0002-0654-387X","observed_orcids":["https://orcid.org/0000-0002-0654-387X","https://orcid.org/0000-0003-0810-2178"]},"institutions":[{"id":"https://openalex.org/I3018771216","display_name":"LMU Klinikum","ror":"https://ror.org/02jet3w32","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I4210113080","display_name":"Munich Cluster for Systems Neurology","ror":"https://ror.org/025z3z560","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210113080","https://openalex.org/I62916508","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I4405259612","display_name":"Institut f\u00fcr Schlaganfall- und Demenzforschung","ror":"https://ror.org/02fa5cb34","country_code":"DE","type":"education","lineage":["https://openalex.org/I3018771216","https://openalex.org/I4405259612","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin Dichgans","raw_affiliation_strings":["Institute for Stroke and Dementia Research, Klinikum der Universit\u00e4t M\u00fcnchen, Ludwig-Maximillians-Universit\u00e4t, 81377, Munich, Germany","Munich Cluster for Systems Neurology (SyNergy), 81377, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Stroke and Dementia Research, Klinikum der Universit\u00e4t M\u00fcnchen, Ludwig-Maximillians-Universit\u00e4t, 81377, Munich, Germany","institution_ids":["https://openalex.org/I3018771216","https://openalex.org/I4405259612","https://openalex.org/I8204097"]},{"raw_affiliation_string":"Munich Cluster for Systems Neurology (SyNergy), 81377, Munich, Germany","institution_ids":["https://openalex.org/I4210113080"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013184354","display_name":"George Davey Smith","orcid":"https://orcid.org/0000-0002-1407-8314","observed_orcids":["https://orcid.org/0000-0002-1407-8314"]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]},{"id":"https://openalex.org/I4387155195","display_name":"MRC Integrative Epidemiology Unit","ror":"https://ror.org/030qtrs05","country_code":"GB","type":"facility","lineage":["https://openalex.org/I36234482","https://openalex.org/I4210087105","https://openalex.org/I4387155195","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"George Davey Smith","raw_affiliation_strings":["Medical Research Council Integrative Epidemiology Unit (IEU), School of Social and Community Medicine, University of Bristol, Bristol, BS8 2PS, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Integrative Epidemiology Unit (IEU), School of Social and Community Medicine, University of Bristol, Bristol, BS8 2PS, UK","institution_ids":["https://openalex.org/I36234482","https://openalex.org/I4387155195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018239255","display_name":"K\u0101ri Stef\u00e1nsson","orcid":"https://orcid.org/0000-0003-1676-864X","observed_orcids":["https://orcid.org/0000-0003-1676-864X"]},"institutions":[{"id":"https://openalex.org/I1327191685","display_name":"deCODE Genetics (Iceland)","ror":"https://ror.org/04dzdm737","country_code":"IS","type":"company","lineage":["https://openalex.org/I1327191685"]},{"id":"https://openalex.org/I165368041","display_name":"University of Iceland","ror":"https://ror.org/01db6h964","country_code":"IS","type":"education","lineage":["https://openalex.org/I165368041"]}],"countries":["IS"],"is_corresponding":false,"raw_author_name":"Kari Stefansson","raw_affiliation_strings":["School of Medicine, University of Iceland, 101, Reykjavik, Iceland","deCODE Genetics, 101, Reykjavik, Iceland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, University of Iceland, 101, Reykjavik, Iceland","institution_ids":["https://openalex.org/I165368041"]},{"raw_affiliation_string":"deCODE Genetics, 101, Reykjavik, Iceland","institution_ids":["https://openalex.org/I1327191685"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085708490","display_name":"Aarno V. Palotie","orcid":"https://orcid.org/0000-0002-2527-5874","observed_orcids":["https://orcid.org/0000-0002-2527-5874"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I4392738323","display_name":"Stanley Center for Psychiatric Research","ror":"https://ror.org/01tm9b530","country_code":"US","type":"facility","lineage":["https://openalex.org/I107606265","https://openalex.org/I4392738323"]}],"countries":["FI","US"],"is_corresponding":false,"raw_author_name":"Aarno Palotie","raw_affiliation_strings":["Analytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA","Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00290, Helsinki, Finland","Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA","Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Analytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00290, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"raw_affiliation_string":"Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I4392738323"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013920089","display_name":"Daniel I. Chasman","orcid":"https://orcid.org/0000-0003-3357-0862","observed_orcids":["https://orcid.org/0000-0003-3357-0862"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel I. Chasman","raw_affiliation_strings":["Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02215-1204, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02215-1204, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039941295","display_name":"Michel Dominique Ferrari","orcid":"https://orcid.org/0000-0001-9691-9449","observed_orcids":["https://orcid.org/0000-0001-9691-9449"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Michel D. Ferrari","raw_affiliation_strings":["Department of Neurology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054269152","display_name":"Gisela Marie Terwindt","orcid":"https://orcid.org/0000-0003-3140-6882","observed_orcids":["https://orcid.org/0000-0003-3140-6882"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Gisela M. Terwindt","raw_affiliation_strings":["Department of Neurology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044520975","display_name":"Boukje de Vries","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Boukje de Vries","raw_affiliation_strings":["Department of Human Genetics, Leiden University Medical Center, 2333 ZC, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, Leiden University Medical Center, 2333 ZC, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042709773","display_name":"Dale R. Nyholt","orcid":"https://orcid.org/0000-0001-7159-3040","observed_orcids":["https://orcid.org/0000-0001-7159-3040"]},"institutions":[{"id":"https://openalex.org/I160993911","display_name":"Queensland University of Technology","ror":"https://ror.org/03pnv4752","country_code":"AU","type":"education","lineage":["https://openalex.org/I160993911"]},{"id":"https://openalex.org/I217937681","display_name":"QIMR Berghofer Medical Research Institute","ror":"https://ror.org/004y8wk30","country_code":"AU","type":"facility","lineage":["https://openalex.org/I217937681"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Dale R. Nyholt","raw_affiliation_strings":["Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Brisbane, QLD, 4059, Australia","Queensland Institute of Medical Research (QIMR) Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Brisbane, QLD, 4059, Australia","institution_ids":["https://openalex.org/I160993911"]},{"raw_affiliation_string":"Queensland Institute of Medical Research (QIMR) Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia","institution_ids":["https://openalex.org/I217937681"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019003563","display_name":"Boudewijn P. F. Lelieveldt","orcid":"https://orcid.org/0000-0001-8269-7603","observed_orcids":["https://orcid.org/0000-0001-8269-7603"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]},{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Boudewijn P. F. Lelieveldt","raw_affiliation_strings":["Delft Bioinformatics Lab, Department of Intelligent Systems, Delft University of Technology, 2628 CD, Delft, The Netherlands","Division of Image Processing, Department of Radiology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Delft Bioinformatics Lab, Department of Intelligent Systems, Delft University of Technology, 2628 CD, Delft, The Netherlands","institution_ids":["https://openalex.org/I98358874"]},{"raw_affiliation_string":"Division of Image Processing, Department of Radiology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012664216","display_name":"Arn M. J. M. van den Maagdenberg","orcid":"https://orcid.org/0000-0002-9310-5535","observed_orcids":["https://orcid.org/0000-0002-9310-5535"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Arn M. J. M. van den Maagdenberg","raw_affiliation_strings":["Department of Human Genetics, Leiden University Medical Center, 2333 ZC, Leiden, The Netherlands. A.M.J.M.van_den_Maagdenberg@lumc.nl","Department of Neurology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands. A.M.J.M.van_den_Maagdenberg@lumc.nl","Department of Neurology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, Leiden University Medical Center, 2333 ZC, Leiden, The Netherlands. A.M.J.M.van_den_Maagdenberg@lumc.nl","institution_ids":["https://openalex.org/I2800006345"]},{"raw_affiliation_string":"Department of Neurology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands. A.M.J.M.van_den_Maagdenberg@lumc.nl","institution_ids":["https://openalex.org/I2800006345"]},{"raw_affiliation_string":"Department of Neurology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052699801","display_name":"Marcel J. T. Reinders","orcid":"https://orcid.org/0000-0002-1148-1562","observed_orcids":["https://orcid.org/0000-0002-1148-1562"]},"institutions":[{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Marcel J. T. Reinders","raw_affiliation_strings":["Delft Bioinformatics Lab, Department of Intelligent Systems, Delft University of Technology, 2628 CD, Delft, The Netherlands. m.j.t.reinders@tudelft.nl","Delft Bioinformatics Lab, Department of Intelligent Systems, Delft University of Technology, 2628 CD, Delft, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Delft Bioinformatics Lab, Department of Intelligent Systems, Delft University of Technology, 2628 CD, Delft, The Netherlands. m.j.t.reinders@tudelft.nl","institution_ids":["https://openalex.org/I98358874"]},{"raw_affiliation_string":"Delft Bioinformatics Lab, Department of Intelligent Systems, Delft University of Technology, 2628 CD, Delft, The Netherlands","institution_ids":["https://openalex.org/I98358874"]}]}],"institutions":[],"countries_distinct_count":8,"institutions_distinct_count":33,"corresponding_author_ids":["https://openalex.org/A5012664216","https://openalex.org/A5052699801"],"corresponding_institution_ids":["https://openalex.org/I2800006345","https://openalex.org/I98358874"],"apc_list":{"value":3690,"currency":"USD","value_usd":3690},"apc_paid":{"value":3690,"currency":"USD","value_usd":3690},"fwci":8.2885,"has_fulltext":true,"cited_by_count":56,"citation_normalized_percentile":{"value":0.97988097,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"135","issue":"4","first_page":"425","last_page":"439"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/migraine","display_name":"migraine","score":0.9869999885559082},{"id":"https://openalex.org/keywords/migraine-pathophysiology","display_name":"migraine pathophysiology","score":0.9599999785423279},{"id":"https://openalex.org/keywords/gene-co-expression","display_name":"gene co-expression","score":0.7770000100135803},{"id":"https://openalex.org/keywords/brain-regions","display_name":"brain regions","score":0.5979999899864197},{"id":"https://openalex.org/keywords/cell-types","display_name":"cell types","score":0.8379999995231628},{"id":"https://openalex.org/keywords/allen-human-brain-atlas","display_name":"Allen Human Brain Atlas","score":0.7400000095367432},{"id":"https://openalex.org/keywords/gene-co-expression-modules","display_name":"gene co-expression modules","score":0.7110000252723694},{"id":"https://openalex.org/keywords/gene-co-expression-network","display_name":"gene co-expression network","score":0.7870000004768372},{"id":"https://openalex.org/keywords/neurotransmission","display_name":"neurotransmission","score":0.7549999952316284},{"id":"https://openalex.org/keywords/mitochondria","display_name":"mitochondria","score":0.8199999928474426},{"id":"https://openalex.org/keywords/oligodendrocytes","display_name":"oligodendrocytes","score":0.8970000147819519},{"id":"https://openalex.org/keywords/cerebellum","display_name":"cerebellum","score":0.8880000114440918},{"id":"https://openalex.org/keywords/cortex","display_name":"cortex","score":0.7419999837875366},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.722000002861023},{"id":"https://openalex.org/keywords/protein-degradation","display_name":"protein degradation","score":0.8840000033378601}],"concepts":[{"id":"https://openalex.org/C2778541695","wikidata":"https://www.wikidata.org/wiki/Q133823","display_name":"Migraine","level":2,"score":0.79703688621521},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.7359694242477417},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6745257377624512},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5346658825874329},{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.5307092070579529},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4023432731628418},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3329432010650635},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19452494382858276},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18346130847930908},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.13485977053642273},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.09204912185668945}],"mesh":[{"descriptor_ui":"D001271","descriptor_name":"Atlases as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":23,"locations":[{"id":"doi:10.1007/s00439-016-1638-x","doi":"https://doi.org/10.1007/s00439-016-1638-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00439-016-1638-x","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00439-016-1638-x.pdf","source":{"id":"https://openalex.org/S199832308","display_name":"Human Genetics","issn_l":"0018-7348","issn":["0018-7348","0340-6717","1432-1203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Genetics","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3796117","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4796339","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4796339","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4796339","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hum Genet","raw_type":"Text"},{"id":"pmid:26899160","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26899160","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human genetics","raw_type":"Journal Article"},{"id":"pmh:oai:pure.eur.nl:openaire/9db5ee62-231e-4bdb-aa25-9e54d757342c","doi":null,"is_oa":true,"landing_page_url":"https://pure.eur.nl/en/publications/9db5ee62-231e-4bdb-aa25-9e54d757342c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:research.vu.nl:openaire/d6e9d257-70d7-4dc1-adfd-d01b3add03d1","doi":null,"is_oa":true,"landing_page_url":"https://research.vu.nl/en/publications/d6e9d257-70d7-4dc1-adfd-d01b3add03d1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401107","display_name":"VU Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I865915315","host_organization_name":"Vrije Universiteit Amsterdam","host_organization_lineage":["https://openalex.org/I865915315"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:openaccess.sgul.ac.uk:107772","doi":null,"is_oa":false,"landing_page_url":"http://openaccess.sgul.ac.uk/107772/1/Gene%20co%2Dexpression%20analysis%20identifies%20brain%20regions%20and%20cell%20types%20involved%20in%20migraine%20pathophysiology:%20a%20GWAS%2Dbased%20study%20using%20the%20Allen%20Human%20Brain%20Atlas..pdf","pdf_url":"http://openaccess.sgul.ac.uk/107772/1/Gene%20co%2Dexpression%20analysis%20identifies%20brain%20regions%20and%20cell%20types%20involved%20in%20migraine%20pathophysiology:%20a%20GWAS%2Dbased%20study%20using%20the%20Allen%20Human%20Brain%20Atlas..pdf","source":{"id":"https://openalex.org/S4306400552","display_name":"St George's Online Research Archive (St George's University of London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165862685","host_organization_name":"St George's, University of London","host_organization_lineage":["https://openalex.org/I165862685"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:eprints.qut.edu.au:110392","doi":null,"is_oa":true,"landing_page_url":"https://eprints.qut.edu.au/110392/1/s00439-016-1638-x.pdf","pdf_url":"https://eprints.qut.edu.au/110392/1/s00439-016-1638-x.pdf","source":{"id":"https://openalex.org/S4306402607","display_name":"QUT ePrints (Queensland University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I160993911","host_organization_name":"Queensland University of Technology","host_organization_lineage":["https://openalex.org/I160993911"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Human Genetics","raw_type":"Contribution to Journal"},{"id":"pmh:oai:eprints.qut.edu.au:222180","doi":null,"is_oa":true,"landing_page_url":"https://eprints.qut.edu.au/222180/1/s00439-016-1638-x.pdf","pdf_url":"https://eprints.qut.edu.au/222180/1/s00439-016-1638-x.pdf","source":{"id":"https://openalex.org/S4306402607","display_name":"QUT ePrints (Queensland University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I160993911","host_organization_name":"Queensland University of Technology","host_organization_lineage":["https://openalex.org/I160993911"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Human Genetics","raw_type":"Contribution to Journal"},{"id":"pmh:oai:research-information.bris.ac.uk:openaire/a244268a-8623-4ced-b49f-bad91cc64006","doi":null,"is_oa":true,"landing_page_url":"https://research-information.bris.ac.uk/en/publications/a244268a-8623-4ced-b49f-bad91cc64006","pdf_url":"https://research-information.bris.ac.uk/files/90448131/art_3A10.1007_2Fs00439_016_1638_x.pdf","source":{"id":"https://openalex.org/S4306400895","display_name":"Bristol Research (University of Bristol)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I36234482","host_organization_name":"University of Bristol","host_organization_lineage":["https://openalex.org/I36234482"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Eising, E, Huisman, S, Mahfouz, A, Vijfhuizen, L, Anttila, V, Winsvold, B S, Kurth, T, Ikram, M A, Freilinger, T, Kaprio, J, Boomsma, D I, van Duijn, C M, Davey Smith, G, van den Maagdenberg, A M J M & Reinders, M J T 2016, 'Gene co-expression analysis identifies brain regions and cell types involved in migraine pathophysiology : a GWAS-based study using the Allen Human Brain Atlas', Human Genetics, vol. 135, no. 4, pp. 425-439. https://doi.org/10.1007/s00439-016-1638-x","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dash.harvard.edu:1/26860309","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:26860309","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:eur:oai:pure.eur.nl:publications/9db5ee62-231e-4bdb-aa25-9e54d757342c","doi":null,"is_oa":true,"landing_page_url":"https://pure.eur.nl/en/publications/9db5ee62-231e-4bdb-aa25-9e54d757342c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Human Genetics, 135(4), 425 - 439. Springer-Verlag","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:eur:oai:repub.eur.nl:85327","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1765/85327","pdf_url":null,"source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Human Genetics, 135(4), 425 - 439","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:lumc:oai:scholarlypublications.universiteitleiden.nl:item_2998289","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1887/112498","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Human Genetics, 135(4), 425 - 439","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:alma.31UKB_LEU:9940750983402711","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1887/112498","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Human Genetics, Vol. 135, no. 4, p. 425-439","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:escidoc.org:escidoc:2315761","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11858/00-001M-0000-002B-024D-5","pdf_url":null,"source":{"id":"https://openalex.org/S7407052962","display_name":"Max Planck Digital Library","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210088280","host_organization_name":"Max Planck Digital Library","host_organization_lineage":["https://openalex.org/I4210088280"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:helda.helsinki.fi:10138/161279","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/161279","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:openaccess.leidenuniv.nl:1887/112498","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1887/112498","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"135","raw_type":"Article / Letter to editor"},{"id":"pmh:oai:pure.mpg.de:item_2315761","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11858/00-001M-0000-002B-024D-5","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Human Genetics","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:repub.eur.nl:85327","doi":null,"is_oa":false,"landing_page_url":"https://repub.eur.nl/pub/85327","pdf_url":null,"source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Human Genetics vol. 135 no. 4, pp. 425-439","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:scholarlypublications.universiteitleiden.nl:item_2998289","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1887/112498","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Human Genetics","raw_type":"Article / Letter to editor"},{"id":"pmh:oai:spiral.imperial.ac.uk:10044/1/38375","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10044/1/38375","pdf_url":null,"source":{"id":"https://openalex.org/S4306401396","display_name":"Spiral (Imperial College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I47508984","host_organization_name":"Imperial College London","host_organization_lineage":["https://openalex.org/I47508984"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"439","raw_type":"Journal Article"},{"id":"pmh:vu:oai:research.vu.nl:publications/d6e9d257-70d7-4dc1-adfd-d01b3add03d1","doi":null,"is_oa":true,"landing_page_url":"https://research.vu.nl/en/publications/d6e9d257-70d7-4dc1-adfd-d01b3add03d1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Human Genetics, 135(4), 425 - 439. Springer Verlag","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1007/s00439-016-1638-x","doi":"https://doi.org/10.1007/s00439-016-1638-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00439-016-1638-x","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00439-016-1638-x.pdf","source":{"id":"https://openalex.org/S199832308","display_name":"Human Genetics","issn_l":"0018-7348","issn":["0018-7348","0340-6717","1432-1203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Genetics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1095062678","display_name":"The Human Brain Project","funder_award_id":"604102","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G1144258087","display_name":null,"funder_award_id":"604102","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G1844275805","display_name":null,"funder_award_id":"12721","funder_id":"https://openalex.org/F4320334893","funder_display_name":"Stichting voor de Technische Wetenschappen"},{"id":"https://openalex.org/G2050597735","display_name":"Mechanisms and Treatment of Migraine and its Chronification","funder_award_id":"602633","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G2138066930","display_name":null,"funder_award_id":"STW Project 12721","funder_id":"https://openalex.org/F4320334893","funder_display_name":"Stichting voor de Technische Wetenschappen"},{"id":"https://openalex.org/G3445821079","display_name":null,"funder_award_id":"MR/N01104X/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G3987576704","display_name":null,"funder_award_id":"050\u2010060\u2010409","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G4467937127","display_name":"The Avon Longitudinal Study for Parents and Children: An international resource for population genomic and lifecourse epidemiology. Core programme support 2014-2019.","funder_award_id":"102215","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G4598234423","display_name":null,"funder_award_id":"602633","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G5882002799","display_name":"The Women's Health Study: Infrastructure Support for Continued Cohort Follow-up","funder_award_id":"UM1CA182913","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6689231961","display_name":null,"funder_award_id":"MC_PC_15018","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G8293913073","display_name":null,"funder_award_id":"602633","funder_id":"https://openalex.org/F4320334960","funder_display_name":"Seventh Framework Programme"},{"id":"https://openalex.org/G8750896698","display_name":null,"funder_award_id":"604102","funder_id":"https://openalex.org/F4320334960","funder_display_name":"Seventh Framework Programme"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"},{"id":"https://openalex.org/F4320328608","display_name":"Centre for Medical Systems Biology","ror":"https://ror.org/00e7dfm13"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334893","display_name":"Stichting voor de Technische Wetenschappen","ror":"https://ror.org/057tq3593"},{"id":"https://openalex.org/F4320334960","display_name":"Seventh Framework Programme","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2280484307.pdf","grobid_xml":"https://content.openalex.org/works/W2280484307.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W46438429","https://openalex.org/W1500980879","https://openalex.org/W1841463848","https://openalex.org/W1848644457","https://openalex.org/W1964610585","https://openalex.org/W1966049079","https://openalex.org/W1967158398","https://openalex.org/W1969509610","https://openalex.org/W1973157975","https://openalex.org/W1974479808","https://openalex.org/W1978150238","https://openalex.org/W1988626104","https://openalex.org/W1995839968","https://openalex.org/W2008022422","https://openalex.org/W2009742334","https://openalex.org/W2011410325","https://openalex.org/W2012555794","https://openalex.org/W2022689242","https://openalex.org/W2025197615","https://openalex.org/W2025549939","https://openalex.org/W2027455260","https://openalex.org/W2043601400","https://openalex.org/W2044325685","https://openalex.org/W2053863093","https://openalex.org/W2054275187","https://openalex.org/W2055448024","https://openalex.org/W2055655674","https://openalex.org/W2055850604","https://openalex.org/W2060705109","https://openalex.org/W2061093976","https://openalex.org/W2063829584","https://openalex.org/W2067414866","https://openalex.org/W2069107563","https://openalex.org/W2070215711","https://openalex.org/W2071598557","https://openalex.org/W2074274058","https://openalex.org/W2081038787","https://openalex.org/W2082095188","https://openalex.org/W2083472882","https://openalex.org/W2085607345","https://openalex.org/W2089007824","https://openalex.org/W2096043905","https://openalex.org/W2097795961","https://openalex.org/W2101071606","https://openalex.org/W2104156485","https://openalex.org/W2119942549","https://openalex.org/W2122708962","https://openalex.org/W2123675905","https://openalex.org/W2128676798","https://openalex.org/W2129185980","https://openalex.org/W2131075613","https://openalex.org/W2136453726","https://openalex.org/W2147059013","https://openalex.org/W2148564836","https://openalex.org/W2159059192","https://openalex.org/W2160259152","https://openalex.org/W2163946681","https://openalex.org/W2166504702","https://openalex.org/W2167806431","https://openalex.org/W2260830658","https://openalex.org/W2323758675","https://openalex.org/W2326795202","https://openalex.org/W2571918371","https://openalex.org/W2769724041","https://openalex.org/W4211163766","https://openalex.org/W4294329053"],"related_works":["https://openalex.org/W2954614170","https://openalex.org/W2569188662","https://openalex.org/W3209284804","https://openalex.org/W7160896739","https://openalex.org/W4309043931","https://openalex.org/W7128161028","https://openalex.org/W4416966318","https://openalex.org/W4380201832","https://openalex.org/W4406624964","https://openalex.org/W4389437591"],"abstract_inverted_index":{"Migraine":[0,22],"is":[1,23],"a":[2,40,129,181],"common":[3],"disabling":[4],"neurovascular":[5],"brain":[6,72,115,193,215],"disorder":[7],"typically":[8],"characterised":[9],"by":[10,25],"attacks":[11],"of":[12,28,59,106,120,128,191],"severe":[13],"headache":[14],"and":[15,19,30,74,99,149,160,162,165,195,217],"associated":[16,44],"with":[17,45,53,125],"autonomic":[18],"neurological":[20],"symptoms.":[21],"caused":[24],"an":[26],"interplay":[27],"genetic":[29,42],"environmental":[31],"factors.":[32],"Genome-wide":[33],"association":[34,124],"studies":[35],"(GWAS)":[36],"have":[37],"identified":[38],"over":[39],"dozen":[41],"loci":[43],"migraine.":[46,126],"Here,":[47],"we":[48,87,102,171],"integrated":[49],"migraine":[50,82,97,130,142,178,223],"GWAS":[51,93,131,179],"data":[52,58,94,117],"high-resolution":[54],"spatial":[55],"gene":[56,188],"expression":[57,116],"normal":[60],"adult":[61],"brains":[62],"from":[63,95,176],"the":[64,152,158,173,177,201,207],"Allen":[65],"Human":[66],"Brain":[67],"Atlas":[68],"to":[69,183],"identify":[70],"specific":[71],"regions":[73,194,216],"molecular":[75],"pathways":[76,196,218],"that":[77,109,122,138,197,213],"are":[78,219],"possibly":[79],"involved":[80,221],"in":[81,141,151,157,167,200,206,222],"pathophysiology.":[83,224],"To":[84],"this":[85],"end,":[86],"used":[88,172],"two":[89],"complementary":[90],"methods.":[91],"In":[92],"23,285":[96],"cases":[98],"95,425":[100],"controls,":[101],"first":[103,202],"studied":[104],"modules":[105,137],"co-expressed":[107],"genes":[108,121,175],"were":[110,198],"calculated":[111],"based":[112],"on":[113],"human":[114],"for":[118,135],"enrichment":[119],"showed":[123],"Enrichment":[127],"signal":[132],"was":[133],"found":[134],"five":[136],"suggest":[139],"involvement":[140],"pathophysiology":[143],"of:":[144],"(i)":[145],"neurotransmission,":[146],"protein":[147],"catabolism":[148],"mitochondria":[150,166],"cortex;":[153],"(ii)":[154],"transcription":[155],"regulation":[156],"cortex":[159],"cerebellum;":[161],"(iii)":[163],"oligodendrocytes":[164],"subcortical":[168],"areas.":[169],"Second,":[170],"high-confidence":[174],"as":[180],"basis":[182],"construct":[184],"local":[185],"migraine-related":[186],"co-expression":[187],"networks.":[189],"Signatures":[190],"all":[192],"prominent":[199],"method":[203],"also":[204],"surfaced":[205],"second":[208],"method,":[209],"thus":[210],"providing":[211],"support":[212],"these":[214],"indeed":[220]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
