{"id":"https://openalex.org/W2280218404","doi":"https://doi.org/10.1155/2016/9571464","title":"Brain Activation and Psychomotor Speed in Middle-Aged Patients with Type 1 Diabetes: Relationships with Hyperglycemia and Brain Small Vessel Disease","display_name":"Brain Activation and Psychomotor Speed in Middle-Aged Patients with Type 1 Diabetes: Relationships with Hyperglycemia and Brain Small Vessel Disease","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2280218404","doi":"https://doi.org/10.1155/2016/9571464","mag":"2280218404","pmid":"https://pubmed.ncbi.nlm.nih.gov/26998494","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4779538"},"language":"en","primary_location":{"id":"doi:10.1155/2016/9571464","doi":"https://doi.org/10.1155/2016/9571464","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2016/9571464","pdf_url":"http://downloads.hindawi.com/journals/jdr/2016/9571464.pdf","source":{"id":"https://openalex.org/S4210192749","display_name":"Journal of Diabetes Research","issn_l":"2314-6745","issn":["2314-6745","2314-6753"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Diabetes Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://downloads.hindawi.com/journals/jdr/2016/9571464.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026999160","display_name":"Misun Hwang","orcid":"https://orcid.org/0000-0002-0125-2686","observed_orcids":["https://orcid.org/0000-0002-0125-2686"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Misun Hwang","raw_affiliation_strings":["Department of Radiology, University of Pittsburgh, 3600 Forbes Avenue, Plaza Level, Pittsburgh, PA 15213, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, University of Pittsburgh, 3600 Forbes Avenue, Plaza Level, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001794663","display_name":"Dana Tudorascu","orcid":"https://orcid.org/0000-0003-4675-3692","observed_orcids":["https://orcid.org/0000-0003-4675-3692"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dana L. Tudorascu","raw_affiliation_strings":["Department of Internal Medicine, Department of Psychiatry, and Department of Biostatistics, University of Pittsburgh, 200 Meyran Avenue, Suite 326, Pittsburgh, PA 15213, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Department of Psychiatry, and Department of Biostatistics, University of Pittsburgh, 200 Meyran Avenue, Suite 326, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075842398","display_name":"Karen A. Nunley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen Nunley","raw_affiliation_strings":["Department of Epidemiology, University of Pittsburgh, 130 N. Bellefield Avenue, Suite 443, Pittsburgh, PA 15213, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, University of Pittsburgh, 130 N. Bellefield Avenue, Suite 443, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002115637","display_name":"Helmet Talib Karim","orcid":"https://orcid.org/0000-0002-9286-0694","observed_orcids":["https://orcid.org/0000-0002-9286-0694"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Helmet Karim","raw_affiliation_strings":["Department of Bioengineering, University of Pittsburgh, 253 Sterling Plaza, Pittsburgh, PA 15213, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Pittsburgh, 253 Sterling Plaza, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056508217","display_name":"Howard Jay Aizenstein","orcid":"https://orcid.org/0000-0003-4897-6582","observed_orcids":["https://orcid.org/0000-0003-4897-6582"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Howard J. Aizenstein","raw_affiliation_strings":["Department of Psychiatry, University of Pittsburgh, 3811 O\u2019Hara Street, Pittsburgh, PA 15213, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Pittsburgh, 3811 O\u2019Hara Street, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005102981","display_name":"Trevor John Orchard","orcid":"https://orcid.org/0000-0001-9552-3215","observed_orcids":["https://orcid.org/0000-0001-9552-3215"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Trevor J. Orchard","raw_affiliation_strings":["Department of Epidemiology, University of Pittsburgh, 3512 Fifth Avenue, Pittsburgh, PA 15213, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, University of Pittsburgh, 3512 Fifth Avenue, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087201620","display_name":"Caterina Rosano","orcid":"https://orcid.org/0000-0002-0909-1506","observed_orcids":["https://orcid.org/0000-0002-0909-1506","https://orcid.org/0000-0002-4271-6010"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Caterina Rosano","raw_affiliation_strings":["Department of Epidemiology, University of Pittsburgh, 130 N. Bellefield Avenue, Suite 467, Pittsburgh, PA 15213, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, University of Pittsburgh, 130 N. Bellefield Avenue, Suite 467, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5087201620"],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":{"value":2760,"currency":"USD","value_usd":2760},"apc_paid":{"value":2760,"currency":"USD","value_usd":2760},"fwci":2.0072,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.86339257,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"2016","issue":null,"first_page":"1","last_page":"11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10042","display_name":"Neural and Behavioral Psychology Studies","score":0.018400000408291817,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10793","display_name":"Diabetes Management and Education","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9639999866485596},{"id":"https://openalex.org/keywords/psychomotor-speed","display_name":"psychomotor speed","score":0.9470000267028809},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.925000011920929},{"id":"https://openalex.org/keywords/brain-activation","display_name":"brain activation","score":0.8410000205039978},{"id":"https://openalex.org/keywords/cerebral-small-vessel-disease","display_name":"cerebral small vessel disease","score":0.8669999837875366},{"id":"https://openalex.org/keywords/processing-speed","display_name":"processing speed","score":0.609000027179718},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.8330000042915344},{"id":"https://openalex.org/keywords/inferior-frontal-gyrus","display_name":"inferior frontal gyrus","score":0.9210000038146973},{"id":"https://openalex.org/keywords/primary-sensorimotor-cortex","display_name":"primary sensorimotor cortex","score":0.8420000076293945},{"id":"https://openalex.org/keywords/superior-parietal-lobule","display_name":"superior parietal lobule","score":0.9089999794960022},{"id":"https://openalex.org/keywords/thalamus","display_name":"thalamus","score":0.8040000200271606},{"id":"https://openalex.org/keywords/cuneus","display_name":"cuneus","score":0.625},{"id":"https://openalex.org/keywords/reaction-time-psychology","display_name":"reaction time (psychology)","score":0.6200000047683716},{"id":"https://openalex.org/keywords/middle-aged-adults","display_name":"middle-aged adults","score":0.8700000047683716}],"concepts":[{"id":"https://openalex.org/C2780608534","wikidata":"https://www.wikidata.org/wiki/Q961620","display_name":"Cuneus","level":4,"score":0.752385139465332},{"id":"https://openalex.org/C2780621315","wikidata":"https://www.wikidata.org/wiki/Q5407200","display_name":"Middle temporal gyrus","level":3,"score":0.6614687442779541},{"id":"https://openalex.org/C164953862","wikidata":"https://www.wikidata.org/wiki/Q7256440","display_name":"Psychomotor learning","level":3,"score":0.6219425797462463},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.604143500328064},{"id":"https://openalex.org/C2779991468","wikidata":"https://www.wikidata.org/wiki/Q3063753","display_name":"Middle frontal gyrus","level":3,"score":0.5787969827651978},{"id":"https://openalex.org/C2776286752","wikidata":"https://www.wikidata.org/wiki/Q5272263","display_name":"Precentral gyrus","level":3,"score":0.5096645355224609},{"id":"https://openalex.org/C2777127467","wikidata":"https://www.wikidata.org/wiki/Q749520","display_name":"Frontal lobe","level":2,"score":0.48699623346328735},{"id":"https://openalex.org/C2778180168","wikidata":"https://www.wikidata.org/wiki/Q815334","display_name":"Parietal lobe","level":2,"score":0.4796871840953827},{"id":"https://openalex.org/C2781099131","wikidata":"https://www.wikidata.org/wiki/Q744385","display_name":"Temporal lobe","level":3,"score":0.4534386396408081},{"id":"https://openalex.org/C2781423396","wikidata":"https://www.wikidata.org/wiki/Q1558534","display_name":"Inferior frontal gyrus","level":3,"score":0.4144759476184845},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4006659984588623},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39458411931991577},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.33401599526405334},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.323543518781662},{"id":"https://openalex.org/C2779226451","wikidata":"https://www.wikidata.org/wiki/Q903809","display_name":"Functional magnetic resonance imaging","level":2,"score":0.3093959093093872},{"id":"https://openalex.org/C2781441883","wikidata":"https://www.wikidata.org/wiki/Q1632835","display_name":"Precuneus","level":3,"score":0.22742342948913574},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.18007156252861023},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.15567809343338013},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.1465039849281311},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001931","descriptor_name":"Brain Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D003925","descriptor_name":"Diabetic Angiopathies","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003925","descriptor_name":"Diabetic Angiopathies","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D003925","descriptor_name":"Diabetic Angiopathies","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003925","descriptor_name":"Diabetic Angiopathies","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006442","descriptor_name":"Glycated Hemoglobin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009483","descriptor_name":"Neuropsychological Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011597","descriptor_name":"Psychomotor Performance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011930","descriptor_name":"Reaction Time","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D059345","descriptor_name":"Cerebral Small Vessel Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D059345","descriptor_name":"Cerebral Small Vessel Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D059345","descriptor_name":"Cerebral Small Vessel Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D059345","descriptor_name":"Cerebral Small Vessel Diseases","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1155/2016/9571464","doi":"https://doi.org/10.1155/2016/9571464","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2016/9571464","pdf_url":"http://downloads.hindawi.com/journals/jdr/2016/9571464.pdf","source":{"id":"https://openalex.org/S4210192749","display_name":"Journal of Diabetes Research","issn_l":"2314-6745","issn":["2314-6745","2314-6753"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Diabetes Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3765871","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4779538","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4779538","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4779538","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Diabetes Res","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5376462","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5376462","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Diabetes Res","raw_type":"Text"},{"id":"pmid:26998494","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26998494","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of diabetes research","raw_type":"Journal Article"},{"id":"pmid:28409161","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28409161","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of diabetes research","raw_type":"Published Erratum"},{"id":"pmh:oai:doaj.org/article:ae76f172a2fd4b5984ee01700bfca176","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ae76f172a2fd4b5984ee01700bfca176","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Diabetes Research, Vol 2016 (2016)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1155/2016/9571464","doi":"https://doi.org/10.1155/2016/9571464","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2016/9571464","pdf_url":"http://downloads.hindawi.com/journals/jdr/2016/9571464.pdf","source":{"id":"https://openalex.org/S4210192749","display_name":"Journal of Diabetes Research","issn_l":"2314-6745","issn":["2314-6745","2314-6753"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Diabetes Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1094250637","display_name":"Epidemiology of Diabetes Complications (EDC) Phase II: renewal","funder_award_id":"R37DK034818","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G1587842475","display_name":null,"funder_award_id":"DK034818","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3692396631","display_name":"Epidemiology of Diabetes Complications (EDC) Phase II: Renewal","funder_award_id":"R01DK034818","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7762699905","display_name":null,"funder_award_id":"RO1DK089028","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8039745786","display_name":"Imaging biomarkers of accelerated brain aging in Type-1 Diabetes","funder_award_id":"R01DK089028","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000154471","display_name":null,"funder_award_id":"DK034818","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000862121","display_name":"Pittsburgh Older Americans Independence Center","funder_award_id":"P30AG024827","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2280218404.pdf","grobid_xml":"https://content.openalex.org/works/W2280218404.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W1548083211","https://openalex.org/W1553269373","https://openalex.org/W1592762266","https://openalex.org/W1918747299","https://openalex.org/W1964311148","https://openalex.org/W1976313368","https://openalex.org/W1977879939","https://openalex.org/W1981628452","https://openalex.org/W1985480637","https://openalex.org/W1985891733","https://openalex.org/W1990396751","https://openalex.org/W1996644269","https://openalex.org/W2003191738","https://openalex.org/W2007812693","https://openalex.org/W2019724009","https://openalex.org/W2020049634","https://openalex.org/W2025163597","https://openalex.org/W2025272839","https://openalex.org/W2026983868","https://openalex.org/W2034721926","https://openalex.org/W2035392048","https://openalex.org/W2044437167","https://openalex.org/W2057920967","https://openalex.org/W2059681996","https://openalex.org/W2061019354","https://openalex.org/W2064330815","https://openalex.org/W2064971077","https://openalex.org/W2066785847","https://openalex.org/W2067820820","https://openalex.org/W2070647100","https://openalex.org/W2078917301","https://openalex.org/W2082065679","https://openalex.org/W2083183563","https://openalex.org/W2092829693","https://openalex.org/W2093095199","https://openalex.org/W2097068600","https://openalex.org/W2103271881","https://openalex.org/W2105525405","https://openalex.org/W2107884508","https://openalex.org/W2109062191","https://openalex.org/W2112770241","https://openalex.org/W2113622874","https://openalex.org/W2116649573","https://openalex.org/W2117796169","https://openalex.org/W2117800611","https://openalex.org/W2126685399","https://openalex.org/W2129885901","https://openalex.org/W2136919205","https://openalex.org/W2137245572","https://openalex.org/W2141628938","https://openalex.org/W2142542516","https://openalex.org/W2144021121","https://openalex.org/W2148751730","https://openalex.org/W2153793093","https://openalex.org/W2168306513","https://openalex.org/W2169579059","https://openalex.org/W2169605136","https://openalex.org/W2171242179","https://openalex.org/W2245415100","https://openalex.org/W2313527545","https://openalex.org/W2316564488","https://openalex.org/W2410963147","https://openalex.org/W2411645407","https://openalex.org/W2472593283","https://openalex.org/W4212838134"],"related_works":["https://openalex.org/W2576384101","https://openalex.org/W2153793093","https://openalex.org/W2768320749","https://openalex.org/W2886847942","https://openalex.org/W2144021121","https://openalex.org/W2061019354","https://openalex.org/W7099005626","https://openalex.org/W3002572116","https://openalex.org/W2948298110","https://openalex.org/W3032422865"],"abstract_inverted_index":{"Slower":[0],"psychomotor":[1,29,74],"speed":[2,30,75,169],"is":[3,25],"very":[4],"common":[5],"in":[6,60,95,109,125,129,147,182,191,194],"patients":[7],"with":[8,27,47,87,92,136,159,166],"type":[9],"1":[10],"diabetes":[11],"mellitus":[12],"(T1D),":[13],"but":[14,176],"the":[15,96,130,148,161,183,195],"underlying":[16],"mechanisms":[17],"are":[18],"not":[19,177],"clear.":[20],"We":[21],"propose":[22],"that":[23],"hyperglycemia":[24,165],"associated":[26,86,135],"slower":[28,167],"via":[31],"disruption":[32],"of":[33,143,156,197],"brain":[34,67,149,174,192],"activation.":[35],"Eighty-five":[36],"adults":[37,158],"(48%":[38],"women,":[39],"mean":[40,44],"age:":[41],"49.0":[42],"years,":[43],"duration:":[45],"40.8)":[46],"childhood":[48],"onset":[49],"T1D":[50],"were":[51,69,141],"recruited":[52],"for":[53,189],"this":[54,154],"cross-sectional":[55],"study.":[56],"Median":[57],"response":[58,89,123,138],"time":[59,90],"seconds":[61],"(longer":[62],"=":[63],"worse":[64],"performance)":[65],"and":[66,91,100,103,117],"activation":[68,94,108,128,193],"measured":[70,80],"while":[71],"performing":[72],"a":[73],"task.":[76],"Exposure":[77],"to":[78,121,171],"hyperglycemia,":[79],"as":[81],"glycosylated":[82],"hemoglobin":[83],"A1c,":[84],"was":[85,119,134],"longer":[88,122],"higher":[93,127],"inferior":[97,110],"frontal":[98,111],"gyrus":[99],"primary":[101,113],"sensorimotor":[102,114],"dorsal":[104],"cingulate":[105],"cortex.":[106],"Higher":[107],"gyrus,":[112],"cortex,":[115],"thalamus,":[116],"cuneus":[118],"related":[120],"times;":[124],"contrast,":[126],"superior":[131,184],"parietal":[132,185],"lobe":[133,186],"shorter":[137],"times.":[139],"Associations":[140],"independent":[142],"small":[144,178],"vessel":[145,179],"disease":[146],"or":[150],"other":[151],"organs.":[152],"In":[153],"group":[155],"middle-aged":[157],"T1D,":[160],"pathway":[162],"linking":[163],"chronic":[164],"processing":[168],"appears":[170],"include":[172],"increased":[173],"activation,":[175],"disease.":[180],"Activation":[181],"may":[187],"compensate":[188],"dysregulation":[190],"presence":[196],"hyperglycemia.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}