{"id":"https://openalex.org/W2280055230","doi":"https://doi.org/10.1200/jco.2004.22.14_suppl.2550","title":"A Phase I evaluation of IFN \u03b1-1b in solid tumors, lymphoma or myeloma","display_name":"A Phase I evaluation of IFN \u03b1-1b in solid tumors, lymphoma or myeloma","publication_year":2004,"publication_date":"2004-07-15","ids":{"openalex":"https://openalex.org/W2280055230","doi":"https://doi.org/10.1200/jco.2004.22.14_suppl.2550","mag":"2280055230"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2004.22.14_suppl.2550","doi":"https://doi.org/10.1200/jco.2004.22.14_suppl.2550","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2004.22.14_suppl.2550","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046567271","display_name":"P. Masci","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. Masci","raw_affiliation_strings":["Cleveland Clinic Foundation, Cleveland, OH; Ministry of Health/Shanghai Institute of Biologic, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic Foundation, Cleveland, OH; Ministry of Health/Shanghai Institute of Biologic, Shanghai, China","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046052708","display_name":"Lisa A Rybicki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Rybicki","raw_affiliation_strings":["Cleveland Clinic Foundation, Cleveland, OH; Ministry of Health/Shanghai Institute of Biologic, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic Foundation, Cleveland, OH; Ministry of Health/Shanghai Institute of Biologic, Shanghai, China","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080314482","display_name":"Khanh Linh Tong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Tong","raw_affiliation_strings":["Cleveland Clinic Foundation, Cleveland, OH; Ministry of Health/Shanghai Institute of Biologic, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic Foundation, Cleveland, OH; Ministry of Health/Shanghai Institute of Biologic, Shanghai, China","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063621818","display_name":"Thomas E. Olencki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. Olencki","raw_affiliation_strings":["Cleveland Clinic Foundation, Cleveland, OH; Ministry of Health/Shanghai Institute of Biologic, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic Foundation, Cleveland, OH; Ministry of Health/Shanghai Institute of Biologic, Shanghai, China","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024321049","display_name":"Barbara Jacobs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. Jacobs","raw_affiliation_strings":["Cleveland Clinic Foundation, Cleveland, OH; Ministry of Health/Shanghai Institute of Biologic, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic Foundation, Cleveland, OH; Ministry of Health/Shanghai Institute of Biologic, Shanghai, China","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113548771","display_name":"L. Wood","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Wood","raw_affiliation_strings":["Cleveland Clinic Foundation, Cleveland, OH; Ministry of Health/Shanghai Institute of Biologic, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic Foundation, Cleveland, OH; Ministry of Health/Shanghai Institute of Biologic, Shanghai, China","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112252438","display_name":"Ernest C. Borden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Borden","raw_affiliation_strings":["Cleveland Clinic Foundation, Cleveland, OH; Ministry of Health/Shanghai Institute of Biologic, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic Foundation, Cleveland, OH; Ministry of Health/Shanghai Institute of Biologic, Shanghai, China","institution_ids":["https://openalex.org/I1316902750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1316902750"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"14_suppl","first_page":"2550","last_page":"2550"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9140999913215637,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9140999913215637,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.022600000724196434,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.009600000455975533,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interferon-alpha-1b","display_name":"interferon alpha-1b","score":0.9610000252723694},{"id":"https://openalex.org/keywords/recombinant-interferon","display_name":"recombinant interferon","score":0.8149999976158142},{"id":"https://openalex.org/keywords/solid-tumors","display_name":"solid tumors","score":0.800000011920929},{"id":"https://openalex.org/keywords/lymphoma","display_name":"lymphoma","score":0.9549999833106995},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.949999988079071},{"id":"https://openalex.org/keywords/metastatic-cancer","display_name":"metastatic cancer","score":0.7400000095367432},{"id":"https://openalex.org/keywords/dose-limiting-toxicity","display_name":"dose-limiting toxicity","score":0.8489999771118164},{"id":"https://openalex.org/keywords/safety-and-tolerability","display_name":"safety and tolerability","score":0.8539999723434448},{"id":"https://openalex.org/keywords/interferon-stimulated-genes","display_name":"interferon-stimulated genes","score":0.8389999866485596},{"id":"https://openalex.org/keywords/beta2-microglobulin","display_name":"beta2-microglobulin","score":0.9789999723434448},{"id":"https://openalex.org/keywords/gtp-cyclohydrolase","display_name":"GTP cyclohydrolase","score":0.9610000252723694},{"id":"https://openalex.org/keywords/isg15","display_name":"ISG15","score":0.9290000200271606},{"id":"https://openalex.org/keywords/trail","display_name":"TRAIL","score":0.9620000123977661},{"id":"https://openalex.org/keywords/renal-cell-carcinoma","display_name":"renal cell carcinoma","score":0.671999990940094}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9400172233581543},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.7620694041252136},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.6678799986839294},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.638202428817749},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5283818244934082},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.477475643157959},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.46462541818618774},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4311378598213196},{"id":"https://openalex.org/C2909179924","wikidata":"https://www.wikidata.org/wiki/Q6046488","display_name":"Alpha interferon","level":3,"score":0.4211941957473755},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.3261284828186035},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.32023996114730835},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.25315356254577637}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1200/jco.2004.22.14_suppl.2550","doi":"https://doi.org/10.1200/jco.2004.22.14_suppl.2550","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2004.22.14_suppl.2550","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"doi:10.1200/jco.2004.22.90140.2550","doi":"https://doi.org/10.1200/jco.2004.22.90140.2550","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2004.22.90140.2550","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2043928247","https://openalex.org/W2027898486","https://openalex.org/W1638582063","https://openalex.org/W1045045433","https://openalex.org/W3179216067","https://openalex.org/W3122717601","https://openalex.org/W193477023","https://openalex.org/W2173422486","https://openalex.org/W2088556774","https://openalex.org/W2035566433"],"abstract_inverted_index":{"2550":[0],"Background:":[1],"Interferon":[2],"alpha":[3],"1":[4],"(IFN":[5],"\u03b1-1)":[6],"has":[7,259],"been":[8],"suggested":[9],"from":[10,74],"prior":[11],"clinical":[12],"data":[13],"to":[14,28,42,61,90,97,157,172,237,271,329],"be":[15],"potentially":[16],"better":[17],"tolerated":[18,318],"than":[19],"IFN":[20,39,47,51,58,102,127,136,165,238,314],"\u03b1-2.":[21],"The":[22],"objectives":[23],"of":[24,36,46,77,101,126,134,164,243],"this":[25],"trial":[26],"were":[27,94,110,116,129,170,204],"confirm":[29],"the":[30,44,75,119,135,158,173,197,207,218,244,255,297,307],"safety,":[31],"tolerability":[32],"and":[33,41,113,143,147,152,176,179,183,193,209,277,281,320],"maximum":[34],"dose":[35,257,299,310],"recombinant":[37],"human":[38,57],"\u03b1-1b":[40,48,59,103,128,166,239,315],"measure":[43],"effects":[45,115,125],"on":[49,69,148],"known":[50],"induced":[52],"gene":[53],"products.":[54],"Methods:":[55],"Recombinant":[56],"purified":[60],"homogeneity":[62],"(specific":[63],"activity":[64],"1.0":[65],"*":[66],"108":[67],"units/mg":[68],"MDBK":[70],"cells)":[71],"was":[72],"obtained":[73],"Ministry":[76],"Public":[78],"Health":[79],"in":[80,196,206,217,229,241,254,294,306],"Shanghai.":[81],"Eligible":[82],"patients":[83,155,169,222,295],"had":[84,260],"histologically":[85],"confirmed":[86,262],"metastatic":[87,249],"malignancy":[88],"refractory":[89],"standard":[91],"treatments.":[92],"Patients":[93,109],"sequentially":[95],"enrolled":[96,156,171],"receive":[98],"increasing":[99],"doses":[100],"administered":[104],"by":[105,118,131],"SQ":[106],"injection":[107],"daily.":[108,167],"monitored":[111],"weekly":[112],"side":[114],"graded":[117],"NCI":[120],"common":[121],"toxicity":[122,235],"criteria.":[123],"Biologic":[124],"assessed":[130],"measuring":[132],"products":[133],"stimulated":[137],"genes":[138],"\u03b22-microglobulin,":[139],"GTP-cyclohydrolase,":[140],"ISG":[141,288],"15":[142,162,289],"TRAIL":[144,301],"at":[145,273],"baseline":[146,272,293],"days":[149,274],"2,":[150,275],"8":[151,276],"29.":[153],"Seven":[154],"first":[159,198],"cohort":[160,258],"received":[161,180],"\u03bcg/m2":[163,185],"Six":[168],"second,":[174],"third":[175,210],"fourth":[177,219],"cohorts":[178,286,311],"45,":[181],"135":[182],"270":[184],"respectively.":[186],"Results:":[187],"Two":[188],"grade":[189,201,233],"III":[190,202,213],"toxicities":[191,203],"(fatigue":[192],"headache)":[194],"occurred":[195,240],"cohort.":[199,220],"No":[200,221,232,325],"observed":[205],"second":[208],"cohorts.":[211,245],"Grade":[212],"fever":[214],"defined":[215],"DLT":[216],"experienced":[223],"significant":[224,268,303,326],"weight":[225],"loss":[226],"or":[227],"decline":[228],"performance":[230],"status.":[231],"IV":[234],"related":[236],"any":[242],"One":[246],"patient":[247],"with":[248],"renal":[250],"cell":[251],"cancer":[252],"treated":[253],"highest":[256],"a":[261],"partial":[263],"response.":[264],"Combined":[265],"analysis":[266],"demonstrated":[267],"increases":[269,305],"compared":[270],"29":[278],"for":[279,283],"\u03b22-microglobulin":[280],"GTP-cyclohydrolase":[282],"all":[284],"four":[285],"(p<0.01).":[287,312],"increased":[290],"significantly":[291],"over":[292],"receiving":[296],"lowest":[298],"while":[300],"showed":[302],"sustained":[304],"three":[308],"higher":[309],"Conclusions:":[313],"appears":[316],"well":[317],"clinically":[319],"demonstrates":[321],"differential":[322],"biologic":[323],"effects.":[324],"financial":[327],"relationships":[328],"disclose.":[330]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}
