{"id":"https://openalex.org/W2279879372","doi":null,"title":"Mechanisms of transcriptional activation of estrogen responsive genes in breast cancer cells","display_name":"Mechanisms of transcriptional activation of estrogen responsive genes in breast cancer cells","publication_year":2009,"publication_date":"2009-06-02","ids":{"openalex":"https://openalex.org/W2279879372","mag":"2279879372"},"language":"en","primary_location":{"id":"pmh:oai:oaktrust.library.tamu.edu:1969.1/ETD-TAMU-1869","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1969.1/ETD-TAMU-1869","pdf_url":null,"source":{"id":"https://openalex.org/S4306400291","display_name":"OakTrust (Texas A&M University Libraries)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I91045830","host_organization_name":"Texas A&M University","host_organization_lineage":["https://openalex.org/I91045830"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010043566","display_name":"Chien-Cheng Chen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Chien-Cheng Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5010043566"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.8090000152587891},{"id":"https://openalex.org/keywords/estrogen-responsive-genes","display_name":"estrogen-responsive genes","score":0.6740000247955322},{"id":"https://openalex.org/keywords/transcriptional-activation","display_name":"transcriptional activation","score":0.8159999847412109},{"id":"https://openalex.org/keywords/nongenomic-estrogen-signaling","display_name":"non-genomic estrogen signaling","score":0.7329999804496765},{"id":"https://openalex.org/keywords/egr1","display_name":"EGR1","score":0.9229999780654907},{"id":"https://openalex.org/keywords/serum-response-element","display_name":"serum response element","score":0.8870000243186951},{"id":"https://openalex.org/keywords/elk-1","display_name":"Elk-1","score":0.9240000247955322},{"id":"https://openalex.org/keywords/serum-response-factor","display_name":"serum response factor","score":0.8510000109672546},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.6919999718666077},{"id":"https://openalex.org/keywords/pi3k-signaling","display_name":"PI3K signaling","score":0.7070000171661377},{"id":"https://openalex.org/keywords/coup-tf1","display_name":"COUP-TF1","score":0.7419999837875366},{"id":"https://openalex.org/keywords/coactivation","display_name":"coactivation","score":0.6230000257492065},{"id":"https://openalex.org/keywords/af-2","display_name":"AF-2","score":0.9599999785423279},{"id":"https://openalex.org/keywords/dna-binding-domain","display_name":"DNA-binding domain","score":0.6909999847412109},{"id":"https://openalex.org/keywords/breast-cancer-cells","display_name":"breast cancer cells","score":0.7490000128746033},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.7710000276565552},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.8640000224113464}],"concepts":[{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.6206743717193604},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.6119177341461182},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.5951763987541199},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5496358871459961},{"id":"https://openalex.org/C51445715","wikidata":"https://www.wikidata.org/wiki/Q410477","display_name":"Hormone response element","level":5,"score":0.5367874503135681},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4580714702606201},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.45139381289482117},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.43262815475463867},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4213923215866089},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.41431811451911926},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3858740031719208},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37529051303863525},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.3491833209991455},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3413354754447937},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2826117277145386},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2695632874965668},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11191630363464355},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10159116983413696}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:oaktrust.library.tamu.edu:1969.1/ETD-TAMU-1869","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1969.1/ETD-TAMU-1869","pdf_url":null,"source":{"id":"https://openalex.org/S4306400291","display_name":"OakTrust (Texas A&M University Libraries)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I91045830","host_organization_name":"Texas A&M University","host_organization_lineage":["https://openalex.org/I91045830"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2279879372","doi":null,"is_oa":false,"landing_page_url":"http://oaktrust.library.tamu.edu/bitstream/1969.1/ETD-TAMU-1869/1/CHEN-DISSERTATION.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":386,"referenced_works":["https://openalex.org/W4443349","https://openalex.org/W53306865","https://openalex.org/W56834202","https://openalex.org/W139260057","https://openalex.org/W160409177","https://openalex.org/W166479034","https://openalex.org/W260259550","https://openalex.org/W1490604571","https://openalex.org/W1493677739","https://openalex.org/W1494515794","https://openalex.org/W1495912963","https://openalex.org/W1497990622","https://openalex.org/W1498355112","https://openalex.org/W1508838109","https://openalex.org/W1511930757","https://openalex.org/W1513368550","https://openalex.org/W1527352757","https://openalex.org/W1531051035","https://openalex.org/W1533942578","https://openalex.org/W1547617108","https://openalex.org/W1551632868","https://openalex.org/W1552727140","https://openalex.org/W1560420809","https://openalex.org/W1566472466","https://openalex.org/W1567559129","https://openalex.org/W1580129093","https://openalex.org/W1588517436","https://openalex.org/W1592463243","https://openalex.org/W1598062712","https://openalex.org/W1602722523","https://openalex.org/W1603613943","https://openalex.org/W1603742465","https://openalex.org/W1608648269","https://openalex.org/W1646199134","https://openalex.org/W1661647511","https://openalex.org/W1662062786","https://openalex.org/W1664472327","https://openalex.org/W1723187988","https://openalex.org/W1745028851","https://openalex.org/W1757562380","https://openalex.org/W1761190703","https://openalex.org/W1765879118","https://openalex.org/W1775510084","https://openalex.org/W1824488209","https://openalex.org/W1833213491","https://openalex.org/W1834339553","https://openalex.org/W1850198354","https://openalex.org/W1898626329","https://openalex.org/W1919133853","https://openalex.org/W1922618037","https://openalex.org/W1957494568","https://openalex.org/W1964195679","https://openalex.org/W1964247465","https://openalex.org/W1964957120","https://openalex.org/W1965687707","https://openalex.org/W1966475217","https://openalex.org/W1967119334","https://openalex.org/W1968905365","https://openalex.org/W1969345387","https://openalex.org/W1969973975","https://openalex.org/W1970316586","https://openalex.org/W1970569586","https://openalex.org/W1970848829","https://openalex.org/W1971147345","https://openalex.org/W1972086601","https://openalex.org/W1972978588","https://openalex.org/W1973038628","https://openalex.org/W1973341497","https://openalex.org/W1973972092","https://openalex.org/W1974545855","https://openalex.org/W1976968355","https://openalex.org/W1976999163","https://openalex.org/W1978978275","https://openalex.org/W1979903836","https://openalex.org/W1980183006","https://openalex.org/W1980611435","https://openalex.org/W1980714126","https://openalex.org/W1981364887","https://openalex.org/W1981467972","https://openalex.org/W1981686096","https://openalex.org/W1981746913","https://openalex.org/W1981813507","https://openalex.org/W1981851893","https://openalex.org/W1983057459","https://openalex.org/W1984975544","https://openalex.org/W1986926802","https://openalex.org/W1987157684","https://openalex.org/W1987183940","https://openalex.org/W1987779399","https://openalex.org/W1988351397","https://openalex.org/W1990065094","https://openalex.org/W1990529844","https://openalex.org/W1990939350","https://openalex.org/W1991834127","https://openalex.org/W1992222695","https://openalex.org/W1992262527","https://openalex.org/W1992808869","https://openalex.org/W1993280298","https://openalex.org/W1994110056","https://openalex.org/W1994219871","https://openalex.org/W1994359425","https://openalex.org/W1994525965","https://openalex.org/W1994673724","https://openalex.org/W1994839764","https://openalex.org/W1994904616","https://openalex.org/W1995754186","https://openalex.org/W1996405087","https://openalex.org/W1996729768","https://openalex.org/W1997779912","https://openalex.org/W1998653181","https://openalex.org/W2000082154","https://openalex.org/W2000269495","https://openalex.org/W2000829661","https://openalex.org/W2000930609","https://openalex.org/W2001444296","https://openalex.org/W2001488290","https://openalex.org/W2002032260","https://openalex.org/W2002050823","https://openalex.org/W2002340616","https://openalex.org/W2003726111","https://openalex.org/W2004023134","https://openalex.org/W2004174427","https://openalex.org/W2005429042","https://openalex.org/W2005766913","https://openalex.org/W2006431526","https://openalex.org/W2007768755","https://openalex.org/W2008632158","https://openalex.org/W2008822380","https://openalex.org/W2009443603","https://openalex.org/W2009558707","https://openalex.org/W2010296464","https://openalex.org/W2011115477","https://openalex.org/W2011192675","https://openalex.org/W2011369010","https://openalex.org/W2011467252","https://openalex.org/W2011935366","https://openalex.org/W2011957030","https://openalex.org/W2012467485","https://openalex.org/W2013582920","https://openalex.org/W2013673460","https://openalex.org/W2013890168","https://openalex.org/W2015357565","https://openalex.org/W2015472477","https://openalex.org/W2015987142","https://openalex.org/W2018211174","https://openalex.org/W2018299273","https://openalex.org/W2018336213","https://openalex.org/W2018410089","https://openalex.org/W2020678193","https://openalex.org/W2020725121","https://openalex.org/W2021451131","https://openalex.org/W2021768020","https://openalex.org/W2022840703","https://openalex.org/W2022989917","https://openalex.org/W2023307129","https://openalex.org/W2023693943","https://openalex.org/W2025267983","https://openalex.org/W2027167250","https://openalex.org/W2027242349","https://openalex.org/W2027395750","https://openalex.org/W2028075225","https://openalex.org/W2028379425","https://openalex.org/W2028691872","https://openalex.org/W2028725230","https://openalex.org/W2029032935","https://openalex.org/W2030103375","https://openalex.org/W2031247571","https://openalex.org/W2031906658","https://openalex.org/W2032227909","https://openalex.org/W2032297232","https://openalex.org/W2032711371","https://openalex.org/W2033354144","https://openalex.org/W2034064102","https://openalex.org/W2035210330","https://openalex.org/W2036290684","https://openalex.org/W2036402179","https://openalex.org/W2037131591","https://openalex.org/W2037330610","https://openalex.org/W2037913174","https://openalex.org/W2038208040","https://openalex.org/W2038364731","https://openalex.org/W2038459913","https://openalex.org/W2041144670","https://openalex.org/W2041642374","https://openalex.org/W2042901562","https://openalex.org/W2043620901","https://openalex.org/W2043681309","https://openalex.org/W2045567585","https://openalex.org/W2046314213","https://openalex.org/W2047556340","https://openalex.org/W2048397315","https://openalex.org/W2049953612","https://openalex.org/W2051115584","https://openalex.org/W2051152566","https://openalex.org/W2051227097","https://openalex.org/W2051596977","https://openalex.org/W2051663421","https://openalex.org/W2052306492","https://openalex.org/W2052977964","https://openalex.org/W2053961392","https://openalex.org/W2054188881","https://openalex.org/W2056155028","https://openalex.org/W2056950843","https://openalex.org/W2057696560","https://openalex.org/W2058903258","https://openalex.org/W2059057915","https://openalex.org/W2059415631","https://openalex.org/W2059506882","https://openalex.org/W2059792018","https://openalex.org/W2060015758","https://openalex.org/W2060275385","https://openalex.org/W2064282853","https://openalex.org/W2065209749","https://openalex.org/W2065282404","https://openalex.org/W2065819260","https://openalex.org/W2067429173","https://openalex.org/W2067781735","https://openalex.org/W2069532898","https://openalex.org/W2070428103","https://openalex.org/W2070907292","https://openalex.org/W2071901592","https://openalex.org/W2072726484","https://openalex.org/W2072787342","https://openalex.org/W2072793384","https://openalex.org/W2073353512","https://openalex.org/W2073883348","https://openalex.org/W2074362522","https://openalex.org/W2075172998","https://openalex.org/W2075788654","https://openalex.org/W2075922536","https://openalex.org/W2076189206","https://openalex.org/W2077657264","https://openalex.org/W2078684758","https://openalex.org/W2078802143","https://openalex.org/W2078950703","https://openalex.org/W2079726561","https://openalex.org/W2080174206","https://openalex.org/W2080459436","https://openalex.org/W2080987913","https://openalex.org/W2081501399","https://openalex.org/W2081662078","https://openalex.org/W2081846665","https://openalex.org/W2083118618","https://openalex.org/W2083907895","https://openalex.org/W2084053175","https://openalex.org/W2084424064","https://openalex.org/W2084722787","https://openalex.org/W2085062279","https://openalex.org/W2085451506","https://openalex.org/W2085995738","https://openalex.org/W2086422627","https://openalex.org/W2087892362","https://openalex.org/W2088002379","https://openalex.org/W2089734899","https://openalex.org/W2090054404","https://openalex.org/W2092327074","https://openalex.org/W2093676604","https://openalex.org/W2094317517","https://openalex.org/W2094838095","https://openalex.org/W2095152292","https://openalex.org/W2095708141","https://openalex.org/W2095949552","https://openalex.org/W2096858800","https://openalex.org/W2096958727","https://openalex.org/W2097611918","https://openalex.org/W2098056422","https://openalex.org/W2100907853","https://openalex.org/W2101073935","https://openalex.org/W2101738855","https://openalex.org/W2102238058","https://openalex.org/W2103009160","https://openalex.org/W2103031848","https://openalex.org/W2103309832","https://openalex.org/W2103970959","https://openalex.org/W2104074771","https://openalex.org/W2104795646","https://openalex.org/W2105846317","https://openalex.org/W2105848735","https://openalex.org/W2106214793","https://openalex.org/W2106787323","https://openalex.org/W2106797333","https://openalex.org/W2110279965","https://openalex.org/W2110328765","https://openalex.org/W2110687233","https://openalex.org/W2111319010","https://openalex.org/W2111650618","https://openalex.org/W2111719548","https://openalex.org/W2113249646","https://openalex.org/W2113422684","https://openalex.org/W2113456624","https://openalex.org/W2113732478","https://openalex.org/W2114334107","https://openalex.org/W2114353725","https://openalex.org/W2115446838","https://openalex.org/W2118144733","https://openalex.org/W2118527372","https://openalex.org/W2118555706","https://openalex.org/W2118650392","https://openalex.org/W2118897660","https://openalex.org/W2120448591","https://openalex.org/W2121456510","https://openalex.org/W2122015809","https://openalex.org/W2122057254","https://openalex.org/W2122399064","https://openalex.org/W2122767915","https://openalex.org/W2122828787","https://openalex.org/W2125471242","https://openalex.org/W2126264787","https://openalex.org/W2131103656","https://openalex.org/W2134106936","https://openalex.org/W2134246871","https://openalex.org/W2134454666","https://openalex.org/W2134461114","https://openalex.org/W2135168517","https://openalex.org/W2135619115","https://openalex.org/W2136032233","https://openalex.org/W2136740910","https://openalex.org/W2139372524","https://openalex.org/W2140388293","https://openalex.org/W2141020434","https://openalex.org/W2141369673","https://openalex.org/W2141686420","https://openalex.org/W2143471382","https://openalex.org/W2143658931","https://openalex.org/W2144783650","https://openalex.org/W2144792857","https://openalex.org/W2144886407","https://openalex.org/W2145303832","https://openalex.org/W2146689455","https://openalex.org/W2147537177","https://openalex.org/W2150408454","https://openalex.org/W2151849975","https://openalex.org/W2151888740","https://openalex.org/W2152067338","https://openalex.org/W2152675122","https://openalex.org/W2152898418","https://openalex.org/W2153111398","https://openalex.org/W2153392210","https://openalex.org/W2153918480","https://openalex.org/W2154005091","https://openalex.org/W2154854793","https://openalex.org/W2156246789","https://openalex.org/W2157530175","https://openalex.org/W2157607230","https://openalex.org/W2157632679","https://openalex.org/W2159867778","https://openalex.org/W2160084272","https://openalex.org/W2160772231","https://openalex.org/W2161121464","https://openalex.org/W2161352669","https://openalex.org/W2162295343","https://openalex.org/W2163339050","https://openalex.org/W2164154631","https://openalex.org/W2164301360","https://openalex.org/W2165064522","https://openalex.org/W2166131386","https://openalex.org/W2166448321","https://openalex.org/W2167978187","https://openalex.org/W2168943199","https://openalex.org/W2170187210","https://openalex.org/W2170728568","https://openalex.org/W2172224570","https://openalex.org/W2172256092","https://openalex.org/W2172295707","https://openalex.org/W2187452737","https://openalex.org/W2216094174","https://openalex.org/W2224584267","https://openalex.org/W2267232346","https://openalex.org/W2271762807","https://openalex.org/W2292736786","https://openalex.org/W2293935040","https://openalex.org/W2312454132","https://openalex.org/W2313869316","https://openalex.org/W2313934125","https://openalex.org/W2315037039","https://openalex.org/W2340617814","https://openalex.org/W2343796556","https://openalex.org/W2406539631","https://openalex.org/W2409129279","https://openalex.org/W2411493061","https://openalex.org/W2415539763","https://openalex.org/W2415833423","https://openalex.org/W2435848038","https://openalex.org/W2502539503","https://openalex.org/W2603306439","https://openalex.org/W2796635798"],"related_works":["https://openalex.org/W2083784140","https://openalex.org/W1987157684","https://openalex.org/W2124359890","https://openalex.org/W2239599272","https://openalex.org/W2039576757","https://openalex.org/W1835355927","https://openalex.org/W2041144670","https://openalex.org/W1969751023","https://openalex.org/W2786165431","https://openalex.org/W2029821696"],"abstract_inverted_index":{"Estrogen":[0],"receptor":[1],"(ER)":[2],"acts":[3],"as":[4],"a":[5,91,125,184,342],"ligand-activated":[6],"transcription":[7],"factor":[8,107],"that":[9,95,159,244,287,318,337],"regulates":[10],"the":[11,33,77,87,140,144,147,211,234,238,264,270,288,305,319],"expression":[12,63],"of":[13,18,24,35,43,56,64,86,115,134,143,168,174,186,201,227,247,258,266,281,294,300,304,308,313,322],"genes.":[14,37,66],"The":[15],"genomic":[16],"mechanisms":[17,42],"ER":[19,25,44],"action":[20,45,170],"include":[21],"ligand-induced":[22],"dimerization":[23],"which":[26,46,60,101,150],"binds":[27],"estrogen":[28,169],"responsive":[29],"elements":[30],"(EREs)":[31],"in":[32,76,109,117,146,183,205,311],"promoters":[34],"target":[36,65],"There":[38],"are":[39,47,178],"also":[40,61,224],"nongenomic":[41],"associated":[48],"with":[49,139,210,233,315,332],"membrane":[50],"bound":[51,102],"or":[52,237],"cytosol":[53],"ER-dependent":[54],"activation":[55,142,173],"various":[57],"protein-kinase":[58],"cascades":[59],"influence":[62],"Egr-1":[67,88,116],"is":[68,163,249,260,268,274,324],"an":[69,132],"immediate-early":[70],"gene":[71],"induced":[72],"by":[73,123,130,153,203,254,278],"17\u03b2-estradiol":[74],"(E2)":[75],"rodent":[78],"uterus":[79],"and":[80,104,156,193,291],"breast":[81],"cancer":[82],"cells.":[83],"Deletion":[84],"analysis":[85],"promoter":[89],"identified":[90],"minimal":[92],"E2-responsive":[93],"region":[94,293],"contained":[96],"serum":[97,105],"response":[98,106],"element":[99],"(SRE3)":[100],"Elk-1":[103],"(SRF)":[108],"gel":[110],"mobility":[111],"shift":[112],"assays.":[113],"Hormone-responsiveness":[114],"MCF-7":[118],"cells":[119,230],"was":[120,151],"specifically":[121],"inhibited":[122,152],"PD98059,":[124],"MAPKK":[126],"inhibitor,":[127],"but":[128,171,218],"not":[129,250],"LY294002,":[131,157],"inhibitor":[133],"PI3-K.":[135],"These":[136,241,334],"results":[137,335],"contrasted":[138],"hormone-dependent":[141],"SRE":[145],"c-fos":[148],"promoter,":[149],"both":[154],"PD98059":[155],"suggesting":[158,317],"Egr-1,":[160],"like":[161],"c-fos,":[162],"activated":[164],"through":[165,172,341],"non-genomic":[166],"pathways":[167],"different":[175],"kinases.":[176],"COUP-TFs":[177],"orphan":[179],"nuclear":[180],"receptors":[181],"expressed":[182],"variety":[185],"tissues":[187],"where":[188],"they":[189],"regulate":[190],"biological":[191],"functions":[192],"organogenesis.":[194],"In":[195],"this":[196],"study,":[197],"we":[198],"investigated":[199],"coactivation":[200,253,277,299,328],"ER\u03b1":[202,228,248,259,267,340],"COUP-TF1":[204],"cell":[206],"lines":[207],"transiently":[208],"cotransfected":[209,232],"pERE3":[212],"construct.":[213],"COUP-TFI":[214,223,255,283,295,309,323,338],"coactivated":[215,339],"ER\u03b1-mediated":[216],"transactivation,":[217],"unlike":[219],"many":[220],"other":[221],"coactivators,":[222],"enhanced":[225],"transactivation":[226],"when":[229,256,263],"were":[231,296],"TAF1-ER\u03b1":[235],"mutant":[236],"19c-ER\u03b1":[239],"mutant.":[240],"data":[242],"indicate":[243],"helix":[245],"12":[246],"required":[251,275],"for":[252,276,298,326],"AF-1":[257,265],"intact.":[261],"However,":[262],"deleted,":[269],"intact":[271],"AF-2":[272],"function":[273],"COUP-TFI.":[279],"Analysis":[280],"multiple":[282],"deletion":[284],"mutants":[285],"showed":[286],"DNA-binding":[289,306,320],"domain":[290,307,321],"C-terminal":[292],"important":[297,325],"ER\u03b1.":[301,333],"Point":[302],"mutations":[303],"resulted":[310],"loss":[312],"interactions":[314,331],"ER\u03b1,":[316],"its":[327],"activity":[329],"facilitating":[330],"demonstrate":[336],"non-classical":[343],"LXXLL-independent":[344],"pathway.":[345]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}