{"id":"https://openalex.org/W2279790677","doi":null,"title":"Epigenetics of lncRNAs","display_name":"Epigenetics of lncRNAs","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2279790677","mag":"2279790677"},"language":"en","primary_location":{"id":"pmh:oai:ddd.uab.cat:146876","doi":null,"is_oa":true,"landing_page_url":"https://ddd.uab.cat/record/146876","pdf_url":"https://ddd.uab.cat/record/146876","source":{"id":"https://openalex.org/S4306400380","display_name":"Dip\u00f2sit Digital de Documents de la UAB (Universitat Aut\u00f2noma de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I123044942","host_organization_name":"Universitat Aut\u00f2noma de Barcelona","host_organization_lineage":["https://openalex.org/I123044942"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Treball final de grau"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ddd.uab.cat/record/146876","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074918537","display_name":"Marta Urtizberea Merino","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marta Urtizberea Merino","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5007482490","display_name":"N\u00e9stor G\u00f3mez","orcid":"https://orcid.org/0000-0002-1348-2737","observed_orcids":["https://orcid.org/0000-0002-1348-2737"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N\u00e8stor G\u00f3mez i Trias","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hotair","display_name":"HOTAIR","score":0.9660000205039978},{"id":"https://openalex.org/keywords/long-non-coding-rna","display_name":"long non-coding RNA","score":0.8999999761581421},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.8610000014305115},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.703000009059906},{"id":"https://openalex.org/keywords/estrogen-response-element","display_name":"estrogen response element","score":0.9890000224113464},{"id":"https://openalex.org/keywords/polycomb-repressive-complex-2","display_name":"polycomb repressive complex 2","score":0.8240000009536743},{"id":"https://openalex.org/keywords/lsd1","display_name":"LSD1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/h3k27me3","display_name":"H3K27me3","score":0.9750000238418579},{"id":"https://openalex.org/keywords/h3k4-demethylation","display_name":"H3K4 demethylation","score":0.9739999771118164},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7940000295639038},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.8730000257492065},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.722000002861023},{"id":"https://openalex.org/keywords/chromatin-modification","display_name":"chromatin modification","score":0.6679999828338623}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.7126244902610779},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5110851526260376},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41696426272392273},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.37605392932891846},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3305927515029907},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3261408805847168},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2542486786842346},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0969136655330658}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:ddd.uab.cat:146876","doi":null,"is_oa":true,"landing_page_url":"https://ddd.uab.cat/record/146876","pdf_url":"https://ddd.uab.cat/record/146876","source":{"id":"https://openalex.org/S4306400380","display_name":"Dip\u00f2sit Digital de Documents de la UAB (Universitat Aut\u00f2noma de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I123044942","host_organization_name":"Universitat Aut\u00f2noma de Barcelona","host_organization_lineage":["https://openalex.org/I123044942"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Treball final de grau"},{"id":"mag:2279790677","doi":null,"is_oa":false,"landing_page_url":"https://ddd.uab.cat/pub/tfg/2015/146876/TFG_martaurtizbereamerino.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"mag:2804553234","doi":null,"is_oa":false,"landing_page_url":"https://ddd.uab.cat/pub/tfg/2015/146876/TFG_martaurtizbereamerino.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:ddd.uab.cat:146876","doi":null,"is_oa":true,"landing_page_url":"https://ddd.uab.cat/record/146876","pdf_url":"https://ddd.uab.cat/record/146876","source":{"id":"https://openalex.org/S4306400380","display_name":"Dip\u00f2sit Digital de Documents de la UAB (Universitat Aut\u00f2noma de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I123044942","host_organization_name":"Universitat Aut\u00f2noma de Barcelona","host_organization_lineage":["https://openalex.org/I123044942"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Treball final de grau"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2279790677.pdf","grobid_xml":"https://content.openalex.org/works/W2279790677.grobid-xml"},"referenced_works_count":6,"referenced_works":["https://openalex.org/W1974450480","https://openalex.org/W2024148591","https://openalex.org/W2079210988","https://openalex.org/W2132015542","https://openalex.org/W2146648170","https://openalex.org/W2171598473"],"related_works":["https://openalex.org/W2804553234","https://openalex.org/W2274304771","https://openalex.org/W2131190398","https://openalex.org/W2170615602","https://openalex.org/W6906809590","https://openalex.org/W2365582964","https://openalex.org/W3029913597","https://openalex.org/W6981552505","https://openalex.org/W2791719456","https://openalex.org/W2946005676"],"abstract_inverted_index":{"HOTAIR":[0,20,56,86,96],"is":[1,82,120],"induced":[2],"by":[3],"estradiol":[4],"(E2)":[5],"in":[6,60],"a":[7,42,99],"dose":[8],"dependant":[9],"manner,":[10],"because":[11],"of":[12,34,41,49,54,73,78],"its":[13,58],"estrogen":[14],"response":[15],"elements":[16],"(EREs)":[17],"[5].":[18],"Regulation\u2022":[19],"recruits":[21],"de":[22],"chromatin":[23],"modifying":[24],"complexes":[25],"PRCS":[26],"and":[27,67],"LSD1.It":[28],"brings":[29],"them":[30],"to":[31,69],"the":[32,70,76,110],"promoter":[33],"their":[35],"target":[36],"genes.\u2022":[37],"PRC2":[38,74],"H3K27me3":[39],"gain":[40],"repressive":[43],"mark\u2022":[44],"LSD1":[45],"demethylation":[46],"H3K4":[47],"loss":[48],"an":[50],"activating":[51],"mark":[52],"Mechanisms":[53],"action\u2022":[55],"incresses":[57],"expression":[59,77,107],"primary":[61],"breast":[62],"cancer":[63],"tissue":[64,105],"2000":[65],"folds,":[66],"metastasizes":[68],"lung.The":[71],"retargeting":[72],"alters":[75],"854":[79],"genes,":[80],"although,":[81],"not":[83],"clearly":[84],"if":[85],"levels":[87],"can":[88,97],"serve":[89],"as":[90],"diagnostic":[91],"or":[92],"prognosis.":[93],"Breast":[94],"cancer\u2022":[95],"be":[98,114],"good":[100],"biomarker":[101],"because:\u2022":[102],"It":[103,119],"has":[104],"specific":[106],"\u2022":[108],"It's":[109],"effector":[111],"molecule\u2022":[112],"Can":[113],"easily":[115,121],"accessible":[116],"(body":[117],"fluids)\u2022":[118],"quantifiable":[122],"[2]":[123]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}