{"id":"https://openalex.org/W2279655414","doi":"https://doi.org/10.25677/js6d-ka97","title":"Thermodynamic and kinetic analyses of androgen and glucocorticoid receptor-promoter interactions suggest phylogenetic partitioning of energetics and the presence of functionally distinct DNA-bound state","display_name":"Thermodynamic and kinetic analyses of androgen and glucocorticoid receptor-promoter interactions suggest phylogenetic partitioning of energetics and the presence of functionally distinct DNA-bound state","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2279655414","doi":"https://doi.org/10.25677/js6d-ka97","mag":"2279655414"},"language":"en","primary_location":{"id":"pmh:doi:10.25677/29keh-m4d76","doi":null,"is_oa":false,"landing_page_url":"https://digitalcollections.cuanschutz.edu/:29keh-m4d76","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.25677/29keh-m4d76","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103682888","display_name":"De Angelis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"De Angelis, Rolando Wray","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5103682888"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.5946999788284302,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.5946999788284302,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.1145000010728836,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.06949999928474426,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":0.996999979019165},{"id":"https://openalex.org/keywords/glucocorticoid-receptor","display_name":"glucocorticoid receptor","score":1.0},{"id":"https://openalex.org/keywords/steroid-hormone-receptors","display_name":"steroid hormone receptors","score":0.7789999842643738},{"id":"https://openalex.org/keywords/transcription-factor-dna-interaction","display_name":"transcription factor-DNA interaction","score":0.8740000128746033},{"id":"https://openalex.org/keywords/receptor-dimerization","display_name":"receptor dimerization","score":0.6959999799728394},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.8579999804496765},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.5249999761581421},{"id":"https://openalex.org/keywords/progesterone-receptor","display_name":"progesterone receptor","score":0.8560000061988831},{"id":"https://openalex.org/keywords/mineralocorticoid-receptor","display_name":"mineralocorticoid receptor","score":0.8870000243186951},{"id":"https://openalex.org/keywords/mouse-mammary-tumor-virus-promoter","display_name":"mouse mammary tumor virus promoter","score":0.7979999780654907}],"concepts":[{"id":"https://openalex.org/C97514900","wikidata":"https://www.wikidata.org/wiki/Q719597","display_name":"Energetics","level":2,"score":0.6905136108398438},{"id":"https://openalex.org/C59493245","wikidata":"https://www.wikidata.org/wiki/Q14877410","display_name":"Glucocorticoid receptor","level":3,"score":0.5028404593467712},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.49214690923690796},{"id":"https://openalex.org/C135889238","wikidata":"https://www.wikidata.org/wiki/Q46276","display_name":"Kinetic energy","level":2,"score":0.48787808418273926},{"id":"https://openalex.org/C193252679","wikidata":"https://www.wikidata.org/wiki/Q242125","display_name":"Phylogenetic tree","level":3,"score":0.47482356429100037},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.46155405044555664},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4508516490459442},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.4300056993961334},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4160207509994507},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3871980607509613},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3571386933326721},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.3249948024749756},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2606038451194763},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2151643931865692},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.10382381081581116},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.07393825054168701},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:doi:10.25677/29keh-m4d76","doi":null,"is_oa":false,"landing_page_url":"https://digitalcollections.cuanschutz.edu/:29keh-m4d76","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"pmh:oai:mountainscholar.org:10968/1166","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10968/1166","pdf_url":null,"source":{"id":"https://openalex.org/S4306402292","display_name":"Digital Collections of Colorado (Colorado State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I92446798","host_organization_name":"Colorado State University","host_organization_lineage":["https://openalex.org/I92446798"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"mag:2279655414","doi":null,"is_oa":false,"landing_page_url":"https://dspace.library.colostate.edu:443/handle/10968/1166","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"doi:10.25677/29keh-m4d76","doi":"https://doi.org/10.25677/29keh-m4d76","is_oa":true,"landing_page_url":"https://doi.org/10.25677/29keh-m4d76","pdf_url":null,"source":{"id":"https://openalex.org/S7407050547","display_name":"University of Colorado: Anschutz Medical Campus","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I51713134","host_organization_name":"University of Colorado Anschutz","host_organization_lineage":["https://openalex.org/I51713134"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"doi:10.25677/js6d-ka97","doi":"https://doi.org/10.25677/js6d-ka97","is_oa":true,"landing_page_url":"https://doi.org/10.25677/js6d-ka97","pdf_url":null,"source":{"id":"https://openalex.org/S7407050547","display_name":"University of Colorado: Anschutz Medical Campus","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I51713134","host_organization_name":"University of Colorado Anschutz","host_organization_lineage":["https://openalex.org/I51713134"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"}],"best_oa_location":{"id":"doi:10.25677/29keh-m4d76","doi":"https://doi.org/10.25677/29keh-m4d76","is_oa":true,"landing_page_url":"https://doi.org/10.25677/29keh-m4d76","pdf_url":null,"source":{"id":"https://openalex.org/S7407050547","display_name":"University of Colorado: Anschutz Medical Campus","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I51713134","host_organization_name":"University of Colorado Anschutz","host_organization_lineage":["https://openalex.org/I51713134"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":74,"referenced_works":["https://openalex.org/W597159688","https://openalex.org/W650214199","https://openalex.org/W1501286679","https://openalex.org/W1504034854","https://openalex.org/W1507863951","https://openalex.org/W1521470590","https://openalex.org/W1541971708","https://openalex.org/W1543166364","https://openalex.org/W1629044468","https://openalex.org/W1632044028","https://openalex.org/W1907321242","https://openalex.org/W1925363699","https://openalex.org/W1960503626","https://openalex.org/W1964520567","https://openalex.org/W1966068861","https://openalex.org/W1971128922","https://openalex.org/W1972197313","https://openalex.org/W1974563661","https://openalex.org/W1975317507","https://openalex.org/W1978237152","https://openalex.org/W1979817391","https://openalex.org/W1987417875","https://openalex.org/W1998105880","https://openalex.org/W2000262156","https://openalex.org/W2000935153","https://openalex.org/W2002662963","https://openalex.org/W2003769338","https://openalex.org/W2005986251","https://openalex.org/W2010764705","https://openalex.org/W2013837963","https://openalex.org/W2014838489","https://openalex.org/W2019424210","https://openalex.org/W2022458056","https://openalex.org/W2023307129","https://openalex.org/W2025919590","https://openalex.org/W2033965812","https://openalex.org/W2036711500","https://openalex.org/W2044203168","https://openalex.org/W2045206677","https://openalex.org/W2053535211","https://openalex.org/W2055654988","https://openalex.org/W2059086045","https://openalex.org/W2059612204","https://openalex.org/W2063233246","https://openalex.org/W2063559733","https://openalex.org/W2066441904","https://openalex.org/W2067722023","https://openalex.org/W2075054508","https://openalex.org/W2077801261","https://openalex.org/W2079768382","https://openalex.org/W2081495213","https://openalex.org/W2082181748","https://openalex.org/W2084424064","https://openalex.org/W2085124463","https://openalex.org/W2089000345","https://openalex.org/W2093016292","https://openalex.org/W2093437789","https://openalex.org/W2096594220","https://openalex.org/W2097371203","https://openalex.org/W2098643358","https://openalex.org/W2102744337","https://openalex.org/W2107093842","https://openalex.org/W2111650618","https://openalex.org/W2111652946","https://openalex.org/W2125957951","https://openalex.org/W2143539785","https://openalex.org/W2144899441","https://openalex.org/W2160534562","https://openalex.org/W2168208027","https://openalex.org/W2169529794","https://openalex.org/W2169993152","https://openalex.org/W2172256092","https://openalex.org/W2340799873","https://openalex.org/W2605614532"],"related_works":["https://openalex.org/W2061676572","https://openalex.org/W1979344867","https://openalex.org/W1925363699","https://openalex.org/W2077801261","https://openalex.org/W1979817391","https://openalex.org/W7043790934","https://openalex.org/W7134979817","https://openalex.org/W2077854579","https://openalex.org/W2098643358","https://openalex.org/W4389022653"],"abstract_inverted_index":{"The":[0],"fundamental":[1],"principles":[2],"governing":[3],"transcriptional":[4],"activation":[5],"in":[6,160,214,300],"higher":[7],"eukaryotes":[8],"are":[9,87,213,289,307],"not":[10],"well":[11],"understood.":[12],"As":[13,51],"a":[14,22,52,136,190,250,311],"step":[15],"towards":[16],"defining":[17],"these":[18,211],"principles,":[19],"we":[20,32,124],"seek":[21],"quantitative":[23],"understanding":[24],"of":[25,47,62,70,76,100,131,155,247,252,279,283,317],"transcription":[26,48,64],"factor":[27,49],"interactions.":[28,50],"To":[29],"this":[30,158,194],"end,":[31],"use":[33],"thermodynamics":[34],"coupled":[35],"with":[36,140,168,197,235,305],"statistical":[37],"thermodynamic":[38,242],"modeling":[39],"and":[40,83,114,121,128,135,202,230,256],"transient":[41,293],"state":[42],"kinetics":[43,246],"to":[44,90,162,216,241,267,281],"elucidate":[45],"mechanisms":[46],"model":[53],"system,":[54],"our":[55,169,198],"lab":[56],"studies":[57,171,199],"the":[58,77,115,126,149,163,173,182,217,224,244,257,268,277],"steroid":[59,94,225],"receptor":[60,80,95,106,109,112,118,221,303],"family":[61,67],"ligand-activated":[63],"factors.":[65],"This":[66],"is":[68,159,166,195,298],"comprised":[69],"two":[71,78,116,204,328,333],"subgroups.":[72],"Subgroup":[73,97],"3A":[74],"consists":[75,99],"estrogen":[79],"isoforms":[81,119],"(ER-\u03b1":[82],"ER-\u03b2),":[84],"receptors":[85,226],"that":[86,148,181,286,321],"closely":[88],"related":[89,103,220],"an":[91,325],"ancient":[92],"ER-like":[93],"ancestor.":[96],"3C":[98,176,207],"more":[101,218,308],"distantly":[102,219],"proteins:":[104],"androgen":[105],"(AR),":[107],"glucocorticoid":[108],"(GR),":[110],"mineralocorticoid":[111],"(MR),":[113],"progesterone":[117],"(PR-A":[120],"PR-B).":[122],"Here,":[123],"investigated":[125],"self-assembly":[127],"promoter":[129,231,262],"energetics":[130,233],"wild":[132],"type":[133],"AR":[134,150,183],"point":[137],"mutation":[138],"associated":[139],"prostate":[141],"cancer":[142],"progression,":[143],"T877A.":[144],"I":[145,178],"first":[146],"found":[147,180],"constructs":[151,184],"show":[152],"no":[153],"evidence":[154],"dimerization.":[156],"Although":[157],"contrast":[161,215,266],"literature,":[164,269],"it":[165],"in-line":[167,234],"previous":[170],"on":[172,200,276],"other":[174,205],"subgroup":[175,206],"members.":[177,208],"also":[179],"display":[185],"strong":[186],"intersite":[187],"cooperativity":[188],"at":[189],"two-site":[191],"promoter.":[192],"Again,":[193],"consistent":[196],"PR-B":[201],"GR,":[203],"Taken":[209],"together,":[210],"results":[212],"ER-\u03b1.":[222],"Thus,":[223],"partition":[227],"their":[228,236],"self-association":[229],"assembly":[232],"phylogenetic":[237],"divergence.":[238],"In":[239,265],"addition":[240],"studies,":[243],"dissociation":[245,297,323],"GR":[248,270,296,322],"from":[249,272],"panel":[251],"six":[253],"response":[254,274],"elements":[255,275],"mouse":[258],"mammary":[259],"tumor":[260],"virus":[261],"were":[263],"examined.":[264],"dissociates":[271],"its":[273],"timescale":[278],"seconds":[280],"tens":[282],"seconds,":[284],"indicating":[285],"receptor-DNA":[287],"interactions":[288,304],"primarily":[290],"responsible":[291],"for":[292],"behavior.":[294],"Also,":[295],"biphasic":[299],"character,":[301],"suggesting":[302,332],"DNA":[306],"complex":[309],"than":[310],"rigid":[312],"body":[313],"interaction.":[314],"Direct":[315],"fitting":[316],"kinetic":[318],"data":[319],"indicates":[320],"involves":[324],"isomerization":[326],"between":[327],"distinct":[329,335],"GR-DNA":[330],"states,":[331],"functionally":[334],"states.":[336]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
