{"id":"https://openalex.org/W2279592199","doi":null,"title":"The effect of oncogenes on the growth and differentiation of oligodendrocyte type 2 astrocyte progenitor cells.","display_name":"The effect of oncogenes on the growth and differentiation of oligodendrocyte type 2 astrocyte progenitor cells.","publication_year":1995,"publication_date":"1995-01-01","ids":{"openalex":"https://openalex.org/W2279592199","mag":"2279592199","pmid":"https://pubmed.ncbi.nlm.nih.gov/7718486"},"language":"en","primary_location":{"id":"pmid:7718486","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7718486","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031478913","display_name":"Susan Carol Barnett","orcid":"https://orcid.org/0000-0003-1009-0575","observed_orcids":["https://orcid.org/0000-0003-1009-0575"]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S C Barnett","raw_affiliation_strings":["Department of Neurology, University of Glasgow"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Glasgow","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109449194","display_name":"Dorothy H. Crouch","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D H Crouch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3993,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.52714286,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"6","issue":"1","first_page":"69","last_page":"80"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.7728999853134155,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.7728999853134155,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.19429999589920044,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oncogenes","display_name":"oncogenes","score":0.996999979019165},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.8240000009536743},{"id":"https://openalex.org/keywords/sv40-large-t-antigen","display_name":"SV40 large T antigen","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ras","display_name":"Ras","score":0.703000009059906},{"id":"https://openalex.org/keywords/src-kinase","display_name":"Src kinase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/glial-differentiation","display_name":"glial differentiation","score":0.6169999837875366},{"id":"https://openalex.org/keywords/cell-immortalization","display_name":"cell immortalization","score":0.796999990940094},{"id":"https://openalex.org/keywords/glioma","display_name":"glioma","score":0.9409999847412109},{"id":"https://openalex.org/keywords/oncogenic-cooperation","display_name":"oncogene cooperation","score":0.8240000009536743},{"id":"https://openalex.org/keywords/retroviral-vectors","display_name":"retroviral vectors","score":0.7089999914169312},{"id":"https://openalex.org/keywords/temperature-sensitive-sv40-t-antigen","display_name":"temperature-sensitive SV40 T antigen","score":0.6579999923706055}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8710507750511169},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.7730159759521484},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.6974964141845703},{"id":"https://openalex.org/C2776985911","wikidata":"https://www.wikidata.org/wiki/Q916698","display_name":"Oligodendrocyte","level":4,"score":0.6849793195724487},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.5851986408233643},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.5317942500114441},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5254546403884888},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.5141820907592773},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5137358903884888},{"id":"https://openalex.org/C15729860","wikidata":"https://www.wikidata.org/wiki/Q2329919","display_name":"Progenitor","level":4,"score":0.4617938995361328},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.40854912996292114},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.39017197489738464},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34225696325302124},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.3295783996582031},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.29500874876976013},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.27963709831237793},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.195545494556427},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1803169846534729},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.1432180106639862},{"id":"https://openalex.org/C2778609137","wikidata":"https://www.wikidata.org/wiki/Q105790271","display_name":"Myelin","level":3,"score":0.13980883359909058}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005904","descriptor_name":"Glial Fibrillary Acidic Protein","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D009836","descriptor_name":"Oligodendroglia","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D009836","descriptor_name":"Oligodendroglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009857","descriptor_name":"Oncogenes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009900","descriptor_name":"Optic Nerve","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011905","descriptor_name":"Genes, ras","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012190","descriptor_name":"Retroviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012190","descriptor_name":"Retroviridae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D016391","descriptor_name":"Genes, src","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:7718486","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7718486","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"mag:2279592199","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7718486","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W99359245","https://openalex.org/W228407023","https://openalex.org/W1574348335","https://openalex.org/W1624896304","https://openalex.org/W1893545268","https://openalex.org/W1967761879","https://openalex.org/W1971955171","https://openalex.org/W1972524334","https://openalex.org/W1985723318","https://openalex.org/W1987107175","https://openalex.org/W1987885030","https://openalex.org/W1989009382","https://openalex.org/W1992656072","https://openalex.org/W1998822013","https://openalex.org/W2006659499","https://openalex.org/W2010488494","https://openalex.org/W2013152746","https://openalex.org/W2013480860","https://openalex.org/W2013973825","https://openalex.org/W2022870173","https://openalex.org/W2031324202","https://openalex.org/W2035208645","https://openalex.org/W2037888087","https://openalex.org/W2038931362","https://openalex.org/W2049856211","https://openalex.org/W2054003244","https://openalex.org/W2063385900","https://openalex.org/W2067809410","https://openalex.org/W2074558188","https://openalex.org/W2091942447","https://openalex.org/W2117066001","https://openalex.org/W2117079180","https://openalex.org/W2133887238","https://openalex.org/W2144634347","https://openalex.org/W2155009866","https://openalex.org/W2156872475","https://openalex.org/W2221064544","https://openalex.org/W2404520726","https://openalex.org/W2411874880","https://openalex.org/W2413929757"],"related_works":["https://openalex.org/W2057279818","https://openalex.org/W1978648109","https://openalex.org/W80223076","https://openalex.org/W2415919235","https://openalex.org/W2090758857","https://openalex.org/W2019152431","https://openalex.org/W2010994870","https://openalex.org/W2039588396","https://openalex.org/W1971526515","https://openalex.org/W2111357533"],"abstract_inverted_index":{"Oncogenes":[0],"represent":[1],"altered":[2],"versions":[3],"of":[4,10,39,47,55,62,108,139,172,178,183,196,206,212,246],"cellular":[5],"genes":[6],"instrumental":[7],"for":[8],"control":[9],"cell":[11,22,49,79,115,152,221],"proliferation":[12],"and":[13,24,32,60,146,161,200,226,238],"differentiation.":[14],"Several":[15],"oncogenes":[16,56,99,133,208],"have":[17],"been":[18],"implicated":[19],"in":[20,26,103,233,243],"glial":[21,48,66,220],"transformation":[23],"immortalization":[25],"culture":[27],"(myc,":[28],"src,":[29],"mos,":[30],"ras,":[31],"SV40":[33,125,148],"large":[34,126,149],"T":[35,127,150],"antigen).":[36],"The":[37,144],"purpose":[38],"this":[40],"study":[41,169,216,231],"is":[42],"to":[43,89,97,157,168,194,230],"further":[44],"our":[45],"understanding":[46],"neoplasia":[50],"by":[51],"investigating":[52],"the":[53,58,70,132,155,170,176,204,210,234,239,244],"effect":[54],"on":[57,175,203],"growth":[59],"differentiation":[61,197,232],"central":[63,235],"nervous":[64,236],"system":[65,229,237],"progenitor":[67,78,114,142],"cells":[68,185],"from":[69],"oligodendrocyte":[71,83],"type":[72],"2":[73],"astrocyte":[74,87],"(O-2A)":[75],"lineage.":[76],"This":[77,215],"differentiates":[80],"into":[81,105,159],"an":[82,166,224],"or":[84,102,124,191],"a":[85],"type-2":[86,162],"according":[88],"environmental":[90],"cues.":[91],"Drug-selectable":[92],"retroviral":[93],"vectors":[94],"were":[95,117,137],"used":[96],"introduce":[98],"either":[100],"alone":[101],"combination":[104,205],"primary":[106],"cultures":[107],"rat":[109],"O-2A":[110,113,141,179],"cells.":[111,143,181],"Established":[112],"lines":[116,153,186,222],"only":[118,135],"obtained":[119],"after":[120],"infection":[121],"with":[122,187],"c-myc":[123],"antigen,":[128],"suggesting":[129],"that":[130,218],"among":[131],"tested":[134],"these":[136,184],"capable":[138],"immortalizing":[140],"O-2A/c-myc":[145],"O-2A/temperature-sensitive":[147],"antigen":[151],"retained":[154],"capacity":[156],"differentiate":[158],"oligodendrocytes":[160],"astrocytes,":[163],"thereby":[164],"providing":[165],"opportunity":[167],"effects":[171],"oncogene":[173],"cooperation":[174],"phenotype":[177],"lineage":[180],"Superinfection":[182],"retroviruses":[188],"encoding":[189],"ras":[190],"src":[192],"led":[193],"abnormalities":[195],"whose":[198],"nature":[199],"severity":[201],"depended":[202],"cooperating":[207],"and/or":[209],"levels":[211],"expression":[213],"obtained.":[214],"demonstrates":[217],"oncogene-modified":[219],"provide":[223],"amenable":[225],"unique":[227],"model":[228],"genetic":[240],"changes":[241],"involved":[242],"development":[245],"glioma.":[247]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
