{"id":"https://openalex.org/W2279570","doi":null,"title":"The dynamics of excitatory synapse formation on dendritic spines.","display_name":"The dynamics of excitatory synapse formation on dendritic spines.","publication_year":2009,"publication_date":"2009-04-27","ids":{"openalex":"https://openalex.org/W2279570","mag":"2279570","pmid":"https://pubmed.ncbi.nlm.nih.gov/20072712","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2805008"},"language":"en","primary_location":{"id":"pmid:20072712","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20072712","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellscience","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2805008/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054258919","display_name":"Michelle D. Amaral","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle D Amaral","raw_affiliation_strings":["Department of Neurobiology, McKnight Brain Institute, The University of Alabama at Birmingham, Birmingham, AL 35294, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, McKnight Brain Institute, The University of Alabama at Birmingham, Birmingham, AL 35294, USA","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080296924","display_name":"Lucas D. Pozzo\u2010Miller","orcid":"https://orcid.org/0000-0001-6085-5527","observed_orcids":["https://orcid.org/0000-0001-6085-5527"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lucas Pozzo-Miller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2343,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.48297393,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"5","issue":"4","first_page":"19","last_page":"25"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dendritic-spines","display_name":"dendritic spines","score":0.878000020980835},{"id":"https://openalex.org/keywords/excitatory-synapse-formation","display_name":"excitatory synapse formation","score":0.9039999842643738},{"id":"https://openalex.org/keywords/spine-maturation","display_name":"spine maturation","score":0.8759999871253967},{"id":"https://openalex.org/keywords/glutamate-uncaging","display_name":"glutamate uncaging","score":0.8080000281333923},{"id":"https://openalex.org/keywords/nmda-receptor-currents","display_name":"NMDA receptor currents","score":0.9940000176429749},{"id":"https://openalex.org/keywords/calcium-transients","display_name":"calcium transients","score":0.8870000243186951},{"id":"https://openalex.org/keywords/ca1-pyramidal-neurons","display_name":"CA1 pyramidal neurons","score":0.9240000247955322},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.875},{"id":"https://openalex.org/keywords/postsynaptic-currents","display_name":"postsynaptic currents","score":0.7490000128746033},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.5619999766349792},{"id":"https://openalex.org/keywords/organotypic-slice-cultures","display_name":"organotypic slice cultures","score":0.6729999780654907}],"concepts":[{"id":"https://openalex.org/C174884520","wikidata":"https://www.wikidata.org/wiki/Q902079","display_name":"Dendritic spine","level":3,"score":0.9079715013504028},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.7496232986450195},{"id":"https://openalex.org/C197341189","wikidata":"https://www.wikidata.org/wiki/Q863533","display_name":"Postsynaptic potential","level":3,"score":0.7390609979629517},{"id":"https://openalex.org/C53250682","wikidata":"https://www.wikidata.org/wiki/Q5256674","display_name":"Dendritic filopodia","level":4,"score":0.7224562764167786},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6900332570075989},{"id":"https://openalex.org/C160268369","wikidata":"https://www.wikidata.org/wiki/Q295251","display_name":"AMPA receptor","level":4,"score":0.6412732005119324},{"id":"https://openalex.org/C127445978","wikidata":"https://www.wikidata.org/wiki/Q187181","display_name":"Synapse","level":2,"score":0.5384021401405334},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.5082309246063232},{"id":"https://openalex.org/C187541742","wikidata":"https://www.wikidata.org/wiki/Q4374336","display_name":"Postsynaptic density","level":4,"score":0.49829983711242676},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49074801802635193},{"id":"https://openalex.org/C154559735","wikidata":"https://www.wikidata.org/wiki/Q7514768","display_name":"Silent synapse","level":5,"score":0.48801055550575256},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.4751719832420349},{"id":"https://openalex.org/C205383261","wikidata":"https://www.wikidata.org/wiki/Q7392570","display_name":"SPINE (molecular biology)","level":2,"score":0.4501285254955292},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.3970337510108948},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3498949408531189},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2478533685207367},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.1910436451435089},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.17701533436775208},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06717905402183533}],"mesh":[],"locations_count":3,"locations":[{"id":"pmid:20072712","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20072712","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellscience","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2805008","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2805008/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cellscience","raw_type":"Text"},{"id":"mag:2279570","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20072712","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2805008","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2805008/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cellscience","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3564953616","display_name":"Actions of BDNF on Ca2+ Signals in Hippocampal Neurons","funder_award_id":"R01NS040593","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1572640432","https://openalex.org/W1577778731","https://openalex.org/W1618384257","https://openalex.org/W1677457722","https://openalex.org/W1983284219","https://openalex.org/W1983553517","https://openalex.org/W1983630632","https://openalex.org/W1998708235","https://openalex.org/W2018554421","https://openalex.org/W2022286642","https://openalex.org/W2032192786","https://openalex.org/W2059890547","https://openalex.org/W2071318481","https://openalex.org/W2092326283","https://openalex.org/W2098917165","https://openalex.org/W2116875316","https://openalex.org/W2117664079","https://openalex.org/W2131039108","https://openalex.org/W2145026073","https://openalex.org/W2148714108","https://openalex.org/W2151251384","https://openalex.org/W2168544268","https://openalex.org/W2485635537"],"related_works":["https://openalex.org/W2098917165","https://openalex.org/W1706034886","https://openalex.org/W2161002250","https://openalex.org/W2064032105","https://openalex.org/W2312670130","https://openalex.org/W2116875316","https://openalex.org/W2054391282","https://openalex.org/W2122092731","https://openalex.org/W2060584787","https://openalex.org/W2141331098"],"abstract_inverted_index":{"Dendritic":[0],"spines,":[1],"the":[2,11,21,66,82,118,121,161,209],"postsynaptic":[3,92,123],"compartments":[4,93],"of":[5,34,40,94,120,139,211,233],"most":[6],"functional":[7,91],"excitatory":[8,95,254],"synapses":[9],"in":[10,29,44,51,100,110,132,136,180,220],"Central":[12],"Nervous":[13],"System":[14],"(CNS),":[15],"are":[16,149,170],"highly":[17],"dynamic":[18,38],"structures,":[19],"having":[20],"ability":[22],"to":[23,31,112,151,153,160,225],"grow,":[24],"change":[25],"shape,":[26],"or":[27],"retract":[28],"response":[30,111],"varying":[32],"levels":[33],"neuronal":[35],"activity.":[36],"This":[37],"nature":[39],"spines":[41,75,131,148,183,189,223,238],"allows":[42],"modifications":[43],"brain":[45],"circuitry":[46],"and":[47,58,70,125,166],"connectivity,":[48],"thus":[49,244],"participating":[50],"fundamental":[52],"processes":[53],"such":[54],"as":[55],"learning,":[56],"recall,":[57],"emotional":[59],"behaviors.":[60],"Although":[61],"many":[62],"studies":[63],"have":[64],"characterized":[65],"precise":[67],"molecular":[68],"identities":[69],"signaling":[71],"pathways":[72],"by":[73,105,241],"which":[74,87],"initially":[76],"form,":[77],"little":[78],"is":[79],"known":[80],"about":[81],"actual":[83],"time":[84],"course":[85],"over":[86],"they":[88],"mature":[89,188,227,253],"into":[90,195],"synapses.":[96,255],"A":[97],"recent":[98],"publication":[99],"Neuron":[101],"addresses":[102],"this":[103],"issue":[104],"studying":[106],"dendritic":[107,147],"spine":[108,164,206],"growth":[109,165],"multiphoton":[113],"glutamate":[114,154,167],"uncaging,":[115],"simultaneously":[116],"monitoring":[117],"amplitudes":[119,179],"resultant":[122],"currents":[124,176,201],"intracellular":[126],"Ca(2+)":[127,212],"transients":[128],"within":[129],"individual":[130],"CA1":[133],"pyramidal":[134],"neurons":[135],"organotypic":[137],"cultures":[138],"postnatal":[140],"hippocampal":[141],"slices.":[142],"The":[143],"authors":[144],"describe":[145],"that":[146,163],"able":[150],"respond":[152],"shortly":[155],"after":[156,205],"their":[157,191],"formation,":[158,207],"leading":[159],"conclusion":[162],"receptor":[168],"recruitment":[169],"closely":[171],"coupled":[172],"temporally.":[173],"AMPA":[174],"receptor-mediated":[175,200],"exhibited":[177],"similar":[178],"newly":[181,221,236],"formed":[182,222,237],"compared":[184,224],"with":[185],"older,":[186,226],"more":[187],"when":[190],"volume":[192],"was":[193,217],"taken":[194],"account.":[196],"In":[197],"addition,":[198],"NMDA":[199],"also":[202],"appeared":[203],"early":[204],"although":[208],"amount":[210],"entry":[213],"through":[214],"these":[215,235],"receptors":[216],"significantly":[218],"lower":[219],"spines.":[228],"Within":[229],"just":[230],"a":[231,246],"couple":[232],"hours,":[234],"were":[239],"contacted":[240],"presynaptic":[242],"terminals,":[243],"acquiring":[245],"morphological":[247],"appearance":[248],"indistinguishable":[249],"from":[250],"already":[251],"existing":[252]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}