{"id":"https://openalex.org/W2279458404","doi":"https://doi.org/10.1016/j.imr.2015.04.064","title":"Effects of Rosae Laevigatae Fructus on the cyclic AMP response element modulator (CREM) expression during spermatogenesis","display_name":"Effects of Rosae Laevigatae Fructus on the cyclic AMP response element modulator (CREM) expression during spermatogenesis","publication_year":2015,"publication_date":"2015-05-01","ids":{"openalex":"https://openalex.org/W2279458404","doi":"https://doi.org/10.1016/j.imr.2015.04.064","mag":"2279458404"},"language":"en","primary_location":{"id":"doi:10.1016/j.imr.2015.04.064","doi":"https://doi.org/10.1016/j.imr.2015.04.064","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.imr.2015.04.064","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2213422015000888/pdf","source":{"id":"https://openalex.org/S2764611727","display_name":"Integrative Medicine Research","issn_l":"2213-4220","issn":["2213-4220","2213-4239"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","kci-registered","norway-1","oarl","poland-40"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Integrative Medicine Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S2213422015000888/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100726314","display_name":"Ho\u2010Jin Lee","orcid":"https://orcid.org/0000-0002-3251-4984","observed_orcids":["https://orcid.org/0000-0002-3251-4984"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]},{"id":"https://openalex.org/I4405259603","display_name":"Kyung Hee University Korean Medicine Hospital","ror":"https://ror.org/02f33kj63","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I35928602","https://openalex.org/I4210112503","https://openalex.org/I4405258385","https://openalex.org/I4405259603"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Hojin Lee","raw_affiliation_strings":["Department of prescriptionology, College of Korean Medicine, Kyung Hee University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of prescriptionology, College of Korean Medicine, Kyung Hee University","institution_ids":["https://openalex.org/I35928602","https://openalex.org/I4405259603"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025112702","display_name":"Ho Chul Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]},{"id":"https://openalex.org/I4405259603","display_name":"Kyung Hee University Korean Medicine Hospital","ror":"https://ror.org/02f33kj63","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I35928602","https://openalex.org/I4210112503","https://openalex.org/I4405258385","https://openalex.org/I4405259603"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ho Chul Lee","raw_affiliation_strings":["Department of prescriptionology, College of Korean Medicine, Kyung Hee University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of prescriptionology, College of Korean Medicine, Kyung Hee University","institution_ids":["https://openalex.org/I35928602","https://openalex.org/I4405259603"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100635332","display_name":"Ha Young Kim","orcid":"https://orcid.org/0000-0001-6752-9353","observed_orcids":["https://orcid.org/0000-0001-6752-9353"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]},{"id":"https://openalex.org/I4405259603","display_name":"Kyung Hee University Korean Medicine Hospital","ror":"https://ror.org/02f33kj63","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I35928602","https://openalex.org/I4210112503","https://openalex.org/I4405258385","https://openalex.org/I4405259603"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ha Young Kim","raw_affiliation_strings":["Department of prescriptionology, College of Korean Medicine, Kyung Hee University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of prescriptionology, College of Korean Medicine, Kyung Hee University","institution_ids":["https://openalex.org/I35928602","https://openalex.org/I4405259603"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072270016","display_name":"Do Rim Kim","orcid":"https://orcid.org/0000-0002-8131-3409","observed_orcids":["https://orcid.org/0000-0002-8131-3409"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]},{"id":"https://openalex.org/I4405259603","display_name":"Kyung Hee University Korean Medicine Hospital","ror":"https://ror.org/02f33kj63","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I35928602","https://openalex.org/I4210112503","https://openalex.org/I4405258385","https://openalex.org/I4405259603"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Do Rim Kim","raw_affiliation_strings":["Department of prescriptionology, College of Korean Medicine, Kyung Hee University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of prescriptionology, College of Korean Medicine, Kyung Hee University","institution_ids":["https://openalex.org/I35928602","https://openalex.org/I4405259603"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Bong Jae Choi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]},{"id":"https://openalex.org/I4405259603","display_name":"Kyung Hee University Korean Medicine Hospital","ror":"https://ror.org/02f33kj63","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I35928602","https://openalex.org/I4210112503","https://openalex.org/I4405258385","https://openalex.org/I4405259603"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Bong Jae Choi","raw_affiliation_strings":["Department of prescriptionology, College of Korean Medicine, Kyung Hee University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of prescriptionology, College of Korean Medicine, Kyung Hee University","institution_ids":["https://openalex.org/I35928602","https://openalex.org/I4405259603"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102968663","display_name":"Seong Kyu Park","orcid":"https://orcid.org/0000-0002-3589-6180","observed_orcids":["https://orcid.org/0000-0002-3589-6180"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]},{"id":"https://openalex.org/I4405259603","display_name":"Kyung Hee University Korean Medicine Hospital","ror":"https://ror.org/02f33kj63","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I35928602","https://openalex.org/I4210112503","https://openalex.org/I4405258385","https://openalex.org/I4405259603"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seong Kyu Park","raw_affiliation_strings":["Department of prescriptionology, College of Korean Medicine, Kyung Hee University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of prescriptionology, College of Korean Medicine, Kyung Hee University","institution_ids":["https://openalex.org/I35928602","https://openalex.org/I4405259603"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102179124","display_name":"Mun Seog Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]},{"id":"https://openalex.org/I4405259603","display_name":"Kyung Hee University Korean Medicine Hospital","ror":"https://ror.org/02f33kj63","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I35928602","https://openalex.org/I4210112503","https://openalex.org/I4405258385","https://openalex.org/I4405259603"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Mun Seog Chang","raw_affiliation_strings":["Department of prescriptionology, College of Korean Medicine, Kyung Hee University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of prescriptionology, College of Korean Medicine, Kyung Hee University","institution_ids":["https://openalex.org/I35928602","https://openalex.org/I4405259603"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100726314"],"corresponding_institution_ids":["https://openalex.org/I35928602","https://openalex.org/I4405259603"],"apc_list":{"value":1700,"currency":"USD","value_usd":1700},"apc_paid":{"value":1700,"currency":"USD","value_usd":1700},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.17492457,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"4","issue":"1","first_page":"63","last_page":"63"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14331","display_name":"Medicinal Plant Pharmacodynamics Research","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crem","display_name":"CREM","score":0.8100000023841858},{"id":"https://openalex.org/keywords/spermatogenesis","display_name":"spermatogenesis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/male-reproductive-function","display_name":"male reproductive function","score":0.7599999904632568},{"id":"https://openalex.org/keywords/serum-testosterone","display_name":"serum testosterone","score":0.7179999947547913},{"id":"https://openalex.org/keywords/sperm-count","display_name":"sperm count","score":0.671999990940094},{"id":"https://openalex.org/keywords/sperm-motility","display_name":"sperm motility","score":0.9940000176429749},{"id":"https://openalex.org/keywords/testicular-weight","display_name":"testicular weight","score":0.8539999723434448},{"id":"https://openalex.org/keywords/herbal-medicine","display_name":"herbal medicine","score":0.3330000042915344}],"concepts":[{"id":"https://openalex.org/C123765429","wikidata":"https://www.wikidata.org/wiki/Q36961","display_name":"Spermatogenesis","level":2,"score":0.8234668970108032},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.7592777013778687},{"id":"https://openalex.org/C2781087480","wikidata":"https://www.wikidata.org/wiki/Q17145","display_name":"Sperm","level":2,"score":0.606518030166626},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5989258289337158},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.5964349508285522},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5834337472915649},{"id":"https://openalex.org/C2777632594","wikidata":"https://www.wikidata.org/wiki/Q27116486","display_name":"Sperm motility","level":3,"score":0.4711170196533203},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.42422235012054443},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41713422536849976},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.333164781332016},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.11602506041526794}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.imr.2015.04.064","doi":"https://doi.org/10.1016/j.imr.2015.04.064","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.imr.2015.04.064","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2213422015000888/pdf","source":{"id":"https://openalex.org/S2764611727","display_name":"Integrative Medicine Research","issn_l":"2213-4220","issn":["2213-4220","2213-4239"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","kci-registered","norway-1","oarl","poland-40"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Integrative Medicine Research","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.imr.2015.04.064","doi":"https://doi.org/10.1016/j.imr.2015.04.064","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.imr.2015.04.064","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2213422015000888/pdf","source":{"id":"https://openalex.org/S2764611727","display_name":"Integrative Medicine Research","issn_l":"2213-4220","issn":["2213-4220","2213-4239"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","kci-registered","norway-1","oarl","poland-40"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Integrative Medicine Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.766700029373169,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2279458404.pdf","grobid_xml":"https://content.openalex.org/works/W2279458404.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2511845824","https://openalex.org/W2593300481","https://openalex.org/W108499966","https://openalex.org/W2035608651","https://openalex.org/W2093224244","https://openalex.org/W2767468643","https://openalex.org/W2176309354","https://openalex.org/W1967993809","https://openalex.org/W1580398096","https://openalex.org/W2521326065"],"abstract_inverted_index":{"ICCMR":[0],"2015":[1],"Poster":[2],"Presentation":[3],"Abstracts":[4],"only-treated":[5,66],"group":[6,19,67],"and":[7,12,29,37,45],"several":[8],"concentrations":[9],"of":[10,16,50],"WSH":[11,24,51,76],"CP":[13,42],"(100":[14],"mg/kg":[15,49],"CP)":[17],"treated":[18,43],"for":[20],"the":[21,56,65,69,82],"same":[22],"period.Results:":[23],"has":[25],"effect":[26],"on":[27],"absolute":[28],"relative":[30],"testes":[31],"weight,":[32],"sperm":[33,35],"count,":[34],"motility":[36],"serum":[38,88],"testosterone":[39,57,89],"level":[40],"in":[41,68,81],"mice.CP":[44],"100,":[46],"500,":[47],"1000":[48],"treatment":[52],"groups":[53],"significantly":[54],"increased":[55],"levels":[58],"by":[59,86],"144.38,":[60],"142.73,":[61],"154.96%":[62],"compared":[63],"to":[64],"mouse":[70],"serum.Conclusion:":[71],"Our":[72],"results":[73],"suggest":[74],"that":[75],"plays":[77],"an":[78],"important":[79],"role":[80],"male":[83],"reproductive":[84],"function":[85],"improving":[87],"level.":[90]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}
