{"id":"https://openalex.org/W2279400264","doi":"https://doi.org/10.1523/jneurosci.3480-13.2016","title":"Estrogen Restores Multisynaptic Boutons in the Dorsolateral Prefrontal Cortex while Promoting Working Memory in Aged Rhesus Monkeys","display_name":"Estrogen Restores Multisynaptic Boutons in the Dorsolateral Prefrontal Cortex while Promoting Working Memory in Aged Rhesus Monkeys","publication_year":2016,"publication_date":"2016-01-20","ids":{"openalex":"https://openalex.org/W2279400264","doi":"https://doi.org/10.1523/jneurosci.3480-13.2016","mag":"2279400264","pmid":"https://pubmed.ncbi.nlm.nih.gov/26791219","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4719022"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.3480-13.2016","doi":"https://doi.org/10.1523/jneurosci.3480-13.2016","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.3480-13.2016","pdf_url":"https://www.jneurosci.org/content/jneuro/36/3/901.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.jneurosci.org/content/jneuro/36/3/901.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026254238","display_name":"Yuko Hara","orcid":"https://orcid.org/0000-0001-5828-442X","observed_orcids":["https://orcid.org/0000-0001-5828-442X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuko Hara","raw_affiliation_strings":["Fishberg Department of Neuroscience and Kastor Neurobiology of Aging Laboratories, Friedman Brain Institute","1Fishberg Department of Neuroscience and Kastor Neurobiology of Aging Laboratories,","2Friedman Brain Institute,"],"raw_orcid":"https://orcid.org/0000-0001-5828-442X","affiliations":[{"raw_affiliation_string":"Fishberg Department of Neuroscience and Kastor Neurobiology of Aging Laboratories, Friedman Brain Institute","institution_ids":[]},{"raw_affiliation_string":"1Fishberg Department of Neuroscience and Kastor Neurobiology of Aging Laboratories,","institution_ids":[]},{"raw_affiliation_string":"2Friedman Brain Institute,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060033328","display_name":"Frank Yuk","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frank Yuk","raw_affiliation_strings":["Fishberg Department of Neuroscience and Kastor Neurobiology of Aging Laboratories, Friedman Brain Institute","1Fishberg Department of Neuroscience and Kastor Neurobiology of Aging Laboratories,","2Friedman Brain Institute,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fishberg Department of Neuroscience and Kastor Neurobiology of Aging Laboratories, Friedman Brain Institute","institution_ids":[]},{"raw_affiliation_string":"1Fishberg Department of Neuroscience and Kastor Neurobiology of Aging Laboratories,","institution_ids":[]},{"raw_affiliation_string":"2Friedman Brain Institute,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087247030","display_name":"Rishi Puri","orcid":"https://orcid.org/0000-0001-8849-7426","observed_orcids":["https://orcid.org/0000-0001-8849-7426","https://orcid.org/0000-0003-2402-6953"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rishi Puri","raw_affiliation_strings":["Fishberg Department of Neuroscience and Kastor Neurobiology of Aging Laboratories, Friedman Brain Institute","1Fishberg Department of Neuroscience and Kastor Neurobiology of Aging Laboratories,","2Friedman Brain Institute,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fishberg Department of Neuroscience and Kastor Neurobiology of Aging Laboratories, Friedman Brain Institute","institution_ids":[]},{"raw_affiliation_string":"1Fishberg Department of Neuroscience and Kastor Neurobiology of Aging Laboratories,","institution_ids":[]},{"raw_affiliation_string":"2Friedman Brain Institute,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037156084","display_name":"William G.M. Janssen","orcid":"https://orcid.org/0000-0003-3954-7866","observed_orcids":["https://orcid.org/0000-0003-3954-7866"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William G. M. Janssen","raw_affiliation_strings":["Fishberg Department of Neuroscience and Kastor Neurobiology of Aging Laboratories, Friedman Brain Institute","1Fishberg Department of Neuroscience and Kastor Neurobiology of Aging Laboratories,","2Friedman Brain Institute,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fishberg Department of Neuroscience and Kastor Neurobiology of Aging Laboratories, Friedman Brain Institute","institution_ids":[]},{"raw_affiliation_string":"1Fishberg Department of Neuroscience and Kastor Neurobiology of Aging Laboratories,","institution_ids":[]},{"raw_affiliation_string":"2Friedman Brain Institute,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080046742","display_name":"Peter R. Rapp","orcid":"https://orcid.org/0000-0002-0983-3944","observed_orcids":["https://orcid.org/0000-0002-0983-3944"]},"institutions":[{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter R. Rapp","raw_affiliation_strings":["National Institute on Aging, Laboratory of Behavioral Neuroscience, Baltimore, Maryland 21224","5National Institute on Aging, Laboratory of Behavioral Neuroscience, Baltimore, Maryland 21224,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute on Aging, Laboratory of Behavioral Neuroscience, Baltimore, Maryland 21224","institution_ids":["https://openalex.org/I4210136897"]},{"raw_affiliation_string":"5National Institute on Aging, Laboratory of Behavioral Neuroscience, Baltimore, Maryland 21224,","institution_ids":["https://openalex.org/I4210136897"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045886993","display_name":"John H. Morrison","orcid":"https://orcid.org/0000-0002-8292-0964","observed_orcids":["https://orcid.org/0000-0002-8292-0964"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John H. Morrison","raw_affiliation_strings":["Fishberg Department of Neuroscience and Kastor Neurobiology of Aging Laboratories, Friedman Brain Institute, Department of Geriatrics and Palliative Medicine, and Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, California National Primate Research Center, Davis, California 95616, and Department of Neurology, School of Medicine, University of California, Davis, California 95616 jhmorrison@ucdavis.edu","1Fishberg Department of Neuroscience and Kastor Neurobiology of Aging Laboratories,","2Friedman Brain Institute,","3Department of Geriatrics and Palliative Medicine, and","4Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029,","6California National Primate Research Center, Davis, California 95616, and","7Department of Neurology, School of Medicine, University of California, Davis, California 95616"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fishberg Department of Neuroscience and Kastor Neurobiology of Aging Laboratories, Friedman Brain Institute, Department of Geriatrics and Palliative Medicine, and Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, California National Primate Research Center, Davis, California 95616, and Department of Neurology, School of Medicine, University of California, Davis, California 95616 jhmorrison@ucdavis.edu","institution_ids":["https://openalex.org/I84218800","https://openalex.org/I98704320"]},{"raw_affiliation_string":"1Fishberg Department of Neuroscience and Kastor Neurobiology of Aging Laboratories,","institution_ids":[]},{"raw_affiliation_string":"2Friedman Brain Institute,","institution_ids":[]},{"raw_affiliation_string":"3Department of Geriatrics and Palliative Medicine, and","institution_ids":[]},{"raw_affiliation_string":"4Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029,","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"6California National Primate Research Center, Davis, California 95616, and","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"7Department of Neurology, School of Medicine, University of California, Davis, California 95616","institution_ids":["https://openalex.org/I84218800"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.6767,"has_fulltext":true,"cited_by_count":50,"citation_normalized_percentile":{"value":0.9375,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"36","issue":"3","first_page":"901","last_page":"910"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.5321999788284302,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.5321999788284302,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.1656000018119812,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.11969999969005585,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dorsolateral-prefrontal-cortex","display_name":"dorsolateral prefrontal cortex","score":0.9570000171661377},{"id":"https://openalex.org/keywords/working-memory","display_name":"working memory","score":0.9850000143051147},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.6179999709129333},{"id":"https://openalex.org/keywords/menopause","display_name":"menopause","score":0.968999981880188},{"id":"https://openalex.org/keywords/estrogen","display_name":"estrogen","score":0.7179999947547913},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.6679999828338623},{"id":"https://openalex.org/keywords/ovariectomy","display_name":"ovariectomy","score":0.9079999923706055},{"id":"https://openalex.org/keywords/presynaptic-mitochondria","display_name":"presynaptic mitochondria","score":0.7099999785423279},{"id":"https://openalex.org/keywords/mitochondrial-morphology","display_name":"mitochondrial morphology","score":0.6980000138282776},{"id":"https://openalex.org/keywords/synaptic-organization","display_name":"synaptic organization","score":0.6179999709129333},{"id":"https://openalex.org/keywords/hormone-replacement-therapy","display_name":"hormone replacement therapy","score":0.7009999752044678},{"id":"https://openalex.org/keywords/rhesus-macaques","display_name":"rhesus monkeys","score":0.9309999942779541},{"id":"https://openalex.org/keywords/area-46","display_name":"area 46","score":0.7559999823570251},{"id":"https://openalex.org/keywords/cognitive-aging","display_name":"cognitive aging","score":0.6269999742507935},{"id":"https://openalex.org/keywords/presynaptic-input","display_name":"presynaptic input","score":0.5709999799728394},{"id":"https://openalex.org/keywords/serial-section-electron-microscopy","display_name":"serial section electron microscopy","score":0.621999979019165}],"concepts":[{"id":"https://openalex.org/C2780508717","wikidata":"https://www.wikidata.org/wiki/Q72788","display_name":"Dorsolateral prefrontal cortex","level":4,"score":0.7276448011398315},{"id":"https://openalex.org/C21963081","wikidata":"https://www.wikidata.org/wiki/Q11337567","display_name":"Working memory","level":3,"score":0.6827243566513062},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5634302496910095},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.5303113460540771},{"id":"https://openalex.org/C8264082","wikidata":"https://www.wikidata.org/wiki/Q7113259","display_name":"Ovariectomized rat","level":3,"score":0.5123614072799683},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.494975745677948},{"id":"https://openalex.org/C2780509455","wikidata":"https://www.wikidata.org/wiki/Q7380","display_name":"Primate","level":2,"score":0.47378039360046387},{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.4694872498512268},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.46342575550079346},{"id":"https://openalex.org/C2776464000","wikidata":"https://www.wikidata.org/wiki/Q545787","display_name":"Dentate gyrus","level":3,"score":0.45829471945762634},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4521104395389557},{"id":"https://openalex.org/C2778562196","wikidata":"https://www.wikidata.org/wiki/Q177708","display_name":"Menopause","level":2,"score":0.4427988529205322},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.44220268726348877},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.4130643904209137},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3715391457080841},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33038491010665894},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3245754837989807},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29734960198402405},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.19910290837287903},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008253","descriptor_name":"Macaca mulatta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008570","descriptor_name":"Memory, Short-Term","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008570","descriptor_name":"Memory, Short-Term","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010052","descriptor_name":"Ovariectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015914","descriptor_name":"Estrogen Replacement Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017729","descriptor_name":"Presynaptic Terminals","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017729","descriptor_name":"Presynaptic Terminals","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1523/jneurosci.3480-13.2016","doi":"https://doi.org/10.1523/jneurosci.3480-13.2016","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.3480-13.2016","pdf_url":"https://www.jneurosci.org/content/jneuro/36/3/901.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4719022","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4719022","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"pmid:26791219","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26791219","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt64m7z13k","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/64m7z13k","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Neuroscience, vol 36, iss 3","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.3480-13.2016","doi":"https://doi.org/10.1523/jneurosci.3480-13.2016","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.3480-13.2016","pdf_url":"https://www.jneurosci.org/content/jneuro/36/3/901.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4309675716","display_name":null,"funder_award_id":"P01 AG06647","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5613315861","display_name":"GLUTAMATE receptors in aging cortical circuits","funder_award_id":"R01AG006647","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5733824146","display_name":"COGNITIVE FUNCTION IN THE AGED MONKEY","funder_award_id":"R01AG010606","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7899224412","display_name":"Glutamate receptors in aging cortical circuits","funder_award_id":"R37AG006647","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000878280","display_name":"California National Primate Research Center","funder_award_id":"P51OD011107","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2279400264.pdf","grobid_xml":"https://content.openalex.org/works/W2279400264.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W343647061","https://openalex.org/W1550411069","https://openalex.org/W1642243794","https://openalex.org/W1913092771","https://openalex.org/W1939596644","https://openalex.org/W1964606698","https://openalex.org/W1965597399","https://openalex.org/W1970359645","https://openalex.org/W1971984112","https://openalex.org/W1974782589","https://openalex.org/W1974855479","https://openalex.org/W1976892327","https://openalex.org/W1977113801","https://openalex.org/W1981834819","https://openalex.org/W1981875905","https://openalex.org/W1982900915","https://openalex.org/W1987611774","https://openalex.org/W1993394859","https://openalex.org/W1994994698","https://openalex.org/W1996412009","https://openalex.org/W2003700179","https://openalex.org/W2006720433","https://openalex.org/W2014022149","https://openalex.org/W2021005581","https://openalex.org/W2024522456","https://openalex.org/W2025474157","https://openalex.org/W2028905629","https://openalex.org/W2031534534","https://openalex.org/W2039190163","https://openalex.org/W2040361127","https://openalex.org/W2043955468","https://openalex.org/W2046137253","https://openalex.org/W2064312303","https://openalex.org/W2065393074","https://openalex.org/W2070524933","https://openalex.org/W2076433134","https://openalex.org/W2077417387","https://openalex.org/W2078129863","https://openalex.org/W2087139961","https://openalex.org/W2087809804","https://openalex.org/W2089059900","https://openalex.org/W2092194262","https://openalex.org/W2092787033","https://openalex.org/W2103567674","https://openalex.org/W2103813752","https://openalex.org/W2111811285","https://openalex.org/W2114347193","https://openalex.org/W2117890073","https://openalex.org/W2119302018","https://openalex.org/W2119691301","https://openalex.org/W2144317269","https://openalex.org/W2144907160","https://openalex.org/W2153022468","https://openalex.org/W2155376638","https://openalex.org/W2161591122","https://openalex.org/W2203314189"],"related_works":["https://openalex.org/W1981875905","https://openalex.org/W2901883649","https://openalex.org/W1994994698","https://openalex.org/W2320579993","https://openalex.org/W2899606512","https://openalex.org/W2077725650","https://openalex.org/W2046137253","https://openalex.org/W2602167790","https://openalex.org/W2104260362","https://openalex.org/W3008937375"],"abstract_inverted_index":{"Humans":[0],"and":[1,8,35,65,70,80,92,97,175,217,238,241,282,290,304,310],"nonhuman":[2],"primates":[3],"are":[4,61,233,242],"vulnerable":[5],"to":[6,106,170,173,235,244,279],"age-":[7],"menopause-":[9],"related":[10],"decline":[11],"in":[12,37,67,101,110,157,163,214,254,325,357,364],"working":[13,43,81,187,255,322],"memory,":[14,256],"a":[15,133,334],"cognitive":[16,236,355],"function":[17,237,259],"reliant":[18,260],"on":[19,196,261],"area":[20],"46":[21],"of":[22,55,94,120,125,138,182,210,223,264,276,296,337],"the":[23,50,53,90,102,111,122,180,193,197,208,221,274,365],"dorsolateral":[24],"prefrontal":[25,265],"cortex":[26,266],"(dlPFC).":[27],"We":[28,313],"showed":[29],"previously":[30],"that":[31,52,71,231,315,339,350],"presynaptic":[32,277,309],"mitochondrial":[33,78,239],"number":[34,209,222],"morphology":[36],"monkey":[38,112],"dlPFC":[39,126,215],"neurons":[40,281],"correlate":[41],"with":[42,63,77,151,186,207,220,288,320,342],"memory":[44,188,323],"performance.":[45],"The":[46,136],"current":[47],"study":[48],"tested":[49],"hypothesis":[51],"types":[54],"synaptic":[56,362],"connections":[57],"these":[58,72,280],"boutons":[59,99,127,216,293],"form":[60,301],"altered":[62,142,287],"aging":[64,289],"menopause":[66,153],"rhesus":[68,326],"monkeys":[69,332],"metrics":[73],"may":[74,285],"be":[75,286],"coupled":[76,234],"measures":[79],"memory.":[82],"Using":[83],"serial":[84],"section":[85],"electron":[86],"microscopy,":[87],"we":[88],"examined":[89],"frequencies":[91,169],"characteristics":[93],"nonsynaptic,":[95],"single-synaptic,":[96,129],"multisynaptic":[98],"(MSBs)":[100,294],"dlPFC.":[103],"In":[104],"contrast":[105],"our":[107,228,347],"previous":[108],"observations":[109],"hippocampal":[113],"dentate":[114],"gyrus,":[115],"where":[116],"MSBs":[117,131,139,183,232,338],"comprised":[118],"\u223c40%":[119],"boutons,":[121],"vast":[123],"majority":[124],"were":[128,295],"whereas":[130],"constituted":[132],"mere":[134],"10%.":[135],"frequency":[137,181,318],"was":[140,340],"not":[141],"by":[143,148,155,192,359],"normal":[144],"aging,":[145,356],"but":[146],"decreased":[147],"over":[149],"50%":[150,335],"surgical":[152],"induced":[154],"ovariectomy":[156],"aged":[158,164,176,249,329],"monkeys.":[159,178,327],"Cyclic":[160],"estradiol":[161,344],"treatment":[162],"ovariectomized":[165],"animals":[166],"restored":[167,341],"MSB":[168,203,317],"levels":[171],"comparable":[172],"young":[174],"premenopausal":[177],"Notably,":[179],"positively":[184,205],"correlated":[185,206,219,319],"scores,":[189],"as":[190],"measured":[191],"average":[194],"accuracy":[195],"delayed":[198],"response":[199],"(DR)":[200],"test.":[201],"Furthermore,":[202],"incidence":[204],"healthy":[211],"straight":[212],"mitochondria":[213],"inversely":[218],"pathological":[224],"donut-shaped":[225],"mitochondria.":[226],"Together,":[227,346],"data":[229],"suggest":[230,349],"health":[240],"sensitive":[243],"estrogen.":[245],"Significance":[246],"statement:":[247],"Many":[248],"menopausal":[250,331],"individuals":[251],"experience":[252],"deficits":[253],"an":[257],"executive":[258],"recurrent":[262],"firing":[263],"(PFC)":[267],"neurons.":[268,312],"However,":[269],"little":[270],"is":[271],"known":[272],"about":[273],"organization":[275],"inputs":[278],"how":[283],"they":[284,300],"menopause.":[291],"Multisynaptic":[292],"particular":[297],"interest,":[298],"because":[299],"multiple":[302],"synapses":[303],"can":[305],"enhance":[306],"coupling":[307],"between":[308],"postsynaptic":[311],"found":[314],"higher":[316],"better":[321],"performance":[324],"Additionally,":[328],"surgically":[330],"experienced":[333],"loss":[336],"cyclic":[343],"treatment.":[345],"findings":[348],"hormone":[351],"replacement":[352],"therapy":[353],"benefits":[354],"part":[358],"retaining":[360],"complex":[361],"organizations":[363],"PFC.":[366]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}