{"id":"https://openalex.org/W2279320372","doi":"https://doi.org/10.1152/ajplung.1999.277.3.l589","title":"Mitogen-activated protein kinase pathway mediates hyperoxia-induced apoptosis in cultured macrophage cells","display_name":"Mitogen-activated protein kinase pathway mediates hyperoxia-induced apoptosis in cultured macrophage cells","publication_year":1999,"publication_date":"1999-09-01","ids":{"openalex":"https://openalex.org/W2279320372","doi":"https://doi.org/10.1152/ajplung.1999.277.3.l589","mag":"2279320372","pmid":"https://pubmed.ncbi.nlm.nih.gov/10484467"},"language":"en","primary_location":{"id":"doi:10.1152/ajplung.1999.277.3.l589","doi":"https://doi.org/10.1152/ajplung.1999.277.3.l589","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajplung.1999.277.3.l589","pdf_url":null,"source":{"id":"https://openalex.org/S47245711","display_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","issn_l":"1040-0605","issn":["1040-0605","1522-1504"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026411789","display_name":"Irina Petrache","orcid":"https://orcid.org/0000-0003-1094-2600","observed_orcids":["https://orcid.org/0000-0003-1094-2600"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Irina Petrache","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020032238","display_name":"Mary E. Choi","orcid":"https://orcid.org/0000-0002-6853-336X","observed_orcids":["https://orcid.org/0000-0002-6853-336X"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210086971","display_name":"VA Connecticut Healthcare System","ror":"https://ror.org/000rgm762","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210086971","https://openalex.org/I4210095851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary E. Choi","raw_affiliation_strings":["Connecticut Veterans Affairs HealthCare System, West Haven, Connecticut 06516;","Section of Nephrology, Department of Internal Medicine, Yale University School of Medicine, New Haven 06520;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Connecticut Veterans Affairs HealthCare System, West Haven, Connecticut 06516;","institution_ids":["https://openalex.org/I4210086971"]},{"raw_affiliation_string":"Section of Nephrology, Department of Internal Medicine, Yale University School of Medicine, New Haven 06520;","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026924053","display_name":"Leo Edmond Otterbein","orcid":"https://orcid.org/0000-0002-7900-0825","observed_orcids":["https://orcid.org/0000-0002-7900-0825"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leo E. Otterbein","raw_affiliation_strings":["Department of Environmental Health Sciences, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health Sciences, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085057086","display_name":"Beek Yoke Chin","orcid":"https://orcid.org/0000-0003-2369-0908","observed_orcids":["https://orcid.org/0000-0003-2369-0908"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beek Yoke Chin","raw_affiliation_strings":["Department of Environmental Health Sciences, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health Sciences, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000867488","display_name":"Lin L. Mantell","orcid":"https://orcid.org/0000-0003-0367-1507","observed_orcids":["https://orcid.org/0000-0003-0367-1507"]},"institutions":[{"id":"https://openalex.org/I1289739345","display_name":"Winthrop-University Hospital","ror":"https://ror.org/03eksqx74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289739345"]},{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I4210087560","display_name":"Stony Brook School","ror":"https://ror.org/003wx9n05","country_code":"US","type":"education","lineage":["https://openalex.org/I4210087560"]},{"id":"https://openalex.org/I4210102711","display_name":"Stony Brook Medicine","ror":"https://ror.org/01882y777","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210102711","https://openalex.org/I59553526"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lin L. Mantell","raw_affiliation_strings":["Departments of Thoracic Cardiovascular Surgery and Pediatrics, The CardioPulmonary Research Institute, Winthrop-University Hospital, State University of New York at Stony Brook School of Medicine, Mineola, New York 11501; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Thoracic Cardiovascular Surgery and Pediatrics, The CardioPulmonary Research Institute, Winthrop-University Hospital, State University of New York at Stony Brook School of Medicine, Mineola, New York 11501; and","institution_ids":["https://openalex.org/I1289739345","https://openalex.org/I1327163397","https://openalex.org/I4210087560","https://openalex.org/I4210102711","https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113561155","display_name":"Stuart Horowitz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289739345","display_name":"Winthrop-University Hospital","ror":"https://ror.org/03eksqx74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289739345"]},{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I4210087560","display_name":"Stony Brook School","ror":"https://ror.org/003wx9n05","country_code":"US","type":"education","lineage":["https://openalex.org/I4210087560"]},{"id":"https://openalex.org/I4210102711","display_name":"Stony Brook Medicine","ror":"https://ror.org/01882y777","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210102711","https://openalex.org/I59553526"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stuart Horowitz","raw_affiliation_strings":["Departments of Thoracic Cardiovascular Surgery and Pediatrics, The CardioPulmonary Research Institute, Winthrop-University Hospital, State University of New York at Stony Brook School of Medicine, Mineola, New York 11501; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Thoracic Cardiovascular Surgery and Pediatrics, The CardioPulmonary Research Institute, Winthrop-University Hospital, State University of New York at Stony Brook School of Medicine, Mineola, New York 11501; and","institution_ids":["https://openalex.org/I1289739345","https://openalex.org/I1327163397","https://openalex.org/I4210087560","https://openalex.org/I4210102711","https://openalex.org/I59553526"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028298831","display_name":"Augustine M.K. Choi","orcid":"https://orcid.org/0000-0002-4836-305X","observed_orcids":["https://orcid.org/0000-0002-4836-305X"]},"institutions":[{"id":"https://openalex.org/I4210086971","display_name":"VA Connecticut Healthcare System","ror":"https://ror.org/000rgm762","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210086971","https://openalex.org/I4210095851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Augustine M. K. Choi","raw_affiliation_strings":["Connecticut Veterans Affairs HealthCare System, West Haven, Connecticut 06516;","Section of Pulmonary and Critical Care Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Connecticut Veterans Affairs HealthCare System, West Haven, Connecticut 06516;","institution_ids":["https://openalex.org/I4210086971"]},{"raw_affiliation_string":"Section of Pulmonary and Critical Care Medicine and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7243,"has_fulltext":false,"cited_by_count":105,"citation_normalized_percentile":{"value":0.83329149,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"277","issue":"3","first_page":"L589","last_page":"L595"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.7949000000953674,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.7949000000953674,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.03590000048279762,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.03189999982714653,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyperoxia","display_name":"hyperoxia","score":0.9309999942779541},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9100000262260437},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.8759999871253967},{"id":"https://openalex.org/keywords/extracellular-signal-regulated-kinase-1-2","display_name":"ERK1/ERK2","score":0.9259999990463257},{"id":"https://openalex.org/keywords/pd98059","display_name":"PD98059","score":0.906000018119812},{"id":"https://openalex.org/keywords/lung-injury","display_name":"lung injury","score":0.531000018119812},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.503000020980835}],"concepts":[{"id":"https://openalex.org/C155878803","wikidata":"https://www.wikidata.org/wiki/Q5205755","display_name":"DNA laddering","level":5,"score":0.8146035075187683},{"id":"https://openalex.org/C2780672939","wikidata":"https://www.wikidata.org/wiki/Q5958429","display_name":"Hyperoxia","level":3,"score":0.7749781608581543},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.7145766615867615},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6124153733253479},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5769896507263184},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5678961277008057},{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.5389801263809204},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.5268467664718628},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47946202754974365},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.44993048906326294},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4325403869152069},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.42604291439056396},{"id":"https://openalex.org/C124160383","wikidata":"https://www.wikidata.org/wiki/Q14914383","display_name":"ASK1","level":5,"score":0.42134976387023926},{"id":"https://openalex.org/C132149769","wikidata":"https://www.wikidata.org/wiki/Q899651","display_name":"Mitogen-activated protein kinase","level":3,"score":0.42122164368629456},{"id":"https://openalex.org/C90934575","wikidata":"https://www.wikidata.org/wiki/Q6593810","display_name":"Mitogen-activated protein kinase kinase","level":4,"score":0.3959963321685791},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2743331491947174},{"id":"https://openalex.org/C43759708","wikidata":"https://www.wikidata.org/wiki/Q3749256","display_name":"DNA fragmentation","level":4,"score":0.17512398958206177},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.137177973985672},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018496","descriptor_name":"Hyperoxia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018496","descriptor_name":"Hyperoxia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D019950","descriptor_name":"Mitogen-Activated Protein Kinase 1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D048052","descriptor_name":"Mitogen-Activated Protein Kinase 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajplung.1999.277.3.l589","doi":"https://doi.org/10.1152/ajplung.1999.277.3.l589","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajplung.1999.277.3.l589","pdf_url":null,"source":{"id":"https://openalex.org/S47245711","display_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","issn_l":"1040-0605","issn":["1040-0605","1522-1504"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","raw_type":"journal-article"},{"id":"pmid:10484467","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10484467","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1212920289","display_name":"OXIDANT STRESS INDUCED APOPTOSIS--ROLE OF HEME OXYGENASE","funder_award_id":"F32HL010028","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1353784913","display_name":"Inflammasomes: Regulation and Function in Acute Lung Injury","funder_award_id":"R01HL055330","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G413146721","display_name":"Heme Oxygenase-1/Carbon Monoxide in Lung Vascular Injury","funder_award_id":"R01HL060234","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5136736065","display_name":"HEME OXYGENASE-1 AND SEPSIS USING TRANSGENIC MICE","funder_award_id":"R01AI042365","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1550989404","https://openalex.org/W1749982418","https://openalex.org/W1938846285","https://openalex.org/W1965191768","https://openalex.org/W1974907467","https://openalex.org/W1976005843","https://openalex.org/W1976385326","https://openalex.org/W1978719611","https://openalex.org/W1984966904","https://openalex.org/W1990232793","https://openalex.org/W1994014733","https://openalex.org/W1998574404","https://openalex.org/W2013480319","https://openalex.org/W2014777348","https://openalex.org/W2020549199","https://openalex.org/W2029684134","https://openalex.org/W2032582358","https://openalex.org/W2034580062","https://openalex.org/W2035463002","https://openalex.org/W2036224418","https://openalex.org/W2055884802","https://openalex.org/W2056168344","https://openalex.org/W2059938714","https://openalex.org/W2062412222","https://openalex.org/W2070017383","https://openalex.org/W2071452423","https://openalex.org/W2074169536","https://openalex.org/W2083545792","https://openalex.org/W2091287415","https://openalex.org/W2109330502","https://openalex.org/W2120787511","https://openalex.org/W2139457563","https://openalex.org/W2172010722","https://openalex.org/W2244487778","https://openalex.org/W2276039603","https://openalex.org/W2316381700","https://openalex.org/W2999948784","https://openalex.org/W4292820908"],"related_works":["https://openalex.org/W2054618461","https://openalex.org/W2142079271","https://openalex.org/W2386163628","https://openalex.org/W1980429500","https://openalex.org/W2075976369","https://openalex.org/W2354229511","https://openalex.org/W4400037737","https://openalex.org/W2065882173","https://openalex.org/W1968353269","https://openalex.org/W2089348878"],"abstract_inverted_index":{"We":[0],"have":[1],"previously":[2],"demonstrated":[3],"that":[4,27,71,161,171],"the":[5,58,75,81,103,110,125,172],"lungs":[6],"of":[7,61,96,124,135,142],"mice":[8],"can":[9,32,73,163],"exhibit":[10],"increased":[11,94],"programmed":[12],"cell":[13],"death":[14],"or":[15,121],"apoptosis":[16,35,63,147,165],"after":[17],"hyperoxic":[18,28],"exposure":[19,29],"in":[20,30,36,64,87,117,166],"vivo.":[21],"In":[22],"this":[23],"report,":[24],"we":[25,68],"show":[26,70],"vitro":[31],"also":[33],"induce":[34,164],"cultured":[37,167],"murine":[38,168],"macrophage":[39],"cells":[40],"(RAW":[41],"264.7)":[42],"as":[43,91,148],"assessed":[44,92,149],"by":[45,93,98,115,130,150],"DNA-laddering,":[46],"terminal":[47],"deoxynucleotidyltransferase":[48],"dUTP":[49],"nick":[50],"end-labeling,":[51],"and":[52,138,153,170],"nucleosomal":[53,154],"assays.":[54],"To":[55],"further":[56],"delineate":[57],"signaling":[59],"pathway":[60,129,174],"hyperoxia-induced":[62,146,176],"RAW":[65],"264.7":[66],"macrophages,":[67],"first":[69],"hyperoxia":[72,116,162],"activate":[74],"mitogen-activated":[76],"protein":[77,107],"kinase":[78,108],"(MAPK)":[79],"pathway,":[80],"extracellular":[82],"signal-regulated":[83],"kinases":[84],"(ERKs)":[85],"p42/p44,":[86],"a":[88,132],"time-dependent":[89],"manner":[90],"phosphorylation":[95],"ERK1/ERK2":[97],"Western":[99],"blot":[100],"analyses.":[101],"Neither":[102],"c-Jun":[104],"NH(2)-terminal":[105],"kinase/stress-activated":[106],"nor":[109],"p38":[111],"MAPK":[112,128,136,173],"was":[113],"activated":[114],"these":[118],"cells.":[119],"Chemical":[120],"genetic":[122],"inhibition":[123],"ERK":[126],"p42/p44":[127],"PD-98059,":[131],"selective":[133],"inhibitor":[134],"kinase,":[137],"dominant":[139],"negative":[140],"mutants":[141],"ERK,":[143],"respectively,":[144],"attenuated":[145],"DNA":[151],"laddering":[152],"ELISAs.":[155],"Taken":[156],"together,":[157],"our":[158],"data":[159],"suggest":[160],"macrophages":[169],"mediates":[175],"apoptosis.":[177]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
