{"id":"https://openalex.org/W2279304485","doi":"https://doi.org/10.4049/jimmunol.182.supp.84.17","title":"A conserved salt bridge in the G-loop of multiple protein kinases is essential for catalysis, in vivo Lyn function and prevention of autoimmune disease (84.17)","display_name":"A conserved salt bridge in the G-loop of multiple protein kinases is essential for catalysis, in vivo Lyn function and prevention of autoimmune disease (84.17)","publication_year":2009,"publication_date":"2009-04-01","ids":{"openalex":"https://openalex.org/W2279304485","doi":"https://doi.org/10.4049/jimmunol.182.supp.84.17","mag":"2279304485"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.182.supp.84.17","doi":"https://doi.org/10.4049/jimmunol.182.supp.84.17","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.182.supp.84.17","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082196069","display_name":"Karsten Sauer","orcid":"https://orcid.org/0000-0002-8355-9429","observed_orcids":["https://orcid.org/0000-0002-8355-9429"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karsten Sauer","raw_affiliation_strings":["Immunology and Microbial Science, The Scripps Research Institute , La Jolla, CA","1Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology and Microbial Science, The Scripps Research Institute , La Jolla, CA","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"1Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079325672","display_name":"Jianwei Che","orcid":"https://orcid.org/0000-0003-4956-4811","observed_orcids":["https://orcid.org/0000-0003-4956-4811"]},"institutions":[{"id":"https://openalex.org/I127128434","display_name":"Genomics Institute of the Novartis Research Foundation","ror":"https://ror.org/017136v53","country_code":"US","type":"facility","lineage":["https://openalex.org/I127128434","https://openalex.org/I1283582996","https://openalex.org/I4210117619"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianwei Che","raw_affiliation_strings":["GNF , San Diego, CA","2GNF, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GNF , San Diego, CA","institution_ids":["https://openalex.org/I127128434"]},{"raw_affiliation_string":"2GNF, San Diego, CA","institution_ids":["https://openalex.org/I127128434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020736516","display_name":"Christian C. Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127128434","display_name":"Genomics Institute of the Novartis Research Foundation","ror":"https://ror.org/017136v53","country_code":"US","type":"facility","lineage":["https://openalex.org/I127128434","https://openalex.org/I1283582996","https://openalex.org/I4210117619"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christian C Lee","raw_affiliation_strings":["GNF , San Diego, CA","2GNF, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GNF , San Diego, CA","institution_ids":["https://openalex.org/I127128434"]},{"raw_affiliation_string":"2GNF, San Diego, CA","institution_ids":["https://openalex.org/I127128434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101635495","display_name":"Yating Yang","orcid":"https://orcid.org/0000-0003-4671-8061","observed_orcids":["https://orcid.org/0000-0003-4671-8061"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yating Yang","raw_affiliation_strings":["Immunology and Microbial Science, The Scripps Research Institute , La Jolla, CA","1Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology and Microbial Science, The Scripps Research Institute , La Jolla, CA","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"1Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010643717","display_name":"Ann E. Herman","orcid":"https://orcid.org/0000-0003-3947-0213","observed_orcids":["https://orcid.org/0000-0003-3947-0213"]},"institutions":[{"id":"https://openalex.org/I127128434","display_name":"Genomics Institute of the Novartis Research Foundation","ror":"https://ror.org/017136v53","country_code":"US","type":"facility","lineage":["https://openalex.org/I127128434","https://openalex.org/I1283582996","https://openalex.org/I4210117619"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ann Herman","raw_affiliation_strings":["GNF , San Diego, CA","2GNF, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GNF , San Diego, CA","institution_ids":["https://openalex.org/I127128434"]},{"raw_affiliation_string":"2GNF, San Diego, CA","institution_ids":["https://openalex.org/I127128434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051876391","display_name":"Yong Jia","orcid":"https://orcid.org/0000-0002-0394-3966","observed_orcids":["https://orcid.org/0000-0002-0394-3966"]},"institutions":[{"id":"https://openalex.org/I127128434","display_name":"Genomics Institute of the Novartis Research Foundation","ror":"https://ror.org/017136v53","country_code":"US","type":"facility","lineage":["https://openalex.org/I127128434","https://openalex.org/I1283582996","https://openalex.org/I4210117619"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yong Jia","raw_affiliation_strings":["GNF , San Diego, CA","2GNF, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GNF , San Diego, CA","institution_ids":["https://openalex.org/I127128434"]},{"raw_affiliation_string":"2GNF, San Diego, CA","institution_ids":["https://openalex.org/I127128434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081236513","display_name":"Anastasia V. Velentza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127128434","display_name":"Genomics Institute of the Novartis Research Foundation","ror":"https://ror.org/017136v53","country_code":"US","type":"facility","lineage":["https://openalex.org/I127128434","https://openalex.org/I1283582996","https://openalex.org/I4210117619"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anastasia Velentza","raw_affiliation_strings":["GNF , San Diego, CA","2GNF, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GNF , San Diego, CA","institution_ids":["https://openalex.org/I127128434"]},{"raw_affiliation_string":"2GNF, San Diego, CA","institution_ids":["https://openalex.org/I127128434"]}]},{"author_position":"middle","author":{"id":null,"display_name":"James Watson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127128434","display_name":"Genomics Institute of the Novartis Research Foundation","ror":"https://ror.org/017136v53","country_code":"US","type":"facility","lineage":["https://openalex.org/I127128434","https://openalex.org/I1283582996","https://openalex.org/I4210117619"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Watson","raw_affiliation_strings":["GNF , San Diego, CA","2GNF, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GNF , San Diego, CA","institution_ids":["https://openalex.org/I127128434"]},{"raw_affiliation_string":"2GNF, San Diego, CA","institution_ids":["https://openalex.org/I127128434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053945557","display_name":"Luise Sternberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luise Sternberg","raw_affiliation_strings":["Immunology and Microbial Science, The Scripps Research Institute , La Jolla, CA","1Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology and Microbial Science, The Scripps Research Institute , La Jolla, CA","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"1Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sunjun Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127128434","display_name":"Genomics Institute of the Novartis Research Foundation","ror":"https://ror.org/017136v53","country_code":"US","type":"facility","lineage":["https://openalex.org/I127128434","https://openalex.org/I1283582996","https://openalex.org/I4210117619"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sunjun Kim","raw_affiliation_strings":["GNF , San Diego, CA","2GNF, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GNF , San Diego, CA","institution_ids":["https://openalex.org/I127128434"]},{"raw_affiliation_string":"2GNF, San Diego, CA","institution_ids":["https://openalex.org/I127128434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043653383","display_name":"Niusha Ziaee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127128434","display_name":"Genomics Institute of the Novartis Research Foundation","ror":"https://ror.org/017136v53","country_code":"US","type":"facility","lineage":["https://openalex.org/I127128434","https://openalex.org/I1283582996","https://openalex.org/I4210117619"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Niusha Ziaee","raw_affiliation_strings":["GNF , San Diego, CA","2GNF, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GNF , San Diego, CA","institution_ids":["https://openalex.org/I127128434"]},{"raw_affiliation_string":"2GNF, San Diego, CA","institution_ids":["https://openalex.org/I127128434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076322374","display_name":"Andrew H. Miller","orcid":"https://orcid.org/0000-0001-8260-7997","observed_orcids":["https://orcid.org/0000-0001-8260-7997","https://orcid.org/0009-0000-0426-0297"]},"institutions":[{"id":"https://openalex.org/I127128434","display_name":"Genomics Institute of the Novartis Research Foundation","ror":"https://ror.org/017136v53","country_code":"US","type":"facility","lineage":["https://openalex.org/I127128434","https://openalex.org/I1283582996","https://openalex.org/I4210117619"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Miller","raw_affiliation_strings":["GNF , San Diego, CA","2GNF, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GNF , San Diego, CA","institution_ids":["https://openalex.org/I127128434"]},{"raw_affiliation_string":"2GNF, San Diego, CA","institution_ids":["https://openalex.org/I127128434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031018274","display_name":"Carie Jackson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127128434","display_name":"Genomics Institute of the Novartis Research Foundation","ror":"https://ror.org/017136v53","country_code":"US","type":"facility","lineage":["https://openalex.org/I127128434","https://openalex.org/I1283582996","https://openalex.org/I4210117619"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carie Jackson","raw_affiliation_strings":["GNF , San Diego, CA","2GNF, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GNF , San Diego, CA","institution_ids":["https://openalex.org/I127128434"]},{"raw_affiliation_string":"2GNF, San Diego, CA","institution_ids":["https://openalex.org/I127128434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103616037","display_name":"Mike Young","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127128434","display_name":"Genomics Institute of the Novartis Research Foundation","ror":"https://ror.org/017136v53","country_code":"US","type":"facility","lineage":["https://openalex.org/I127128434","https://openalex.org/I1283582996","https://openalex.org/I4210117619"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mike Young","raw_affiliation_strings":["GNF , San Diego, CA","2GNF, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GNF , San Diego, CA","institution_ids":["https://openalex.org/I127128434"]},{"raw_affiliation_string":"2GNF, San Diego, CA","institution_ids":["https://openalex.org/I127128434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004260180","display_name":"Serge Batalov","orcid":"https://orcid.org/0000-0002-0925-0554","observed_orcids":["https://orcid.org/0000-0002-0925-0554"]},"institutions":[{"id":"https://openalex.org/I127128434","display_name":"Genomics Institute of the Novartis Research Foundation","ror":"https://ror.org/017136v53","country_code":"US","type":"facility","lineage":["https://openalex.org/I127128434","https://openalex.org/I1283582996","https://openalex.org/I4210117619"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Serge Batalov","raw_affiliation_strings":["GNF , San Diego, CA","2GNF, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GNF , San Diego, CA","institution_ids":["https://openalex.org/I127128434"]},{"raw_affiliation_string":"2GNF, San Diego, CA","institution_ids":["https://openalex.org/I127128434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100330542","display_name":"Yi Fan Liu","orcid":"https://orcid.org/0000-0002-4998-5547","observed_orcids":["https://orcid.org/0000-0002-4998-5547"]},"institutions":[{"id":"https://openalex.org/I127128434","display_name":"Genomics Institute of the Novartis Research Foundation","ror":"https://ror.org/017136v53","country_code":"US","type":"facility","lineage":["https://openalex.org/I127128434","https://openalex.org/I1283582996","https://openalex.org/I4210117619"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi Liu","raw_affiliation_strings":["GNF , San Diego, CA","2GNF, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GNF , San Diego, CA","institution_ids":["https://openalex.org/I127128434"]},{"raw_affiliation_string":"2GNF, San Diego, CA","institution_ids":["https://openalex.org/I127128434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084059598","display_name":"Markus Warmuth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127128434","display_name":"Genomics Institute of the Novartis Research Foundation","ror":"https://ror.org/017136v53","country_code":"US","type":"facility","lineage":["https://openalex.org/I127128434","https://openalex.org/I1283582996","https://openalex.org/I4210117619"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Markus Warmuth","raw_affiliation_strings":["GNF , San Diego, CA","2GNF, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GNF , San Diego, CA","institution_ids":["https://openalex.org/I127128434"]},{"raw_affiliation_string":"2GNF, San Diego, CA","institution_ids":["https://openalex.org/I127128434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042956546","display_name":"Tim Wiltshire","orcid":"https://orcid.org/0000-0001-5960-4034","observed_orcids":["https://orcid.org/0000-0001-5960-4034"]},"institutions":[{"id":"https://openalex.org/I127128434","display_name":"Genomics Institute of the Novartis Research Foundation","ror":"https://ror.org/017136v53","country_code":"US","type":"facility","lineage":["https://openalex.org/I127128434","https://openalex.org/I1283582996","https://openalex.org/I4210117619"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tim Wiltshire","raw_affiliation_strings":["GNF , San Diego, CA","2GNF, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GNF , San Diego, CA","institution_ids":["https://openalex.org/I127128434"]},{"raw_affiliation_string":"2GNF, San Diego, CA","institution_ids":["https://openalex.org/I127128434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102961078","display_name":"Michael P. Cooke","orcid":"https://orcid.org/0000-0001-6662-0315","observed_orcids":["https://orcid.org/0000-0001-6662-0315"]},"institutions":[{"id":"https://openalex.org/I127128434","display_name":"Genomics Institute of the Novartis Research Foundation","ror":"https://ror.org/017136v53","country_code":"US","type":"facility","lineage":["https://openalex.org/I127128434","https://openalex.org/I1283582996","https://openalex.org/I4210117619"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael P Cooke","raw_affiliation_strings":["GNF , San Diego, CA","2GNF, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GNF , San Diego, CA","institution_ids":["https://openalex.org/I127128434"]},{"raw_affiliation_string":"2GNF, San Diego, CA","institution_ids":["https://openalex.org/I127128434"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068771985","display_name":"Rina Barouch\u2010Bentov","orcid":"https://orcid.org/0000-0002-5964-2329","observed_orcids":["https://orcid.org/0000-0002-5964-2329"]},"institutions":[{"id":"https://openalex.org/I127128434","display_name":"Genomics Institute of the Novartis Research Foundation","ror":"https://ror.org/017136v53","country_code":"US","type":"facility","lineage":["https://openalex.org/I127128434","https://openalex.org/I1283582996","https://openalex.org/I4210117619"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rina Barouch-Bentov","raw_affiliation_strings":["GNF , San Diego, CA","2GNF, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GNF , San Diego, CA","institution_ids":["https://openalex.org/I127128434"]},{"raw_affiliation_string":"2GNF, San Diego, CA","institution_ids":["https://openalex.org/I127128434"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"182","issue":"Supplement_1","first_page":"84.17","last_page":"84.17"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lyn-kinase","display_name":"Lyn kinase","score":0.7239999771118164},{"id":"https://openalex.org/keywords/src-family-kinases","display_name":"Src family kinases","score":0.9409999847412109},{"id":"https://openalex.org/keywords/c-abl","display_name":"c-Abl","score":0.843999981880188},{"id":"https://openalex.org/keywords/atp-binding","display_name":"ATP binding","score":0.8899999856948853},{"id":"https://openalex.org/keywords/imatinib","display_name":"imatinib","score":0.6600000262260437},{"id":"https://openalex.org/keywords/b-cell-receptor-signaling","display_name":"B cell receptor signaling","score":0.8169999718666077},{"id":"https://openalex.org/keywords/b-cell-development","display_name":"B cell development","score":0.9309999942779541},{"id":"https://openalex.org/keywords/autoimmune-glomerulonephritis","display_name":"autoimmune glomerulonephritis","score":0.9700000286102295},{"id":"https://openalex.org/keywords/electrostatic-interactions","display_name":"electrostatic interactions","score":0.5289999842643738},{"id":"https://openalex.org/keywords/kinase-inhibition","display_name":"kinase inhibition","score":0.38199999928474426}],"concepts":[{"id":"https://openalex.org/C175818844","wikidata":"https://www.wikidata.org/wiki/Q2463389","display_name":"LYN","level":4,"score":0.9613089561462402},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.6434736847877502},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5415765047073364},{"id":"https://openalex.org/C196347352","wikidata":"https://www.wikidata.org/wiki/Q24771787","display_name":"SH3 domain","level":4,"score":0.5088710784912109},{"id":"https://openalex.org/C30765947","wikidata":"https://www.wikidata.org/wiki/Q899119","display_name":"Salt bridge","level":4,"score":0.44823190569877625},{"id":"https://openalex.org/C108636557","wikidata":"https://www.wikidata.org/wiki/Q21109354","display_name":"Proto-oncogene tyrosine-protein kinase Src","level":3,"score":0.43873119354248047},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4378671646118164},{"id":"https://openalex.org/C183141693","wikidata":"https://www.wikidata.org/wiki/Q5005962","display_name":"Tyrosine-protein kinase CSK","level":5,"score":0.4301382303237915},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4053358733654022},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3886343538761139},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.08489865064620972},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.182.supp.84.17","doi":"https://doi.org/10.4049/jimmunol.182.supp.84.17","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.182.supp.84.17","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2163674612","https://openalex.org/W2272723045","https://openalex.org/W2883017776","https://openalex.org/W2291582508","https://openalex.org/W1994024295","https://openalex.org/W4317745817","https://openalex.org/W2062348424","https://openalex.org/W1982338224","https://openalex.org/W2153404441","https://openalex.org/W2162658917"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"glycine-rich":[2],"G-loop":[3,56,124],"controls":[4,59],"ATP":[5,60],"binding":[6],"and":[7,22,63,90,109,111,127],"phosphate":[8],"transfer":[9],"in":[10,43,80,91,105,134],"protein":[11,24,48,85],"kinases.":[12],"Here":[13],"we":[14],"show":[15,102],"that":[16,40],"the":[17,77,118,122,129,133,138,147],"functions":[18,145],"of":[19,76,82,121,146],"Src":[20],"family":[21],"Abl":[23],"tyrosine":[25],"kinases":[26,49],"require":[27],"an":[28],"electrostatic":[29],"interaction":[30,78],"between":[31],"oppositely":[32],"charged":[33],"amino":[34],"acids":[35],"within":[36],"their":[37],"G":[38],"loops":[39],"is":[41],"conserved":[42,123],"multiple":[44],"other":[45,143],"phylogenetically":[46],"distinct":[47],"from":[50,142],"plants":[51],"to":[52,113],"humans.":[53],"By":[54],"limiting":[55],"flexibility,":[57],"it":[58],"binding,":[61],"catalysis":[62],"inhibition":[64],"by":[65],"ATP-competitive":[66],"compounds":[67],"such":[68],"as":[69],"Imatinib.":[70],"In":[71],"WeeB":[72,100],"mice,":[73,99],"mutational":[74],"disruption":[75],"results":[79],"expression":[81],"a":[83],"Lyn":[84,139],"with":[86],"reduced":[87],"catalytic":[88],"activity,":[89],"perturbed":[92],"B":[93,106],"cell":[94,107],"receptor":[95],"signaling.":[96],"Like":[97],"Lyn-/-":[98],"mice":[101],"profound":[103],"defects":[104],"development":[108],"function":[110],"succumb":[112],"autoimmune":[114],"glomerulonephritis.":[115],"This":[116],"demonstrates":[117],"physiological":[119],"importance":[120],"salt":[125],"bridge":[126],"at":[128],"same":[130],"time":[131],"distinguishes":[132],"vivo":[135],"requirement":[136],"for":[137],"kinase":[140],"activity":[141],"potential":[144],"protein.":[148]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2016-06-24T00:00:00"}