{"id":"https://openalex.org/W2279214483","doi":"https://doi.org/10.1182/blood.v66.3.548.548","title":"Establishment of two new myeloma cell lines from bilateral pleural effusions: evidence for sequential in vivo clonal change","display_name":"Establishment of two new myeloma cell lines from bilateral pleural effusions: evidence for sequential in vivo clonal change","publication_year":1985,"publication_date":"1985-09-01","ids":{"openalex":"https://openalex.org/W2279214483","doi":"https://doi.org/10.1182/blood.v66.3.548.548","mag":"2279214483","pmid":"https://pubmed.ncbi.nlm.nih.gov/3927997"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v66.3.548.548","doi":"https://doi.org/10.1182/blood.v66.3.548.548","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.v66.3.548.548","pdf_url":"https://ashpublications.org/blood/article-pdf/66/3/548/1639324/548.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ashpublications.org/blood/article-pdf/66/3/548/1639324/548.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113435224","display_name":"BG Durie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"BG Durie","raw_affiliation_strings":["Section of Hematology/Oncology, the Cancer Center, and the Department of Pathology, University of Arizona Health Sciences Center, Tucson"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Hematology/Oncology, the Cancer Center, and the Department of Pathology, University of Arizona Health Sciences Center, Tucson","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":null,"display_name":"E Vela","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E Vela","raw_affiliation_strings":["Section of Hematology/Oncology, the Cancer Center, and the Department of Pathology, University of Arizona Health Sciences Center, Tucson"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Hematology/Oncology, the Cancer Center, and the Department of Pathology, University of Arizona Health Sciences Center, Tucson","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032164393","display_name":"V Baum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V Baum","raw_affiliation_strings":["Section of Hematology/Oncology, the Cancer Center, and the Department of Pathology, University of Arizona Health Sciences Center, Tucson"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Hematology/Oncology, the Cancer Center, and the Department of Pathology, University of Arizona Health Sciences Center, Tucson","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018357823","display_name":"A Leibovitz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Leibovitz","raw_affiliation_strings":["Section of Hematology/Oncology, the Cancer Center, and the Department of Pathology, University of Arizona Health Sciences Center, Tucson"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Hematology/Oncology, the Cancer Center, and the Department of Pathology, University of Arizona Health Sciences Center, Tucson","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023500007","display_name":"CM Payne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"CM Payne","raw_affiliation_strings":["Section of Hematology/Oncology, the Cancer Center, and the Department of Pathology, University of Arizona Health Sciences Center, Tucson"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Hematology/Oncology, the Cancer Center, and the Department of Pathology, University of Arizona Health Sciences Center, Tucson","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113668953","display_name":"L Richter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"LC Richter","raw_affiliation_strings":["Section of Hematology/Oncology, the Cancer Center, and the Department of Pathology, University of Arizona Health Sciences Center, Tucson"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Hematology/Oncology, the Cancer Center, and the Department of Pathology, University of Arizona Health Sciences Center, Tucson","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112159786","display_name":"TM Grogan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"TM Grogan","raw_affiliation_strings":["Section of Hematology/Oncology, the Cancer Center, and the Department of Pathology, University of Arizona Health Sciences Center, Tucson"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Hematology/Oncology, the Cancer Center, and the Department of Pathology, University of Arizona Health Sciences Center, Tucson","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113828382","display_name":"JM Trent","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JM Trent","raw_affiliation_strings":["Section of Hematology/Oncology, the Cancer Center, and the Department of Pathology, University of Arizona Health Sciences Center, Tucson"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Hematology/Oncology, the Cancer Center, and the Department of Pathology, University of Arizona Health Sciences Center, Tucson","institution_ids":["https://openalex.org/I138006243"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I138006243"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":5.1943,"has_fulltext":true,"cited_by_count":57,"citation_normalized_percentile":{"value":0.95830153,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"66","issue":"3","first_page":"548","last_page":"555"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9869999885559082},{"id":"https://openalex.org/keywords/igg-kappa-myeloma","display_name":"IgG kappa myeloma","score":0.847000002861023},{"id":"https://openalex.org/keywords/malignant-pleural-effusion","display_name":"malignant pleural effusion","score":0.9639999866485596},{"id":"https://openalex.org/keywords/myeloma-cell-lines","display_name":"myeloma cell lines","score":0.9330000281333923},{"id":"https://openalex.org/keywords/clonal-evolution","display_name":"clonal evolution","score":0.9259999990463257},{"id":"https://openalex.org/keywords/chromosomal-abnormalities","display_name":"chromosomal abnormalities","score":0.7009999752044678},{"id":"https://openalex.org/keywords/karyotype","display_name":"karyotype","score":0.8130000233650208},{"id":"https://openalex.org/keywords/chromosome-7p","display_name":"chromosome 7p","score":0.6299999952316284},{"id":"https://openalex.org/keywords/osteoclast-activating-factor","display_name":"osteoclast activating factor","score":0.906000018119812},{"id":"https://openalex.org/keywords/beta2-microglobulin","display_name":"beta2-microglobulin","score":0.8489999771118164},{"id":"https://openalex.org/keywords/immunophenotype","display_name":"immunophenotype","score":0.75},{"id":"https://openalex.org/keywords/epstein-barr-virus-exclusion","display_name":"Epstein-Barr virus exclusion","score":0.6480000019073486},{"id":"https://openalex.org/keywords/refractory-multiple-myeloma","display_name":"refractory multiple myeloma","score":0.8500000238418579}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.634475827217102},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.530584990978241},{"id":"https://openalex.org/C53226629","wikidata":"https://www.wikidata.org/wiki/Q189967","display_name":"Karyotype","level":4,"score":0.47488516569137573},{"id":"https://openalex.org/C2776396001","wikidata":"https://www.wikidata.org/wiki/Q250694","display_name":"Plasma cell","level":3,"score":0.4554325342178345},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.44866475462913513},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4461880922317505},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.40740180015563965},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.31639382243156433},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.21751540899276733},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20281916856765747},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12295931577682495},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002469","descriptor_name":"Cell Separation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D002999","descriptor_name":"Clone Cells","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D002999","descriptor_name":"Clone Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002999","descriptor_name":"Clone Cells","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006651","descriptor_name":"Histocytochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D007145","descriptor_name":"Immunoglobulin kappa-Chains","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007621","descriptor_name":"Karyotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010996","descriptor_name":"Pleural Effusion","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1182/blood.v66.3.548.548","doi":"https://doi.org/10.1182/blood.v66.3.548.548","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.v66.3.548.548","pdf_url":"https://ashpublications.org/blood/article-pdf/66/3/548/1639324/548.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"doi:10.1182/blood.v66.3.548.bloodjournal663548","doi":"https://doi.org/10.1182/blood.v66.3.548.bloodjournal663548","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.v66.3.548.bloodjournal663548","pdf_url":"https://ashpublications.org/blood/article-pdf/66/3/548/362440/548.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:3927997","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3927997","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"},{"id":"mag:2314509126","doi":null,"is_oa":false,"landing_page_url":"http://myeloma.org/pdfs/Durie_Articles/23-1985.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1182/blood.v66.3.548.548","doi":"https://doi.org/10.1182/blood.v66.3.548.548","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.v66.3.548.548","pdf_url":"https://ashpublications.org/blood/article-pdf/66/3/548/1639324/548.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3494388860","display_name":"Therapeutic Targeting of Hypoxic and Oxidative Stress","funder_award_id":"P01CA017094","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320310160","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2279214483.pdf","grobid_xml":"https://content.openalex.org/works/W2279214483.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W4772462","https://openalex.org/W41243025","https://openalex.org/W55440173","https://openalex.org/W188775144","https://openalex.org/W1576511239","https://openalex.org/W1595882495","https://openalex.org/W1965996366","https://openalex.org/W1973119558","https://openalex.org/W2013358719","https://openalex.org/W2017963255","https://openalex.org/W2018610554","https://openalex.org/W2021998439","https://openalex.org/W2029994209","https://openalex.org/W2038450925","https://openalex.org/W2043605153","https://openalex.org/W2046997848","https://openalex.org/W2055036493","https://openalex.org/W2055787036","https://openalex.org/W2063450941","https://openalex.org/W2073815986","https://openalex.org/W2081114596","https://openalex.org/W2085885116","https://openalex.org/W2093482153","https://openalex.org/W2109582366","https://openalex.org/W2161402720","https://openalex.org/W2165748309","https://openalex.org/W2170045209","https://openalex.org/W2216501506","https://openalex.org/W2281128878","https://openalex.org/W2312421622","https://openalex.org/W2316545351","https://openalex.org/W2327665287","https://openalex.org/W2339359539","https://openalex.org/W2414234725","https://openalex.org/W2417006377","https://openalex.org/W2418875295","https://openalex.org/W2793168408","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2314509126","https://openalex.org/W1993585891","https://openalex.org/W344306772","https://openalex.org/W2140587752","https://openalex.org/W2097539881","https://openalex.org/W2049754845","https://openalex.org/W2413347632","https://openalex.org/W7094220390","https://openalex.org/W1968900701","https://openalex.org/W2002087131"],"abstract_inverted_index":{"Two":[0,63],"new":[1,219],"human":[2],"myeloma":[3,18,126],"cell":[4,66,90,113,151,195,222],"lines":[5,223],"have":[6,224],"been":[7,225],"established":[8,73],"from":[9,30],"a":[10,37,154,180],"36-year-old":[11],"woman":[12],"with":[13,160],"refractory":[14],"IgG":[15,64,102,132],"kappa":[16,65,103],"multiple":[17],"in":[19,36,208,214],"whom":[20],"bilateral":[21],"malignant":[22,27],"pleural":[23,121],"effusions":[24],"developed.":[25],"The":[26,128],"plasma":[28,89],"cells":[29],"each":[31,112],"effusion":[32],"were":[33,72],"set":[34],"up":[35],"liquid":[38],"culture":[39],"using":[40,81],"an":[41,101],"L-15":[42],"medium":[43],"containing":[44],"catalase,":[45],"glutathione,":[46],"selenous":[47],"acid,":[48,50],"ascorbic":[49],"insulin,":[51],"transferrin,":[52],"additional":[53,199,203],"glutamine":[54],"hydrocortisone,":[55],"and":[56,58,70,74,96,123,137,172,179],"2-mercaptoethanol":[57],"designated":[59],"as":[60,115,117],"M-3":[61],"medium.":[62],"lines,":[67],"LB":[68],"-831":[69],"LB-832,":[71],"proved":[75],"to":[76],"be":[77],"Epstein-Barr":[78],"virus":[79],"negative":[80],"the":[82,119,149,193],"internal":[83],"repeat":[84],"sequence":[85],"DNA":[86],"probe.":[87],"Characteristic":[88],"morphology":[91],"was":[92],"evident":[93],"by":[94],"light":[95],"electron":[97],"microscopy.":[98],"Immunotyping":[99],"revealed":[100,153,197],",":[104],"B1+,":[105],"B2-,":[106],"Ia":[107],"(HLA-DR)+,":[108],"CALLA+":[109],"phenotype":[110],"for":[111,118,231],"line":[114,152,196],"well":[116],"original":[120],"fluid":[122],"bone":[124],"marrow":[125],"cells.":[127],"supernatants":[129],"also":[130],"contained":[131],"kappa,":[133],"beta":[134],"2":[135],"microglobulin,":[136],"large":[138],"amounts":[139],"of":[140,148,192],"osteoclast-activating":[141],"factor":[142],"(indicating":[143],"bone-resorbing":[144],"activity).":[145],"Cytogenetic":[146],"analysis":[147],"LB-831":[150],"nearly":[155],"triploid":[156],"highly":[157],"abnormal":[158,176],"karyotype":[159],"numerous":[161],"clonal":[162,200,211],"chromosomal":[163],"abnormalities":[164],"involving":[165],"chromosomes":[166],"1,":[167],"3,":[168],"5,":[169],"7,":[170],"13,":[171],"15;":[173],"several":[174,198],"structurally":[175],"marker":[177],"chromosomes;":[178],"putative":[181],"homogeneously":[182],"staining":[183],"region":[184],"on":[185],"chromosome":[186],"7p":[187],"at":[188],"band":[189],"p22.":[190],"Analysis":[191],"LB-832":[194],"abnormalities.":[201],"These":[202],"cytogenetic":[204],"changes":[205],"suggest":[206],"that":[207],"vivo":[209],"sequential":[210],"evolution":[212],"occurred":[213],"this":[215],"patient.":[216],"Therefore,":[217],"two":[218],"but":[220],"related":[221],"established,":[226],"which":[227],"should":[228],"prove":[229],"useful":[230],"further":[232],"biological":[233],"studies.":[234]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
