{"id":"https://openalex.org/W2279166322","doi":null,"title":"Biomechanical properties of the sciatic nerve following repair: effects of topical application of hyaluronic acid or tacrolimus.","display_name":"Biomechanical properties of the sciatic nerve following repair: effects of topical application of hyaluronic acid or tacrolimus.","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2279166322","mag":"2279166322","pmid":"https://pubmed.ncbi.nlm.nih.gov/26884934","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4723779"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4723779","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4723779","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Med","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4723779","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054300413","display_name":"Agon Mekaj","orcid":"https://orcid.org/0000-0003-1094-5182","observed_orcids":["https://orcid.org/0000-0003-1094-5182"]},"institutions":[{"id":"https://openalex.org/I78768387","display_name":"University of Prishtina","ror":"https://ror.org/05t3p2g92","country_code":"XK","type":"education","lineage":["https://openalex.org/I78768387"]}],"countries":["XK"],"is_corresponding":false,"raw_author_name":"Agon Y Mekaj","raw_affiliation_strings":["Clinic of Neurosurgery, Faculty of Medicine, University of Prishtina Prishtina 10000, Kosovo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic of Neurosurgery, Faculty of Medicine, University of Prishtina Prishtina 10000, Kosovo","institution_ids":["https://openalex.org/I78768387"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110558148","display_name":"Arsim A. Morina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78768387","display_name":"University of Prishtina","ror":"https://ror.org/05t3p2g92","country_code":"XK","type":"education","lineage":["https://openalex.org/I78768387"]}],"countries":["XK"],"is_corresponding":false,"raw_author_name":"Arsim A Morina","raw_affiliation_strings":["Clinic of Neurosurgery, Faculty of Medicine, University of Prishtina Prishtina 10000, Kosovo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic of Neurosurgery, Faculty of Medicine, University of Prishtina Prishtina 10000, Kosovo","institution_ids":["https://openalex.org/I78768387"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060769039","display_name":"Shp\u00ebtim Lajqi","orcid":"https://orcid.org/0000-0001-5091-2460","observed_orcids":["https://orcid.org/0000-0001-5091-2460"]},"institutions":[{"id":"https://openalex.org/I78768387","display_name":"University of Prishtina","ror":"https://ror.org/05t3p2g92","country_code":"XK","type":"education","lineage":["https://openalex.org/I78768387"]}],"countries":["XK"],"is_corresponding":false,"raw_author_name":"Shpetim Lajqi","raw_affiliation_strings":["Department of Construction and Mechanism, Faculty of Mechanical Engineering, University of Prishtina Bregu i Diellit p.n., Prishtina 10000, Kosovo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Construction and Mechanism, Faculty of Mechanical Engineering, University of Prishtina Bregu i Diellit p.n., Prishtina 10000, Kosovo","institution_ids":["https://openalex.org/I78768387"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063309978","display_name":"Suzana Manxhuka-K\u00ebrliu","orcid":"https://orcid.org/0000-0003-2202-3409","observed_orcids":["https://orcid.org/0000-0003-2202-3409"]},"institutions":[{"id":"https://openalex.org/I78768387","display_name":"University of Prishtina","ror":"https://ror.org/05t3p2g92","country_code":"XK","type":"education","lineage":["https://openalex.org/I78768387"]}],"countries":["XK"],"is_corresponding":false,"raw_author_name":"Suzana Manxhuka-Kerliu","raw_affiliation_strings":["Institute of Pathology, Faculty of Medicine, University of Prishtina Prishtina 10000, Kosovo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, Faculty of Medicine, University of Prishtina Prishtina 10000, Kosovo","institution_ids":["https://openalex.org/I78768387"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021641685","display_name":"Fatos M. Kelmendi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78768387","display_name":"University of Prishtina","ror":"https://ror.org/05t3p2g92","country_code":"XK","type":"education","lineage":["https://openalex.org/I78768387"]}],"countries":["XK"],"is_corresponding":false,"raw_author_name":"Fatos M Kelmendi","raw_affiliation_strings":["Clinic of Neurosurgery, Faculty of Medicine, University of Prishtina Prishtina 10000, Kosovo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic of Neurosurgery, Faculty of Medicine, University of Prishtina Prishtina 10000, Kosovo","institution_ids":["https://openalex.org/I78768387"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042538407","display_name":"Shkelzen B. Duci","orcid":"https://orcid.org/0000-0002-8956-3779","observed_orcids":["https://orcid.org/0000-0002-8956-3779"]},"institutions":[{"id":"https://openalex.org/I78768387","display_name":"University of Prishtina","ror":"https://ror.org/05t3p2g92","country_code":"XK","type":"education","lineage":["https://openalex.org/I78768387"]}],"countries":["XK"],"is_corresponding":false,"raw_author_name":"Shkelzen B Duci","raw_affiliation_strings":["Clinic of Plastic and Reconstructive Surgery, Faculty of Medicine, University of Prishtina Prishtina 10000, Kosovo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic of Plastic and Reconstructive Surgery, Faculty of Medicine, University of Prishtina Prishtina 10000, Kosovo","institution_ids":["https://openalex.org/I78768387"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I78768387"],"apc_list":null,"apc_paid":null,"fwci":0.7713,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.65411751,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"8","issue":"11","first_page":"20218","last_page":"26"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12459","display_name":"Nerve Injury and Rehabilitation","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sciatic-nerve","display_name":"sciatic nerve","score":0.906000018119812},{"id":"https://openalex.org/keywords/nerve-repair","display_name":"nerve repair","score":0.7889999747276306},{"id":"https://openalex.org/keywords/nerve-regeneration","display_name":"nerve regeneration","score":0.7960000038146973},{"id":"https://openalex.org/keywords/hyaluronic-acid","display_name":"hyaluronic acid","score":0.8569999933242798},{"id":"https://openalex.org/keywords/tacrolimus","display_name":"tacrolimus","score":0.996999979019165},{"id":"https://openalex.org/keywords/fk506","display_name":"FK506","score":0.9769999980926514},{"id":"https://openalex.org/keywords/topical-administration","display_name":"topical administration","score":0.753000020980835},{"id":"https://openalex.org/keywords/elastic-limit","display_name":"elastic limit","score":0.6430000066757202},{"id":"https://openalex.org/keywords/rabbit-model","display_name":"rabbit model","score":0.5}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8349155783653259},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.758355438709259},{"id":"https://openalex.org/C2781149210","wikidata":"https://www.wikidata.org/wiki/Q307869","display_name":"Sciatic nerve","level":2,"score":0.7521891593933105},{"id":"https://openalex.org/C2777529286","wikidata":"https://www.wikidata.org/wiki/Q337231","display_name":"Hyaluronic acid","level":2,"score":0.6184076070785522},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.5873057246208191},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4289936423301697},{"id":"https://openalex.org/C170700871","wikidata":"https://www.wikidata.org/wiki/Q193378","display_name":"Biomechanics","level":2,"score":0.41133347153663635},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.32148873805999756},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3079069256782532}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:4723779","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4723779","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Med","raw_type":"Text"},{"id":"pmid:26884934","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26884934","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental medicine","raw_type":"Journal Article"},{"id":"mag:2279166322","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26884934","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4723779","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4723779","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Med","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1524914333","https://openalex.org/W1557220830","https://openalex.org/W1605773257","https://openalex.org/W1972900653","https://openalex.org/W1987318576","https://openalex.org/W1992880536","https://openalex.org/W1994505268","https://openalex.org/W1994972961","https://openalex.org/W1997446351","https://openalex.org/W1998392083","https://openalex.org/W2012578778","https://openalex.org/W2012705499","https://openalex.org/W2022308075","https://openalex.org/W2029243547","https://openalex.org/W2039949457","https://openalex.org/W2055222360","https://openalex.org/W2066207241","https://openalex.org/W2076665630","https://openalex.org/W2087392022","https://openalex.org/W2117030792","https://openalex.org/W2147124111","https://openalex.org/W2157529734","https://openalex.org/W2161037068","https://openalex.org/W2172103539","https://openalex.org/W2398543968","https://openalex.org/W2405206791","https://openalex.org/W2405577680"],"related_works":["https://openalex.org/W2264622866","https://openalex.org/W2398198736","https://openalex.org/W2082457758","https://openalex.org/W1975478086","https://openalex.org/W2157529734","https://openalex.org/W7160097806","https://openalex.org/W1963898252","https://openalex.org/W1524914333","https://openalex.org/W1997745372","https://openalex.org/W2124923337"],"abstract_inverted_index":{"UNLABELLED:":[0],"Recovery":[1],"following":[2,68],"nerve":[3,39,44,176,224],"repair":[4],"can":[5],"be":[6],"evaluated":[7],"based":[8],"on":[9,32],"electrophysiological":[10],"and":[11,96,109,139,149,180,192,209],"morphological":[12],"assessments":[13],"of":[14,22,36,66,113,123,161,194,206,216],"biomechanical":[15,34,163,204],"properties.":[16],"This":[17],"study":[18],"compared":[19],"the":[20,33,37,67,114,129,146,162,168,197,207,217],"effects":[21],"topical":[23],"hyaluronic":[24],"acid":[25],"(HA),":[26],"tacrolimus":[27],"(FK-506)":[28],"or":[29,77],"saline":[30,218],"administration":[31],"properties":[35,205],"sciatic":[38,90],"at":[40,220],"12":[41,173,221],"weeks":[42,174,222],"after":[43,175,223],"repair.":[45,225],"MATERIALS":[46],"AND":[47],"METHODS:":[48],"Eighteen":[49],"male":[50],"European":[51],"rabbits":[52],"(Oryctolagus":[53],"cuniculus)":[54],"(weight":[55],"from":[56,121],"2.5":[57],"to":[58,64,214],"3":[59],"kg)":[60],"were":[61,94,117,142,165,189,212],"randomly":[62],"assigned":[63],"one":[65],"experimental":[69,126,152,169],"groups":[70,153,170,182,211],"(six":[71],"animals":[72],"per":[73],"group):":[74],"Saline,":[75,178],"HA,":[76,179],"FK-506.":[78],"The":[79,100,203],"non-transected":[80],"left":[81],"leg":[82],"was":[83],"used":[84],"as":[85],"a":[86],"control":[87,115,147,198],"group":[88,116,148,199,219],"(eighteen":[89],"nerves).":[91],"Biomechanical":[92],"assays":[93],"performed":[95],"statistically":[97],"analyzed.":[98],"RESULTS:":[99],"average":[101,184],"maximal":[102,107,134,140,185],"load,":[103,106],"elastic":[104,110,136],"limit":[105,111,137],"stress,":[108,138],"strain":[112],"significantly":[118,143],"different":[119,144],"(P<0.001)":[120],"those":[122,195,215],"all":[124,150],"three":[125,151],"groups.":[127],"Moreover,":[128],"other":[130],"examined":[131],"parameters":[132,164],"(i.e.,":[133],"displacement,":[135],"strain)":[141],"between":[145,167],"(P<0.0001).":[154],"However,":[155],"no":[156],"significant":[157],"differences":[158],"in":[159,196],"any":[160],"observed":[166],"(P>0.05).":[171],"At":[172],"repair,":[177],"FK-506":[181,210],"displayed":[183],"stress":[186],"values":[187],"that":[188],"72.6%,":[190],"77.38%,":[191],"73.8%":[193],"(100%),":[200],"respectively.":[201],"CONCLUSION:":[202],"HA":[208],"similar":[213]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}