{"id":"https://openalex.org/W2279125451","doi":null,"title":"\u03b21 integrin regulation","display_name":"\u03b21 integrin regulation","publication_year":2009,"publication_date":"2009-04-08","ids":{"openalex":"https://openalex.org/W2279125451","mag":"2279125451"},"language":"en","primary_location":{"id":"pmh:oai:utupub.fi:11111/26869","doi":null,"is_oa":true,"landing_page_url":"https://www.utupub.fi/handle/11111/26869","pdf_url":"https://www.utupub.fi/bitstreams/813f6779-887e-4af8-baca-999e8be07f11/download","source":{"id":"https://openalex.org/S4306402470","display_name":"UTUPub (University of Turku)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I155660961","host_organization_name":"University of Turku","host_organization_lineage":["https://openalex.org/I155660961"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.utupub.fi/handle/10024/44486","raw_type":"fi=Artikkeliv\u00e4it\u00f6skirja|en=Doctoral dissertation (article-based)|"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.utupub.fi/bitstreams/813f6779-887e-4af8-baca-999e8be07f11/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031007847","display_name":"Teijo S. Pellinen","orcid":"https://orcid.org/0000-0001-9652-7373","observed_orcids":["https://orcid.org/0000-0001-9652-7373"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Teijo Pellinen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9652-7373","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5031007847"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rab21","display_name":"Rab21","score":0.9660000205039978},{"id":"https://openalex.org/keywords/integrin-endocytosis","display_name":"integrin endocytosis","score":0.7850000262260437},{"id":"https://openalex.org/keywords/integrin-trafficking","display_name":"integrin trafficking","score":0.7929999828338623},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.800000011920929},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9629999995231628},{"id":"https://openalex.org/keywords/cytokinesis","display_name":"cytokinesis","score":0.9909999966621399},{"id":"https://openalex.org/keywords/multinucleation","display_name":"multinucleation","score":0.9789999723434448},{"id":"https://openalex.org/keywords/tetraploidy","display_name":"tetraploidy","score":0.972000002861023},{"id":"https://openalex.org/keywords/aneuploidy","display_name":"aneuploidy","score":0.984000027179718},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.781000018119812},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":1.0},{"id":"https://openalex.org/keywords/chromosomal-deletion","display_name":"chromosomal deletion","score":0.800000011920929},{"id":"https://openalex.org/keywords/sirna-knockdown","display_name":"siRNA knockdown","score":0.7900000214576721}],"concepts":[{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.36310020089149475},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3217065632343292}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:utupub.fi:11111/26869","doi":null,"is_oa":true,"landing_page_url":"https://www.utupub.fi/handle/11111/26869","pdf_url":"https://www.utupub.fi/bitstreams/813f6779-887e-4af8-baca-999e8be07f11/download","source":{"id":"https://openalex.org/S4306402470","display_name":"UTUPub (University of Turku)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I155660961","host_organization_name":"University of Turku","host_organization_lineage":["https://openalex.org/I155660961"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.utupub.fi/handle/10024/44486","raw_type":"fi=Artikkeliv\u00e4it\u00f6skirja|en=Doctoral dissertation (article-based)|"},{"id":"pmh:oai:www.utupub.fi:10024/44486","doi":null,"is_oa":true,"landing_page_url":"http://www.utupub.fi/handle/10024/44486","pdf_url":"http://www.utupub.fi/handle/10024/44486","source":{"id":"https://openalex.org/S4306402470","display_name":"UTUPub (University of Turku)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I155660961","host_organization_name":"University of Turku","host_organization_lineage":["https://openalex.org/I155660961"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"fi=Artikkeliv\u00e4it\u00f6skirja|en=Doctoral dissertation (article-based)|"},{"id":"pmh:oai:www.doria.fi:10024/44486","doi":null,"is_oa":false,"landing_page_url":"http://www.doria.fi/handle/10024/44486","pdf_url":null,"source":{"id":"https://openalex.org/S4377196760","display_name":"Doria (University of Helsinki)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I133731052","host_organization_name":"University of Helsinki","host_organization_lineage":["https://openalex.org/I133731052"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral disseratin (article-based)"},{"id":"mag:2279125451","doi":null,"is_oa":false,"landing_page_url":"https://www.utupub.fi/bitstream/10024/44486/1/Annales%20D%20846%20Pellinen%20Diss.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:utupub.fi:11111/26869","doi":null,"is_oa":true,"landing_page_url":"https://www.utupub.fi/handle/11111/26869","pdf_url":"https://www.utupub.fi/bitstreams/813f6779-887e-4af8-baca-999e8be07f11/download","source":{"id":"https://openalex.org/S4306402470","display_name":"UTUPub (University of Turku)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I155660961","host_organization_name":"University of Turku","host_organization_lineage":["https://openalex.org/I155660961"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.utupub.fi/handle/10024/44486","raw_type":"fi=Artikkeliv\u00e4it\u00f6skirja|en=Doctoral dissertation (article-based)|"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323313","display_name":"Turun Yliopisto","ror":"https://ror.org/05vghhr25"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2279125451.pdf","grobid_xml":"https://content.openalex.org/works/W2279125451.grobid-xml"},"referenced_works_count":360,"referenced_works":["https://openalex.org/W39809497","https://openalex.org/W152635266","https://openalex.org/W179550893","https://openalex.org/W201030272","https://openalex.org/W1490760691","https://openalex.org/W1491459594","https://openalex.org/W1500612905","https://openalex.org/W1522774123","https://openalex.org/W1526383449","https://openalex.org/W1537880401","https://openalex.org/W1545481755","https://openalex.org/W1557170290","https://openalex.org/W1557239654","https://openalex.org/W1558152539","https://openalex.org/W1560325574","https://openalex.org/W1561516029","https://openalex.org/W1562441478","https://openalex.org/W1574203921","https://openalex.org/W1576773659","https://openalex.org/W1578227824","https://openalex.org/W1582842326","https://openalex.org/W1590619267","https://openalex.org/W1593184969","https://openalex.org/W1595083713","https://openalex.org/W1599302006","https://openalex.org/W1618672876","https://openalex.org/W1657825487","https://openalex.org/W1669562987","https://openalex.org/W1672149392","https://openalex.org/W1844203024","https://openalex.org/W1906510141","https://openalex.org/W1914062369","https://openalex.org/W1940309621","https://openalex.org/W1945997263","https://openalex.org/W1961720709","https://openalex.org/W1964181260","https://openalex.org/W1964754149","https://openalex.org/W1965326031","https://openalex.org/W1965428800","https://openalex.org/W1965451329","https://openalex.org/W1965680643","https://openalex.org/W1965740748","https://openalex.org/W1966070464","https://openalex.org/W1966790817","https://openalex.org/W1967869559","https://openalex.org/W1967933675","https://openalex.org/W1968260614","https://openalex.org/W1968454199","https://openalex.org/W1969182145","https://openalex.org/W1969342647","https://openalex.org/W1969348568","https://openalex.org/W1970224298","https://openalex.org/W1970265615","https://openalex.org/W1970374681","https://openalex.org/W1970442105","https://openalex.org/W1972035895","https://openalex.org/W1972134646","https://openalex.org/W1972147469","https://openalex.org/W1972359652","https://openalex.org/W1972761783","https://openalex.org/W1974512564","https://openalex.org/W1975725737","https://openalex.org/W1977235238","https://openalex.org/W1977444277","https://openalex.org/W1978721703","https://openalex.org/W1979815209","https://openalex.org/W1979878166","https://openalex.org/W1979925032","https://openalex.org/W1980794705","https://openalex.org/W1981181636","https://openalex.org/W1981368559","https://openalex.org/W1981459977","https://openalex.org/W1982536372","https://openalex.org/W1984567041","https://openalex.org/W1985278107","https://openalex.org/W1986343746","https://openalex.org/W1986781302","https://openalex.org/W1987672004","https://openalex.org/W1987956579","https://openalex.org/W1988019232","https://openalex.org/W1988642004","https://openalex.org/W1989987282","https://openalex.org/W1990127032","https://openalex.org/W1990130046","https://openalex.org/W1990404393","https://openalex.org/W1990565440","https://openalex.org/W1990842021","https://openalex.org/W1990892549","https://openalex.org/W1991590387","https://openalex.org/W1992127071","https://openalex.org/W1992273782","https://openalex.org/W1993371359","https://openalex.org/W1994108205","https://openalex.org/W1994266173","https://openalex.org/W1994992313","https://openalex.org/W1995553619","https://openalex.org/W1996349206","https://openalex.org/W1996406153","https://openalex.org/W1996636585","https://openalex.org/W1997007146","https://openalex.org/W1997482864","https://openalex.org/W1998539678","https://openalex.org/W1998759184","https://openalex.org/W1999768740","https://openalex.org/W1999838168","https://openalex.org/W2000084597","https://openalex.org/W2000520321","https://openalex.org/W2001640037","https://openalex.org/W2002064198","https://openalex.org/W2002943653","https://openalex.org/W2003003494","https://openalex.org/W2003072982","https://openalex.org/W2003698382","https://openalex.org/W2004857553","https://openalex.org/W2006832551","https://openalex.org/W2006912182","https://openalex.org/W2007269646","https://openalex.org/W2007902132","https://openalex.org/W2008153140","https://openalex.org/W2008276517","https://openalex.org/W2008732608","https://openalex.org/W2009400023","https://openalex.org/W2009487870","https://openalex.org/W2009707750","https://openalex.org/W2009831024","https://openalex.org/W2010435020","https://openalex.org/W2011542351","https://openalex.org/W2011960630","https://openalex.org/W2012662402","https://openalex.org/W2012678565","https://openalex.org/W2012871894","https://openalex.org/W2013932372","https://openalex.org/W2014344387","https://openalex.org/W2015612697","https://openalex.org/W2018172915","https://openalex.org/W2019472123","https://openalex.org/W2020455973","https://openalex.org/W2020898985","https://openalex.org/W2021076495","https://openalex.org/W2022685865","https://openalex.org/W2026002008","https://openalex.org/W2026331945","https://openalex.org/W2027802778","https://openalex.org/W2028528961","https://openalex.org/W2029174607","https://openalex.org/W2030340102","https://openalex.org/W2030588238","https://openalex.org/W2031735540","https://openalex.org/W2032629917","https://openalex.org/W2035809865","https://openalex.org/W2036143536","https://openalex.org/W2038800531","https://openalex.org/W2039071788","https://openalex.org/W2039205173","https://openalex.org/W2039490597","https://openalex.org/W2039949381","https://openalex.org/W2040379229","https://openalex.org/W2041134111","https://openalex.org/W2042704418","https://openalex.org/W2043823402","https://openalex.org/W2043838721","https://openalex.org/W2043889563","https://openalex.org/W2044687503","https://openalex.org/W2044895919","https://openalex.org/W2045802318","https://openalex.org/W2045980139","https://openalex.org/W2046175632","https://openalex.org/W2046477120","https://openalex.org/W2046737719","https://openalex.org/W2049360086","https://openalex.org/W2049897598","https://openalex.org/W2050593322","https://openalex.org/W2050892933","https://openalex.org/W2051152907","https://openalex.org/W2051185006","https://openalex.org/W2051580348","https://openalex.org/W2051974311","https://openalex.org/W2052664316","https://openalex.org/W2052893878","https://openalex.org/W2053087881","https://openalex.org/W2053099898","https://openalex.org/W2053146002","https://openalex.org/W2055236991","https://openalex.org/W2055523552","https://openalex.org/W2055584330","https://openalex.org/W2056990001","https://openalex.org/W2059105213","https://openalex.org/W2059701371","https://openalex.org/W2061566801","https://openalex.org/W2063053901","https://openalex.org/W2063220206","https://openalex.org/W2063812667","https://openalex.org/W2065807153","https://openalex.org/W2066759198","https://openalex.org/W2066975912","https://openalex.org/W2067394538","https://openalex.org/W2069294982","https://openalex.org/W2069820450","https://openalex.org/W2069975235","https://openalex.org/W2070536351","https://openalex.org/W2072173537","https://openalex.org/W2072983720","https://openalex.org/W2073121233","https://openalex.org/W2073246597","https://openalex.org/W2073296814","https://openalex.org/W2073863205","https://openalex.org/W2074143045","https://openalex.org/W2074322827","https://openalex.org/W2074798100","https://openalex.org/W2075033192","https://openalex.org/W2075210551","https://openalex.org/W2075318281","https://openalex.org/W2075363343","https://openalex.org/W2075372304","https://openalex.org/W2075647074","https://openalex.org/W2075723649","https://openalex.org/W2078636414","https://openalex.org/W2079384041","https://openalex.org/W2079612785","https://openalex.org/W2079671002","https://openalex.org/W2079695285","https://openalex.org/W2080647249","https://openalex.org/W2081165906","https://openalex.org/W2082462837","https://openalex.org/W2085024794","https://openalex.org/W2086285294","https://openalex.org/W2086554451","https://openalex.org/W2086641174","https://openalex.org/W2087210265","https://openalex.org/W2087947799","https://openalex.org/W2087963453","https://openalex.org/W2088816549","https://openalex.org/W2089472706","https://openalex.org/W2089736751","https://openalex.org/W2090851364","https://openalex.org/W2094719437","https://openalex.org/W2096563079","https://openalex.org/W2096878710","https://openalex.org/W2097139362","https://openalex.org/W2097407366","https://openalex.org/W2098492566","https://openalex.org/W2098573845","https://openalex.org/W2099100446","https://openalex.org/W2099675490","https://openalex.org/W2099957891","https://openalex.org/W2100326225","https://openalex.org/W2100973132","https://openalex.org/W2100979233","https://openalex.org/W2102461299","https://openalex.org/W2102855030","https://openalex.org/W2103513673","https://openalex.org/W2103746902","https://openalex.org/W2103890955","https://openalex.org/W2104317124","https://openalex.org/W2105117807","https://openalex.org/W2106429913","https://openalex.org/W2107036354","https://openalex.org/W2107151233","https://openalex.org/W2107487363","https://openalex.org/W2107967984","https://openalex.org/W2108467543","https://openalex.org/W2109513838","https://openalex.org/W2111718207","https://openalex.org/W2111803487","https://openalex.org/W2111939342","https://openalex.org/W2114621233","https://openalex.org/W2116422958","https://openalex.org/W2117539984","https://openalex.org/W2117571939","https://openalex.org/W2117737431","https://openalex.org/W2118040019","https://openalex.org/W2118399632","https://openalex.org/W2119836020","https://openalex.org/W2119974530","https://openalex.org/W2120011621","https://openalex.org/W2120627772","https://openalex.org/W2121158863","https://openalex.org/W2122129887","https://openalex.org/W2123859694","https://openalex.org/W2123941139","https://openalex.org/W2123945077","https://openalex.org/W2125447414","https://openalex.org/W2126326200","https://openalex.org/W2127130537","https://openalex.org/W2127580070","https://openalex.org/W2128005590","https://openalex.org/W2128428920","https://openalex.org/W2128494600","https://openalex.org/W2128744203","https://openalex.org/W2128793357","https://openalex.org/W2129356601","https://openalex.org/W2130947423","https://openalex.org/W2131602901","https://openalex.org/W2133110080","https://openalex.org/W2134186999","https://openalex.org/W2136641692","https://openalex.org/W2137108685","https://openalex.org/W2137373737","https://openalex.org/W2137850515","https://openalex.org/W2138140031","https://openalex.org/W2138155367","https://openalex.org/W2139075939","https://openalex.org/W2139202492","https://openalex.org/W2140051496","https://openalex.org/W2140929616","https://openalex.org/W2141288132","https://openalex.org/W2141750075","https://openalex.org/W2142623337","https://openalex.org/W2143205348","https://openalex.org/W2144470999","https://openalex.org/W2144576290","https://openalex.org/W2144584955","https://openalex.org/W2145885594","https://openalex.org/W2146122766","https://openalex.org/W2146494362","https://openalex.org/W2146904167","https://openalex.org/W2148048449","https://openalex.org/W2148324690","https://openalex.org/W2148946562","https://openalex.org/W2149317242","https://openalex.org/W2149332837","https://openalex.org/W2151306467","https://openalex.org/W2153219837","https://openalex.org/W2153382986","https://openalex.org/W2153463811","https://openalex.org/W2153724323","https://openalex.org/W2153811538","https://openalex.org/W2156293127","https://openalex.org/W2156581417","https://openalex.org/W2157747593","https://openalex.org/W2157809114","https://openalex.org/W2157913822","https://openalex.org/W2157943033","https://openalex.org/W2157978028","https://openalex.org/W2158670211","https://openalex.org/W2158690845","https://openalex.org/W2158752744","https://openalex.org/W2159265736","https://openalex.org/W2159804098","https://openalex.org/W2160025503","https://openalex.org/W2160826898","https://openalex.org/W2161045918","https://openalex.org/W2162430111","https://openalex.org/W2162436188","https://openalex.org/W2165052021","https://openalex.org/W2165078795","https://openalex.org/W2167652900","https://openalex.org/W2167884612","https://openalex.org/W2167916551","https://openalex.org/W2168160590","https://openalex.org/W2169481463","https://openalex.org/W2170437356","https://openalex.org/W2170963117","https://openalex.org/W2171278825","https://openalex.org/W2171573054","https://openalex.org/W2200945223","https://openalex.org/W2332208732","https://openalex.org/W2414934272","https://openalex.org/W3139752542","https://openalex.org/W7062888037"],"related_works":["https://openalex.org/W2166135064","https://openalex.org/W7095597577","https://openalex.org/W2282891094","https://openalex.org/W3080422128","https://openalex.org/W2943898728","https://openalex.org/W2154313522","https://openalex.org/W2054315594","https://openalex.org/W2315742396","https://openalex.org/W2092518641","https://openalex.org/W2109170166"],"abstract_inverted_index":{"Integrins":[0,15,33,62,78],"are":[1,16,34,63,79],"heterodimeric":[2],"adhesion":[3,6,279,365],"receptors":[4],"mediating":[5],"to":[7,12,55,66,85,93,109,144,150,203,224,356],"extracellular":[8],"matrix":[9],"proteins":[10,36],"and":[11,29,88,99,157,208,216,226,238,242,272,280,282,366],"other":[13],"cells.":[14,214],"important":[17,95,152,171,268],"in":[18,173,180,205,210,233,236,254,277,317,346,362],"embryonic":[19],"development,":[20],"structural":[21],"integrity":[22],"of":[23,104,184,193,212,342],"connective":[24],"tissue,":[25],"blood":[26],"thrombus":[27],"formation,":[28],"immune":[30],"defense":[31],"system.":[32],"transmembrane":[35],"whose":[37],"ligand":[38,49],"binding":[39,50,54,143],"capacity":[40],"(activity)":[41],"is":[42,72,119,125],"regulated":[43,74],"by":[44,75,261],"large":[45],"conformational":[46],"changes.":[47],"Extracellular":[48],"or":[51,115,196],"intracellular":[52,76,160],"effector":[53],"integrin":[56,60,105,123,136,145,155,198,274,293,328,344],"cytoplasmic":[57,146],"face":[58],"regulate":[59],"activity.":[61],"thus":[64],"able":[65],"mediate":[67],"bi-directional":[68],"signaling.":[69],"Integrin":[70],"function":[71,195],"also":[73,120,251,297],"location.":[77],"constantly":[80],"recycled":[81],"from":[82],"endocytic":[83,199],"vesicles":[84],"plasma":[86],"membrane,":[87],"this":[89,131,167,290,351],"has":[90,169],"been":[91],"shown":[92,149,165],"be":[94,151,220,259],"for":[96,153,270,304],"cell":[97,174,185,206,246,255,278,301,364],"migration":[98],"invasion":[100],"as":[101,113,177,179],"well.":[102],"Deregulation":[103],"functionality":[106],"can":[107,201,219],"lead":[108,202],"deleterious":[110],"illnesses,":[111],"such":[112],"bleeding":[114],"inflammatory":[116],"disorders.":[117],"It":[118,162],"evident":[121],"that":[122,166,191,244,338],"deregulation":[124],"associated":[126],"with":[127,248,287],"cancer":[128,240,319,363],"progression.":[129],"In":[130,289,349],"study,":[132,291],"a":[133,221,245,284],"novel":[134,300],"Beta1":[135,154,273,292,327,343],"associating":[137],"protein,":[138],"Rab21,":[139],"was":[140,148,163,296,308],"characterized.":[141],"Rab21":[142,194,262,271],"tail":[147],"endo-":[156],"exocytosis":[158],"\u2013":[159],"trafficking.":[161],"furher":[164],"interaction":[168],"an":[170,267],"role":[172,269],"adhesion,":[175],"migration,":[176],"well":[178],"the":[181],"final":[182],"step":[183],"division,":[186,256,281],"cytokinesis.":[187],"This":[188,228],"work":[189,229,265,352],"showed":[190,243],"abrogation":[192],"\u03b21":[197],"traffic,":[200],"defects":[204],"division":[207],"results":[209],"formation":[211],"multinucleated":[213],"Multinucleation":[215],"especially":[217],"tetraploidy":[218],"transient":[222],"pathway":[223],"aneuploidy":[225],"tumorigenesis.":[227,288],"characterized":[230,309],"chromosomal":[231],"deletions":[232],"rab21":[234,249],"locus":[235],"ovarian":[237],"prostate":[239,318,347],"samples":[241],"line":[247],"deletion":[250],"had":[252],"impairment":[253],"which":[257],"could":[258],"rescued":[260],"re-expression.":[263],"The":[264,324,334],"demonstrates":[266],"traffic":[275],"regulation":[276,295],"suggests":[283],"probable":[285],"associaton":[286],"activity":[294,329,345],"addressed.":[298],"A":[299],"array":[302],"platform":[303],"genome-scale":[305],"RNAi":[306],"screenings":[307],"here.":[310],"More":[311],"than":[312],"4500":[313],"genes":[314],"were":[315,330],"knocked-down":[316],"cells":[320],"using":[321],"siRNA-mediated":[322],"silencing.":[323],"effects":[325],"on":[326],"analyzed":[331],"upon":[332],"knock-downs.":[333],"screen":[335],"identified":[336],"more":[337],"400":[339],"putative":[340],"regulators":[341],"cancer.":[348],"conclusion,":[350],"will":[353],"help":[354],"us":[355],"understand":[357],"complex":[358],"regulatory":[359],"pathways":[360],"involved":[361],"migration.":[367]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}