{"id":"https://openalex.org/W2278897938","doi":null,"title":"The assay of penicillin in blood-serum using Sarcina lutea.","display_name":"The assay of penicillin in blood-serum using Sarcina lutea.","publication_year":1957,"publication_date":"1957-01-01","ids":{"openalex":"https://openalex.org/W2278897938","mag":"2278897938","pmid":"https://pubmed.ncbi.nlm.nih.gov/13511134","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2537685"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:1452212","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC2537685","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC2537685","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110821918","display_name":"James W. Lightbown","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J W LIGHTBOWN","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5031454423","display_name":"D. Sulitzeanu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D SULITZEANU","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.114,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.85661493,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"17","issue":"4-5","first_page":"553","last_page":"67"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.5234000086784363,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.5234000086784363,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.40549999475479126,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12167","display_name":"Bacterial Identification and Susceptibility Testing","score":0.037700001150369644,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/penicillin-assay","display_name":"penicillin assay","score":0.9449999928474426},{"id":"https://openalex.org/keywords/sarcina-lutea","display_name":"Sarcina lutea","score":0.9300000071525574},{"id":"https://openalex.org/keywords/dose-response-curves","display_name":"dose-response curves","score":0.8040000200271606},{"id":"https://openalex.org/keywords/procaine-penicillin","display_name":"procaine penicillin","score":0.8769999742507935},{"id":"https://openalex.org/keywords/antibiotic-potency","display_name":"antibiotic potency","score":0.42100000381469727}],"concepts":[{"id":"https://openalex.org/C174802600","wikidata":"https://www.wikidata.org/wiki/Q12190","display_name":"Penicillin","level":3,"score":0.8379595279693604},{"id":"https://openalex.org/C2776156320","wikidata":"https://www.wikidata.org/wiki/Q309504","display_name":"Sarcina","level":3,"score":0.7252007126808167},{"id":"https://openalex.org/C104488531","wikidata":"https://www.wikidata.org/wiki/Q864212","display_name":"Bioassay","level":2,"score":0.6064233183860779},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5836961269378662},{"id":"https://openalex.org/C146763376","wikidata":"https://www.wikidata.org/wiki/Q81714","display_name":"Petri dish","level":2,"score":0.4440366327762604},{"id":"https://openalex.org/C2776341680","wikidata":"https://www.wikidata.org/wiki/Q258450","display_name":"Benzylpenicillin","level":4,"score":0.43942010402679443},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3611808121204376},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3549167513847351},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3401995897293091},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.323481947183609},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.11030703783035278},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001681","descriptor_name":"Biological Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010406","descriptor_name":"Penicillins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012505","descriptor_name":"Sarcina","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:1452212","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC2537685","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:13511134","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/13511134","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bulletin of the World Health Organization","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2537685","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2537685/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bull World Health Organ","raw_type":"Text"},{"id":"mag:2278897938","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/13511134","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1452212","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC2537685","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.428600013256073,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":2,"referenced_works":["https://openalex.org/W2014743827","https://openalex.org/W2056793973"],"related_works":["https://openalex.org/W2000663231","https://openalex.org/W2344244873","https://openalex.org/W1538157461","https://openalex.org/W2043928747","https://openalex.org/W2412494100","https://openalex.org/W203856125","https://openalex.org/W2612897848","https://openalex.org/W2409838294","https://openalex.org/W2022151649","https://openalex.org/W2002720586"],"abstract_inverted_index":{"When":[0],"Sarcina":[1],"lutea":[2],"is":[3,80,109],"used":[4],"as":[5],"test":[6,100],"organism":[7],"in":[8,20,48,96],"a":[9],"cup-plate":[10],"assay,":[11],"the":[12,16,29,32,43,97,124],"dose-response":[13,44],"curves":[14],"for":[15,46,53,94,101,116,123],"assay":[17,73,91],"of":[18,22,31,38,86,104],"penicillin":[19,39,47,106],"sera":[21],"humans":[23],"and":[24,35,40,63,70,77,84,88],"rabbits":[25],"are":[26,56],"linear":[27],"with":[28],"square":[30,61],"zone":[33],"diameter":[34],"log":[36],"concentration":[37],"parallel":[41],"to":[42,119],"curve":[45],"phosphate":[49],"buffer.":[50],"Suitable":[51],"conditions":[52],"such":[54],"assays":[55],"described,":[57],"using":[58,74],"either":[59],"large":[60,75],"assay-plates":[62],"fish-spine":[64,78],"beads":[65,79],"or":[66],"conventional":[67],"Petri":[68],"dishes":[69],"cylinders.":[71],"The":[72,111],"plates":[76],"much":[81],"more":[82],"accurate":[83],"economical":[85],"effort":[87],"serum.":[89],"An":[90],"method":[92,112],"suitable":[93],"inclusion":[95],"blood-level":[98],"duration":[99],"oily":[102],"injection":[103],"procaine":[105],"(International":[107],"Pharmacopoeia)":[108],"described.":[110],"makes":[113],"it":[114],"possible":[115],"fiducial":[117],"limits":[118],"be":[120],"readily":[121],"computed":[122],"potencies":[125],"obtained.":[126]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}