{"id":"https://openalex.org/W227874052","doi":null,"title":"Bone mineral density in hypogonadal men remains low after long-term testosterone replacement.","display_name":"Bone mineral density in hypogonadal men remains low after long-term testosterone replacement.","publication_year":2002,"publication_date":"2002-06-01","ids":{"openalex":"https://openalex.org/W227874052","mag":"227874052","pmid":"https://pubmed.ncbi.nlm.nih.gov/12085102"},"language":"en","primary_location":{"id":"pmid:12085102","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12085102","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian journal of andrology","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.cqvip.com/QK/84127X/200202/6458679.html","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087475570","display_name":"KazuhiroIshizaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124220","display_name":"Kanto Central Hospital","ror":"https://ror.org/02tt4fr50","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210124220"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuhiro Ishizaka","raw_affiliation_strings":["Department of Urology, Kanto Central Hospital, Tokyo 158-8531, Japan. E-mail: kazzie@parkcity.ne.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Kanto Central Hospital, Tokyo 158-8531, Japan. E-mail: kazzie@parkcity.ne.jp","institution_ids":["https://openalex.org/I4210124220"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036316755","display_name":"MashitoSuzuki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masahito Suzuki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Yukio Kageyama","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yukio Kageyama","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Kazunori Kihara","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kazunori Kihara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Ken-Ichiro Yoshida","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ken-Ichiro Yoshida","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3131,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.6106879,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"4","issue":"2","first_page":"117","last_page":"21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.01679999940097332,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.8999999761581421},{"id":"https://openalex.org/keywords/hypogonadism","display_name":"hypogonadism","score":0.9089999794960022},{"id":"https://openalex.org/keywords/testosterone-replacement-therapy","display_name":"testosterone replacement therapy","score":0.8920000195503235},{"id":"https://openalex.org/keywords/congenital-hypogonadism","display_name":"congenital hypogonadism","score":0.8830000162124634},{"id":"https://openalex.org/keywords/kallmann-syndrome","display_name":"Kallmann syndrome","score":0.9850000143051147},{"id":"https://openalex.org/keywords/osteopenia","display_name":"osteopenia","score":0.8569999933242798},{"id":"https://openalex.org/keywords/trabecular-bone","display_name":"trabecular bone","score":0.8330000042915344},{"id":"https://openalex.org/keywords/radial-bone","display_name":"radial bone","score":0.6629999876022339},{"id":"https://openalex.org/keywords/bone-specific-alkaline-phosphatase","display_name":"bone-specific alkaline phosphatase","score":0.8140000104904175},{"id":"https://openalex.org/keywords/deoxypyridinoline","display_name":"deoxypyridinoline","score":0.9620000123977661},{"id":"https://openalex.org/keywords/age-at-treatment-initiation","display_name":"age at treatment initiation","score":0.5849999785423279}],"concepts":[{"id":"https://openalex.org/C2776886416","wikidata":"https://www.wikidata.org/wiki/Q4941567","display_name":"Bone mineral","level":3,"score":0.657558798789978},{"id":"https://openalex.org/C3019419337","wikidata":"https://www.wikidata.org/wiki/Q4759440","display_name":"Testosterone replacement","level":4,"score":0.6363635063171387},{"id":"https://openalex.org/C61797465","wikidata":"https://www.wikidata.org/wiki/Q1188986","display_name":"Term (time)","level":2,"score":0.5057539939880371},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45327603816986084},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30746787786483765},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.2357366979122162},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.16680750250816345},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.06932109594345093},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0668916404247284},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003456","descriptor_name":"Cryptorchidism","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007006","descriptor_name":"Hypogonadism","qualifier_ui":"Q000151","qualifier_name":"congenital","is_major_topic":false},{"descriptor_ui":"D007006","descriptor_name":"Hypogonadism","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007006","descriptor_name":"Hypogonadism","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007273","descriptor_name":"Injections, Intramuscular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015519","descriptor_name":"Bone Density","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017436","descriptor_name":"Kallmann Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D020249","descriptor_name":"Hormone Replacement Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:12085102","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12085102","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian journal of andrology","raw_type":"Comparative Study"},{"id":"mag:227874052","doi":null,"is_oa":true,"landing_page_url":"http://www.cqvip.com/QK/84127X/200202/6458679.html","pdf_url":null,"source":{"id":"https://openalex.org/S78604184","display_name":"Asian Journal of Andrology","issn_l":"1008-682X","issn":["1008-682X","1745-7262"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e9a\u6d32\u7537\u6027\u5b66\u6742\u5fd7\uff1a\u82f1\u6587\u7248","raw_type":null},{"id":"mag:2404510816","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12085102","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"mag:227874052","doi":null,"is_oa":true,"landing_page_url":"http://www.cqvip.com/QK/84127X/200202/6458679.html","pdf_url":null,"source":{"id":"https://openalex.org/S78604184","display_name":"Asian Journal of Andrology","issn_l":"1008-682X","issn":["1008-682X","1745-7262"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e9a\u6d32\u7537\u6027\u5b66\u6742\u5fd7\uff1a\u82f1\u6587\u7248","raw_type":null},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2163320305","https://openalex.org/W2166717530","https://openalex.org/W2000625947","https://openalex.org/W418826204","https://openalex.org/W2009247332","https://openalex.org/W2078373258","https://openalex.org/W2055806642","https://openalex.org/W2131166118","https://openalex.org/W1500142735","https://openalex.org/W2134710844"],"abstract_inverted_index":{"AIM:":[0],"In":[1,67],"11":[2,150],"congenital":[3,29],"hypogonadal":[4,30,107,134,151,167,230],"men,":[5,31],"the":[6,16,79,87,113,117,126,133,159,178,182,192,196,212,222,229],"bone":[7,244],"mineral":[8],"density":[9],"(BMD)":[10],"values":[11,146,171],"were":[12,46,84,153,217],"determined":[13],"to":[14],"assess":[15],"effect":[17],"of":[18,53,73,90,94,149,198,207,215],"long-term":[19,233],"androgen":[20,249],"replacement":[21],"therapy":[22],"(ART)":[23],"on":[24],"skeletal":[25],"integrity.":[26],"METHODS:":[27],"Eleven":[28],"including":[32],"8":[33],"isolated":[34],"gonadotropin":[35],"deficiency":[36],"patients,":[37],"2":[38,166],"Kallmann's":[39],"syndrome":[40,45],"and":[41,48,70,81,121,137,211],"1":[42,156],"vanishing":[43],"testes":[44],"recruited":[47],"treated":[49],"with":[50,191],"250":[51],"mg":[52],"testosterone":[54],"enanthate":[55],"intramuscularly":[56],"every":[57],"4":[58],"weeks":[59],"for":[60,162],"7-43":[61],"years":[62],"(mean+/-SD:":[63],"21.5":[64],"+/-13":[65],"years).":[66],"these":[68],"patients":[69,114,238],"a":[71,95,187,240],"group":[72],"10":[74,148],"healthy":[75,118,163,179],"young":[76,164],"men":[77,108,119,135,152,168,231],"(controls),":[78],"whole":[80,103,143,183],"trabecular":[82,127],"BMDs":[83],"examined":[85],"at":[86,154,195],"distal":[88],"end":[89],"radius":[91],"by":[92,248],"means":[93],"peripheral":[96],"quantitative":[97],"computerized":[98],"tomography":[99],"device.":[100],"RESULTS:":[101],"The":[102,142,204],"radial":[104,144,184],"BMD":[105,128,145,170,185],"in":[106,112,116,132,147,228,243],"was":[109,129],"significantly":[110,219],"less":[111],"than":[115,173,177],"(498+/-115":[120],"725+/-134":[122],"mg/cm(3),":[123],"respectively;":[124],"P<0.01);":[125],"also":[130],"lower":[131,176],"(199+/-80":[136],"375+/-89":[138],"mg/cm(3);":[139],"P<":[140],"0.01).":[141],"least":[155],"SD":[157,175],"below":[158],"mean":[160],"value":[161],"men;":[165],"had":[169],"more":[172],"2.5":[174],"mean.":[180],"Additionally,":[181],"showed":[186],"significant":[188],"negative":[189],"correlation":[190],"patient's":[193],"age":[194],"initiation":[197],"ART":[199],"(r":[200],"=":[201],"0.748,":[202],"P<0.01).":[203],"serum":[205],"level":[206,214],"bone-specific":[208],"alkaline":[209],"phosphatase":[210],"urinary":[213],"deoxypyridinoline":[216],"not":[218,246],"different":[220],"between":[221],"two":[223],"groups.":[224],"CONCLUSION:":[225],"Osteopenia":[226],"persists":[227],"after":[232],"ART,":[234],"suggesting":[235],"that":[236],"such":[237],"have":[239],"persistent":[241],"defect":[242],"development":[245],"alleviated":[247],"replacement.":[250]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}