{"id":"https://openalex.org/W2278284019","doi":"https://doi.org/10.1016/j.jep.2016.01.029","title":"Prospective, randomized, double-blinded, double-dummy and multicenter phase IV clinical study comparing the efficacy and safety of PG201 (Layla) and SKI306X in patients with osteoarthritis","display_name":"Prospective, randomized, double-blinded, double-dummy and multicenter phase IV clinical study comparing the efficacy and safety of PG201 (Layla) and SKI306X in patients with osteoarthritis","publication_year":2016,"publication_date":"2016-01-25","ids":{"openalex":"https://openalex.org/W2278284019","doi":"https://doi.org/10.1016/j.jep.2016.01.029","mag":"2278284019","pmid":"https://pubmed.ncbi.nlm.nih.gov/26821189"},"language":"en","primary_location":{"id":"doi:10.1016/j.jep.2016.01.029","doi":"https://doi.org/10.1016/j.jep.2016.01.029","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jep.2016.01.029","pdf_url":null,"source":{"id":"https://openalex.org/S29564236","display_name":"Journal of Ethnopharmacology","issn_l":"0378-8741","issn":["0378-8741","1872-7573"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Ethnopharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://lps3.www.sciencedirect.com.proxy.dsmc.or.kr/science/article/pii/S0378874116300290?via%3Dihub","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002118713","display_name":"Chul\u2010Won Ha","orcid":"https://orcid.org/0000-0001-5123-6513","observed_orcids":["https://orcid.org/0000-0001-5123-6513"]},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Chul-Won Ha","raw_affiliation_strings":["Department of Orthopedic Surgery, Stem Cell & Regenerative Medicine Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, South Korea; Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, 81 Irwon-ro, Gangnam-gu, Seoul 06351, South Korea","Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, 81 Irwon-ro, Gangnam-gu, Seoul 06351, South Korea","Department of Orthopedic Surgery, Stem Cell & Regenerative Medicine Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Stem Cell & Regenerative Medicine Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, South Korea; Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, 81 Irwon-ro, Gangnam-gu, Seoul 06351, South Korea","institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I848706"]},{"raw_affiliation_string":"Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, 81 Irwon-ro, Gangnam-gu, Seoul 06351, South Korea","institution_ids":["https://openalex.org/I848706"]},{"raw_affiliation_string":"Department of Orthopedic Surgery, Stem Cell & Regenerative Medicine Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, South Korea","institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101902027","display_name":"Yong\u2010Beom Park","orcid":"https://orcid.org/0000-0002-3741-2311","observed_orcids":["https://orcid.org/0000-0002-3741-2311"]},"institutions":[{"id":"https://openalex.org/I4210124541","display_name":"Hanyang University Guri Hospital","ror":"https://ror.org/02f9avj37","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210124541","https://openalex.org/I4210152466","https://openalex.org/I4575257"]},{"id":"https://openalex.org/I4210152466","display_name":"Hanyang University Medical Center","ror":"https://ror.org/05tn05n57","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210152466","https://openalex.org/I4575257"]},{"id":"https://openalex.org/I4210153376","display_name":"Chung-Ang University Hospital","ror":"https://ror.org/04gr4mh63","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210153376","https://openalex.org/I4405261496","https://openalex.org/I67900169"]},{"id":"https://openalex.org/I4405261496","display_name":"Chung-Ang University Healthcare System","ror":"https://ror.org/05cxnr816","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4405261496","https://openalex.org/I67900169"]},{"id":"https://openalex.org/I67900169","display_name":"Chung-Ang University","ror":"https://ror.org/01r024a98","country_code":"KR","type":"education","lineage":["https://openalex.org/I67900169"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yong-Beom Park","raw_affiliation_strings":["Department of Orthopedic Surgery, Chung-Ang University Hospital, Chung-Ang University College of Medicine, 102 Heukseok-ro, Dongjak-gu, Seoul 06973, South Korea","Department of Orthopedic Surgery, Hanyang University Medical Center Guri Hospital, 153 Gyeongchun-ro, Guri-si, Gyeonggi-do 11923, South Korea. Electronic address: hyparkys@hanyang.ac.kr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Chung-Ang University Hospital, Chung-Ang University College of Medicine, 102 Heukseok-ro, Dongjak-gu, Seoul 06973, South Korea","institution_ids":["https://openalex.org/I4210153376","https://openalex.org/I4405261496","https://openalex.org/I67900169"]},{"raw_affiliation_string":"Department of Orthopedic Surgery, Hanyang University Medical Center Guri Hospital, 153 Gyeongchun-ro, Guri-si, Gyeonggi-do 11923, South Korea. Electronic address: hyparkys@hanyang.ac.kr","institution_ids":["https://openalex.org/I4210124541","https://openalex.org/I4210152466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011745123","display_name":"Byung-Woo Min","orcid":"https://orcid.org/0000-0002-1727-8872","observed_orcids":["https://orcid.org/0000-0002-1727-8872"]},"institutions":[{"id":"https://openalex.org/I4210128080","display_name":"Keimyung University Dongsan Medical Center","ror":"https://ror.org/035r7hb75","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210128080"]},{"id":"https://openalex.org/I4405261187","display_name":"Keimyung University Dongsan Hospital","ror":"https://ror.org/04xxe0935","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210128080","https://openalex.org/I4405261187"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Byung-Woo Min","raw_affiliation_strings":["Department of Orthopedic Surgery, Keimyung University Dongsan Medical Center, 56 Dalseong-ro, Jung-gu, Daegu 41931, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Keimyung University Dongsan Medical Center, 56 Dalseong-ro, Jung-gu, Daegu 41931, South Korea","institution_ids":["https://openalex.org/I4210128080","https://openalex.org/I4405261187"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064642317","display_name":"Seung-Beom Han","orcid":"https://orcid.org/0000-0003-1880-4229","observed_orcids":["https://orcid.org/0000-0003-1880-4229"]},"institutions":[{"id":"https://openalex.org/I2799980853","display_name":"Korea University Medical Center","ror":"https://ror.org/02cs2sd33","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I197347611","https://openalex.org/I2799980853"]},{"id":"https://openalex.org/I4405260934","display_name":"Korea University Anam Hospital","ror":"https://ror.org/04gjj3027","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I197347611","https://openalex.org/I2799980853","https://openalex.org/I4405260934"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seung-Beom Han","raw_affiliation_strings":["Department of Orthopedic Surgery, Korea University Medical Center Anam Hospital, 73 Inchon-ro, Seongbuk-gu, Seoul 02841, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Korea University Medical Center Anam Hospital, 73 Inchon-ro, Seongbuk-gu, Seoul 02841, South Korea","institution_ids":["https://openalex.org/I2799980853","https://openalex.org/I4405260934"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088439083","display_name":"Jae Hyup Lee","orcid":"https://orcid.org/0000-0002-2141-0266","observed_orcids":["https://orcid.org/0000-0002-2141-0266"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2801402630","display_name":"Seoul Metropolitan Government","ror":"https://ror.org/002wfgr58","country_code":"KR","type":"government","lineage":["https://openalex.org/I2801402630"]},{"id":"https://openalex.org/I4210100437","display_name":"SNUH SMG-SNU Boramae Medical Center","ror":"https://ror.org/014xqzt56","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I4210100437"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jae Hyup Lee","raw_affiliation_strings":["Department of Orthopedic Surgery, Seoul Metropolitan Government Seoul National University Boramae Medical Center, 20 Boramae-ro 5-gil, Dongjak-gu, Seoul 07061, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Seoul Metropolitan Government Seoul National University Boramae Medical Center, 20 Boramae-ro 5-gil, Dongjak-gu, Seoul 07061, South Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2801402630","https://openalex.org/I4210100437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037467645","display_name":"Ye\u2010Yeon Won","orcid":"https://orcid.org/0000-0002-1880-4336","observed_orcids":["https://orcid.org/0000-0002-1880-4336"]},"institutions":[{"id":"https://openalex.org/I4210103252","display_name":"Ajou University Hospital","ror":"https://ror.org/01bzpky79","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210103252","https://openalex.org/I57664883"]},{"id":"https://openalex.org/I4405261832","display_name":"Ajou University Medical Center","ror":"https://ror.org/05xkxf605","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4405261832","https://openalex.org/I57664883"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ye-Yeon Won","raw_affiliation_strings":["Department of Orthopedic Surgery, Ajou University Medical Center, 164 World Cup-ro, Yeongtong-gu, Suwon-si, Gyeonggi-do 16499, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Ajou University Medical Center, 164 World Cup-ro, Yeongtong-gu, Suwon-si, Gyeonggi-do 16499, South Korea","institution_ids":["https://openalex.org/I4210103252","https://openalex.org/I4405261832"]}]},{"author_position":"last","author":{"id":null,"display_name":"Ye-Soo Park","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124541","display_name":"Hanyang University Guri Hospital","ror":"https://ror.org/02f9avj37","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210124541","https://openalex.org/I4210152466","https://openalex.org/I4575257"]},{"id":"https://openalex.org/I4210152466","display_name":"Hanyang University Medical Center","ror":"https://ror.org/05tn05n57","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210152466","https://openalex.org/I4575257"]},{"id":"https://openalex.org/I4210153376","display_name":"Chung-Ang University Hospital","ror":"https://ror.org/04gr4mh63","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210153376","https://openalex.org/I4405261496","https://openalex.org/I67900169"]},{"id":"https://openalex.org/I4405261496","display_name":"Chung-Ang University Healthcare System","ror":"https://ror.org/05cxnr816","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4405261496","https://openalex.org/I67900169"]},{"id":"https://openalex.org/I67900169","display_name":"Chung-Ang University","ror":"https://ror.org/01r024a98","country_code":"KR","type":"education","lineage":["https://openalex.org/I67900169"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Ye-Soo Park","raw_affiliation_strings":["Department of Orthopedic Surgery, Chung-Ang University Hospital, Chung-Ang University College of Medicine, 102 Heukseok-ro, Dongjak-gu, Seoul 06973, South Korea","Department of Orthopedic Surgery, Hanyang University Medical Center Guri Hospital, 153 Gyeongchun-ro, Guri-si, Gyeonggi-do 11923, South Korea. Electronic address: hyparkys@hanyang.ac.kr","Department of Orthopedic Surgery, Hanyang University Medical Center Guri Hospital, 153 Gyeongchun-ro, Guri-si, Gyeonggi-do 11923, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Chung-Ang University Hospital, Chung-Ang University College of Medicine, 102 Heukseok-ro, Dongjak-gu, Seoul 06973, South Korea","institution_ids":["https://openalex.org/I4210153376","https://openalex.org/I4405261496","https://openalex.org/I67900169"]},{"raw_affiliation_string":"Department of Orthopedic Surgery, Hanyang University Medical Center Guri Hospital, 153 Gyeongchun-ro, Guri-si, Gyeonggi-do 11923, South Korea. Electronic address: hyparkys@hanyang.ac.kr","institution_ids":["https://openalex.org/I4210124541","https://openalex.org/I4210152466"]},{"raw_affiliation_string":"Department of Orthopedic Surgery, Hanyang University Medical Center Guri Hospital, 153 Gyeongchun-ro, Guri-si, Gyeonggi-do 11923, South Korea","institution_ids":["https://openalex.org/I4210124541","https://openalex.org/I4210152466"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":16,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210124541","https://openalex.org/I4210152466","https://openalex.org/I4210153376","https://openalex.org/I4405261496","https://openalex.org/I67900169"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":2.8376,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.88794427,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"181","issue":null,"first_page":"1","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9550999999046326,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9550999999046326,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13335","display_name":"Pharmacological Effects of Medicinal Plants","score":0.026900000870227814,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10902","display_name":"Complementary and Alternative Medicine Studies","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/knee-osteoarthritis","display_name":"knee osteoarthritis","score":0.8920000195503235},{"id":"https://openalex.org/keywords/herbal-medicine","display_name":"herbal medicine","score":0.9110000133514404},{"id":"https://openalex.org/keywords/plant-extracts","display_name":"plant extracts","score":0.375},{"id":"https://openalex.org/keywords/pain-relief","display_name":"analgesia","score":0.6610000133514404},{"id":"https://openalex.org/keywords/womac","display_name":"WOMAC","score":0.9160000085830688},{"id":"https://openalex.org/keywords/eq-5d","display_name":"EQ-5D","score":0.8550000190734863},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.8360000252723694},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.4950000047683716},{"id":"https://openalex.org/keywords/rescue-medication-use","display_name":"rescue medication use","score":0.44200000166893005},{"id":"https://openalex.org/keywords/non-inferiority","display_name":"non-inferiority","score":0.5509999990463257},{"id":"https://openalex.org/keywords/kellgren-lawrence-grade","display_name":"Kellgren-Lawrence grade","score":0.6259999871253967},{"id":"https://openalex.org/keywords/layla","display_name":"Layla","score":0.4740000069141388},{"id":"https://openalex.org/keywords/join","display_name":"join","score":0.9649999737739563}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6890800595283508},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.6134724617004395},{"id":"https://openalex.org/C2992435398","wikidata":"https://www.wikidata.org/wiki/Q6934595","display_name":"Multicenter study","level":3,"score":0.5317427515983582},{"id":"https://openalex.org/C2994504663","wikidata":"https://www.wikidata.org/wiki/Q608510","display_name":"Double blinded","level":4,"score":0.49770501255989075},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.42604219913482666},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.40246137976646423},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3738631010055542},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.32956597208976746},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3232365846633911},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.14592459797859192},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.13196569681167603},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09927916526794434}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007719","descriptor_name":"Knee Joint","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007719","descriptor_name":"Knee Joint","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007719","descriptor_name":"Knee Joint","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008517","descriptor_name":"Phytotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008517","descriptor_name":"Phytotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008517","descriptor_name":"Phytotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010147","descriptor_name":"Pain Measurement","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010147","descriptor_name":"Pain Measurement","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010147","descriptor_name":"Pain Measurement","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020370","descriptor_name":"Osteoarthritis, Knee","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D020370","descriptor_name":"Osteoarthritis, Knee","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D020370","descriptor_name":"Osteoarthritis, Knee","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.jep.2016.01.029","doi":"https://doi.org/10.1016/j.jep.2016.01.029","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jep.2016.01.029","pdf_url":null,"source":{"id":"https://openalex.org/S29564236","display_name":"Journal of Ethnopharmacology","issn_l":"0378-8741","issn":["0378-8741","1872-7573"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Ethnopharmacology","raw_type":"journal-article"},{"id":"pmid:26821189","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26821189","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of ethnopharmacology","raw_type":"Clinical Trial, Phase IV"},{"id":"pmh:oai:kumel.medlib.dsmc.or.kr:2015.oak/33268","doi":null,"is_oa":true,"landing_page_url":"http://lps3.www.sciencedirect.com.proxy.dsmc.or.kr/science/article/pii/S0378874116300290?via%3Dihub","pdf_url":null,"source":{"id":"https://openalex.org/S4377196386","display_name":"KUMeL Repository (Keimyung University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I52010207","host_organization_name":"Keimyung University","host_organization_lineage":["https://openalex.org/I52010207"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:repository.ajou.ac.kr:201003/15104","doi":null,"is_oa":false,"landing_page_url":"http://repository.ajou.ac.kr/handle/201003/15104","pdf_url":null,"source":{"id":"https://openalex.org/S4306401331","display_name":"AJOU Open Repository (Ajou University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I57664883","host_organization_name":"Ajou University","host_organization_lineage":["https://openalex.org/I57664883"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:kumel.medlib.dsmc.or.kr:2015.oak/33268","doi":null,"is_oa":true,"landing_page_url":"http://lps3.www.sciencedirect.com.proxy.dsmc.or.kr/science/article/pii/S0378874116300290?via%3Dihub","pdf_url":null,"source":{"id":"https://openalex.org/S4377196386","display_name":"KUMeL Repository (Keimyung University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I52010207","host_organization_name":"Keimyung University","host_organization_lineage":["https://openalex.org/I52010207"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"sustainable_development_goals_aurora":[],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1778761211","https://openalex.org/W1946457104","https://openalex.org/W1977929761","https://openalex.org/W1979622703","https://openalex.org/W2002883643","https://openalex.org/W2004217578","https://openalex.org/W2034180562","https://openalex.org/W2035709184","https://openalex.org/W2053618083","https://openalex.org/W2058147305","https://openalex.org/W2065563691","https://openalex.org/W2094046051","https://openalex.org/W2113737049","https://openalex.org/W2115805053","https://openalex.org/W2120762957","https://openalex.org/W2132036656","https://openalex.org/W2135385212","https://openalex.org/W2144114662","https://openalex.org/W2144729683","https://openalex.org/W2161739351","https://openalex.org/W2167792025","https://openalex.org/W3001577926","https://openalex.org/W3108279398","https://openalex.org/W4248226706","https://openalex.org/W6638033448"],"related_works":["https://openalex.org/W2035709184","https://openalex.org/W2132036656","https://openalex.org/W2120762957","https://openalex.org/W4402655019","https://openalex.org/W4417515871","https://openalex.org/W7098106851","https://openalex.org/W3004138425","https://openalex.org/W2021774145","https://openalex.org/W7046784794","https://openalex.org/W2090973653"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":6},{"year":2017,"cited_by_count":2}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}