{"id":"https://openalex.org/W2277895129","doi":null,"title":"Age-related macular degeneration: anti-vascular endothelial growth factor treatment.","display_name":"Age-related macular degeneration: anti-vascular endothelial growth factor treatment.","publication_year":2016,"publication_date":"2016-02-24","ids":{"openalex":"https://openalex.org/W2277895129","mag":"2277895129","pmid":"https://pubmed.ncbi.nlm.nih.gov/26909890","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4765776"},"language":"en","primary_location":{"id":"pmid:26909890","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26909890","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ clinical evidence","raw_type":"Journal Article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4765776/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019510374","display_name":"Jennifer Arnold","orcid":"https://orcid.org/0000-0002-8065-9715","observed_orcids":["https://orcid.org/0000-0002-8065-9715"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jennifer J Arnold","raw_affiliation_strings":["Marsden Eye Specialists, Parramatta, New South Wales, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marsden Eye Specialists, Parramatta, New South Wales, Australia","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5019510374"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3721,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.28393006,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"2016","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11377","display_name":"Retinal and Macular Surgery","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/age-related-macular-degeneration","display_name":"age-related macular degeneration","score":0.9919999837875366},{"id":"https://openalex.org/keywords/neovascular-age-related-macular-degeneration","display_name":"neovascular age-related macular degeneration","score":0.8859999775886536},{"id":"https://openalex.org/keywords/anti-vegf-therapy","display_name":"anti-VEGF therapy","score":0.953000009059906},{"id":"https://openalex.org/keywords/anti-angiogenic-therapy","display_name":"anti-angiogenic therapy","score":0.6800000071525574},{"id":"https://openalex.org/keywords/aflibercept","display_name":"aflibercept","score":0.9860000014305115},{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":0.9929999709129333},{"id":"https://openalex.org/keywords/ranibizumab","display_name":"ranibizumab","score":1.0},{"id":"https://openalex.org/keywords/verteporfin","display_name":"verteporfin","score":0.8149999976158142},{"id":"https://openalex.org/keywords/photodynamic-therapy","display_name":"photodynamic therapy","score":0.9829999804496765},{"id":"https://openalex.org/keywords/drusen","display_name":"drusen","score":0.7960000038146973},{"id":"https://openalex.org/keywords/central-vision-loss","display_name":"central vision loss","score":0.699999988079071},{"id":"https://openalex.org/keywords/treatment-efficacy-and-safety","display_name":"treatment efficacy and safety","score":0.9010000228881836}],"concepts":[{"id":"https://openalex.org/C2776403814","wikidata":"https://www.wikidata.org/wiki/Q27429789","display_name":"Macular degeneration","level":2,"score":0.9238342046737671},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8497731685638428},{"id":"https://openalex.org/C2779093074","wikidata":"https://www.wikidata.org/wiki/Q1140528","display_name":"Drusen","level":3,"score":0.813546895980835},{"id":"https://openalex.org/C2778749236","wikidata":"https://www.wikidata.org/wiki/Q4689286","display_name":"Aflibercept","level":4,"score":0.7440699934959412},{"id":"https://openalex.org/C2781100027","wikidata":"https://www.wikidata.org/wiki/Q414270","display_name":"Ranibizumab","level":4,"score":0.7359245419502258},{"id":"https://openalex.org/C2781148688","wikidata":"https://www.wikidata.org/wiki/Q782318","display_name":"Verteporfin","level":4,"score":0.6537225246429443},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.5931258201599121},{"id":"https://openalex.org/C2776478404","wikidata":"https://www.wikidata.org/wiki/Q1105187","display_name":"Cochrane Library","level":3,"score":0.5801469087600708},{"id":"https://openalex.org/C2780699112","wikidata":"https://www.wikidata.org/wiki/Q7246796","display_name":"Pro re nata","level":5,"score":0.4825727045536041},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.47406619787216187},{"id":"https://openalex.org/C2777512022","wikidata":"https://www.wikidata.org/wiki/Q409935","display_name":"Pegaptanib","level":5,"score":0.453390896320343},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.3185636103153229},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2425926923751831},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.22571280598640442},{"id":"https://openalex.org/C2781359195","wikidata":"https://www.wikidata.org/wiki/Q5105209","display_name":"Choroidal neovascularization","level":3,"score":0.18118807673454285},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000069579","descriptor_name":"Ranibizumab","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D010778","descriptor_name":"Photochemotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:26909890","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26909890","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ clinical evidence","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4765776","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4765776/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Clin Evid","raw_type":"Text"},{"id":"mag:2277895129","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26909890","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4765776","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4765776/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Clin Evid","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W163157393","https://openalex.org/W1481978003","https://openalex.org/W1500728559","https://openalex.org/W1696340081","https://openalex.org/W1968189763","https://openalex.org/W1969775043","https://openalex.org/W1971222308","https://openalex.org/W1972642682","https://openalex.org/W1982733715","https://openalex.org/W1986531295","https://openalex.org/W1996171994","https://openalex.org/W1996821302","https://openalex.org/W2004117352","https://openalex.org/W2042043244","https://openalex.org/W2053567993","https://openalex.org/W2059547624","https://openalex.org/W2072311143","https://openalex.org/W2095251825","https://openalex.org/W2096773438","https://openalex.org/W2123232376","https://openalex.org/W2124415048","https://openalex.org/W2125191076","https://openalex.org/W2133904455","https://openalex.org/W2146673937","https://openalex.org/W2147322584","https://openalex.org/W2157848273","https://openalex.org/W2160226180","https://openalex.org/W2160726762","https://openalex.org/W2170468054","https://openalex.org/W2327207950","https://openalex.org/W2766004112","https://openalex.org/W2915852396"],"related_works":["https://openalex.org/W4300986455","https://openalex.org/W4400778823","https://openalex.org/W2592144310","https://openalex.org/W2140181275","https://openalex.org/W4327730117","https://openalex.org/W4200553095","https://openalex.org/W2806212448","https://openalex.org/W1553160311","https://openalex.org/W2166334471","https://openalex.org/W2591221551"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Sight-threatening":[1],"(late)":[2],"age-related":[3,75],"macular":[4,76],"degeneration":[5],"(AMD)":[6],"is":[7,27,49],"found":[8],"in":[9,135],"about":[10],"1.4%":[11],"of":[12,14,71,108,116,126,139,147,154,183,186,213],"people":[13],"European":[15],"ancestry":[16],"aged":[17],"70":[18],"years,":[19],"with":[20,23,225],"prevalence":[21],"increasing":[22],"age.":[24],"Early-stage":[25],"disease":[26],"marked":[28],"by":[29],"normal":[30],"vision":[31,48],"but":[32,46],"retinal":[33],"changes":[34],"(drusen":[35],"and":[36,85,124,141,150,169,211,218,220],"pigment":[37],"changes).":[38],"Disease":[39],"progression":[40],"leads":[41],"to":[42,61,90,144,208],"worsening":[43],"central":[44],"vision,":[45],"peripheral":[47],"generally":[50],"preserved.":[51],"METHODS":[52],"AND":[53],"OUTCOMES:":[54],"We":[55,78,178],"conducted":[56],"a":[57,180],"systematic":[58,165,195],"overview,":[59,196],"aiming":[60],"answer":[62],"the":[63,69,104,136,145,151,159,184,199,209],"following":[64],"clinical":[65],"question:":[66],"What":[67],"are":[68,96],"effects":[70],"treatments":[72],"for":[73,103,133,188,201],"exudative":[74],"degeneration?":[77],"searched:":[79],"Medline,":[80],"Embase,":[81],"The":[82],"Cochrane":[83],"Library,":[84],"other":[86],"important":[87],"databases":[88,118],"up":[89],"January":[91],"2014":[92],"(Clinical":[93],"Evidence":[94],"overviews":[95],"updated":[97],"periodically;":[98],"please":[99],"check":[100],"our":[101],"website":[102],"most":[105],"up-to-date":[106],"version":[107],"this":[109,113,176,194],"overview).":[110],"RESULTS:":[111],"At":[112],"update,":[114],"searching":[115],"electronic":[117],"retrieved":[119],"901":[120],"studies.":[121],"After":[122],"deduplication":[123],"removal":[125],"conference":[127],"abstracts,":[128],"597":[129],"records":[130],"were":[131,173],"screened":[132],"inclusion":[134],"overview.":[137],"Appraisal":[138],"titles":[140],"abstracts":[142],"led":[143],"exclusion":[146],"423":[148],"studies":[149],"further":[152,171],"review":[153],"174":[155,160],"full":[156,161],"publications.":[157],"Of":[158],"articles":[162],"evaluated,":[163],"two":[164],"reviews,":[166],"10":[167],"RCTs,":[168],"four":[170,202],"reports":[172],"added":[174],"at":[175],"update.":[177],"performed":[179],"GRADE":[181],"evaluation":[182],"quality":[185],"evidence":[187],"nine":[189],"PICO":[190],"combinations.":[191],"CONCLUSIONS:":[192],"In":[193],"we":[197],"categorised":[198],"efficacy":[200],"interventions,":[203],"based":[204],"on":[205],"information":[206],"relating":[207],"effectiveness":[210],"safety":[212],"anti-angiogenesis":[214],"(using":[215],"aflibercept,":[216],"bevazicumab,":[217],"ranibizumab)":[219],"ranibizumab":[221],"plus":[222],"photodynamic":[223],"therapy":[224],"verteporfin.":[226]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
