{"id":"https://openalex.org/W2277778922","doi":"https://doi.org/10.1200/jco.2007.25.18_suppl.15155","title":"A phase II study of amplitude-modulated electromagnetic fields in the treatment of advanced hepatocellular carcinoma (HCC)","display_name":"A phase II study of amplitude-modulated electromagnetic fields in the treatment of advanced hepatocellular carcinoma (HCC)","publication_year":2007,"publication_date":"2007-06-20","ids":{"openalex":"https://openalex.org/W2277778922","doi":"https://doi.org/10.1200/jco.2007.25.18_suppl.15155","mag":"2277778922"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2007.25.18_suppl.15155","doi":"https://doi.org/10.1200/jco.2007.25.18_suppl.15155","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2007.25.18_suppl.15155","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"F. Costa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145268","display_name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo","ror":"https://ror.org/03se9eg94","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210145268"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"F. Costa","raw_affiliation_strings":["Hospital das Cl\u00ednicas, Sao Paulo, Brazil; Cabinet M\u00e9dical, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital das Cl\u00ednicas, Sao Paulo, Brazil; Cabinet M\u00e9dical, Lausanne, Switzerland","institution_ids":["https://openalex.org/I4210145268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108554186","display_name":"A. C. de Oliveira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145268","display_name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo","ror":"https://ror.org/03se9eg94","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210145268"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"A. C. de Oliveira","raw_affiliation_strings":["Hospital das Cl\u00ednicas, Sao Paulo, Brazil; Cabinet M\u00e9dical, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital das Cl\u00ednicas, Sao Paulo, Brazil; Cabinet M\u00e9dical, Lausanne, Switzerland","institution_ids":["https://openalex.org/I4210145268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013398330","display_name":"Roberto Ferreira Meirelles","orcid":"https://orcid.org/0000-0001-5597-8100","observed_orcids":["https://orcid.org/0000-0001-5597-8100"]},"institutions":[{"id":"https://openalex.org/I4210145268","display_name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo","ror":"https://ror.org/03se9eg94","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210145268"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"R. Meirelles","raw_affiliation_strings":["Hospital das Cl\u00ednicas, Sao Paulo, Brazil; Cabinet M\u00e9dical, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital das Cl\u00ednicas, Sao Paulo, Brazil; Cabinet M\u00e9dical, Lausanne, Switzerland","institution_ids":["https://openalex.org/I4210145268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056984998","display_name":"Tatiana Zanesco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145268","display_name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo","ror":"https://ror.org/03se9eg94","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210145268"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"T. Zanesco","raw_affiliation_strings":["Hospital das Cl\u00ednicas, Sao Paulo, Brazil; Cabinet M\u00e9dical, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital das Cl\u00ednicas, Sao Paulo, Brazil; Cabinet M\u00e9dical, Lausanne, Switzerland","institution_ids":["https://openalex.org/I4210145268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041268459","display_name":"Rodrigo Ca\u00f1ada Trofo Surjan","orcid":"https://orcid.org/0000-0003-3918-8920","observed_orcids":["https://orcid.org/0000-0003-3918-8920"]},"institutions":[{"id":"https://openalex.org/I4210145268","display_name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo","ror":"https://ror.org/03se9eg94","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210145268"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"R. Surjan","raw_affiliation_strings":["Hospital das Cl\u00ednicas, Sao Paulo, Brazil; Cabinet M\u00e9dical, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital das Cl\u00ednicas, Sao Paulo, Brazil; Cabinet M\u00e9dical, Lausanne, Switzerland","institution_ids":["https://openalex.org/I4210145268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102723070","display_name":"Mario F. Chammas","orcid":"https://orcid.org/0000-0002-6365-9940","observed_orcids":["https://orcid.org/0000-0002-6365-9940"]},"institutions":[{"id":"https://openalex.org/I4210145268","display_name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo","ror":"https://ror.org/03se9eg94","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210145268"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"M. Chammas","raw_affiliation_strings":["Hospital das Cl\u00ednicas, Sao Paulo, Brazil; Cabinet M\u00e9dical, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital das Cl\u00ednicas, Sao Paulo, Brazil; Cabinet M\u00e9dical, Lausanne, Switzerland","institution_ids":["https://openalex.org/I4210145268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004949723","display_name":"Alexandre Barbault","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145268","display_name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo","ror":"https://ror.org/03se9eg94","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210145268"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"A. Barbault","raw_affiliation_strings":["Hospital das Cl\u00ednicas, Sao Paulo, Brazil; Cabinet M\u00e9dical, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital das Cl\u00ednicas, Sao Paulo, Brazil; Cabinet M\u00e9dical, Lausanne, Switzerland","institution_ids":["https://openalex.org/I4210145268"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042254050","display_name":"Boris Pasche","orcid":"https://orcid.org/0000-0002-3750-7898","observed_orcids":["https://orcid.org/0000-0002-3750-7898"]},"institutions":[{"id":"https://openalex.org/I4210145268","display_name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo","ror":"https://ror.org/03se9eg94","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210145268"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"B. Pasche","raw_affiliation_strings":["Hospital das Cl\u00ednicas, Sao Paulo, Brazil; Cabinet M\u00e9dical, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital das Cl\u00ednicas, Sao Paulo, Brazil; Cabinet M\u00e9dical, Lausanne, Switzerland","institution_ids":["https://openalex.org/I4210145268"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210145268"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"18_suppl","first_page":"15155","last_page":"15155"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.5708000063896179,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.5708000063896179,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10874","display_name":"Electromagnetic Fields and Biological Effects","score":0.375,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.015399999916553497,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/advanced-hepatocellular-carcinoma","display_name":"advanced hepatocellular carcinoma","score":0.8370000123977661},{"id":"https://openalex.org/keywords/radiofrequency-therapy","display_name":"radiofrequency therapy","score":0.574999988079071},{"id":"https://openalex.org/keywords/tumor-response-rate","display_name":"tumor response rate","score":0.49799999594688416},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.6859999895095825},{"id":"https://openalex.org/keywords/pain-relief","display_name":"analgesia","score":0.8569999933242798},{"id":"https://openalex.org/keywords/treatment-related-toxicity","display_name":"treatment toxicity","score":0.4339999854564667}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9587517976760864},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.7315841913223267},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5748728513717651},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.48731836676597595},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.46318718791007996},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.4507916569709778},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4145588278770447},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3609130382537842}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2007.25.18_suppl.15155","doi":"https://doi.org/10.1200/jco.2007.25.18_suppl.15155","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2007.25.18_suppl.15155","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2279838788","https://openalex.org/W2146698462","https://openalex.org/W7100811452","https://openalex.org/W2321748119","https://openalex.org/W3185604916","https://openalex.org/W4376631021","https://openalex.org/W3121502959","https://openalex.org/W4406869792","https://openalex.org/W3121205494","https://openalex.org/W2134654576"],"abstract_inverted_index":{"15155":[0],"Background:":[1],"Phase":[2],"I":[3],"data":[4],"show":[5],"that":[6],"low":[7],"levels":[8],"of":[9,130,149,161,173,231,233,249,262,314],"electromagnetic":[10],"fields":[11],"modulated":[12],"at":[13,41,258],"specific":[14],"frequencies":[15,43],"administered":[16],"intrabucally":[17],"with":[18,67,77,89,210,227,290],"the":[19,61,312],"THERABIONIC":[20,293],"device":[21,33,51],"are":[22,166,178,189],"a":[23,35,55,95,228,295],"safe":[24,296],"and":[25,70,124,182,218,283,297,307],"potentially":[26],"effective":[27,298],"treatment":[28,76],"for":[29,191,241],"advanced":[30,68,90,291],"cancer.":[31],"The":[32,50,99,112,193,221,246],"emits":[34],"27.12":[36],"MHz":[37],"radiofrequency":[38],"signal,":[39],"amplitude-modulated":[40],"tumor-specific":[42],"ranging":[44],"from":[45],"0.2":[46],"to":[47,54,84,138,180,323],"23,000":[48],"Hz.":[49],"is":[52,251,294],"connected":[53],"spoon-":[56],"like":[57],"coupler":[58],"placed":[59],"in":[60,94,208,311],"patient\u2019s":[62],"mouth":[63],"during":[64,268],"treatment.":[65,269],"Patients":[66],"HCC":[69,91],"limited":[71],"therapeutic":[72,300],"options":[73],"were":[74,92,122,271],"offered":[75],"HCC-specific":[78],"frequencies.":[79],"Methods:":[80],"From":[81],"October":[82,85],"2005":[83],"2006,":[86],"38":[87],"patients":[88,100,121,126,142,165,171,177,184,188,209,237,255,289],"recruited":[93],"phase":[96],"II":[97],"study.":[98],"received":[101,145,239],"three":[102],"daily":[103],"40":[104],"min":[105],"treatments":[106],"until":[107],"disease":[108,131,206],"progression":[109,129],"or":[110,204],"death.":[111],"median":[113,222,229,247],"age":[114],"was":[115,214,224],"64.0":[116],"\u00b1":[117],"14.2":[118],"years.":[119],"32":[120],"male":[123],"29":[125],"had":[127,143,279],"documented":[128,212],"(POD)":[132],"by":[133,200],"IV":[134],"contrast":[135],"imaging":[136],"prior":[137,146,211],"study":[139,259],"entry.":[140],"8":[141,261],"not":[144],"therapy":[147,232,240],"because":[148],"metastases":[150],"(3),":[151,155],"poor":[152],"medical":[153],"condition":[154],"declined":[156],"chemotherapy":[157],"(2).":[158],"Results:":[159],"As":[160],"January":[162],"2007,":[163],"12":[164,254],"still":[167],"on":[168],"therapy,":[169],"20":[170],"died":[172],"tumor":[174],"progression,":[175],"2":[176],"lost":[179],"follow-up":[181],"3":[183,216],"withdrew":[185],"consent.":[186],"27":[187],"eligible":[190],"response.":[192],"overall":[194],"objective":[195],"response":[196,202,250],"rate":[197],"as":[198],"defined":[199],"partial":[201],"(PR)":[203],"stable":[205],"(SD)":[207],"POD":[213],"31.6%:":[215],"PR":[217],"9":[219],"SD.":[220],"survival":[223],"20.7":[225],"weeks":[226],"duration":[230,248],"17.5":[234],"weeks.":[235,253],"13":[236],"have":[238],"more":[242],"than":[243],"six":[244],"months.":[245],"12.9":[252],"reported":[256],"pain":[257,267,309],"entry:":[260],"them":[263],"(66%)":[264],"experienced":[265],"decreased":[266],"There":[270],"no":[272],"NCI":[273],"grade":[274,280,284],"2/3/4":[275],"toxicities.":[276],"One":[277],"patient":[278],"1":[281,285],"mucositis":[282],"fatigue.":[286],"Conclusion:":[287],"In":[288],"HCC,":[292],"novel":[299],"option,":[301],"which":[302],"has":[303],"significant":[304,320],"anti-tumor":[305],"effect":[306],"provides":[308],"relief":[310],"majority":[313],"patients.":[315],"[Table:":[316],"see":[317],"text]":[318],"No":[319],"financial":[321],"relationships":[322],"disclose.":[324]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2016-06-24T00:00:00"}