{"id":"https://openalex.org/W2277675375","doi":null,"title":"[Establishment of PD-L1 transgenic mouse model and recovery of the motion after spinal cord injury].","display_name":"[Establishment of PD-L1 transgenic mouse model and recovery of the motion after spinal cord injury].","publication_year":2011,"publication_date":"2011-04-01","ids":{"openalex":"https://openalex.org/W2277675375","mag":"2277675375","pmid":"https://pubmed.ncbi.nlm.nih.gov/21481304"},"language":"zh","primary_location":{"id":"pmid:21481304","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21481304","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044611199","display_name":"Liang V. Tang","orcid":"https://orcid.org/0000-0002-3253-0220","observed_orcids":["https://orcid.org/0000-0002-3253-0220"]},"institutions":[{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liang Tang","raw_affiliation_strings":["Department of Neurobiology, Fourth Military Medical University, Xi'an 710032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Fourth Military Medical University, Xi'an 710032, China","institution_ids":["https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066005247","display_name":"Caiyong Yu","orcid":"https://orcid.org/0000-0002-4482-2319","observed_orcids":["https://orcid.org/0000-0002-4482-2319"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cai-yong Yu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100680619","display_name":"Rui Feng","orcid":"https://orcid.org/0000-0003-4151-7228","observed_orcids":["https://orcid.org/0000-0003-4151-7228"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rui Feng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100386524","display_name":"Fangfang Liu","orcid":"https://orcid.org/0000-0003-1347-6414","observed_orcids":["https://orcid.org/0000-0003-1347-6414"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fang-fang Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102786361","display_name":"Yu Zhao","orcid":"https://orcid.org/0000-0003-1062-3837","observed_orcids":["https://orcid.org/0000-0003-1062-3837"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yu Zhao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103950687","display_name":"Hongmin Guo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hong-min Guo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102018250","display_name":"Ju Gong","orcid":"https://orcid.org/0000-0003-2224-5722","observed_orcids":["https://orcid.org/0000-0003-2224-5722"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gong Ju","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Jian Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jian Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4487,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.69541488,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"27","issue":"4","first_page":"357","last_page":"9, 363"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/transgenic-mouse-model","display_name":"transgenic mouse model","score":0.8999999761581421},{"id":"https://openalex.org/keywords/spinal-cord-injury","display_name":"spinal cord injury","score":0.9810000061988831},{"id":"https://openalex.org/keywords/motor-recovery","display_name":"motor recovery","score":0.9440000057220459},{"id":"https://openalex.org/keywords/locomotor-recovery","display_name":"locomotor recovery","score":0.6990000009536743},{"id":"https://openalex.org/keywords/pronuclear-microinjection","display_name":"pronuclear microinjection","score":0.7200000286102295},{"id":"https://openalex.org/keywords/t-and-b-lymphocytes","display_name":"T and B lymphocytes","score":0.7129999995231628}],"concepts":[{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.7072443962097168},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6743345260620117},{"id":"https://openalex.org/C2778334475","wikidata":"https://www.wikidata.org/wiki/Q1415275","display_name":"Spinal cord injury","level":3,"score":0.6130505800247192},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.610227108001709},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.6066051721572876},{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.5713861584663391},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5594019293785095},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.5487852096557617},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.5453850030899048},{"id":"https://openalex.org/C81089528","wikidata":"https://www.wikidata.org/wiki/Q5134986","display_name":"clone (Java method)","level":3,"score":0.5448496341705322},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.49744299054145813},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3831453323364258},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3407512307167053},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3100852370262146},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.25742876529693604},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24840012192726135},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10684803128242493},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008124","descriptor_name":"Locomotion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008813","descriptor_name":"Mice, Inbred ICR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013119","descriptor_name":"Spinal Cord Injuries","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D018122","descriptor_name":"B7-1 Antigen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D018122","descriptor_name":"B7-1 Antigen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018122","descriptor_name":"B7-1 Antigen","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060890","descriptor_name":"B7-H1 Antigen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:21481304","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21481304","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.4399999976158142,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3129408413","https://openalex.org/W2067522902","https://openalex.org/W1587617457","https://openalex.org/W2094054809","https://openalex.org/W2785763049","https://openalex.org/W2084693693","https://openalex.org/W7097813530","https://openalex.org/W2167994792","https://openalex.org/W1964289645","https://openalex.org/W4409082672"],"abstract_inverted_index":{"AIM:":[0],"To":[1],"establish":[2],"a":[3],"ubiquitously":[4],"expressed":[5],"PD-L1":[6,28,39,46,75,92,104,155,163,221],"transgenic":[7,34,47],"mouse":[8,27,82],"model":[9],"and":[10,23,30,61,78,130,152,173,179,216],"evaluate":[11],"its":[12],"recovery":[13,113,226],"of":[14,74,91,103,114,144,200,220],"motor":[15,115],"function":[16,116],"after":[17,133,227],"spinal":[18,106,134,168,228],"cord":[19,229],"injury.":[20],"METHODS:":[21],"Clone":[22],"sequence":[24],"the":[25,32,38,42,62,153],"complete":[26],"cDNA":[29,40],"construct":[31],"pCAG-PD-L1":[33],"vector":[35],"by":[36,52,66,86,98,110,119],"inserting":[37],"into":[41],"pCAGGS":[43],"vector.":[44],"The":[45,72,89,100,112,186,206],"(TgPD-L1)":[48],"mice":[49,60,146,203,208],"were":[50,64,84,150,189,213],"established":[51,214],"pronuclear":[53],"micro-injection":[54],"with":[55,68,137],"fertilized":[56],"eggs":[57],"from":[58,81],"C57BL/6":[59,148,212],"genotypes":[63],"confirmed":[65],"PCR":[67],"tail":[69],"genomic":[70],"DNA.":[71],"expression":[73,90,101,218],"on":[76],"T":[77,172],"B":[79,174],"lymphocytes":[80,175],"spleen":[83],"detected":[85],"flow":[87,180],"cytometry.":[88],"in":[93,105,139,147,167,183,196,201,222,231],"peripheral":[94,170],"tissues":[95,223],"was":[96,108,117,164],"displayed":[97],"immunohistochemistry.":[99],"level":[102,219],"tissue":[107],"evaluated":[109],"RT-PCR.":[111],"analyzed":[118],"Basso-Beattie-Bresnahan(BBB)":[120],"locomotion":[121,225],"testing":[122],"system":[123],"at":[124,192],"3,":[125],"7,":[126],"14,":[127],"21,":[128],"28":[129],"35":[131],"day":[132,194],"severe":[135],"crush":[136],"forceps":[138],"mice.":[140,185,233],"RESULTS:":[141],"Three":[142],"lines":[143],"TgPD-L1":[145,184,197,207,232],"background":[149,210],"generated":[151],"exogenous":[154],"gene":[156],"can":[157],"be":[158],"heritable":[159],"steadily":[160],"to":[161],"offsprings.":[162],"highly":[165],"exppressed":[166],"tissue,":[169],"tissues,":[171],"using":[176],"RT-PCR,":[177],"immunohistochemistry":[178],"cytometry":[181],"respectively":[182],"BBB":[187],"scores":[188],"obviously":[190],"higher":[191],"21":[193],"post-injury":[195],"than":[198],"those":[199],"WT":[202],"(P<0.05).":[204],"CONCLUSION:":[205],"whose":[209],"are":[211],"successfully":[215],"high":[217],"promotes":[224],"injury":[230]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}