{"id":"https://openalex.org/W2277639422","doi":"https://doi.org/10.1093/jnci/89.7.497","title":"Portal Vein Chemotherapy for Colorectal Cancer: a Meta-analysis of 4000 Patients in 10 Studies","display_name":"Portal Vein Chemotherapy for Colorectal Cancer: a Meta-analysis of 4000 Patients in 10 Studies","publication_year":1997,"publication_date":"1997-04-02","ids":{"openalex":"https://openalex.org/W2277639422","doi":"https://doi.org/10.1093/jnci/89.7.497","mag":"2277639422","pmid":"https://pubmed.ncbi.nlm.nih.gov/9086006"},"language":"en","primary_location":{"id":"doi:10.1093/jnci/89.7.497","doi":"https://doi.org/10.1093/jnci/89.7.497","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jnci/89.7.497","pdf_url":null,"source":{"id":"https://openalex.org/S98010888","display_name":"JNCI Journal of the National Cancer Institute","issn_l":"0027-8874","issn":["0027-8874","1460-2105"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JNCI Journal of the National Cancer Institute","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Liver Infusion Meta-analysis Group","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Liver Infusion Meta-analysis Group","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5436,"currency":"USD","value_usd":5436},"apc_paid":null,"fwci":2.0875,"has_fulltext":false,"cited_by_count":121,"citation_normalized_percentile":{"value":0.9127907,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"89","issue":"7","first_page":"497","last_page":"505"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9541000127792358,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9541000127792358,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.04410000145435333,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9710000157356262},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.9160000085830688},{"id":"https://openalex.org/keywords/postoperative-chemotherapy","display_name":"postoperative chemotherapy","score":0.765999972820282},{"id":"https://openalex.org/keywords/liver-recurrence","display_name":"liver recurrence","score":0.5950000286102295},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.5619999766349792},{"id":"https://openalex.org/keywords/recurrence","display_name":"recurrence","score":0.3610000014305115},{"id":"https://openalex.org/keywords/mitomycin-c","display_name":"mitomycin C","score":0.7390000224113464},{"id":"https://openalex.org/keywords/heparin","display_name":"heparin","score":0.7360000014305115},{"id":"https://openalex.org/keywords/urokinase-type-plasminogen-activator","display_name":"urokinase","score":0.8199999928474426},{"id":"https://openalex.org/keywords/dukes-stage","display_name":"Dukes stage","score":0.6290000081062317},{"id":"https://openalex.org/keywords/systemic-chemotherapy-comparison","display_name":"systemic chemotherapy comparison","score":0.5649999976158142},{"id":"https://openalex.org/keywords/subgroup-analysis","display_name":"subgroup analysis","score":0.3190000057220459},{"id":"https://openalex.org/keywords/postoperative-adjuvant-therapy","display_name":"postoperative adjuvant therapy","score":0.414000004529953}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9255563020706177},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7139515280723572},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5985420346260071},{"id":"https://openalex.org/C2779338040","wikidata":"https://www.wikidata.org/wiki/Q19856779","display_name":"Mitomycin C","level":2,"score":0.5297152996063232},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5295996069908142},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5108663439750671},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.444199800491333},{"id":"https://openalex.org/C2776892390","wikidata":"https://www.wikidata.org/wiki/Q7119591","display_name":"Urokinase","level":2,"score":0.4390879273414612},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4372923970222473},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.43461477756500244},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.39188244938850403},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3437749147415161}],"mesh":[{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011169","descriptor_name":"Portal Vein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016685","descriptor_name":"Mitomycin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/jnci/89.7.497","doi":"https://doi.org/10.1093/jnci/89.7.497","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jnci/89.7.497","pdf_url":null,"source":{"id":"https://openalex.org/S98010888","display_name":"JNCI Journal of the National Cancer Institute","issn_l":"0027-8874","issn":["0027-8874","1460-2105"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JNCI Journal of the National Cancer Institute","raw_type":"journal-article"},{"id":"pmid:9086006","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9086006","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the National Cancer Institute","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:publications/5dfad48e-0b50-4ec7-a135-3369b1ba9e64","doi":null,"is_oa":false,"landing_page_url":"https://research-repository.uwa.edu.au/en/publications/5dfad48e-0b50-4ec7-a135-3369b1ba9e64","pdf_url":null,"source":{"id":"https://openalex.org/S4306402492","display_name":"UWA Profiles and Research Repository (UWA)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177877127","host_organization_name":"The University of Western Australia","host_organization_lineage":["https://openalex.org/I177877127"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W40385197","https://openalex.org/W206480088","https://openalex.org/W1742647530","https://openalex.org/W1769344090","https://openalex.org/W1962875322","https://openalex.org/W1965913733","https://openalex.org/W1966703018","https://openalex.org/W1971378447","https://openalex.org/W1974952809","https://openalex.org/W1976941903","https://openalex.org/W1989527459","https://openalex.org/W1993797710","https://openalex.org/W1996761484","https://openalex.org/W2008821649","https://openalex.org/W2010922828","https://openalex.org/W2013256551","https://openalex.org/W2020766221","https://openalex.org/W2042487706","https://openalex.org/W2072968785","https://openalex.org/W2089098721","https://openalex.org/W2112607803","https://openalex.org/W2114263823","https://openalex.org/W2135629945","https://openalex.org/W2159848047","https://openalex.org/W2221006098","https://openalex.org/W2273844457","https://openalex.org/W2275576700","https://openalex.org/W2314635417","https://openalex.org/W2342298610","https://openalex.org/W2413759484","https://openalex.org/W2469345929","https://openalex.org/W2472965276","https://openalex.org/W3199339248","https://openalex.org/W4229896032","https://openalex.org/W4293107555"],"related_works":["https://openalex.org/W4300715050","https://openalex.org/W2369177788","https://openalex.org/W4416706888","https://openalex.org/W1997854971","https://openalex.org/W2098334248","https://openalex.org/W2386877942","https://openalex.org/W2152639997","https://openalex.org/W2053282565","https://openalex.org/W2171909625","https://openalex.org/W2364761054"],"abstract_inverted_index":{"BACKGROUND:":[0],"Systemic":[1],"delivery":[2],"of":[3,16,25,56,93,97,145,155,162,175,182,299,412,439],"cytotoxic":[4,98,128,199,398,407,418],"drugs":[5,99],"yields":[6],"relatively":[7],"low":[8],"doses":[9],"in":[10,79,85,130,143,282,350,354,369,426,436],"the":[11,32,35,50,146,191,220,223,232,258,264,300,302,327,346,355,366,370,386],"liver,":[12],"a":[13,46,87,171,440],"major":[14],"site":[15],"recurrence":[17,53,72],"for":[18,75,124,222,280,308,420],"colorectal":[19,64,429],"cancer.":[20],"Giving":[21],"chemotherapy":[22,60],"by":[23,61],"means":[24],"continuous":[26,94,159,179],"portal":[27],"vein":[28],"infusion":[29,181],"(PVI)":[30],"into":[31],"liver":[33,351],"during":[34],"immediate":[36],"postoperative":[37,95],"period":[38],"may":[39,431],"improve":[40],"therapeutic":[41],"efficacy.":[42],"PURPOSE:":[43],"We":[44],"undertook":[45],"meta-analysis":[47],"to":[48,196,209,218,288,313,345,394],"assess":[49],"effects":[51],"on":[52,69,305],"and":[54,71,114,214,451],"survival":[55,234,266,307,333,392,438],"administering":[57],"fluorouracil":[58],"(5-FU)-based":[59],"PVI":[62,96,161,200,216,240,399,403,411],"after":[63,424],"cancer":[65,430],"surgery.":[66],"METHODS:":[67],"Data":[68,106],"mortality":[70],"were":[73,122,262],"sought":[74],"all":[76,309],"patients":[77,121,156,176,193,289,427,461],"enrolled":[78],"randomized":[80,455],"trials":[81,109,149,261,311,373,387,456],"initiated":[82],"before":[83],"1987":[84],"which":[86],"few":[88,441],"days":[89],"(range,":[90],"5-7":[91],"days)":[92],"was":[100,133,141,268,286,330,374],"compared":[101],"with":[102,136,158,178,213,231,239,290,388,397,401,405,428],"no":[103,202],"further":[104,203],"treatment.":[105],"from":[107,454],"10":[108,310],"(a":[110],"promising":[111],"initial":[112,328,356],"study":[113,329,357],"nine":[115,259,371],"hypothesis-testing":[116,260,372],"trials)":[117],"involving":[118,457],"about":[119,421],"4000":[120],"available":[123],"analysis.":[125],"The":[126],"main":[127],"drug":[129,408],"each":[131],"trial":[132,169],"5-FU":[134,413],"(given":[135],"heparin);":[137],"however,":[138],"mitomycin":[139],"C":[140,296],"co-administered":[142],"two":[144],"trials.":[147],"Four":[148],"included":[150,170],"an":[151,433],"additional":[152,389,452],"control":[153,173,390],"group":[154,174],"treated":[157,177],"noncytotoxic":[160,402],"either":[163,198],"heparin":[164],"or":[165,201,295,404,415],"urokinase":[166],"alone;":[167],"one":[168],"second":[172],"systemic":[180,406],"5-FU.":[183],"Reported":[184],"P":[185,340,363,382],"values":[186],"are":[187,207],"two-sided.":[188],"RESULTS:":[189],"Among":[190],"3499":[192],"randomly":[194],"assigned":[195],"receive":[197],"treatment,":[204],"1557":[205],"deaths":[206],"known":[208],"have":[210],"occurred.":[211],"Survival":[212],"without":[215,416],"appeared":[217,393],"be":[219,395],"same":[221],"first":[224],"2":[225],"years;":[226],"thereafter,":[227],"it":[228],"diverged":[229],"significantly,":[230],"absolute":[233,265,303,434],"difference":[235,267,334],"(i.e.,":[236],"improvement)":[237],"associated":[238],"at":[241],"5":[242],"years":[243],"being":[244],"4.7":[245],"%":[246],"(standard":[247],"deviation":[248],"[SD]":[249],"=":[250,254,271,274,316,319,335,338,341,361,364,380,383],"1.2":[251],"%)":[252],"(P":[253,273,318],".006).":[255],"When":[256],"just":[257],"considered,":[263],"3.6%":[269],"(SD":[270,315],"1.2%)":[272],".04).":[275],"If,":[276],"ignoring":[277],"any":[278],"potential":[279],"bias":[281],"stage":[283,292],"assignment,":[284],"attention":[285],"restricted":[287],"Dukes'":[291],"A,":[293],"B,":[294],"disease":[297],"(88.3%":[298],"total),":[301],"effect":[304],"5-year":[306,437],"increased":[312],"6.0%":[314],"1.8%)":[317],".001);":[320],"this":[321,445],"estimate":[322],"remained":[323],"statistically":[324,449],"significant":[325,348,376],"when":[326],"excluded":[331],"(absolute":[332],"4.8%;":[336],"SD":[337,360,379],"1.8%;":[339],".01).":[342],"In":[343,385],"contrast":[344],"highly":[347],"reduction":[349,367],"metastases":[352],"seen":[353],"(79%":[358],"reduction;":[359,378],"15%;":[362],".00000007),":[365],"found":[368],"not":[375,448],"(14%":[377],"10%;":[381],".2).":[384],"groups,":[391],"better":[396],"than":[400],"infusion.":[409],"CONCLUSIONS:":[410],"(with":[414],"other":[417],"drugs)":[419],"1":[422],"week":[423],"surgery":[425],"produce":[432],"improvement":[435],"percent.":[442],"Although":[443],"encouraging,":[444],"finding":[446],"is":[447,462],"secure,":[450],"evidence":[453],"several":[458],"thousand":[459],"more":[460],"needed.":[463]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}