{"id":"https://openalex.org/W2277580591","doi":null,"title":"Metabolic profiling of prions in the gastro-intestinal tract","display_name":"Metabolic profiling of prions in the gastro-intestinal tract","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2277580591","mag":"2277580591"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-1659","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/624","pdf_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/624","source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations & Theses (Open Access)","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/624","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109291989","display_name":"Uffaf Khan","orcid":"https://orcid.org/0009-0004-3414-5571","observed_orcids":["https://orcid.org/0009-0004-3414-5571"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Uffaf Khan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5109291989"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prions","display_name":"prions","score":0.8899999856948853},{"id":"https://openalex.org/keywords/prion-disease","display_name":"prion disease","score":0.9559999704360962},{"id":"https://openalex.org/keywords/prpsc","display_name":"PrPSc","score":0.6269999742507935},{"id":"https://openalex.org/keywords/oral-transmission","display_name":"oral transmission","score":0.8199999928474426},{"id":"https://openalex.org/keywords/intestinal-barrier","display_name":"intestinal barrier","score":0.5600000023841858},{"id":"https://openalex.org/keywords/chronic-wasting-disease","display_name":"chronic wasting disease","score":0.6880000233650208},{"id":"https://openalex.org/keywords/bovine-spongiform-encephalopathy","display_name":"bovine spongiform encephalopathy","score":0.9800000190734863},{"id":"https://openalex.org/keywords/variant-creutzfeldt-jakob-disease","display_name":"variant Creutzfeldt-Jakob disease","score":0.9959999918937683},{"id":"https://openalex.org/keywords/duodenum","display_name":"duodenum","score":0.5460000038146973},{"id":"https://openalex.org/keywords/jejunum","display_name":"jejunum","score":0.9599999785423279},{"id":"https://openalex.org/keywords/ileum","display_name":"ileum","score":0.9980000257492065}],"concepts":[{"id":"https://openalex.org/C2992581678","wikidata":"https://www.wikidata.org/wiki/Q11829360","display_name":"Digestive tract","level":2,"score":0.6254749298095703},{"id":"https://openalex.org/C22130703","wikidata":"https://www.wikidata.org/wiki/Q6627854","display_name":"Gastro-","level":4,"score":0.5976635813713074},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3303847312927246},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31062763929367065},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18247658014297485},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1511547863483429},{"id":"https://openalex.org/C43270747","wikidata":"https://www.wikidata.org/wiki/Q898610","display_name":"Reflux","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-1659","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/624","pdf_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/624","source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations & Theses (Open Access)","raw_type":"text"},{"id":"mag:2277580591","doi":null,"is_oa":false,"landing_page_url":"http://digitalcommons.library.tmc.edu/cgi/viewcontent.cgi?article=1659&context=utgsbs_dissertations","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-1659","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/624","pdf_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/624","source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations & Theses (Open Access)","raw_type":"text"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2277580591.pdf","grobid_xml":"https://content.openalex.org/works/W2277580591.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W310556292","https://openalex.org/W1502117212","https://openalex.org/W1506040285","https://openalex.org/W1561070497","https://openalex.org/W1601881612","https://openalex.org/W1647631454","https://openalex.org/W1783331345","https://openalex.org/W1815769276","https://openalex.org/W1966170211","https://openalex.org/W1972644169","https://openalex.org/W1973758214","https://openalex.org/W1975922727","https://openalex.org/W1980735475","https://openalex.org/W1991043494","https://openalex.org/W1999100510","https://openalex.org/W2006050607","https://openalex.org/W2009062615","https://openalex.org/W2013679718","https://openalex.org/W2013696290","https://openalex.org/W2018290520","https://openalex.org/W2022392367","https://openalex.org/W2024632347","https://openalex.org/W2026061438","https://openalex.org/W2034084051","https://openalex.org/W2041229020","https://openalex.org/W2045562971","https://openalex.org/W2048393965","https://openalex.org/W2062482039","https://openalex.org/W2064722614","https://openalex.org/W2074199271","https://openalex.org/W2075133203","https://openalex.org/W2076914359","https://openalex.org/W2090202861","https://openalex.org/W2096759599","https://openalex.org/W2104275539","https://openalex.org/W2118064423","https://openalex.org/W2121674689","https://openalex.org/W2124577407","https://openalex.org/W2127764424","https://openalex.org/W2133557706","https://openalex.org/W2134462664","https://openalex.org/W2134864907","https://openalex.org/W2136692054","https://openalex.org/W2138468217","https://openalex.org/W2138520334","https://openalex.org/W2140486326","https://openalex.org/W2150497169","https://openalex.org/W2150554290","https://openalex.org/W2155463696","https://openalex.org/W2158058793","https://openalex.org/W2160881867","https://openalex.org/W2166826058","https://openalex.org/W2267509217","https://openalex.org/W2332347891","https://openalex.org/W2411522233"],"related_works":["https://openalex.org/W2122827512","https://openalex.org/W2153267940","https://openalex.org/W2151697231","https://openalex.org/W2516524950","https://openalex.org/W1587098975","https://openalex.org/W2052735522","https://openalex.org/W1541148800","https://openalex.org/W1966746406","https://openalex.org/W2120361396","https://openalex.org/W2104275539"],"abstract_inverted_index":{"Metabolic":[0],"profiling":[1],"of":[2,29,82,90,96,103,173,188,193,236,239],"prions":[3,143,174,240,245],"in":[4,48,52,71,77,121,132,157,175,180,195,208,241,248],"the":[5,117,129,150,170,185,200],"gastro-intestinal":[6,133,145,176],"tract":[7,177],"Uffaf":[8],"Khan,":[9],"B.S.":[10],"Thesis":[11],"Advisor:":[12],"Claudio":[13],"Soto,":[14],"Ph.D.":[15],"Abstract":[16],"Prion":[17],"diseases,":[18],"also":[19,63,229],"known":[20,107],"as":[21,46,215],"transmissible":[22],"spongiform":[23,69],"encephalopathies":[24],"(TSEs),":[25],"are":[26,246],"a":[27,109],"group":[28],"debilitating":[30],"neurodegenerative":[31],"disorders":[32],"that":[33,141,232],"affect":[34],"both":[35],"humans":[36,61,78],"and":[37,54,126,147,159,183,211,219,251],"animals.":[38],"They":[39],"can":[40],"be":[41],"spread":[42],"by":[43,93,179],"horizontal":[44],"transmission":[45,59,91,104],"seen":[47],"chronic":[49],"wasting":[50],"disease":[51,76],"deer":[53],"elk":[55],"population.":[56],"In":[57,135,162],"addition,":[58],"to":[60,73,80,164,217],"has":[62,105],"been":[64,106],"documented":[65],"which":[66],"includes":[67],"bovine":[68],"encephalopathy":[70],"cattle":[72],"variant":[74],"Creutzfeldt-Jakob":[75],"due":[79],"consumption":[81,95],"contaminated":[83],"meat.":[84],"The":[85],"most":[86],"probable":[87],"natural":[88],"route":[89],"is":[92,113,128,140,225],"oral":[94,237],"infectious":[97,118,142,189],"material.":[98],"Even":[99],"though":[100],"this":[101,136,166],"mode":[102],"for":[108],"long":[110],"time":[111],"it":[112],"still":[114],"unclear":[115],"how":[116],"material":[119,190],"distributes":[120],"vivo":[122],"shortly":[123],"after":[124,153],"ingestion":[125,194,238],"what":[127],"metabolic":[130,171,205],"stability":[131],"tissues.":[134,253],"line,":[137],"our":[138],"hypothesis":[139],"resist":[144],"digestion":[146],"directly":[148],"cross":[149],"intestinal":[151],"barrier":[152],"per-oral":[154],"administration,":[155],"distributing":[156],"blood":[158],"various":[160,252],"organs.":[161],"order":[163],"test":[165],"hypothesis,":[167],"we":[168],"characterized":[169],"profile":[172],"tissues":[178],"vitro":[181],"experiments":[182],"determined":[184],"initial":[186],"distribution":[187],"within":[191,233],"hours":[192,235],"vivo.":[196],"Our":[197],"results":[198],"showed":[199],"radiolabeled":[201],"125I-PrPSc":[202],"undergoes":[203],"limited":[204],"degradation":[206,224],"-mostly":[207],"duodenum,":[209],"jejunum":[210],"ileum":[212],"tissue":[213],"homogenates-":[214],"compared":[216],"stomach":[218],"colon":[220],"homogenates":[221],"where":[222],"little":[223],"observed.":[226],"We":[227],"have":[228],"separately":[230],"shown":[231],"two":[234],"mice":[242],"self":[243],"propagating":[244],"detected":[247],"blood,":[249],"brain":[250]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}