{"id":"https://openalex.org/W2277518166","doi":null,"title":"[A case of poorly differentiated adenocarcinoma of the rectum with disseminated carcinomatosis of the bone marrow successfully treated with mFOLFOX-6/bevacizumab].","display_name":"[A case of poorly differentiated adenocarcinoma of the rectum with disseminated carcinomatosis of the bone marrow successfully treated with mFOLFOX-6/bevacizumab].","publication_year":2010,"publication_date":"2010-07-01","ids":{"openalex":"https://openalex.org/W2277518166","mag":"2277518166","pmid":"https://pubmed.ncbi.nlm.nih.gov/20616483"},"language":"ja","primary_location":{"id":"pmid:20616483","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20616483","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology","raw_type":"Case Reports"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014919709","display_name":"Kentaro Nonaka","orcid":"https://orcid.org/0009-0009-1063-8829","observed_orcids":["https://orcid.org/0009-0009-1063-8829"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kentaro Nonaka","raw_affiliation_strings":["Department of Surgery, Higashinari Hospital. kykms7563@yahoo.co.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Higashinari Hospital. kykms7563@yahoo.co.jp","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038512337","display_name":"Seigo Sha","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seigo Sha","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110218138","display_name":"Michihiro Ito","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michihiro Ito","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047323052","display_name":"Kazuhiko NONAKA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kazuhiko Nonaka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112550560","display_name":"Naoki Yamanaka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Naoki Yamanaka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1624,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.59801306,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"107","issue":"7","first_page":"1151","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.8910999894142151,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.8910999894142151,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.10580000281333923,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rectal-adenocarcinoma","display_name":"rectal adenocarcinoma","score":0.9449999928474426},{"id":"https://openalex.org/keywords/poorly-differentiated-adenocarcinoma","display_name":"poorly differentiated adenocarcinoma","score":0.9860000014305115},{"id":"https://openalex.org/keywords/bone-marrow-metastasis","display_name":"bone marrow metastasis","score":0.7990000247955322},{"id":"https://openalex.org/keywords/disseminated-intravascular-coagulation","display_name":"disseminated intravascular coagulation","score":0.9480000138282776},{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":0.9670000076293945},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.5429999828338623},{"id":"https://openalex.org/keywords/carcinoembryonic-antigen","display_name":"carcinoembryonic antigen","score":0.9430000185966492},{"id":"https://openalex.org/keywords/outpatient-chemotherapy","display_name":"outpatient chemotherapy","score":0.421999990940094}],"concepts":[{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5772021412849426},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.573108971118927},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5595053434371948},{"id":"https://openalex.org/C2778734968","wikidata":"https://www.wikidata.org/wiki/Q823027","display_name":"Disseminated intravascular coagulation","level":2,"score":0.46782344579696655},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3539760708808899}],"mesh":[{"descriptor_ui":"D000068258","descriptor_name":"Bevacizumab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D002955","descriptor_name":"Leucovorin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009944","descriptor_name":"Organoplatinum Compounds","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D012004","descriptor_name":"Rectal Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D012004","descriptor_name":"Rectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D019046","descriptor_name":"Bone Marrow Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D019046","descriptor_name":"Bone Marrow Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:20616483","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20616483","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W124990176","https://openalex.org/W2011161319","https://openalex.org/W2092215947","https://openalex.org/W2121368761","https://openalex.org/W2133399075","https://openalex.org/W2274429414"],"related_works":["https://openalex.org/W2411033470","https://openalex.org/W2159068310","https://openalex.org/W120075871","https://openalex.org/W55492409","https://openalex.org/W2415631345","https://openalex.org/W3007852922","https://openalex.org/W2061596272","https://openalex.org/W1971871888","https://openalex.org/W2522276190","https://openalex.org/W2033762665"],"abstract_inverted_index":{"A":[0],"45-year-old":[1],"woman,":[2],"complaining":[3],"of":[4,14,18,52,66,75,78,90,93,102,116],"back":[5],"pain":[6],"and":[7,27,104],"bloody":[8],"stool":[9],"was":[10,55,97,105],"given":[11],"a":[12,62,73,88],"diagnosis":[13],"poorly":[15],"differentiated":[16],"adenocarcinoma":[17],"the":[19,114],"rectum":[20],"with":[21,38],"disseminated":[22,28],"carcinomatosis":[23],"to":[24,57,70,108],"bone":[25],"marrow":[26],"intravascular":[29],"coagulation":[30],"syndrome":[31],"(DIC).":[32],"We":[33],"started":[34,98],"chemotherapy":[35],"using":[36],"mFOLFOX-6":[37],"simultaneous":[39],"DIC":[40,46],"treatment.":[41],"After":[42],"we":[43],"confirmed":[44],"that":[45],"had":[47],"improved":[48,69],"following":[49],"2":[50],"courses":[51,77,92,101],"mFOLFOX-6,":[53],"bevacizumab":[54],"added":[56],"mFOLFOX-6.":[58],"Laboratory":[59],"studies":[60],"revealed":[61],"serum":[63],"CEA":[64],"level":[65],"314.4ng/ml,":[67],"which":[68],"4.6ng/ml":[71],"after":[72,87,99],"total":[74,89],"6":[76],"chemotherapy.":[79,94],"Colonoscopy":[80],"findings":[81],"showed":[82],"almost":[83],"normal":[84],"rectal":[85],"mucosa":[86],"10":[91],"Outpatient":[95],"treatment":[96],"5":[100],"chemotherapy,":[103],"continuing":[106],"according":[107],"schedule":[109],"at":[110],"7":[111],"months":[112],"from":[113],"onset":[115],"this":[117],"disease.":[118]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}