{"id":"https://openalex.org/W2277386335","doi":null,"title":"Conversion of coral sand to calcium phosphate as a drug delivery system for bone regeneration","display_name":"Conversion of coral sand to calcium phosphate as a drug delivery system for bone regeneration","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2277386335","mag":"2277386335"},"language":"en","primary_location":{"id":"pmh:oai:opus.lib.uts.edu.au:10453/21794","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10453/21794","pdf_url":"https://opus.lib.uts.edu.au/bitstream/10453/21794/2/02_whole.pdf","source":{"id":"https://openalex.org/S4306401357","display_name":"UTS ePRESS (University of Technology Sydney)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114017466","host_organization_name":"University of Technology Sydney","host_organization_lineage":["https://openalex.org/I114017466"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://opus.lib.uts.edu.au/bitstream/10453/21794/2/02_whole.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032199054","display_name":"Joshua Chou","orcid":"https://orcid.org/0000-0002-7472-8016","observed_orcids":["https://orcid.org/0000-0002-7472-8016"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Joshua Chou","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7472-8016","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5032199054"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calcium-phosphate","display_name":"calcium phosphate","score":0.7099999785423279},{"id":"https://openalex.org/keywords/bisphosphonates","display_name":"bisphosphonates","score":0.7630000114440918},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"drug delivery","score":0.718999981880188},{"id":"https://openalex.org/keywords/bone-regeneration","display_name":"bone regeneration","score":0.972000002861023},{"id":"https://openalex.org/keywords/biomimetics","display_name":"biomimetics","score":0.7429999709129333},{"id":"https://openalex.org/keywords/gentamicin","display_name":"gentamicin","score":0.7549999952316284},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.7879999876022339},{"id":"https://openalex.org/keywords/lipid-coating","display_name":"lipid coating","score":0.8270000219345093},{"id":"https://openalex.org/keywords/osteoblast-proliferation","display_name":"osteoblast proliferation","score":0.8790000081062317},{"id":"https://openalex.org/keywords/osteoclast-inhibition","display_name":"osteoclast inhibition","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bone-infection-prevention","display_name":"bone infection prevention","score":0.4860000014305115},{"id":"https://openalex.org/keywords/biodegradable-microspheres","display_name":"biodegradable microspheres","score":0.6069999933242798}],"concepts":[{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.5819746851921082},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.558330774307251},{"id":"https://openalex.org/C143020374","wikidata":"https://www.wikidata.org/wiki/Q2411228","display_name":"Coral","level":2,"score":0.5023961067199707},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.4869118928909302},{"id":"https://openalex.org/C2777132085","wikidata":"https://www.wikidata.org/wiki/Q46220103","display_name":"Phosphate","level":2,"score":0.4538882076740265},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.275276780128479},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.268881618976593},{"id":"https://openalex.org/C111368507","wikidata":"https://www.wikidata.org/wiki/Q43518","display_name":"Oceanography","level":1,"score":0.2567753791809082},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2497963011264801},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.19787761569023132},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18826714158058167},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15907076001167297},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.12191110849380493},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.08506584167480469},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07629203796386719}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:opus.lib.uts.edu.au:10453/21794","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10453/21794","pdf_url":"https://opus.lib.uts.edu.au/bitstream/10453/21794/2/02_whole.pdf","source":{"id":"https://openalex.org/S4306401357","display_name":"UTS ePRESS (University of Technology Sydney)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114017466","host_organization_name":"University of Technology Sydney","host_organization_lineage":["https://openalex.org/I114017466"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2277386335","doi":null,"is_oa":false,"landing_page_url":"https://opus.lib.uts.edu.au/bitstream/10453/21794/2/02_whole.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:opus.lib.uts.edu.au:10453/21794","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10453/21794","pdf_url":"https://opus.lib.uts.edu.au/bitstream/10453/21794/2/02_whole.pdf","source":{"id":"https://openalex.org/S4306401357","display_name":"UTS ePRESS (University of Technology Sydney)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114017466","host_organization_name":"University of Technology Sydney","host_organization_lineage":["https://openalex.org/I114017466"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2277386335.pdf","grobid_xml":"https://content.openalex.org/works/W2277386335.grobid-xml"},"referenced_works_count":113,"referenced_works":["https://openalex.org/W19645973","https://openalex.org/W31255081","https://openalex.org/W134119245","https://openalex.org/W145018013","https://openalex.org/W605181446","https://openalex.org/W1541482853","https://openalex.org/W1645697262","https://openalex.org/W1716781317","https://openalex.org/W1862589716","https://openalex.org/W1899517398","https://openalex.org/W1966416107","https://openalex.org/W1966805140","https://openalex.org/W1967637692","https://openalex.org/W1972940389","https://openalex.org/W1975265519","https://openalex.org/W1975479345","https://openalex.org/W1979253120","https://openalex.org/W1980688132","https://openalex.org/W1984484579","https://openalex.org/W1985542716","https://openalex.org/W1987156394","https://openalex.org/W1994062626","https://openalex.org/W1996433976","https://openalex.org/W1996657564","https://openalex.org/W1997526887","https://openalex.org/W1998852933","https://openalex.org/W1999411922","https://openalex.org/W2008706561","https://openalex.org/W2008822050","https://openalex.org/W2009672068","https://openalex.org/W2011782846","https://openalex.org/W2012562175","https://openalex.org/W2012847873","https://openalex.org/W2014637539","https://openalex.org/W2016158447","https://openalex.org/W2019292653","https://openalex.org/W2020056894","https://openalex.org/W2023847585","https://openalex.org/W2032678092","https://openalex.org/W2034587036","https://openalex.org/W2034909835","https://openalex.org/W2035555277","https://openalex.org/W2037294612","https://openalex.org/W2037442588","https://openalex.org/W2039679522","https://openalex.org/W2040286741","https://openalex.org/W2040883985","https://openalex.org/W2043570090","https://openalex.org/W2046232956","https://openalex.org/W2046679094","https://openalex.org/W2049021375","https://openalex.org/W2050268374","https://openalex.org/W2051303716","https://openalex.org/W2052664550","https://openalex.org/W2053154124","https://openalex.org/W2053419067","https://openalex.org/W2054383875","https://openalex.org/W2056406255","https://openalex.org/W2057255250","https://openalex.org/W2060065099","https://openalex.org/W2062224667","https://openalex.org/W2067952454","https://openalex.org/W2068055563","https://openalex.org/W2070232466","https://openalex.org/W2071361034","https://openalex.org/W2071689334","https://openalex.org/W2072230954","https://openalex.org/W2072508802","https://openalex.org/W2073460165","https://openalex.org/W2077518515","https://openalex.org/W2078419961","https://openalex.org/W2080880437","https://openalex.org/W2083143826","https://openalex.org/W2083453693","https://openalex.org/W2086130473","https://openalex.org/W2086699454","https://openalex.org/W2088966553","https://openalex.org/W2089778365","https://openalex.org/W2093988152","https://openalex.org/W2094562739","https://openalex.org/W2102845456","https://openalex.org/W2103253098","https://openalex.org/W2104907919","https://openalex.org/W2106142458","https://openalex.org/W2109568979","https://openalex.org/W2126051065","https://openalex.org/W2128778774","https://openalex.org/W2131265412","https://openalex.org/W2137140584","https://openalex.org/W2137855626","https://openalex.org/W2140455148","https://openalex.org/W2146299356","https://openalex.org/W2149084424","https://openalex.org/W2150628505","https://openalex.org/W2153149830","https://openalex.org/W2153220309","https://openalex.org/W2154920784","https://openalex.org/W2156788471","https://openalex.org/W2157956984","https://openalex.org/W2158572699","https://openalex.org/W2159254568","https://openalex.org/W2160848453","https://openalex.org/W2164620392","https://openalex.org/W2166556161","https://openalex.org/W2167840876","https://openalex.org/W2218037750","https://openalex.org/W2252346223","https://openalex.org/W2286714891","https://openalex.org/W2415572397","https://openalex.org/W2416818259","https://openalex.org/W2528382760","https://openalex.org/W3162627082","https://openalex.org/W4312861408"],"related_works":["https://openalex.org/W2066171154","https://openalex.org/W6992049039","https://openalex.org/W4381513541","https://openalex.org/W7025082971","https://openalex.org/W2785306434","https://openalex.org/W6999797636","https://openalex.org/W7221720390","https://openalex.org/W6996361883","https://openalex.org/W6996869584","https://openalex.org/W2942511958"],"abstract_inverted_index":{"In":[0,335],"this":[1,34,371,376,381,387],"research,":[2],"we":[3,35,378],"have":[4,379],"for":[5,52,70,97,190,213,390,398],"the":[6,10,23,62,115,132,136,194,198,208,224,229,261,269,276,288,293,317,331,336],"first":[7],"time":[8,290],"harnessed":[9],"architectural":[11],"design":[12,116],"of":[13,61,92,119,207,296,366,396],"biospheres":[14],"from":[15,76],"coral":[16,153,166],"beach":[17,154,167,354],"sand,":[18],"to":[19,39,49,104,113,126,172,218,263,291,360,407],"capture":[20],"and":[21,86,117,130,161,175,192,258,266,274,301,310,358,362,401],"deliver":[22],"drug":[24,41,53,63,184,199,225,262,277,315,395],"bisphosphonate":[25,185,252],"alone,":[26],"or":[27,393],"in":[28,248,382,385],"combination":[29],"with":[30,33,156,177,251,333,342,349,375],"antibiotics.":[31],"Partnered":[32],"used":[36],"lipid":[37],"coatings":[38],"control":[40],"elution":[42,323],"by":[43,239,245,329,370],"design.":[44],"This":[45,211],"is":[46,200,271,356,388],"a":[47,307,350,364],"study":[48,377],"utilise":[50],"biomimetics":[51],"delivery":[54,120],"using":[55,93,148],"these":[56,338],"marine":[57],"structures.":[58],"Importantly,":[59],"release":[60,206,316,363],"was":[64,236,285],"sustained":[65,205],"at":[66,135,287],"physiologically":[67],"relevant":[68],"quantities":[69],"longer":[71],"periods":[72],"than":[73],"those":[74],"originating":[75],"other":[77],"clinically":[78],"practiced":[79],"schemes":[80],"such":[81,180],"as,":[82],"doping":[83],"bone":[84,221,300,399],"cements":[85],"oral":[87],"administration.":[88],"The":[89,254,322],"simple":[90,151],"concept":[91],"natural":[94],"structures":[95],"directly":[96],"human":[98,241],"therapeutics":[99],"can":[100,123,325,339],"yield":[101],"enormous":[102],"benefits":[103],"an":[105,127,187,282],"increasingly":[106],"ageing":[107],"population.":[108],"Currently":[109],"researchers":[110],"are":[111,139],"striving":[112],"perfect":[114],"formulation":[118],"vehicles":[121],"that":[122,344],"be":[124,264,326,340,408],"directed":[125],"exact":[128],"location":[129],"offload":[131],"pharmaceutical":[133,178],"drugs":[134,179],"site.":[137],"There":[138],"many":[140],"promising":[141],"strategies":[142],"including":[143],"bio-inspired":[144],"ones,":[145],"but":[146,384],"none":[147],"something":[149],"as":[150,152,181,193,368],"sand":[155,168,355],"unique":[157],"pore":[158],"size,":[159],"interconnectivity":[160],"architecture.":[162],"\\nThese":[163],"calcium":[164,173,272],"carbonate":[165],"microspheres":[169,195],"were":[170],"converted":[171],"phosphate":[174,273],"loaded":[176,265,286],"bisphosphonate.":[182],"\\nThe":[183],"has":[186,226],"inherent":[188],"affinity":[189],"calcium,":[191],"slowly":[196,320],"degrade,":[197],"released.":[201],"Elution":[202],"kinetics":[203,324],"show":[204],"adsorbed":[209],"drug.":[210],"occurs":[212],"21":[214],"days-":[215],"long":[216],"enough":[217],"influence":[219],"early":[220],"formation.":[222],"Once":[223],"been":[227],"released,":[228],"spheres":[230,332],"also":[231],"safely":[232],"dissipate.":[233],"Drug":[234],"functioning":[235],"positively":[237],"determined":[238],"increased":[240],"osteoblast":[242],"proliferation":[243],"accompanied":[244],"osteoclast":[246],"inhibition":[247],"direct":[249],"association":[250],"bio-spheres.":[253],"unique,":[255],"complex":[256],"topology":[257],"morphology":[259],"enables":[260],"retained":[267],"while":[268],"material":[270],"adsorbes":[275],"very":[278],"efficiently.":[279],"\\nIn":[280],"addition":[281],"antibiotic":[283],"gentamicin":[284],"same":[289],"surmount":[292],"re-current":[294],"problem":[295],"bacterial":[297],"infections":[298],"following":[299],"implant":[302],"surgery.":[303],"Biospheres":[304],"therefore":[305],"offer":[306],"more":[308],"efficient":[309],"convenient":[311],"alternative.":[312],"Following":[313],"complete":[314],"vehicle":[318],"degrades":[319],"in-situ.":[321],"further":[327],"controlled":[328],"coating":[330],"lipid.":[334],"future":[337],"incorporated":[341],"molecules":[343],"provide":[345],"highly":[346],"specific":[347],"associations":[348],"target":[351],"tissue.":[352],"Coral":[353],"plentiful":[357],"pre-designed":[359],"adsorb":[361],"variety":[365],"drugs,":[367],"indicated":[369],"study.":[372],"So":[373],"far":[374],"shown":[380],"vitro,":[383],"principle":[386],"applicable":[389],"any":[391],"orthopaedic":[392],"maxillofacial":[394],"choice":[397],"repair":[400],"reconstruction.":[402],"Biomimetics":[403],"do":[404],"not":[405],"need":[406],"complicated.":[409]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2016-06-24T00:00:00"}