{"id":"https://openalex.org/W2277155337","doi":"https://doi.org/10.1088/1742-6596/611/1/012030","title":"Gamma irradiation induces DNA double-strand breaks in fibroblasts: a model study for the development of biodosimetry","display_name":"Gamma irradiation induces DNA double-strand breaks in fibroblasts: a model study for the development of biodosimetry","publication_year":2015,"publication_date":"2015-05-07","ids":{"openalex":"https://openalex.org/W2277155337","doi":"https://doi.org/10.1088/1742-6596/611/1/012030","mag":"2277155337"},"language":"en","primary_location":{"id":"doi:10.1088/1742-6596/611/1/012030","doi":"https://doi.org/10.1088/1742-6596/611/1/012030","is_oa":true,"landing_page_url":"https://doi.org/10.1088/1742-6596/611/1/012030","pdf_url":"https://iopscience.iop.org/article/10.1088/1742-6596/611/1/012030/pdf","source":{"id":"https://openalex.org/S4210187594","display_name":"Journal of Physics Conference Series","issn_l":"1742-6588","issn":["1742-6588","1742-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","jufo-1","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320083","host_organization_name":"IOP Publishing","host_organization_lineage":["https://openalex.org/P4310320083","https://openalex.org/P4310311669"],"host_organization_lineage_names":["IOP Publishing","Institute of Physics"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Physics: Conference Series","raw_type":"journal-article"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://iopscience.iop.org/article/10.1088/1742-6596/611/1/012030/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032928571","display_name":"Pimpon Uttayarat","orcid":"https://orcid.org/0000-0002-8196-2185","observed_orcids":["https://orcid.org/0000-0002-8196-2185"]},"institutions":[{"id":"https://openalex.org/I4405271347","display_name":"Thailand Institute of Nuclear Technology","ror":"https://ror.org/029wwg820","country_code":"TH","type":"facility","lineage":["https://openalex.org/I4405271347"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"P Uttayarat","raw_affiliation_strings":["Thailand Institute of Nuclear Technology (Public Organization), Ongkharak, Nakhon Nayok 26120 Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thailand Institute of Nuclear Technology (Public Organization), Ongkharak, Nakhon Nayok 26120 Thailand","institution_ids":["https://openalex.org/I4405271347"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028388532","display_name":"Theeranan Tangtong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405271347","display_name":"Thailand Institute of Nuclear Technology","ror":"https://ror.org/029wwg820","country_code":"TH","type":"facility","lineage":["https://openalex.org/I4405271347"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"T Tangtong","raw_affiliation_strings":["Thailand Institute of Nuclear Technology (Public Organization), Ongkharak, Nakhon Nayok 26120 Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thailand Institute of Nuclear Technology (Public Organization), Ongkharak, Nakhon Nayok 26120 Thailand","institution_ids":["https://openalex.org/I4405271347"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075588407","display_name":"Kasama Sukapirom","orcid":"https://orcid.org/0000-0002-4899-9568","observed_orcids":["https://orcid.org/0000-0002-4899-9568"]},"institutions":[{"id":"https://openalex.org/I1332387789","display_name":"Siriraj Hospital","ror":"https://ror.org/0331zs648","country_code":"TH","type":"healthcare","lineage":["https://openalex.org/I1332387789"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"K Sukapirom","raw_affiliation_strings":["Division of Instruments for Research, Office for Research and Development, Faculty of Medicine, Siriraj Hospital, Bangkok 10700 Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Instruments for Research, Office for Research and Development, Faculty of Medicine, Siriraj Hospital, Bangkok 10700 Thailand","institution_ids":["https://openalex.org/I1332387789"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010560801","display_name":"Kanokporn Boonsirichai","orcid":"https://orcid.org/0000-0002-5706-3665","observed_orcids":["https://orcid.org/0000-0002-5706-3665"]},"institutions":[{"id":"https://openalex.org/I4405271347","display_name":"Thailand Institute of Nuclear Technology","ror":"https://ror.org/029wwg820","country_code":"TH","type":"facility","lineage":["https://openalex.org/I4405271347"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"K Boonsirichai","raw_affiliation_strings":["Thailand Institute of Nuclear Technology (Public Organization), Ongkharak, Nakhon Nayok 26120 Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thailand Institute of Nuclear Technology (Public Organization), Ongkharak, Nakhon Nayok 26120 Thailand","institution_ids":["https://openalex.org/I4405271347"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"611","issue":null,"first_page":"012030","last_page":"012030"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.018699999898672104,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gamma-irradiation","display_name":"gamma irradiation","score":0.824999988079071},{"id":"https://openalex.org/keywords/dna-double-strand-breaks","display_name":"DNA double-strand breaks","score":0.9990000128746033},{"id":"https://openalex.org/keywords/biodosimetry","display_name":"biological dosimetry","score":0.9430000185966492},{"id":"https://openalex.org/keywords/h2ax-phosphorylation","display_name":"H2AX phosphorylation","score":0.8709999918937683},{"id":"https://openalex.org/keywords/human-dermal-fibroblasts","display_name":"human dermal fibroblasts","score":0.9580000042915344},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.6150000095367432},{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"ionizing radiation","score":0.6840000152587891},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.609000027179718},{"id":"https://openalex.org/keywords/accidental-radiation-exposure","display_name":"accidental radiation exposure","score":0.7419999837875366}],"concepts":[{"id":"https://openalex.org/C2779254040","wikidata":"https://www.wikidata.org/wiki/Q4914782","display_name":"Biodosimetry","level":4,"score":0.9594273567199707},{"id":"https://openalex.org/C18231593","wikidata":"https://www.wikidata.org/wiki/Q186161","display_name":"Ionizing radiation","level":3,"score":0.6478759050369263},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.5828310251235962},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5567003488540649},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5538307428359985},{"id":"https://openalex.org/C2992406208","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"Double strand","level":4,"score":0.5358484983444214},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.47984597086906433},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.44678744673728943},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.35876035690307617},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3288467526435852},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32732218503952026},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29929396510124207},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28045931458473206},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1904650628566742},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0825071930885315},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1088/1742-6596/611/1/012030","doi":"https://doi.org/10.1088/1742-6596/611/1/012030","is_oa":true,"landing_page_url":"https://doi.org/10.1088/1742-6596/611/1/012030","pdf_url":"https://iopscience.iop.org/article/10.1088/1742-6596/611/1/012030/pdf","source":{"id":"https://openalex.org/S4210187594","display_name":"Journal of Physics Conference Series","issn_l":"1742-6588","issn":["1742-6588","1742-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","jufo-1","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320083","host_organization_name":"IOP Publishing","host_organization_lineage":["https://openalex.org/P4310320083","https://openalex.org/P4310311669"],"host_organization_lineage_names":["IOP Publishing","Institute of Physics"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Physics: Conference Series","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1088/1742-6596/611/1/012030","doi":"https://doi.org/10.1088/1742-6596/611/1/012030","is_oa":true,"landing_page_url":"https://doi.org/10.1088/1742-6596/611/1/012030","pdf_url":"https://iopscience.iop.org/article/10.1088/1742-6596/611/1/012030/pdf","source":{"id":"https://openalex.org/S4210187594","display_name":"Journal of Physics Conference Series","issn_l":"1742-6588","issn":["1742-6588","1742-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","jufo-1","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320083","host_organization_name":"IOP Publishing","host_organization_lineage":["https://openalex.org/P4310320083","https://openalex.org/P4310311669"],"host_organization_lineage_names":["IOP Publishing","Institute of Physics"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Physics: Conference Series","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7246000170707703,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320336004","display_name":"Faculty of Medicine Siriraj Hospital, Mahidol University","ror":"https://ror.org/0331zs648"},{"id":"https://openalex.org/F4320336950","display_name":"Thailand Institute of Nuclear Technology","ror":"https://ror.org/029wwg820"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2277155337.pdf","grobid_xml":"https://content.openalex.org/works/W2277155337.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1878993697","https://openalex.org/W1970225082","https://openalex.org/W1976186736","https://openalex.org/W1985631367","https://openalex.org/W1986327413","https://openalex.org/W2002808160","https://openalex.org/W2019396221","https://openalex.org/W2023398210","https://openalex.org/W2034819289","https://openalex.org/W2035062207","https://openalex.org/W2036643295","https://openalex.org/W2057658557","https://openalex.org/W2062226976","https://openalex.org/W2066684567","https://openalex.org/W2074946397","https://openalex.org/W2082959079","https://openalex.org/W2093463836","https://openalex.org/W2094377580","https://openalex.org/W2116959560","https://openalex.org/W2152639692","https://openalex.org/W2157724508","https://openalex.org/W2167527887","https://openalex.org/W2170008898"],"related_works":["https://openalex.org/W2036643295","https://openalex.org/W3031523054","https://openalex.org/W4200043570","https://openalex.org/W7196968303","https://openalex.org/W2165189442","https://openalex.org/W2044634738","https://openalex.org/W2093463836","https://openalex.org/W4290546765","https://openalex.org/W4404228308","https://openalex.org/W2061117950"],"abstract_inverted_index":{"Double-strand":[0],"breaks":[1],"(DSBs)":[2],"of":[3,67,126,149,170,182,194],"DNAs":[4],"induced":[5],"by":[6,101,141],"ionizing":[7],"radiation":[8,221],"can":[9,206],"pose":[10],"detrimental":[11],"damages":[12],"on":[13,64],"organisms":[14],"which":[15],"include":[16],"genetic":[17],"instability":[18],"and":[19,38,119,122,144],"cell":[20,89,195],"death.":[21],"It":[22],"is":[23],"necessary":[24],"to":[25,28,56,79,187,199,215,219,224],"be":[26,207],"able":[27],"assess":[29],"health":[30],"risks":[31],"associated":[32],"with":[33,76,159],"irradiation":[34,188],"from":[35,104],"both":[36],"accidental":[37,220],"therapeutic":[39],"exposures":[40],"in":[41,61,108,185,222],"a":[42,58,81,86,105,109,123,175,211],"timely":[43],"manner":[44],"for":[45,139],"proper":[46],"medical":[47],"treatments.":[48],"This":[49,204],"present":[50],"study":[51],"showed":[52,174],"the":[53,65,160,192],"first":[54],"attempt":[55],"develop":[57],"biodosimetric":[59,227],"measure":[60],"Thailand":[62],"based":[63],"quantification":[66],"phosphorylated":[68,150],"histone":[69],"H2AX":[70],"(\u03b3-H2AX)":[71],"formed":[72],"at":[73,113,153,164,201],"DSB":[74],"sites":[75],"an":[77],"aim":[78],"establish":[80],"dose":[82,124],"response":[83,177],"curve":[84],"using":[85],"two-dimensional":[87],"(2D)":[88],"culture":[90],"model.":[91],"Human":[92],"dermal":[93],"fibroblasts":[94],"were":[95,136],"grown":[96],"into":[97],"monolayers":[98],"before":[99],"irradiated":[100],"gamma":[102],"rays":[103],"Co-60":[106],"source":[107],"custom-made":[110],"lead":[111],"chamber":[112],"doses":[114],"0,":[115],"0.2,":[116],"1,":[117],"2":[118,179],"4":[120,165],"Gy":[121],"rate":[125],"0.21":[127],"Gy/min.":[128],"After":[129],"30":[130],"min":[131],"post":[132],"exposure,":[133],"\u03b3-H2AX":[134,151],"proteins":[135,152],"immunofluorescently":[137],"labelled":[138],"evaluation":[140],"confocal":[142],"microscopy":[143],"flow":[145,171],"cytometry.":[146],"The":[147],"accumulation":[148],"DSBs":[154],"appeared":[155],"as":[156,210],"nuclear":[157],"foci":[158,183],"most":[161],"prominent":[162],"intensity":[163,184],"Gy.":[166],"Linear":[167],"regression":[168],"analysis":[169],"cytometric":[172],"data":[173],"linear":[176],"(R":[178],"=":[180],"0.9862)":[181],"proportion":[186],"dose.":[189],"In":[190],"addition,":[191],"fraction":[193],"viability":[196],"was":[197],"shown":[198],"decrease":[200],"higher":[202],"doses.":[203],"technique":[205],"further":[208],"developed":[209],"quick":[212],"assessment":[213],"tool":[214],"identify":[216],"individuals":[217],"subjected":[218],"parallel":[223],"other":[225],"established":[226],"measures.":[228]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}