{"id":"https://openalex.org/W2277074589","doi":"https://doi.org/10.1200/jco.2008.26.15_suppl.7000","title":"A phase I/II study of vorinostat, an oral histone deacetylase inhibitor, in combination with azacitidine in patients with the myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Initial results of the phase I trial: A New York Cancer Consortium","display_name":"A phase I/II study of vorinostat, an oral histone deacetylase inhibitor, in combination with azacitidine in patients with the myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Initial results of the phase I trial: A New York Cancer Consortium","publication_year":2008,"publication_date":"2008-05-20","ids":{"openalex":"https://openalex.org/W2277074589","doi":"https://doi.org/10.1200/jco.2008.26.15_suppl.7000","mag":"2277074589"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2008.26.15_suppl.7000","doi":"https://doi.org/10.1200/jco.2008.26.15_suppl.7000","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2008.26.15_suppl.7000","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108426263","display_name":"L.R. Silverman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. R. Silverman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"A. Verma","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Verma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035408133","display_name":"Rosalie Odchimar-Reissig","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Odchimar-Reissig","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008297856","display_name":"Amanda Cozza","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Cozza","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042829932","display_name":"Vesna Najfeld","orcid":"https://orcid.org/0000-0002-0054-7722","observed_orcids":["https://orcid.org/0000-0002-0054-7722"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V. Najfeld","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034992183","display_name":"Jonathan D. Licht","orcid":"https://orcid.org/0000-0002-3942-1369","observed_orcids":["https://orcid.org/0000-0002-3942-1369"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. D. Licht","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5033174879","display_name":"James A. Zwiebel","orcid":"https://orcid.org/0000-0003-4455-8789","observed_orcids":["https://orcid.org/0000-0003-4455-8789"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. A. Zwiebel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"15_suppl","first_page":"7000","last_page":"7000"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vorinostat","display_name":"vorinostat","score":0.8519999980926514},{"id":"https://openalex.org/keywords/azacitidine","display_name":"azacitidine","score":0.972000002861023},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.902999997138977},{"id":"https://openalex.org/keywords/myelodysplastic-syndrome","display_name":"myelodysplastic syndrome","score":0.9769999980926514},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":1.0},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7850000262260437},{"id":"https://openalex.org/keywords/epigenetic-silencing","display_name":"epigenetic silencing","score":0.9110000133514404},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.6510000228881836},{"id":"https://openalex.org/keywords/dose-escalation","display_name":"dose escalation","score":0.6439999938011169},{"id":"https://openalex.org/keywords/hematological-response","display_name":"hematologic response","score":0.5950000286102295},{"id":"https://openalex.org/keywords/fatigue","display_name":"fatigue","score":0.45500001311302185},{"id":"https://openalex.org/keywords/anorexia","display_name":"anorexia","score":0.7440000176429749},{"id":"https://openalex.org/keywords/toxicity","display_name":"toxicity","score":0.34700000286102295},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.6119999885559082},{"id":"https://openalex.org/keywords/methylation","display_name":"methylation","score":0.6880000233650208},{"id":"https://openalex.org/keywords/poor-risk-cytogenetics","display_name":"poor-risk cytogenetics","score":0.6320000290870667}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8265711665153503},{"id":"https://openalex.org/C2776239401","wikidata":"https://www.wikidata.org/wiki/Q416451","display_name":"Azacitidine","level":5,"score":0.7913451194763184},{"id":"https://openalex.org/C2776262904","wikidata":"https://www.wikidata.org/wiki/Q905901","display_name":"Vorinostat","level":5,"score":0.7775160074234009},{"id":"https://openalex.org/C2776012956","wikidata":"https://www.wikidata.org/wiki/Q17125294","display_name":"Hypomethylating agent","level":5,"score":0.6299397945404053},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6040960550308228},{"id":"https://openalex.org/C2780235182","wikidata":"https://www.wikidata.org/wiki/Q1181878","display_name":"Decitabine","level":5,"score":0.5326043963432312},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5056743621826172},{"id":"https://openalex.org/C2780817109","wikidata":"https://www.wikidata.org/wiki/Q954625","display_name":"Myelodysplastic syndromes","level":3,"score":0.41396987438201904},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.21169200539588928},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.19332128763198853},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.13524112105369568},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08515694737434387},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.07934907078742981},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2008.26.15_suppl.7000","doi":"https://doi.org/10.1200/jco.2008.26.15_suppl.7000","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2008.26.15_suppl.7000","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2557408317","https://openalex.org/W2980022549","https://openalex.org/W1992840498","https://openalex.org/W2559831429","https://openalex.org/W2531135360","https://openalex.org/W2560642189","https://openalex.org/W2608406219","https://openalex.org/W4206174687","https://openalex.org/W2564303563","https://openalex.org/W2040852160"],"abstract_inverted_index":{"7000":[0],"Background:":[1],"Epigenetic":[2],"silencing":[3],"plays":[4],"a":[5,108,212],"role":[6],"in":[7,65,107,166,244,247,258,260,283,319],"MDS":[8,21,66],"and":[9,22,36,52,67,105,131,241,249,264,273,286,295,311,324],"AML.":[10],"The":[11,278,302],"hypomethylating":[12],"agent":[13,63],"azacitidine":[14],"(azaC)":[15],"alters":[16],"the":[17,86,101,119,132,145,148,308],"natural":[18],"history":[19],"of":[20,97,103,118,168,201,251,268,328],"improves":[23],"survival":[24,40],"(Silverman":[25,41],"JCO":[26,42],"2002,":[27],"Fenaux":[28],"Blood":[29,70],"2007).":[30],"In":[31,72],"AML,":[32,156],"azaC":[33,78,106,300],"produces":[34],"responses":[35],"appears":[37,287],"to":[38,45,57,79,182,209,291,299,314,321],"affect":[39],"2006).":[43,71],"Time":[44],"response":[46,183,294],"is":[47,184,280],"slow,":[48],"median":[49,157],"4":[50,233,376,387],"cycles":[51,203,285],"CR+PR":[53],"ranges":[54],"from":[55],"7":[56,406],"27%.":[58],"Vorinostat":[59,335],"has":[60],"demonstrated":[61],"single":[62],"activity":[64],"AML":[68],"(Garcia-Manero":[69],"sequenced":[73],"combination":[74,102,279],"vorinostat":[75,104],"synergizes":[76],"with":[77,100,189,211],"reactivate":[80],"epigenetically":[81],"silenced":[82],"genes.":[83],"Methods:":[84],"For":[85],"phase":[87,303],"I":[88],"component":[89],"eligible":[90],"patients":[91],"(pts)":[92],"were":[93,236],"entered":[94],"into":[95],"one":[96],"8":[98,416],"cohorts":[99,135,261],"3+3":[109],"dose":[110,313,331],"escalating":[111],"de-escalating":[112],"design":[113],"(see":[114],"table).":[115],"Results:":[116],"As":[117],"data":[120,140],"cut":[121],"for":[122,129,144,223,289],"this":[123],"submission":[124],"16":[125],"pts":[126,150,163,188,218],"are":[127,275],"evaluable":[128,162],"toxicity":[130],"first":[133],"6":[134,155,396],"have":[136,153,164,204,219],"been":[137,205],"completed,":[138],"full":[139],"will":[141,306],"be":[142],"available":[143],"meeting.":[146],"Among":[147,187],"20":[149],"entered:":[151],"14":[152],"MDS,":[154],"age":[158],"68.":[159],"Responses":[160],"among":[161],"occurred":[165,243,257],"9":[167],"11":[169,210],"(82%);":[170],"5":[171,386],"CR,":[172],"1":[173,208,246,346,407],"CRi,":[174,196],"(CR+CRi=55%),":[175],"3":[176,217,231,263,347,357,366,367,377,397],"HI,":[177],"2":[178,185,197,239,255,356],"SD.":[179],"Median":[180],"time":[181,290],"cycles.":[186,215],"poor":[190],"risk":[191],"cytogenetics":[192],"4/5":[193],"responded":[194],"(CR,":[195],"HI).":[198],"A":[199],"total":[200],"90":[202],"administered,":[206],"range":[207],"mean":[213],"4.7":[214],"Only":[216],"come":[220],"off":[221],"study":[222,305],"progression,":[224],"co-morbidities,":[225],"or":[226,232,429,432],"consent":[227],"withdrawal.":[228],"No":[229,327],"grade":[230,344],"non-hematologic":[234],"toxicities":[235],"observed.":[237],"Grade":[238,254],"anorexia":[240],"fatigue":[242,256],"cycle":[245],"31.6%":[248],"57.9%":[250],"pts,":[252],"respectively.":[253],"89%":[259],"2,":[262],"4.":[265],"Correlative":[266],"studies":[267],"effects":[269],"on":[270],"gene":[271],"expression":[272],"methylation":[274],"underway.":[276],"Conclusion:":[277],"safe,":[281],"tolerated":[282],"repetitive":[284],"superior":[288],"response,":[292],"overall":[293],"CR":[296],"rate":[297],"compared":[298],"alone.":[301],"II":[304],"utilize":[307],"optimal":[309],"epigenetic":[310],"clinical":[312],"determine":[315],"this.":[316],"Cohort":[317,326],"Dosing":[318],"Relation":[320],"Adverse":[322,341],"Events":[323,342],"Response":[325,345],"Pts":[329],"AzaC":[330],"mg/m2/d":[332],"1\u20137":[333],"SQ":[334],"Dose":[336,339],"mg/d":[337],"Total":[338],"AzaC/Vorinostat":[340],"anorexia/Fatigue":[343],"55":[348,358,398,408,418],"200":[349,359,369,379,409],"bid":[350,380,390,400,410,420],"x":[351,361,371,381,391,401,411,421],"14d":[352,362,372,382],"385/5600":[353],"1;0;0/2;1;2":[354],"CR;CR;CR":[355],"tid":[360,370],"385/8400":[363],"2;2;2/2;2;2":[364],"CR;SD;CRi":[365],"75":[368,378,388],"525/8400":[373],"1;0;1/2;0;2":[374],"SD;CR;HI":[375],"525/5600":[383],"2;1;2/2;2;2":[384],"IE;HI;HI":[385],"300":[389,399,419],"7d":[392,402,412],"525/4200":[393],"1;2;0/2;1;0":[394],"TE;TE;TE":[395,404,405],"385/4200":[403],"385/2800":[413],"TE":[414,415],"0":[417],"3d":[422],"385/1800":[423],"NA":[424,425],"Author":[426],"Disclosure":[427],"Employment":[428],"Leadership":[430],"Consultant":[431],"Advisory":[433],"Role":[434],"Stock":[435],"Ownership":[436],"Honoraria":[437],"Research":[438],"Expert":[439],"Testimony":[440],"Other":[441],"Remuneration":[442],"Pharmion":[443]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}
