{"id":"https://openalex.org/W2276958873","doi":null,"title":"Association of Increased Plasma Interleukin-6 and TNF-\u03b1 Levels in Donors with the Complication Rates in Liver Transplant Recipients.","display_name":"Association of Increased Plasma Interleukin-6 and TNF-\u03b1 Levels in Donors with the Complication Rates in Liver Transplant Recipients.","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2276958873","mag":"2276958873","pmid":"https://pubmed.ncbi.nlm.nih.gov/25013647","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4089308"},"language":"en","primary_location":{"id":"pmh:oai:ijotm.com/ojs:article/137","doi":null,"is_oa":true,"landing_page_url":"https://www.ijotm.com/ojs/index.php/IJOTM/article/view/137","pdf_url":"https://www.ijotm.com/ojs/index.php/IJOTM/article/download/137/247","source":{"id":"https://openalex.org/S5407051250","display_name":"International Journal of Organ Transplantation Medicine","issn_l":"2008-6482","issn":["2008-6482","2958-8375"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","dongbi-c","poland-40","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2008-6482","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.ijotm.com/ojs/index.php/IJOTM/article/download/137/247","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064585849","display_name":"Negar Azarpira","orcid":"https://orcid.org/0000-0002-5549-0057","observed_orcids":["https://orcid.org/0000-0002-5549-0057","https://orcid.org/0000-0002-1518-1583"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Azarpira","raw_affiliation_strings":["Shiraz Transplant Research Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shiraz Transplant Research Center","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"S Nikeghbalian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166459259","display_name":"Shiraz University","ror":"https://ror.org/028qtbk54","country_code":"IR","type":"education","lineage":["https://openalex.org/I166459259"]},{"id":"https://openalex.org/I194604659","display_name":"Shiraz University of Medical Sciences","ror":"https://ror.org/01n3s4692","country_code":"IR","type":"education","lineage":["https://openalex.org/I194604659"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"S Nikeghbalian","raw_affiliation_strings":["Shiraz Transplant Research Center, ; Organ Transplantation Center, Shiraz University of Medical Sciences, Shiraz, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shiraz Transplant Research Center, ; Organ Transplantation Center, Shiraz University of Medical Sciences, Shiraz, Iran","institution_ids":["https://openalex.org/I166459259","https://openalex.org/I194604659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057553751","display_name":"Kourosh Kazemi","orcid":"https://orcid.org/0000-0003-4477-7121","observed_orcids":["https://orcid.org/0000-0003-4477-7121"]},"institutions":[{"id":"https://openalex.org/I194604659","display_name":"Shiraz University of Medical Sciences","ror":"https://ror.org/01n3s4692","country_code":"IR","type":"education","lineage":["https://openalex.org/I194604659"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"K Kazemi","raw_affiliation_strings":["Organ Transplantation Center, Shiraz University of Medical Sciences, Shiraz, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Organ Transplantation Center, Shiraz University of Medical Sciences, Shiraz, Iran","institution_ids":["https://openalex.org/I194604659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053554120","display_name":"Bita Geramizadeh","orcid":"https://orcid.org/0000-0002-4867-5686","observed_orcids":["https://orcid.org/0000-0002-4867-5686","https://orcid.org/0000-0003-1009-0049"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Geramizadeh","raw_affiliation_strings":["Shiraz Transplant Research Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shiraz Transplant Research Center","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074494901","display_name":"Zahra Malekpour","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Z Malekpour","raw_affiliation_strings":["Shiraz Transplant Research Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shiraz Transplant Research Center","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065089798","display_name":"Seyed Ali Malek\u2010Hosseini","orcid":"https://orcid.org/0000-0002-0853-9938","observed_orcids":["https://orcid.org/0000-0002-0853-9938"]},"institutions":[{"id":"https://openalex.org/I166459259","display_name":"Shiraz University","ror":"https://ror.org/028qtbk54","country_code":"IR","type":"education","lineage":["https://openalex.org/I166459259"]},{"id":"https://openalex.org/I194604659","display_name":"Shiraz University of Medical Sciences","ror":"https://ror.org/01n3s4692","country_code":"IR","type":"education","lineage":["https://openalex.org/I194604659"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"S A Malek-Hosseini","raw_affiliation_strings":["Shiraz Transplant Research Center, ; Organ Transplantation Center, Shiraz University of Medical Sciences, Shiraz, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shiraz Transplant Research Center, ; Organ Transplantation Center, Shiraz University of Medical Sciences, Shiraz, Iran","institution_ids":["https://openalex.org/I166459259","https://openalex.org/I194604659"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9516,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.74147096,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"4","issue":"1","first_page":"9","last_page":"14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.9038000106811523,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.9038000106811523,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11163","display_name":"Organ Donation and Transplantation","score":0.08619999885559082,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.009200000204145908,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liver-transplantation","display_name":"liver transplantation","score":0.7300000190734863},{"id":"https://openalex.org/keywords/brain-death","display_name":"brain death","score":0.7080000042915344},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":1.0},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.7179999947547913},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.9800000190734863},{"id":"https://openalex.org/keywords/post-transplant-complications","display_name":"post-transplant complications","score":0.890999972820282},{"id":"https://openalex.org/keywords/allograft-dysfunction","display_name":"allograft dysfunction","score":0.8220000267028809},{"id":"https://openalex.org/keywords/organ-procurement","display_name":"organ procurement","score":0.5879999995231628},{"id":"https://openalex.org/keywords/clavien-dindo-classification","display_name":"Clavien-Dindo classification","score":0.8529999852180481}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9497454166412354},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.5789229869842529},{"id":"https://openalex.org/C2779609443","wikidata":"https://www.wikidata.org/wiki/Q1368191","display_name":"Liver transplantation","level":3,"score":0.5580320358276367},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5081708431243896},{"id":"https://openalex.org/C168444539","wikidata":"https://www.wikidata.org/wiki/Q105196","display_name":"Organ transplantation","level":3,"score":0.49767401814460754},{"id":"https://openalex.org/C29374701","wikidata":"https://www.wikidata.org/wiki/Q1931388","display_name":"Cause of death","level":3,"score":0.4516127407550812},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4512062966823578},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.42141416668891907},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.41729143261909485},{"id":"https://openalex.org/C2780084366","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demographics","level":2,"score":0.4167451858520508},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0967138409614563},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:oai:ijotm.com/ojs:article/137","doi":null,"is_oa":true,"landing_page_url":"https://www.ijotm.com/ojs/index.php/IJOTM/article/view/137","pdf_url":"https://www.ijotm.com/ojs/index.php/IJOTM/article/download/137/247","source":{"id":"https://openalex.org/S5407051250","display_name":"International Journal of Organ Transplantation Medicine","issn_l":"2008-6482","issn":["2008-6482","2958-8375"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","dongbi-c","poland-40","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2008-6482","raw_type":"info:eu-repo/semantics/article"},{"id":"pmid:25013647","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25013647","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of organ transplantation medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4089308","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4089308/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Organ Transplant Med","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.780.155","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.780.155","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/70/3a/ijotm-4-009.PMC4089308.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:90287f02904746a4a84d5aed71d2c354","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/90287f02904746a4a84d5aed71d2c354","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Organ Transplantation Medicine, Vol 4, Iss 1, Pp 9-14 (2013)","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:ijotm.com/ojs:article/137","doi":null,"is_oa":true,"landing_page_url":"https://www.ijotm.com/ojs/index.php/IJOTM/article/view/137","pdf_url":"https://www.ijotm.com/ojs/index.php/IJOTM/article/download/137/247","source":{"id":"https://openalex.org/S5407051250","display_name":"International Journal of Organ Transplantation Medicine","issn_l":"2008-6482","issn":["2008-6482","2958-8375"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","dongbi-c","poland-40","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2008-6482","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2276958873.pdf","grobid_xml":"https://content.openalex.org/works/W2276958873.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1947009034","https://openalex.org/W1969407000","https://openalex.org/W1975908033","https://openalex.org/W1979646516","https://openalex.org/W1990038658","https://openalex.org/W1990823740","https://openalex.org/W1992128116","https://openalex.org/W2000375586","https://openalex.org/W2036091266","https://openalex.org/W2047670732","https://openalex.org/W2055505613","https://openalex.org/W2064343642","https://openalex.org/W2069662897","https://openalex.org/W2069697226","https://openalex.org/W2072870576","https://openalex.org/W2078248611","https://openalex.org/W2082146223","https://openalex.org/W2087339396","https://openalex.org/W2103591331","https://openalex.org/W2148868198","https://openalex.org/W2160406808","https://openalex.org/W2163903787","https://openalex.org/W2333378480"],"related_works":["https://openalex.org/W7217152329","https://openalex.org/W7098418570","https://openalex.org/W1992128116","https://openalex.org/W2036091266","https://openalex.org/W2415285555","https://openalex.org/W2931263329","https://openalex.org/W4403666098","https://openalex.org/W4399284893","https://openalex.org/W2279868002","https://openalex.org/W7201923879"],"abstract_inverted_index":{"BACKGROUND:":[0],"Solid":[1],"organ":[2,14,152,284],"transplantation":[3],"is":[4,37,70],"the":[5,22,63,86,98,103,128,171,242],"only":[6],"definitive":[7],"treatment":[8],"available":[9],"for":[10],"patients":[11],"with":[12,51,72,199,213,268,288],"end-stage":[13],"failure.":[15],"Organs":[16],"procured":[17],"from":[18],"brain-death":[19,68,82],"donors":[20,69,83,150,160,282],"are":[21,286],"main":[23],"source":[24],"of":[25,32,43,91,94,100,113,133,159,175,225,258,277],"transplants.":[26],"Following":[27,97],"brain":[28,101,114,176],"death,":[29,102],"a":[30,217],"burst":[31],"inflammatory":[33,46,65],"reaction":[34,47],"develops;":[35],"it":[36],"characterized":[38],"by":[39],"increased":[40,52,64],"plasma":[41,190,223,270,275],"levels":[42,132],"cytokines.":[44],"This":[45],"has":[48],"been":[49],"associated":[50,71,287],"early":[53],"allograft":[54],"dysfunction.":[55],"OBJECTIVE:":[56],"In":[57],"this":[58],"study,":[59],"we":[60],"test":[61],"if":[62],"response":[66],"in":[67,122,148,184,197,245,261,281,292],"more":[73,289],"recipient":[74,109],"complications.":[75],"METHODS:":[76],"We":[77],"prospectively":[78],"recruited":[79],"38":[80],"consecutive":[81],"admitted":[84],"to":[85,127,167,230,247],"intensive":[87],"care":[88],"units":[89],"(ICUs)":[90],"Shiraz":[92],"University":[93],"Medical":[95],"Sciences.":[96],"declaration":[99],"demographics":[104],"data":[105],"on":[106],"donor":[107,222,269],"and":[108,111,137,279],"characteristics":[110],"cause":[112,174],"death":[115,177],"were":[116,124,139],"recorded.":[117],"The":[118,155,179,188],"post-liver":[119,180],"transplant":[120,181,294],"complications":[121,182,203,214,233,259,291],"recipients":[123,198,256],"stratified":[125],"according":[126],"Clavien":[129],"classification.":[130],"Plasma":[131],"cytokines":[134],"IL-6,":[135],"IL-2,":[136],"TNF-\u03b1":[138,191,280],"measured":[140],"using":[141],"enzyme":[142],"linked":[143],"immunosorbent":[144],"assay":[145],"(ELISA)":[146],"kits,":[147],"all":[149],"before":[151,283],"procurement.":[153],"RESULTS:":[154],"mean":[156],"(range)":[157],"age":[158],"was":[161,170,193,239],"44":[162],"(16-74)":[163],"years.":[164],"Trauma":[165],"due":[166],"car":[168],"accident":[169],"most":[172],"common":[173],"(79%).":[178],"occurred":[183],"19":[185],"(50%)":[186],"recipients.":[187,295],"mean\u00b1SD":[189,221],"concentration":[192,224,249],"significantly":[194,218],"(p<0.001)":[195],"higher":[196,220],"grade":[200],"1-3":[201],"post-transplant":[202],"(68.33\u00b127.74":[204],"pg/mL)":[205,228],"than":[206],"those":[207,231],"without":[208,232],"complication":[209],"(22.09\u00b14.14":[210],"pg/mL).":[211,235],"Recipients":[212],"had":[215],"also":[216],"(p=0.001)":[219],"IL-6":[226,278],"(1009\u00b1375.5":[227],"compared":[229],"(779\u00b1202":[234],"No":[236],"significant":[237],"differences":[238],"observed":[240],"between":[241],"two":[243],"groups":[244],"respect":[246],"IL-2":[248],"(0.295\u00b10.333":[250],"vs":[251],"0.285\u00b10.342":[252],"U/mL,":[253],"p=0.207).":[254],"Six":[255],"died":[257],"(grade5),":[260],"whom":[262],"no":[263],"correlation":[264],"could":[265],"be":[266],"found":[267],"cytokine":[271],"concentrations.":[272],"CONCLUSION:":[273],"Higher":[274],"concentrations":[276],"procurement,":[285],"post-operative":[290],"liver":[293]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
