{"id":"https://openalex.org/W2276783448","doi":"https://doi.org/10.1002/jor.23116","title":"Hypoxic culture conditions induce increased metabolic rate and collagen gene expression in ACL\u2010derived cells","display_name":"Hypoxic culture conditions induce increased metabolic rate and collagen gene expression in ACL\u2010derived cells","publication_year":2015,"publication_date":"2015-12-01","ids":{"openalex":"https://openalex.org/W2276783448","doi":"https://doi.org/10.1002/jor.23116","mag":"2276783448","pmid":"https://pubmed.ncbi.nlm.nih.gov/26621359"},"language":"en","primary_location":{"id":"doi:10.1002/jor.23116","doi":"https://doi.org/10.1002/jor.23116","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jor.23116","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jor.23116","source":{"id":"https://openalex.org/S12558119","display_name":"Journal of Orthopaedic Research\u00ae","issn_l":"0736-0266","issn":["0736-0266","1554-527X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jor.23116","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020932985","display_name":"Tomasz J. Kowalski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210116300","display_name":"Orthopaedic Hospital","ror":"https://ror.org/01m2js356","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210116300"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tomasz J. Kowalski","raw_affiliation_strings":["Department of Orthopaedic Surgery, Orthopedic Hospital Research Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, 90095 California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Orthopedic Hospital Research Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, 90095 California","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210116300"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064951476","display_name":"Natalie L. Leong","orcid":"https://orcid.org/0000-0001-6556-9781","observed_orcids":["https://orcid.org/0000-0001-6556-9781"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210116300","display_name":"Orthopaedic Hospital","ror":"https://ror.org/01m2js356","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210116300"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natalie L. Leong","raw_affiliation_strings":["Department of Orthopaedic Surgery, Orthopedic Hospital Research Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, 90095 California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Orthopedic Hospital Research Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, 90095 California","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210116300"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024509747","display_name":"Ayelet Dar","orcid":"https://orcid.org/0000-0003-1076-3960","observed_orcids":["https://orcid.org/0000-0003-1076-3960"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210116300","display_name":"Orthopaedic Hospital","ror":"https://ror.org/01m2js356","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210116300"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ayelet Dar","raw_affiliation_strings":["Department of Orthopaedic Surgery, Orthopedic Hospital Research Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, 90095 California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Orthopedic Hospital Research Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, 90095 California","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210116300"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101738553","display_name":"Ling Wu","orcid":"https://orcid.org/0000-0002-2037-2798","observed_orcids":["https://orcid.org/0000-0002-2037-2798","https://orcid.org/0000-0003-3829-0018"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210116300","display_name":"Orthopaedic Hospital","ror":"https://ror.org/01m2js356","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210116300"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ling Wu","raw_affiliation_strings":["Department of Orthopaedic Surgery, Orthopedic Hospital Research Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, 90095 California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Orthopedic Hospital Research Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, 90095 California","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210116300"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112346789","display_name":"Nima Kabir","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210116300","display_name":"Orthopaedic Hospital","ror":"https://ror.org/01m2js356","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210116300"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nima Kabir","raw_affiliation_strings":["Department of Orthopaedic Surgery, Orthopedic Hospital Research Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, 90095 California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Orthopedic Hospital Research Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, 90095 California","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210116300"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001038115","display_name":"Adam Z. Khan","orcid":"https://orcid.org/0000-0002-7251-6503","observed_orcids":["https://orcid.org/0000-0002-7251-6503","https://orcid.org/0000-0003-4477-270X"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210116300","display_name":"Orthopaedic Hospital","ror":"https://ror.org/01m2js356","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210116300"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam Z. Khan","raw_affiliation_strings":["Department of Orthopaedic Surgery, Orthopedic Hospital Research Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, 90095 California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Orthopedic Hospital Research Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, 90095 California","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210116300"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028565989","display_name":"Claire D. Eliasberg","orcid":"https://orcid.org/0000-0002-4298-5755","observed_orcids":["https://orcid.org/0000-0002-4298-5755"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210116300","display_name":"Orthopaedic Hospital","ror":"https://ror.org/01m2js356","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210116300"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claire D. Eliasberg","raw_affiliation_strings":["Department of Orthopaedic Surgery, Orthopedic Hospital Research Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, 90095 California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Orthopedic Hospital Research Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, 90095 California","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210116300"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021129698","display_name":"Andrew Pedron","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210116300","display_name":"Orthopaedic Hospital","ror":"https://ror.org/01m2js356","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210116300"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Pedron","raw_affiliation_strings":["Department of Orthopaedic Surgery, Orthopedic Hospital Research Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, 90095 California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Orthopedic Hospital Research Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, 90095 California","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210116300"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5096925089","display_name":"Ashant Karayan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210116300","display_name":"Orthopaedic Hospital","ror":"https://ror.org/01m2js356","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210116300"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashant Karayan","raw_affiliation_strings":["Department of Orthopaedic Surgery, Orthopedic Hospital Research Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, 90095 California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Orthopedic Hospital Research Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, 90095 California","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210116300"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100670699","display_name":"Siyoung Lee","orcid":"https://orcid.org/0000-0002-5869-9702","observed_orcids":["https://orcid.org/0000-0002-5869-9702"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210116300","display_name":"Orthopaedic Hospital","ror":"https://ror.org/01m2js356","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210116300"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Siyoung Lee","raw_affiliation_strings":["Department of Orthopaedic Surgery, Orthopedic Hospital Research Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, 90095 California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Orthopedic Hospital Research Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, 90095 California","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210116300"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068671443","display_name":"Theodor Di Pauli von Treuheim","orcid":"https://orcid.org/0000-0002-7281-9758","observed_orcids":["https://orcid.org/0000-0002-7281-9758"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210116300","display_name":"Orthopaedic Hospital","ror":"https://ror.org/01m2js356","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210116300"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Theodor Di Pauli von Treuheim","raw_affiliation_strings":["Department of Orthopaedic Surgery, Orthopedic Hospital Research Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, 90095 California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Orthopedic Hospital Research Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, 90095 California","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210116300"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jin Jiacheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210116300","display_name":"Orthopaedic Hospital","ror":"https://ror.org/01m2js356","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210116300"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jin Jiacheng","raw_affiliation_strings":["Department of Orthopaedic Surgery, Orthopedic Hospital Research Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, 90095 California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Orthopedic Hospital Research Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, 90095 California","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210116300"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013876232","display_name":"Benjamin M. Wu","orcid":"https://orcid.org/0000-0001-5236-8534","observed_orcids":["https://orcid.org/0000-0001-5236-8534"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ben M. Wu","raw_affiliation_strings":["Department of Bioengineering, University of California, Los Angeles, 90095 California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California, Los Angeles, 90095 California","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057634885","display_name":"Denis A. Evseenko","orcid":"https://orcid.org/0000-0002-8389-0015","observed_orcids":["https://orcid.org/0000-0002-8389-0015"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210116300","display_name":"Orthopaedic Hospital","ror":"https://ror.org/01m2js356","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210116300"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Denis Evseenko","raw_affiliation_strings":["Department of Orthopaedic Surgery, Orthopedic Hospital Research Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, 90095 California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Orthopedic Hospital Research Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, 90095 California","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210116300"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058108856","display_name":"David R. McAllister","orcid":"https://orcid.org/0000-0003-2576-1925","observed_orcids":["https://orcid.org/0000-0003-2576-1925"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210116300","display_name":"Orthopaedic Hospital","ror":"https://ror.org/01m2js356","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210116300"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David R. McAllister","raw_affiliation_strings":["Department of Orthopaedic Surgery, Orthopedic Hospital Research Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, 90095 California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Orthopedic Hospital Research Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, 90095 California","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210116300"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073511028","display_name":"Frank A. Petrigliano","orcid":"https://orcid.org/0000-0001-8816-6256","observed_orcids":["https://orcid.org/0000-0001-8816-6256"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210116300","display_name":"Orthopaedic Hospital","ror":"https://ror.org/01m2js356","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210116300"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Frank A. Petrigliano","raw_affiliation_strings":["Department of Orthopaedic Surgery, Orthopedic Hospital Research Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, 90095 California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Orthopedic Hospital Research Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, 90095 California","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210116300"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5073511028"],"corresponding_institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210116300"],"apc_list":{"value":3970,"currency":"USD","value_usd":3970},"apc_paid":null,"fwci":0.6987,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.70831398,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"34","issue":"6","first_page":"985","last_page":"994"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.6220999956130981,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.6220999956130981,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11068","display_name":"Tendon Structure and Treatment","score":0.3337000012397766,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.014100000262260437,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anterior-cruciate-ligament","display_name":"anterior cruciate ligament","score":0.9909999966621399},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.7350000143051147},{"id":"https://openalex.org/keywords/collagen-gene-expression","display_name":"collagen gene expression","score":0.8769999742507935},{"id":"https://openalex.org/keywords/type-i-collagen","display_name":"type I collagen","score":0.75},{"id":"https://openalex.org/keywords/type-iii-collagen","display_name":"type III collagen","score":0.996999979019165},{"id":"https://openalex.org/keywords/metabolic-rate","display_name":"metabolic rate","score":0.734000027179718},{"id":"https://openalex.org/keywords/oxygen-consumption","display_name":"oxygen consumption","score":0.7879999876022339},{"id":"https://openalex.org/keywords/extracellular-acidification","display_name":"extracellular acidification","score":0.9649999737739563},{"id":"https://openalex.org/keywords/ligament-regeneration","display_name":"ligament regeneration","score":0.8040000200271606},{"id":"https://openalex.org/keywords/cell-proliferation-and-differentiation","display_name":"cell proliferation and differentiation","score":0.5630000233650208}],"concepts":[{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.7453534603118896},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.7184969782829285},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.609569787979126},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.5736972689628601},{"id":"https://openalex.org/C2778939058","wikidata":"https://www.wikidata.org/wiki/Q4046167","display_name":"CD31","level":3,"score":0.5609425902366638},{"id":"https://openalex.org/C2779093498","wikidata":"https://www.wikidata.org/wiki/Q14911804","display_name":"CD146","level":4,"score":0.513796865940094},{"id":"https://openalex.org/C2780932548","wikidata":"https://www.wikidata.org/wiki/Q1056532","display_name":"CD44","level":3,"score":0.510952889919281},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4752471446990967},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4284239411354065},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41701480746269226},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37853068113327026},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2790880501270294},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2693449556827545},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.16256067156791687},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.14547857642173767},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0815322995185852}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001481","descriptor_name":"Basal Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016118","descriptor_name":"Anterior Cruciate Ligament","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D016118","descriptor_name":"Anterior Cruciate Ligament","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jor.23116","doi":"https://doi.org/10.1002/jor.23116","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jor.23116","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jor.23116","source":{"id":"https://openalex.org/S12558119","display_name":"Journal of Orthopaedic Research\u00ae","issn_l":"0736-0266","issn":["0736-0266","1554-527X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Research","raw_type":"journal-article"},{"id":"pmid:26621359","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26621359","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of orthopaedic research : official publication of the Orthopaedic Research Society","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/jor.23116","doi":"https://doi.org/10.1002/jor.23116","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jor.23116","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jor.23116","source":{"id":"https://openalex.org/S12558119","display_name":"Journal of Orthopaedic Research\u00ae","issn_l":"0736-0266","issn":["0736-0266","1554-527X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9907000064849854,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306463","display_name":"Orthopaedic Research and Education Foundation","ror":"https://ror.org/029xgej46"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2276783448.pdf","grobid_xml":"https://content.openalex.org/works/W2276783448.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1484043356","https://openalex.org/W1502442150","https://openalex.org/W1967366984","https://openalex.org/W1967942542","https://openalex.org/W1974182237","https://openalex.org/W1975371675","https://openalex.org/W1979782761","https://openalex.org/W1994741619","https://openalex.org/W1995715858","https://openalex.org/W1996803044","https://openalex.org/W2002198698","https://openalex.org/W2004505453","https://openalex.org/W2005149654","https://openalex.org/W2006549340","https://openalex.org/W2006977892","https://openalex.org/W2012309077","https://openalex.org/W2017965105","https://openalex.org/W2034058062","https://openalex.org/W2045696456","https://openalex.org/W2057597564","https://openalex.org/W2057656329","https://openalex.org/W2069668624","https://openalex.org/W2070055159","https://openalex.org/W2073783457","https://openalex.org/W2076491580","https://openalex.org/W2078327597","https://openalex.org/W2084037323","https://openalex.org/W2084974707","https://openalex.org/W2089138024","https://openalex.org/W2090378915","https://openalex.org/W2093142652","https://openalex.org/W2093191361","https://openalex.org/W2100305113","https://openalex.org/W2106365668","https://openalex.org/W2107277218","https://openalex.org/W2112782115","https://openalex.org/W2117479856","https://openalex.org/W2125531516","https://openalex.org/W2136273741","https://openalex.org/W2136842127","https://openalex.org/W2138007542","https://openalex.org/W2143378152","https://openalex.org/W2143451025","https://openalex.org/W2147687016","https://openalex.org/W2148173491","https://openalex.org/W2149461114","https://openalex.org/W2153038687","https://openalex.org/W2153334341","https://openalex.org/W2154503536","https://openalex.org/W2155588618","https://openalex.org/W2156820957","https://openalex.org/W2160293700","https://openalex.org/W2161542014","https://openalex.org/W2167207642"],"related_works":["https://openalex.org/W4416222454","https://openalex.org/W2790368427","https://openalex.org/W2090378915","https://openalex.org/W2119830722","https://openalex.org/W4308367072","https://openalex.org/W1981587348","https://openalex.org/W1989481244","https://openalex.org/W2089138024","https://openalex.org/W4385276482","https://openalex.org/W985667476"],"abstract_inverted_index":{"There":[0],"has":[1],"been":[2,30],"substantial":[3],"effort":[4],"directed":[5],"toward":[6],"the":[7,19,46,61,160,221,224,233],"application":[8],"of":[9,21,35,130,226],"bone":[10],"marrow":[11],"and":[12,43,90,107,113,118,121,134,149,163,171,174,178,181,186,194,200,206,240,254],"adipose-derived":[13],"mesenchymal":[14,36],"stromal":[15],"cells":[16,28,80,93,131,245],"(MSCs)":[17],"in":[18,32,115,125,152,155,167,190,232,250],"regeneration":[20],"musculoskeletal":[22],"tissue.":[23],"Recently,":[24],"resident":[25],"tissue-specific":[26],"stem":[27],"have":[29],"described":[31],"a":[33,248,257],"variety":[34],"structures":[37],"including":[38],"ligament,":[39],"tendon,":[40],"muscle,":[41],"cartilage,":[42],"bone.":[44],"In":[45,215],"current":[47],"study,":[48],"we":[49],"systematically":[50],"characterize":[51],"three":[52,128,227],"novel":[53,228],"anterior":[54],"cruciate":[55],"ligament":[56,64,78,91,252,262],"(ACL)-derived":[57],"cell":[58,143,230,259],"populations":[59,231],"with":[60,145],"potential":[62,124,151,258],"for":[63,220,261],"regeneration:":[65],"ligament-forming":[66],"fibroblasts":[67],"(LFF:":[68],"CD146(neg)":[69,96],",":[70,73,75,85,87,97,99,101],"CD34(neg)":[71,83],"CD44(pos)":[72,84,98],"CD31(neg)":[74,86,100],"CD45(neg)":[76,88,102],"),":[77],"perivascular":[79],"(LPC:":[81],"CD146(pos)":[82],")":[89],"interstitial":[92],"(LIC:":[94],"CD34(pos)":[95],")-and":[103],"describe":[104],"their":[105,122],"proliferative":[106,239],"differentiation":[108,150],"potential,":[109],"collagen":[110,161],"gene":[111,165],"expression":[112,166],"metabolism":[114],"both":[116],"normoxic":[117],"hypoxic":[119],"environments,":[120],"trophic":[123],"vitro.":[126,153],"All":[127],"groups":[129],"(LIC,":[132],"LPC,":[133],"LFF)":[135],"isolated":[136],"from":[137],"adult":[138,234],"human":[139],"ACL":[140,235],"exhibited":[141],"progenitor":[142,229],"characteristics":[144],"regard":[146],"to":[147,211],"proliferation":[148],"Culture":[154],"low":[156],"oxygen":[157,183,213],"tension":[158],"enhanced":[159],"I":[162],"III":[164],"LICs":[168,191],"(by":[169,176,192,198,204],"2.8-":[170],"3.3-fold,":[172],"respectively)":[173,180,208],"LFFs":[175,197],"3-":[177],"3.5-fold,":[179,195],"increased":[182],"consumption":[184],"rate":[185,189],"extracellular":[187],"acidification":[188],"4-":[193],"respectively),":[196,202],"5.5-":[199],"3-fold,":[201],"LPCs":[203],"10-":[205],"4.5-fold,":[207],"as":[209],"compared":[210],"normal":[212],"concentration.":[214],"summary,":[216],"this":[217],"study":[218],"demonstrates":[219],"first":[222],"time":[223],"presence":[225],"that":[236],"demonstrate":[237],"robust":[238],"matrix":[241],"synthetic":[242],"capacity;":[243],"these":[244],"may":[246],"play":[247],"role":[249],"local":[251],"regeneration,":[253],"consequently":[255],"represent":[256],"source":[260],"engineering":[263],"applications.":[264],"\u00a9":[265],"2015":[266],"Orthopaedic":[267],"Research":[268],"Society.":[269],"Published":[270],"by":[271],"Wiley":[272],"Periodicals,":[273],"Inc.":[274],"J":[275],"Orthop":[276],"Res":[277],"34:985-994,":[278],"2016.":[279]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
