{"id":"https://openalex.org/W2276772012","doi":"https://doi.org/10.1042/bst20150174","title":"Phosphatidylinositol 3,5-bisphosphate: regulation of cellular events in space and time","display_name":"Phosphatidylinositol 3,5-bisphosphate: regulation of cellular events in space and time","publication_year":2016,"publication_date":"2016-02-09","ids":{"openalex":"https://openalex.org/W2276772012","doi":"https://doi.org/10.1042/bst20150174","mag":"2276772012","pmid":"https://pubmed.ncbi.nlm.nih.gov/26862203","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4836390"},"language":"en","primary_location":{"id":"doi:10.1042/bst20150174","doi":"https://doi.org/10.1042/bst20150174","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bst20150174","pdf_url":null,"source":{"id":"https://openalex.org/S137670264","display_name":"Biochemical Society Transactions","issn_l":"0300-5127","issn":["0300-5127","1470-8752"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Society Transactions","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4836390","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028855514","display_name":"Natsuko Jin","orcid":"https://orcid.org/0000-0002-0231-3057","observed_orcids":["https://orcid.org/0000-0002-0231-3057"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Natsuko Jin","raw_affiliation_strings":["Department of Cell and Developmental Biology and Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology and Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, U.S.A","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015894009","display_name":"Michael J. Lang","orcid":"https://orcid.org/0000-0003-3544-5221","observed_orcids":["https://orcid.org/0000-0003-3544-5221"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael\u00a0J. Lang","raw_affiliation_strings":["Department of Cell and Developmental Biology and Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology and Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, U.S.A","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081220025","display_name":"Lois S. Weisman","orcid":"https://orcid.org/0000-0001-7740-9785","observed_orcids":["https://orcid.org/0000-0001-7740-9785"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lois\u00a0S. Weisman","raw_affiliation_strings":["Department of Cell and Developmental Biology and Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology and Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, U.S.A","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5028855514"],"corresponding_institution_ids":["https://openalex.org/I27837315"],"apc_list":null,"apc_paid":null,"fwci":1.3376,"has_fulltext":false,"cited_by_count":93,"citation_normalized_percentile":{"value":0.78723404,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"44","issue":"1","first_page":"177","last_page":"184"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.7045999765396118,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.7045999765396118,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.08079999685287476,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.07670000195503235,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phosphatidylinositol-3-5-bisphosphate","display_name":"phosphatidylinositol 3,5-bisphosphate","score":1.0},{"id":"https://openalex.org/keywords/pi-3-5-p2","display_name":"PI(3,5)P2","score":0.9229999780654907},{"id":"https://openalex.org/keywords/lipid-kinase","display_name":"lipid kinase","score":0.6100000143051147},{"id":"https://openalex.org/keywords/phosphoinositide-signaling","display_name":"phosphoinositide signaling","score":0.6370000243186951},{"id":"https://openalex.org/keywords/lipid-signaling","display_name":"lipid signaling","score":0.4560000002384186},{"id":"https://openalex.org/keywords/cellular-homeostasis","display_name":"cellular homeostasis","score":0.753000020980835},{"id":"https://openalex.org/keywords/neurological-disorders","display_name":"neurological disorders","score":0.7599999904632568},{"id":"https://openalex.org/keywords/spatiotemporal-control","display_name":"spatiotemporal control","score":0.6150000095367432}],"concepts":[{"id":"https://openalex.org/C2780610907","wikidata":"https://www.wikidata.org/wiki/Q2273248","display_name":"Phosphatidylinositol","level":3,"score":0.870276153087616},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6265770196914673},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.6173858046531677},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5903417468070984},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.5753594636917114},{"id":"https://openalex.org/C39743133","wikidata":"https://www.wikidata.org/wiki/Q3262595","display_name":"Signalling","level":2,"score":0.5594357848167419},{"id":"https://openalex.org/C53009064","wikidata":"https://www.wikidata.org/wiki/Q167","display_name":"Pi","level":2,"score":0.4619849622249603},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4544858932495117},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.4402483403682709},{"id":"https://openalex.org/C156902634","wikidata":"https://www.wikidata.org/wiki/Q5058346","display_name":"Cellular adaptation","level":3,"score":0.4377394914627075},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3131813406944275},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23849496245384216},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11541980504989624}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002477","descriptor_name":"Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018129","descriptor_name":"Phosphatidylinositol Phosphates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1042/bst20150174","doi":"https://doi.org/10.1042/bst20150174","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bst20150174","pdf_url":null,"source":{"id":"https://openalex.org/S137670264","display_name":"Biochemical Society Transactions","issn_l":"0300-5127","issn":["0300-5127","1470-8752"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Society Transactions","raw_type":"journal-article"},{"id":"pmid:26862203","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26862203","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Society transactions","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4836390","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4836390","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biochem Soc Trans","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4836390","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4836390","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biochem Soc Trans","raw_type":"Text"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1180945378","display_name":"Roles and regulation of PI(3,5)P2 and PI5P in neurons","funder_award_id":"R01NS064015","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G1925723073","display_name":"Inositol Lipid Regulation of Membrane Fusion & Fission","funder_award_id":"R01GM050403","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":79,"referenced_works":["https://openalex.org/W116093739","https://openalex.org/W1542805579","https://openalex.org/W1603758951","https://openalex.org/W1897417227","https://openalex.org/W1965476757","https://openalex.org/W1969515779","https://openalex.org/W1969840664","https://openalex.org/W1973214920","https://openalex.org/W1981026057","https://openalex.org/W1988681396","https://openalex.org/W1989165480","https://openalex.org/W1993401680","https://openalex.org/W1993828912","https://openalex.org/W1993902882","https://openalex.org/W2003331776","https://openalex.org/W2003416728","https://openalex.org/W2011647705","https://openalex.org/W2013131355","https://openalex.org/W2018046158","https://openalex.org/W2020710502","https://openalex.org/W2023198417","https://openalex.org/W2029476353","https://openalex.org/W2029819246","https://openalex.org/W2030721984","https://openalex.org/W2031071878","https://openalex.org/W2032601500","https://openalex.org/W2034320996","https://openalex.org/W2034711331","https://openalex.org/W2035398977","https://openalex.org/W2036145275","https://openalex.org/W2036806208","https://openalex.org/W2045714699","https://openalex.org/W2049848256","https://openalex.org/W2050113854","https://openalex.org/W2060579362","https://openalex.org/W2061720685","https://openalex.org/W2063293961","https://openalex.org/W2066864656","https://openalex.org/W2067638329","https://openalex.org/W2068382369","https://openalex.org/W2068877244","https://openalex.org/W2072317853","https://openalex.org/W2073057670","https://openalex.org/W2074286043","https://openalex.org/W2075027086","https://openalex.org/W2075094914","https://openalex.org/W2075171680","https://openalex.org/W2077160150","https://openalex.org/W2083294698","https://openalex.org/W2086585380","https://openalex.org/W2089543096","https://openalex.org/W2097419416","https://openalex.org/W2109595760","https://openalex.org/W2112605694","https://openalex.org/W2114912316","https://openalex.org/W2118278336","https://openalex.org/W2118612600","https://openalex.org/W2122991277","https://openalex.org/W2125708401","https://openalex.org/W2126659352","https://openalex.org/W2129357225","https://openalex.org/W2132103807","https://openalex.org/W2134748166","https://openalex.org/W2135120386","https://openalex.org/W2136746857","https://openalex.org/W2136820732","https://openalex.org/W2137015675","https://openalex.org/W2144758550","https://openalex.org/W2145625720","https://openalex.org/W2148447088","https://openalex.org/W2156128107","https://openalex.org/W2156748406","https://openalex.org/W2159007909","https://openalex.org/W2160298714","https://openalex.org/W2161476009","https://openalex.org/W2162126864","https://openalex.org/W2164019316","https://openalex.org/W6659146954","https://openalex.org/W6684292695"],"related_works":["https://openalex.org/W2595270190","https://openalex.org/W7168027738","https://openalex.org/W2592320473","https://openalex.org/W2585927953","https://openalex.org/W2071824592","https://openalex.org/W4393167537","https://openalex.org/W4280505228","https://openalex.org/W4389025902","https://openalex.org/W2071440065","https://openalex.org/W1495616591"],"abstract_inverted_index":{"Phosphorylated":[0],"phosphatidylinositol":[1,17],"lipids":[2],"are":[3,49],"crucial":[4],"for":[5,22],"most":[6],"eukaryotes":[7],"and":[8,25],"have":[9],"diverse":[10],"cellular":[11,23],"functions.":[12],"The":[13],"low-abundance":[14],"signalling":[15],"lipid":[16,37],"3,5-bisphosphate":[18],"[PI(3,5)P2]":[19],"is":[20],"critical":[21],"homoeostasis":[24],"adaptation":[26],"to":[27,51,82],"stimuli.":[28],"A":[29],"large":[30],"complex":[31],"of":[32,44,57,70],"proteins":[33],"that":[34],"includes":[35],"the":[36,42,58],"kinase":[38],"Fab1-PIKfyve,":[39],"dynamically":[40],"regulates":[41],"levels":[43],"PI(3,5)P2.":[45],"Deficiencies":[46],"in":[47],"PI(3,5)P2":[48,80],"linked":[50],"some":[52],"human":[53,84],"diseases,":[54],"especially":[55],"those":[56],"nervous":[59],"system.":[60],"Future":[61],"studies":[62],"will":[63],"probably":[64],"determine":[65],"new,":[66],"undiscovered":[67],"regulatory":[68],"roles":[69],"PI(3,5)P2,":[71],"as":[72,74],"well":[73],"uncover":[75],"mechanistic":[76],"insights":[77],"into":[78],"how":[79],"contributes":[81],"normal":[83],"physiology.":[85]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}