{"id":"https://openalex.org/W2276587503","doi":null,"title":"(S)- 3,5-Dihydroxyphenylglycine, an agonist for group I metabotropic glutamate receptors, induces synaptic potentiation at the excitatory synapses of the fast spiking GABAergic cells in the visual cortex","display_name":"(S)- 3,5-Dihydroxyphenylglycine, an agonist for group I metabotropic glutamate receptors, induces synaptic potentiation at the excitatory synapses of the fast spiking GABAergic cells in the visual cortex","publication_year":2008,"publication_date":"2008-08-10","ids":{"openalex":"https://openalex.org/W2276587503","mag":"2276587503"},"language":"en","primary_location":{"id":"mag:2276587503","doi":null,"is_oa":false,"landing_page_url":"https://ppj.phypha.ir/article-1-441-en.html","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Physiology and Pharmacology","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034576234","display_name":"Abdolrahman Sarihi","orcid":"https://orcid.org/0000-0002-2452-5210","observed_orcids":["https://orcid.org/0000-0002-2452-5210","https://orcid.org/0000-0002-1250-9002"]},"institutions":[{"id":"https://openalex.org/I112312016","display_name":"Hamedan University of Medical Sciences","ror":"https://ror.org/02ekfbp48","country_code":"IR","type":"education","lineage":["https://openalex.org/I112312016"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Abdolrahman Sarihi","raw_affiliation_strings":["Department of Physiology, Hamadan University of Medical Sciences"],"raw_orcid":"https://orcid.org/0000-0002-1250-9002","affiliations":[{"raw_affiliation_string":"Department of Physiology, Hamadan University of Medical Sciences","institution_ids":["https://openalex.org/I112312016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054597386","display_name":"Alireza Komaki\u202c","orcid":"https://orcid.org/0000-0003-3865-9583","observed_orcids":["https://orcid.org/0000-0003-3865-9583"]},"institutions":[{"id":"https://openalex.org/I112312016","display_name":"Hamedan University of Medical Sciences","ror":"https://ror.org/02ekfbp48","country_code":"IR","type":"education","lineage":["https://openalex.org/I112312016"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Alireza Komaki\u202c","raw_affiliation_strings":["Department of Physiology, Hamadan University of Medical Sciences"],"raw_orcid":"https://orcid.org/0000-0003-3865-9583","affiliations":[{"raw_affiliation_string":"Department of Physiology, Hamadan University of Medical Sciences","institution_ids":["https://openalex.org/I112312016"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035371436","display_name":"Tadaharu Tsumoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800939219","display_name":"RIKEN Center for Brain Science","ror":"https://ror.org/04j1n1c04","country_code":"JP","type":"facility","lineage":["https://openalex.org/I2800939219","https://openalex.org/I4210110652"]},{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadaharu Tsumoto","raw_affiliation_strings":["Neuronal Circuit Mechanism Research Group, RIKEN Brain Science Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuronal Circuit Mechanism Research Group, RIKEN Brain Science Institute","institution_ids":["https://openalex.org/I2800939219","https://openalex.org/I4210110652"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.2490383,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"2","first_page":"83","last_page":"90"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dhpg","display_name":"DHPG","score":0.8550000190734863},{"id":"https://openalex.org/keywords/group-i-metabotropic-glutamate-receptors","display_name":"group I metabotropic glutamate receptors","score":0.9789999723434448},{"id":"https://openalex.org/keywords/mglur5","display_name":"mGluR5","score":0.9929999709129333},{"id":"https://openalex.org/keywords/mglur1","display_name":"mGluR1","score":0.9240000247955322},{"id":"https://openalex.org/keywords/long-term-potentiation","display_name":"long-term potentiation","score":0.7979999780654907},{"id":"https://openalex.org/keywords/synaptic-potentiation","display_name":"synaptic potentiation","score":0.8230000138282776},{"id":"https://openalex.org/keywords/pyramidal-neurons","display_name":"pyramidal neurons","score":0.7160000205039978},{"id":"https://openalex.org/keywords/visual-cortex","display_name":"visual cortex","score":0.6460000276565552},{"id":"https://openalex.org/keywords/layer-2-3","display_name":"layer 2/3","score":0.9210000038146973},{"id":"https://openalex.org/keywords/excitatory-postsynaptic-potentials","display_name":"excitatory postsynaptic potentials","score":0.8640000224113464},{"id":"https://openalex.org/keywords/theta-burst-stimulation","display_name":"theta burst stimulation","score":0.9760000109672546},{"id":"https://openalex.org/keywords/cortical-synchrony","display_name":"cortical synchronization","score":0.46399998664855957}],"concepts":[{"id":"https://openalex.org/C25274449","wikidata":"https://www.wikidata.org/wiki/Q1805481","display_name":"Long-term potentiation","level":3,"score":0.776134192943573},{"id":"https://openalex.org/C49051014","wikidata":"https://www.wikidata.org/wiki/Q2033959","display_name":"Metabotropic glutamate receptor","level":4,"score":0.7564900517463684},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.7061716318130493},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6413412094116211},{"id":"https://openalex.org/C98229152","wikidata":"https://www.wikidata.org/wiki/Q1551556","display_name":"Synaptic plasticity","level":3,"score":0.5102038383483887},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.4511106610298157},{"id":"https://openalex.org/C73009533","wikidata":"https://www.wikidata.org/wiki/Q1517140","display_name":"Long-term depression","level":5,"score":0.44671815633773804},{"id":"https://openalex.org/C26702167","wikidata":"https://www.wikidata.org/wiki/Q901988","display_name":"Metabotropic receptor","level":4,"score":0.41247424483299255},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40264302492141724},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3557703197002411},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.176977276802063},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1414623260498047},{"id":"https://openalex.org/C160268369","wikidata":"https://www.wikidata.org/wiki/Q295251","display_name":"AMPA receptor","level":4,"score":0.12846052646636963},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0523223876953125}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2276587503","doi":null,"is_oa":false,"landing_page_url":"https://ppj.phypha.ir/article-1-441-en.html","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Physiology and Pharmacology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1963788090","https://openalex.org/W1970354504","https://openalex.org/W1976199729","https://openalex.org/W1985640480","https://openalex.org/W1990997232","https://openalex.org/W1991575631","https://openalex.org/W1996168091","https://openalex.org/W2017638232","https://openalex.org/W2023461966","https://openalex.org/W2024910408","https://openalex.org/W2025603247","https://openalex.org/W2033066785","https://openalex.org/W2044180582","https://openalex.org/W2045651297","https://openalex.org/W2046104691","https://openalex.org/W2050985535","https://openalex.org/W2053001832","https://openalex.org/W2072818925","https://openalex.org/W2080700455","https://openalex.org/W2081234982","https://openalex.org/W2086657106","https://openalex.org/W2088081549","https://openalex.org/W2088475496","https://openalex.org/W2089271111","https://openalex.org/W2095781659","https://openalex.org/W2109372640","https://openalex.org/W2124793944","https://openalex.org/W2146830847","https://openalex.org/W2156780983","https://openalex.org/W2186559661","https://openalex.org/W3142670945"],"related_works":["https://openalex.org/W2290409247","https://openalex.org/W2000407663","https://openalex.org/W1980814556","https://openalex.org/W1678188980","https://openalex.org/W2017638232","https://openalex.org/W2461385878","https://openalex.org/W2150188376","https://openalex.org/W2009080743","https://openalex.org/W2156695450","https://openalex.org/W2057238379"],"abstract_inverted_index":{"Introduction:":[0],"(S)-":[1],"3,5-Dihydroxyphenylglycine":[2],"(DHPG)":[3],"is":[4,24],"an":[5,153,173],"agonist":[6],"for":[7,29,142,155],"group":[8],"I":[9],"metabotropic":[10,145],"glutamate":[11,146],"receptors.":[12],"DHPG-induced":[13,150],"synaptic":[14,30],"depression":[15],"of":[16,19,35,44,51,59,62,68,76,83,118,120,192,195],"excitatory":[17,49,84,138],"synapses":[18,50],"the":[20,36,42,48,52,121,135,177,188],"hippocampal":[21],"pyramidal":[22,53,136,197],"neurons":[23,123],"a":[25,185],"well":[26],"known":[27],"model":[28],"plasticity":[31],"studies.":[32],"The":[33],"aim":[34],"present":[37],"study":[38],"was":[39,70,157],"to":[40],"examine":[41],"effects":[43],"DHPG":[45,69,115],"superfusion":[46],"on":[47,134],"and":[54,126,162],"fast-spiking":[55],"GABAergic":[56],"cells":[57,91,171],"(FS-GABA)":[58],"layer":[60,89,94],"II/III":[61,90],"mice":[63,79],"visual":[64,73],"cortex.":[65],"Methods:":[66],"Effects":[67],"examined":[71],"in":[72,88,124,176,187],"cortical":[74,178,196],"slices":[75],"GAD67-GFP":[77],"knock-in":[78],"using":[80],"whole-cell":[81],"recordings":[82],"postsynaptic":[85,112],"potentials":[86],"(EPSPs)":[87],"evoked":[92],"by":[93,105],"IV":[95],"stimulation.":[96],"Experiments":[97],"also":[98],"included":[99],"long":[100],"term":[101],"potentiation":[102,117,161],"(LTP)":[103],"induction":[104],"theta":[106],"burst":[107],"stimulation":[108],"(TBS)":[109],"paired":[110],"with":[111],"depolarization.":[113],"Results:":[114],"induced":[116],"EPSPs":[119],"FS-GABA":[122,170],"dose-":[125],"use-dependent":[127],"manners":[128],"but":[129],"it":[130],"had":[131],"no":[132],"effect":[133],"cell":[137],"synapses.":[139],"An":[140],"antagonist":[141,154],"type":[143],"5":[144],"receptors":[147],"(mGluR5)":[148],"blocked":[149,165],"LTP,":[151],"while":[152],"mGluR1":[156],"not":[158],"effective.":[159],"This":[160],"TBSinduced":[163],"LTP":[164,182],"each":[166],"other.":[167],"Conclusion:":[168],"Since":[169],"have":[172],"important":[174],"role":[175,186],"neuronal":[179],"circuits,":[180],"mGlur5-dependent":[181],"may":[183],"play":[184],"enhancement":[189],"or":[190],"maintenance":[191],"synchronized":[193],"activity":[194],"neurons.":[198]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}
