{"id":"https://openalex.org/W2276504730","doi":"https://doi.org/10.1128/microbiolspec.mdna3-0021-2014","title":"An Overview of Tyrosine Site-specific Recombination: From an Flp Perspective","display_name":"An Overview of Tyrosine Site-specific Recombination: From an Flp Perspective","publication_year":2015,"publication_date":"2015-06-29","ids":{"openalex":"https://openalex.org/W2276504730","doi":"https://doi.org/10.1128/microbiolspec.mdna3-0021-2014","mag":"2276504730","pmid":"https://pubmed.ncbi.nlm.nih.gov/26350308"},"language":"en","primary_location":{"id":"doi:10.1128/microbiolspec.mdna3-0021-2014","doi":"https://doi.org/10.1128/microbiolspec.mdna3-0021-2014","is_oa":false,"landing_page_url":"https://doi.org/10.1128/microbiolspec.mdna3-0021-2014","pdf_url":null,"source":{"id":"https://openalex.org/S2764766708","display_name":"Microbiology Spectrum","issn_l":"2165-0497","issn":["2165-0497"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiology Spectrum","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046141379","display_name":"Makkuni Jayaram","orcid":"https://orcid.org/0000-0001-9640-6264","observed_orcids":["https://orcid.org/0000-0001-9640-6264"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Makkuni Jayaram","raw_affiliation_strings":["Department of Molecular Biosciences, UT Austin, Austin, TX 78712"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biosciences, UT Austin, Austin, TX 78712","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072631702","display_name":"Chien-Hui Ma","orcid":"https://orcid.org/0000-0001-8753-8556","observed_orcids":["https://orcid.org/0000-0001-8753-8556"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chien-Hui Ma","raw_affiliation_strings":["Department of Molecular Biosciences, UT Austin, Austin, TX 78712"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biosciences, UT Austin, Austin, TX 78712","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073382053","display_name":"Aashiq Hussain Kachroo","orcid":"https://orcid.org/0000-0001-9770-778X","observed_orcids":["https://orcid.org/0000-0001-9770-778X"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aashiq H Kachroo","raw_affiliation_strings":["Department of Molecular Biosciences, UT Austin, Austin, TX 78712"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biosciences, UT Austin, Austin, TX 78712","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002412654","display_name":"Paul Andrew Rowley","orcid":"https://orcid.org/0000-0002-3590-5139","observed_orcids":["https://orcid.org/0000-0002-3590-5139"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul A Rowley","raw_affiliation_strings":["Department of Molecular Biosciences, UT Austin, Austin, TX 78712"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biosciences, UT Austin, Austin, TX 78712","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000940594","display_name":"Piotr Guga","orcid":"https://orcid.org/0000-0002-0803-2440","observed_orcids":["https://orcid.org/0000-0002-0803-2440"]},"institutions":[{"id":"https://openalex.org/I4210150433","display_name":"Centrum Bada\u0144 Molekularnych i Makromolekularnych Polskiej Akademii Nauk","ror":"https://ror.org/05e4zna08","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210150433","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Piotr Guga","raw_affiliation_strings":["Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Department of Bio-organic Chemistry, Lodz, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Department of Bio-organic Chemistry, Lodz, Poland","institution_ids":["https://openalex.org/I4210150433","https://openalex.org/I99542240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089987472","display_name":"Hsui-Fang Fan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387156312","display_name":"National Yang Ming University","ror":"https://ror.org/009h5ks85","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613","https://openalex.org/I4387156312"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hsui-Fang Fan","raw_affiliation_strings":["Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei 112, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei 112, Taiwan","institution_ids":["https://openalex.org/I4387156312"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015175999","display_name":"Yuri Voziyanov","orcid":"https://orcid.org/0000-0003-0232-3105","observed_orcids":["https://orcid.org/0000-0003-0232-3105"]},"institutions":[{"id":"https://openalex.org/I919208787","display_name":"Louisiana Tech University","ror":"https://ror.org/04q9esz89","country_code":"US","type":"education","lineage":["https://openalex.org/I2799628689","https://openalex.org/I919208787"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuri Voziyanov","raw_affiliation_strings":["School of Biosciences, Louisiana Tech University, Ruston, LA 71272"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biosciences, Louisiana Tech University, Ruston, LA 71272","institution_ids":["https://openalex.org/I919208787"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":0.4875,"has_fulltext":false,"cited_by_count":50,"citation_normalized_percentile":{"value":0.42256637,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"3","issue":"4","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.8276000022888184,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.8276000022888184,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.07919999957084656,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.05719999969005585,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/flp","display_name":"FLP","score":0.7570000290870667},{"id":"https://openalex.org/keywords/retrotransposons","display_name":"retrotransposons","score":0.8679999709129333},{"id":"https://openalex.org/keywords/dna-transposons","display_name":"DNA transposons","score":0.7630000114440918},{"id":"https://openalex.org/keywords/dna-rearrangement","display_name":"DNA rearrangement","score":0.593999981880188},{"id":"https://openalex.org/keywords/dna-topology","display_name":"DNA topology","score":0.5879999995231628},{"id":"https://openalex.org/keywords/single-molecule-biophysics","display_name":"single-molecule biophysics","score":0.6729999780654907},{"id":"https://openalex.org/keywords/directed-evolution","display_name":"directed evolution","score":0.6430000066757202},{"id":"https://openalex.org/keywords/genome-editing","display_name":"genome editing","score":0.7979999780654907},{"id":"https://openalex.org/keywords/developmental-biology","display_name":"developmental biology","score":0.39800000190734863}],"concepts":[{"id":"https://openalex.org/C102414288","wikidata":"https://www.wikidata.org/wiki/Q1172461","display_name":"Recombinase","level":4,"score":0.8941266536712646},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6207605600357056},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5899443030357361},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5416747331619263},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5241256356239319},{"id":"https://openalex.org/C4918238","wikidata":"https://www.wikidata.org/wiki/Q121438","display_name":"Transposable element","level":4,"score":0.4991953372955322},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.49590739607810974},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.462808758020401},{"id":"https://openalex.org/C7029365","wikidata":"https://www.wikidata.org/wiki/Q413988","display_name":"Retrotransposon","level":5,"score":0.42763596773147583},{"id":"https://openalex.org/C119898374","wikidata":"https://www.wikidata.org/wiki/Q7531737","display_name":"Site-specific recombination","level":5,"score":0.42211657762527466},{"id":"https://openalex.org/C156695909","wikidata":"https://www.wikidata.org/wiki/Q3373825","display_name":"Recombination","level":3,"score":0.4142012596130371},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22727802395820618}],"mesh":[{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004254","descriptor_name":"DNA Nucleotidyltransferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004254","descriptor_name":"DNA Nucleotidyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004254","descriptor_name":"DNA Nucleotidyltransferases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004718","descriptor_name":"Saccharomycetales","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D004718","descriptor_name":"Saccharomycetales","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004718","descriptor_name":"Saccharomycetales","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1128/microbiolspec.mdna3-0021-2014","doi":"https://doi.org/10.1128/microbiolspec.mdna3-0021-2014","is_oa":false,"landing_page_url":"https://doi.org/10.1128/microbiolspec.mdna3-0021-2014","pdf_url":null,"source":{"id":"https://openalex.org/S2764766708","display_name":"Microbiology Spectrum","issn_l":"2165-0497","issn":["2165-0497"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiology Spectrum","raw_type":"journal-article"},{"id":"pmid:26350308","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26350308","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiology spectrum","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":147,"referenced_works":["https://openalex.org/W11510883","https://openalex.org/W14331597","https://openalex.org/W54930644","https://openalex.org/W215373046","https://openalex.org/W821926544","https://openalex.org/W844312963","https://openalex.org/W940432053","https://openalex.org/W1492672213","https://openalex.org/W1495835504","https://openalex.org/W1508136468","https://openalex.org/W1510489127","https://openalex.org/W1578040179","https://openalex.org/W1588150867","https://openalex.org/W1590546489","https://openalex.org/W1606384407","https://openalex.org/W1862261356","https://openalex.org/W1965789286","https://openalex.org/W1966420504","https://openalex.org/W1966725512","https://openalex.org/W1967231011","https://openalex.org/W1967423136","https://openalex.org/W1970669095","https://openalex.org/W1971984509","https://openalex.org/W1972249453","https://openalex.org/W1973717540","https://openalex.org/W1974145327","https://openalex.org/W1974152748","https://openalex.org/W1974496433","https://openalex.org/W1975954127","https://openalex.org/W1976414476","https://openalex.org/W1977969194","https://openalex.org/W1977976434","https://openalex.org/W1983122465","https://openalex.org/W1984846896","https://openalex.org/W1985903030","https://openalex.org/W1990802904","https://openalex.org/W1991199914","https://openalex.org/W1991785053","https://openalex.org/W1992468396","https://openalex.org/W1999140385","https://openalex.org/W1999346746","https://openalex.org/W2001103680","https://openalex.org/W2001407979","https://openalex.org/W2004130582","https://openalex.org/W2004429664","https://openalex.org/W2004996851","https://openalex.org/W2006444555","https://openalex.org/W2008624131","https://openalex.org/W2009005740","https://openalex.org/W2010653401","https://openalex.org/W2012732176","https://openalex.org/W2013292795","https://openalex.org/W2013771205","https://openalex.org/W2015171781","https://openalex.org/W2017552166","https://openalex.org/W2019741729","https://openalex.org/W2020916353","https://openalex.org/W2021375978","https://openalex.org/W2021933858","https://openalex.org/W2023922223","https://openalex.org/W2024148643","https://openalex.org/W2025395911","https://openalex.org/W2027508477","https://openalex.org/W2028316724","https://openalex.org/W2028767241","https://openalex.org/W2029892652","https://openalex.org/W2040562669","https://openalex.org/W2040802314","https://openalex.org/W2041003602","https://openalex.org/W2041118208","https://openalex.org/W2041421297","https://openalex.org/W2042932242","https://openalex.org/W2045208351","https://openalex.org/W2046545014","https://openalex.org/W2046930317","https://openalex.org/W2047758781","https://openalex.org/W2049459920","https://openalex.org/W2051110150","https://openalex.org/W2053772714","https://openalex.org/W2054811359","https://openalex.org/W2055016164","https://openalex.org/W2058507490","https://openalex.org/W2058608507","https://openalex.org/W2060061851","https://openalex.org/W2061460852","https://openalex.org/W2061865551","https://openalex.org/W2063764249","https://openalex.org/W2064990384","https://openalex.org/W2065045704","https://openalex.org/W2066471914","https://openalex.org/W2066532567","https://openalex.org/W2068737563","https://openalex.org/W2069259673","https://openalex.org/W2070209284","https://openalex.org/W2072069994","https://openalex.org/W2072220590","https://openalex.org/W2073239333","https://openalex.org/W2075225615","https://openalex.org/W2075905554","https://openalex.org/W2077338366","https://openalex.org/W2077357349","https://openalex.org/W2078413571","https://openalex.org/W2081681675","https://openalex.org/W2082572252","https://openalex.org/W2083301155","https://openalex.org/W2084231562","https://openalex.org/W2084369161","https://openalex.org/W2084528000","https://openalex.org/W2084599573","https://openalex.org/W2084773215","https://openalex.org/W2094147917","https://openalex.org/W2094332330","https://openalex.org/W2094853557","https://openalex.org/W2100303812","https://openalex.org/W2104148968","https://openalex.org/W2104650022","https://openalex.org/W2104947386","https://openalex.org/W2110477362","https://openalex.org/W2112444085","https://openalex.org/W2118119432","https://openalex.org/W2119078624","https://openalex.org/W2121985216","https://openalex.org/W2122033230","https://openalex.org/W2123196886","https://openalex.org/W2123381445","https://openalex.org/W2124408385","https://openalex.org/W2126127769","https://openalex.org/W2126361238","https://openalex.org/W2127633067","https://openalex.org/W2132422309","https://openalex.org/W2133318634","https://openalex.org/W2134965440","https://openalex.org/W2135087660","https://openalex.org/W2135542666","https://openalex.org/W2138187877","https://openalex.org/W2138470970","https://openalex.org/W2140420066","https://openalex.org/W2141792895","https://openalex.org/W2146735648","https://openalex.org/W2153612851","https://openalex.org/W2154883662","https://openalex.org/W2156913716","https://openalex.org/W2159491938","https://openalex.org/W2160380372","https://openalex.org/W2167233750","https://openalex.org/W4232322096","https://openalex.org/W4235879813"],"related_works":["https://openalex.org/W4234711904","https://openalex.org/W4312288905","https://openalex.org/W7055929896","https://openalex.org/W1979692237","https://openalex.org/W2464464964","https://openalex.org/W1543514802","https://openalex.org/W2156302625","https://openalex.org/W4375954897","https://openalex.org/W1976918496","https://openalex.org/W4238637334"],"abstract_inverted_index":{"Tyrosine":[0],"site-specific":[1],"recombinases":[2,81],"(YRs)":[3],"are":[4],"widely":[5],"distributed":[6],"among":[7,23],"prokaryotes":[8],"and":[9,12,30,33,91,103,159,176],"their":[10,72,157,164],"viruses,":[11],"were":[13],"thought":[14],"to":[15,18,53,59,115,133],"be":[16],"confined":[17],"the":[19,79,88,95,135],"budding":[20],"yeast":[21],"lineage":[22],"eukaryotes.":[24,44],"However,":[25],"YR-harboring":[26],"retrotransposons":[27],"(the":[28],"DIRS":[29],"PAT":[31],"families)":[32],"DNA":[34,119,139,142],"transposons":[35],"(Cryptons)":[36],"have":[37,112,129],"been":[38,113,131],"identified":[39],"in":[40,71,125,169],"a":[41,48,62],"variety":[42],"of":[43,55,64,78,94,138,151],"The":[45,148],"YRs":[46,107],"utilize":[47],"common":[49],"chemical":[50,89],"mechanism,":[51],"analogous":[52],"that":[54],"type":[56],"IB":[57],"topoisomerases,":[58],"bring":[60,116],"about":[61,117],"plethora":[63],"genetic":[65],"rearrangements":[66,120],"with":[67,108,156,173],"important":[68],"physiological":[69],"consequences":[70],"respective":[73],"biological":[74],"contexts.":[75],"A":[76],"subset":[77],"tyrosine":[80],"has":[82],"provided":[83],"model":[84],"systems":[85],"for":[86,121],"analyzing":[87],"mechanisms":[90],"conformational":[92],"features":[93,137],"recombination":[96],"reaction":[97,110],"using":[98],"chemical,":[99],"biochemical,":[100],"topological,":[101],"structural,":[102],"single":[104],"molecule-biophysical":[105],"approaches.":[106],"simple":[109],"requirements":[111],"utilized":[114],"programmed":[118],"addressing":[122],"fundamental":[123],"questions":[124],"developmental":[126],"biology.":[127],"They":[128],"also":[130],"employed":[132],"trace":[134],"topological":[136],"within":[140],"high-order":[141],"interactions":[143],"established":[144],"by":[145],"protein":[146],"machines.":[147],"directed":[149],"evolution":[150],"altered":[152],"specificity":[153],"YRs,":[154],"combined":[155],"spatially":[158],"temporally":[160],"regulated":[161],"expression,":[162],"heralds":[163],"emergence":[165],"as":[166],"vital":[167],"tools":[168],"genome":[170],"engineering":[171],"projects":[172],"wide-ranging":[174],"biotechnological":[175],"medical":[177],"applications.":[178]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":5},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}
