{"id":"https://openalex.org/W2276461067","doi":null,"title":"Mitochondria: role in ischemia, reperfusion and cell death.","display_name":"Mitochondria: role in ischemia, reperfusion and cell death.","publication_year":2003,"publication_date":"2003-02-01","ids":{"openalex":"https://openalex.org/W2276461067","mag":"2276461067","pmid":"https://pubmed.ncbi.nlm.nih.gov/12769003"},"language":"en","primary_location":{"id":"pmid:12769003","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12769003","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10400.4/926","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031874851","display_name":"Pedro F. Monteiro","orcid":"https://orcid.org/0000-0002-6631-207X","observed_orcids":["https://orcid.org/0000-0002-6631-207X"]},"institutions":[{"id":"https://openalex.org/I2802025818","display_name":"Unidade Local de Sa\u00fade de Coimbra","ror":"https://ror.org/04032fz76","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I2802025818"]},{"id":"https://openalex.org/I4394709155","display_name":"Centro de Neuroci\u00eancias e Biologia Celular","ror":"https://ror.org/01nzkd566","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4394709155","https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Pedro Monteiro","raw_affiliation_strings":["Unidade de Investiga\u00e7\u00e3o B\u00e1sica em Cardiologia, Servi\u00e7o de Cardiologia, Hospitais da Universidade de Coimbra, Cl\u00ednica de Cardiologia, Faculdade de Medicina, Centro de Neuroci\u00eancias e Biologia Celular de Coimbra, Coimbra"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unidade de Investiga\u00e7\u00e3o B\u00e1sica em Cardiologia, Servi\u00e7o de Cardiologia, Hospitais da Universidade de Coimbra, Cl\u00ednica de Cardiologia, Faculdade de Medicina, Centro de Neuroci\u00eancias e Biologia Celular de Coimbra, Coimbra","institution_ids":["https://openalex.org/I2802025818","https://openalex.org/I4394709155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100747732","display_name":"Paulo Jorge Oliveira","orcid":"https://orcid.org/0000-0002-5201-9948","observed_orcids":["https://orcid.org/0000-0002-5201-9948"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paulo J Oliveira","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038080240","display_name":"Lino Manuel Martins Gon\u00e7alves","orcid":"https://orcid.org/0000-0001-9255-3064","observed_orcids":["https://orcid.org/0000-0001-9255-3064"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lino Gon\u00e7alves","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5083191627","display_name":"Lu\u00eds Augusto Provid\u00eancia","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lu\u00eds A Provid\u00eancia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4335,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.68529092,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"22","issue":"2","first_page":"233","last_page":"54"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.03610000014305115,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiac-mitochondria","display_name":"heart mitochondria","score":0.9750000238418579},{"id":"https://openalex.org/keywords/myocardial-ischemia","display_name":"myocardial ischemia","score":0.9900000095367432},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.9409999847412109},{"id":"https://openalex.org/keywords/cell-death","display_name":"cell death","score":0.7289999723434448},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.8790000081062317},{"id":"https://openalex.org/keywords/mitochondrial-morphology","display_name":"mitochondrial morphology","score":0.8320000171661377},{"id":"https://openalex.org/keywords/calcium-homeostasis","display_name":"calcium homeostasis","score":0.9350000023841858},{"id":"https://openalex.org/keywords/preconditioning","display_name":"preconditioning","score":0.8109999895095825},{"id":"https://openalex.org/keywords/ischemic-cardiomyopathy","display_name":"ischemic cardiomyopathy","score":0.8790000081062317},{"id":"https://openalex.org/keywords/mitochondrial-structure","display_name":"mitochondrial structure","score":0.42399999499320984}],"concepts":[{"id":"https://openalex.org/C2779676291","wikidata":"https://www.wikidata.org/wiki/Q25325349","display_name":"Cardioprotection","level":3,"score":0.8205133676528931},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.7880266308784485},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.7699747681617737},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.5808694362640381},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4632744789123535},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.4481087923049927},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42217308282852173},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3994631767272949},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.35865265130996704},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3374602198600769},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3147311806678772},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.27695226669311523},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14066171646118164}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008929","descriptor_name":"Mitochondria, Heart","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008929","descriptor_name":"Mitochondria, Heart","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015428","descriptor_name":"Myocardial Reperfusion Injury","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017202","descriptor_name":"Myocardial Ischemia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:12769003","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12769003","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology","raw_type":"Journal Article"},{"id":"pmh:oai:rihuc.huc.min-saude.pt:10400.4/926","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10400.4/926","pdf_url":"http://hdl.handle.net/10400.4/926","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"mag:2276461067","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12769003","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:rihuc.huc.min-saude.pt:10400.4/926","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10400.4/926","pdf_url":"http://hdl.handle.net/10400.4/926","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8999999761581421}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2276461067.pdf","grobid_xml":"https://content.openalex.org/works/W2276461067.grobid-xml"},"referenced_works_count":121,"referenced_works":["https://openalex.org/W17855639","https://openalex.org/W61333496","https://openalex.org/W69795831","https://openalex.org/W78877859","https://openalex.org/W82234966","https://openalex.org/W1001132020","https://openalex.org/W1533321987","https://openalex.org/W1542197083","https://openalex.org/W1550247880","https://openalex.org/W1553877517","https://openalex.org/W1562324545","https://openalex.org/W1568529372","https://openalex.org/W1595972372","https://openalex.org/W1768713563","https://openalex.org/W1780139514","https://openalex.org/W1797795615","https://openalex.org/W1814497677","https://openalex.org/W1920479129","https://openalex.org/W1934994215","https://openalex.org/W1958141082","https://openalex.org/W1965560696","https://openalex.org/W1967701846","https://openalex.org/W1967824319","https://openalex.org/W1968112618","https://openalex.org/W1969357796","https://openalex.org/W1970988487","https://openalex.org/W1976147623","https://openalex.org/W1978221784","https://openalex.org/W1979995768","https://openalex.org/W1980154954","https://openalex.org/W1985289402","https://openalex.org/W1988355439","https://openalex.org/W1990209584","https://openalex.org/W1991385182","https://openalex.org/W1997156605","https://openalex.org/W1997208169","https://openalex.org/W1999501161","https://openalex.org/W2000762874","https://openalex.org/W2005472139","https://openalex.org/W2006033770","https://openalex.org/W2008757391","https://openalex.org/W2009543520","https://openalex.org/W2009574988","https://openalex.org/W2009777524","https://openalex.org/W2011466641","https://openalex.org/W2011502281","https://openalex.org/W2011925577","https://openalex.org/W2014376812","https://openalex.org/W2019223852","https://openalex.org/W2019745044","https://openalex.org/W2020178087","https://openalex.org/W2020462222","https://openalex.org/W2021418570","https://openalex.org/W2021891143","https://openalex.org/W2027278652","https://openalex.org/W2027310465","https://openalex.org/W2030273408","https://openalex.org/W2030855199","https://openalex.org/W2031959501","https://openalex.org/W2033490638","https://openalex.org/W2036599441","https://openalex.org/W2038007918","https://openalex.org/W2038890366","https://openalex.org/W2039276913","https://openalex.org/W2040219492","https://openalex.org/W2040845269","https://openalex.org/W2046712654","https://openalex.org/W2047563687","https://openalex.org/W2051915518","https://openalex.org/W2052711442","https://openalex.org/W2054474511","https://openalex.org/W2056117281","https://openalex.org/W2060431351","https://openalex.org/W2063069698","https://openalex.org/W2063385957","https://openalex.org/W2066936996","https://openalex.org/W2067532206","https://openalex.org/W2069915206","https://openalex.org/W2072309553","https://openalex.org/W2076706063","https://openalex.org/W2078971279","https://openalex.org/W2085396235","https://openalex.org/W2085794145","https://openalex.org/W2089270902","https://openalex.org/W2089675043","https://openalex.org/W2100405364","https://openalex.org/W2101575450","https://openalex.org/W2113999599","https://openalex.org/W2114709689","https://openalex.org/W2119683782","https://openalex.org/W2123083875","https://openalex.org/W2124027170","https://openalex.org/W2126311981","https://openalex.org/W2126848490","https://openalex.org/W2130866079","https://openalex.org/W2132494613","https://openalex.org/W2132826785","https://openalex.org/W2133272735","https://openalex.org/W2133726443","https://openalex.org/W2140075873","https://openalex.org/W2140380168","https://openalex.org/W2145047965","https://openalex.org/W2146217294","https://openalex.org/W2147461586","https://openalex.org/W2149321851","https://openalex.org/W2149967205","https://openalex.org/W2152194035","https://openalex.org/W2153171640","https://openalex.org/W2154138838","https://openalex.org/W2159650080","https://openalex.org/W2164772129","https://openalex.org/W2171501507","https://openalex.org/W2210726304","https://openalex.org/W2211503899","https://openalex.org/W2231430380","https://openalex.org/W2280577476","https://openalex.org/W2413334023","https://openalex.org/W2421608635","https://openalex.org/W2430283630","https://openalex.org/W2467078248","https://openalex.org/W4230350070"],"related_works":["https://openalex.org/W2117571600","https://openalex.org/W178304047","https://openalex.org/W2483844746","https://openalex.org/W197691874","https://openalex.org/W7096078219","https://openalex.org/W2486590083","https://openalex.org/W2555339002","https://openalex.org/W2069299819","https://openalex.org/W1974466075","https://openalex.org/W2086479300"],"abstract_inverted_index":{"Recent":[0],"advances":[1],"in":[2,24,41,119],"the":[3,6,18,34,62,92,114],"knowledge":[4,94],"of":[5,9,17,21,64,77,84,116,123],"biochemical":[7],"basis":[8],"myocardial":[10],"ischemia":[11,107],"have":[12,52,57],"enabled":[13],"a":[14],"better":[15],"understanding":[16],"complex":[19],"sequence":[20],"events":[22],"occurring":[23],"ischemic":[25,70],"cardiomyopathy,":[26],"whatever":[27],"its":[28],"manifestations.":[29],"This":[30],"has":[31],"clearly":[32,54],"highlighted":[33],"important":[35,59],"role":[36,115],"played":[37],"by":[38,106],"cardiac":[39,117],"mitochondria":[40,51,118],"these":[42,102],"events.":[43],"At":[44],"first":[45],"only":[46],"associated":[47],"with":[48],"energy":[49],"production,":[50],"been":[53],"shown":[55],"to":[56,90,112],"other":[58],"functions,":[60],"like":[61],"maintenance":[63],"calcium":[65],"homeostasis,":[66],"as":[67,69],"well":[68],"and":[71,74,80,98,100,108,110,121],"non-ischemic":[72],"preconditioning,":[73],"also":[75],"modulation":[76,122],"cellular":[78],"life":[79],"death.":[81],"The":[82],"aims":[83],"this":[85],"review":[86,91],"are":[87],"twofold:":[88],"firstly,":[89],"current":[93],"on":[95],"mitochondrial":[96],"morphology":[97],"structure,":[99],"how":[101],"can":[103],"be":[104],"affected":[105],"ischemia-reperfusion;":[109],"secondly,":[111],"summarize":[113],"cardioprotection":[120],"cell":[124],"death":[125],"mechanisms.":[126]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}