{"id":"https://openalex.org/W2276327700","doi":"https://doi.org/10.7907/08kg-x260","title":"Transcriptional control of spatially regulated genes in the early sea urchin embryo","display_name":"Transcriptional control of spatially regulated genes in the early sea urchin embryo","publication_year":2007,"publication_date":"2007-10-24","ids":{"openalex":"https://openalex.org/W2276327700","doi":"https://doi.org/10.7907/08kg-x260","mag":"2276327700"},"language":"en","primary_location":{"id":"pmh:oai:thesis.library.caltech.edu:4223","doi":null,"is_oa":false,"landing_page_url":"https://thesis.library.caltech.edu/4223/1/Zeller_rw_1995.pdf","pdf_url":"https://thesis.library.caltech.edu/4223/1/Zeller_rw_1995.pdf","source":{"id":"https://openalex.org/S4306402402","display_name":"CaltechTHESIS (California Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122411786","host_organization_name":"California Institute of Technology","host_organization_lineage":["https://openalex.org/I122411786"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.7907/08kg-x260","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050682703","display_name":"Robert W. Zeller","orcid":"https://orcid.org/0000-0001-8398-513X","observed_orcids":["https://orcid.org/0000-0001-8398-513X"]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zeller, Robert Werner","raw_affiliation_strings":["California Institute of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"California Institute of Technology","institution_ids":["https://openalex.org/I122411786"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5050682703"],"corresponding_institution_ids":["https://openalex.org/I122411786"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.6929000020027161,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.6929000020027161,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.2985999882221222,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/strongylocentrotus-purpuratus","display_name":"Strongylocentrotus purpuratus","score":0.9190000295639038},{"id":"https://openalex.org/keywords/sea-urchin-embryo","display_name":"sea urchin embryo","score":0.9449999928474426},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.8970000147819519},{"id":"https://openalex.org/keywords/cis-regulatory-elements","display_name":"cis-regulatory elements","score":0.6959999799728394},{"id":"https://openalex.org/keywords/protein-dna-interactions","display_name":"protein-DNA interactions","score":0.5509999990463257},{"id":"https://openalex.org/keywords/cooperative-dna-binding","display_name":"cooperative DNA binding","score":0.578000009059906},{"id":"https://openalex.org/keywords/alternative-translation-initiation","display_name":"alternative translation initiation","score":0.44999998807907104},{"id":"https://openalex.org/keywords/regulatory-modules","display_name":"regulatory modules","score":0.40799999237060547},{"id":"https://openalex.org/keywords/maternal-proteins","display_name":"maternal proteins","score":0.40400001406669617},{"id":"https://openalex.org/keywords/cleavage-stage","display_name":"cleavage stage","score":0.5770000219345093},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.34200000762939453}],"concepts":[{"id":"https://openalex.org/C2777569064","wikidata":"https://www.wikidata.org/wiki/Q1936405","display_name":"Strongylocentrotus purpuratus","level":3,"score":0.8427413702011108},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7257000207901001},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5990806818008423},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5771176815032959},{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.47495412826538086},{"id":"https://openalex.org/C33987129","wikidata":"https://www.wikidata.org/wiki/Q13479514","display_name":"DNA-binding domain","level":4,"score":0.450131356716156},{"id":"https://openalex.org/C5179208","wikidata":"https://www.wikidata.org/wiki/Q3782057","display_name":"HMG-box","level":5,"score":0.4260634183883667},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.42126303911209106},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.4211260974407196},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.4111533761024475},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4057428240776062},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3724064528942108},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.37191420793533325},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35095494985580444},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.31496506929397583},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.18793118000030518}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:thesis.library.caltech.edu:4223","doi":null,"is_oa":false,"landing_page_url":"https://thesis.library.caltech.edu/4223/1/Zeller_rw_1995.pdf","pdf_url":"https://thesis.library.caltech.edu/4223/1/Zeller_rw_1995.pdf","source":{"id":"https://openalex.org/S4306402402","display_name":"CaltechTHESIS (California Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122411786","host_organization_name":"California Institute of Technology","host_organization_lineage":["https://openalex.org/I122411786"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"doi:10.7907/08kg-x260","doi":"https://doi.org/10.7907/08kg-x260","is_oa":true,"landing_page_url":"https://doi.org/10.7907/08kg-x260","pdf_url":null,"source":{"id":"https://openalex.org/S7407050848","display_name":"Caltech Library","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122411786","host_organization_name":"California Institute of Technology","host_organization_lineage":["https://openalex.org/I122411786"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"thesis"}],"best_oa_location":{"id":"doi:10.7907/08kg-x260","doi":"https://doi.org/10.7907/08kg-x260","is_oa":true,"landing_page_url":"https://doi.org/10.7907/08kg-x260","pdf_url":null,"source":{"id":"https://openalex.org/S7407050848","display_name":"Caltech Library","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122411786","host_organization_name":"California Institute of Technology","host_organization_lineage":["https://openalex.org/I122411786"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2026102426","https://openalex.org/W2008694033","https://openalex.org/W1950159988","https://openalex.org/W2128423327","https://openalex.org/W2281798865","https://openalex.org/W2125003236","https://openalex.org/W2409032171","https://openalex.org/W1964863758","https://openalex.org/W2054755467","https://openalex.org/W2292279923"],"abstract_inverted_index":{"The":[0,23,38,175,313],"regulatory":[1,151,173,189,223,324],"domains":[2,190],"of":[3,15,64,91,164,171,191,205,259,275,289],"several":[4,221],"Strongylocentrotus":[5],"purpuratus":[6],"embryo":[7,43,195],"genes":[8,298],"appear":[9],"to":[10,34,111,135,142,181,200,216,269,287,295,300],"be":[11,288],"organized":[12],"into":[13],"\"modules\"":[14],"closely":[16],"associated":[17],"target":[18,146,265,303],"sites":[19,147,266,328],"for":[20,262,278],"DNA-binding":[21,29,85,208],"proteins.":[22],"Sp(G/C)F1":[24,57,107,117,154,176],"protein":[25,30,39,76,134,177,235,243,261,277,283],"is":[26,178,284],"a":[27,61,71,78,82],"novel":[28],"which":[31,166,213],"binds":[32],"specifically":[33,215],"G/C":[35],"rich":[36],"cis-elements.":[37],"was":[40],"purified":[41],"from":[42,60,70,238],"nuclear":[44,203],"extracts":[45],"by":[46,231],"DNA":[47,120,136,165,264],"affinity":[48],"chromatography":[49],"and":[50,81,126,159,211,309,315],"the":[51,105,149,153,169,188,202,239,255,273,279],"corresponding":[52],"cDNA":[53],"isolated.":[54],"Five":[55],"different":[56,113,207,222,263],"polypeptides,":[58],"produced":[59],"nested":[62],"set":[63],"AUG":[65],"initiation":[66],"codons,":[67],"are":[68,109,130,227,267,311],"synthesized":[69],"single":[72],"mRNA":[73],"template.":[74],"Each":[75],"shares":[77],"common":[79],"C-terminus":[80],"centrally":[83],"located":[84],"domain":[86],"but":[87,230],"incorporates":[88],"variable":[89],"amounts":[90],"an":[92,184,322],"N-terminal":[93],"proline-rich":[94,97],"region.":[95],"Since":[96,254],"regions":[98,163],"often":[99],"serve":[100,182,320],"as":[101,124,183,306,321],"transcriptional":[102,114],"activation":[103],"domains,":[104],"five":[106],"proteins":[108,118,226,317],"likely":[110,123,180,286],"possess":[112],"\"activation":[115],"potentials.\"":[116],"bind":[119,214],"cooperatively,":[121],"most":[122],"homodimers,":[125],"multiple":[127],"protein-DNA":[128],"complexes":[129],"formed":[131],"at":[132,247,326],"high":[133],"ratios":[137],"in":[138,148,187,220,293,329],"vitro.":[139],"When":[140],"bound":[141],"two":[143,206],"or":[144],"more":[145],"CyIIIa":[150],"domain,":[152],"polypeptides":[155],"fouu":[156],"protein-protein":[157],"contacts,":[158],"\"loop":[160],"out\"":[161],"intervening":[162],"could":[167],"allow":[168],"interaction":[170],"distant":[172],"modules.":[174],"thus":[179,319],"intermodule":[185],"communicator":[186],"many":[192],"sea":[193,332],"urchin":[194,333],"genes.":[196],"Antibodies":[197],"were":[198],"used":[199],"quantitate":[201],"concentrations":[204],"proteins,":[209],"P3A1":[210,234,260,282,314],"P3A2,":[212],"P3A":[217,302,327],"cis-elements":[218],"found":[219],"domains.":[224],"Both":[225],"present":[228],"maternally,":[229],"late":[232],"gastrula,":[233],"has":[236],"disappeared":[237],"nucleus":[240],"leaving":[241],"P3A2":[242,276,316],"levels":[244],"relatively":[245],"unchanged":[246],"about":[248],"10[superscript":[249],"4]":[250],"molecules":[251],"per":[252],"nucleus.":[253],"relative":[256],"binding":[257],"affinities":[258,274],"up":[268],"50X":[270],"lower":[271],"than":[272],"same":[280],"sites,":[281,304],"therefore":[285],"functional":[290],"significance":[291],"only":[292],"early":[294],"mid-cleavage":[296],"before":[297],"known":[299],"contain":[301],"such":[305],"CyIIIa,":[307],"SM50":[308],"Specla,":[310],"expressed.":[312],"can":[318],"antagonistic":[323],"switch":[325],"cleavage":[330],"stage":[331],"embryos.":[334]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}