{"id":"https://openalex.org/W2276206307","doi":"https://doi.org/10.1152/ajpgi.1998.274.6.g992","title":"H. pyloristimulates gastrin release from canine antral cells in primary culture","display_name":"H. pyloristimulates gastrin release from canine antral cells in primary culture","publication_year":1998,"publication_date":"1998-06-01","ids":{"openalex":"https://openalex.org/W2276206307","doi":"https://doi.org/10.1152/ajpgi.1998.274.6.g992","mag":"2276206307","pmid":"https://pubmed.ncbi.nlm.nih.gov/9696722"},"language":"en","primary_location":{"id":"doi:10.1152/ajpgi.1998.274.6.g992","doi":"https://doi.org/10.1152/ajpgi.1998.274.6.g992","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpgi.1998.274.6.g992","pdf_url":null,"source":{"id":"https://openalex.org/S34136372","display_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","issn_l":"0193-1857","issn":["0193-1857","1522-1547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010348709","display_name":"Frank Serge Lehmann","orcid":"https://orcid.org/0000-0001-8280-4915","observed_orcids":["https://orcid.org/0000-0001-8280-4915"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank S. Lehmann","raw_affiliation_strings":["CURE: Gastroenteric Biology Center, University of California, Los Angeles 90073;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CURE: Gastroenteric Biology Center, University of California, Los Angeles 90073;","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091129386","display_name":"Neal L. Schiller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neal Schiller","raw_affiliation_strings":["University of California, Riverside, California 92521; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, Riverside, California 92521; and","institution_ids":["https://openalex.org/I103635307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017198868","display_name":"Timothy L. Cover","orcid":"https://orcid.org/0000-0001-8503-002X","observed_orcids":["https://orcid.org/0000-0001-8503-002X"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy Cover","raw_affiliation_strings":["Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-2605"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-2605","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091905158","display_name":"Ritchard Hatch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ritchard Hatch","raw_affiliation_strings":["University of California, Riverside, California 92521; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, Riverside, California 92521; and","institution_ids":["https://openalex.org/I103635307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081937972","display_name":"Rein Seensalu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rein Seensalu","raw_affiliation_strings":["CURE: Gastroenteric Biology Center, University of California, Los Angeles 90073;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CURE: Gastroenteric Biology Center, University of California, Los Angeles 90073;","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044891693","display_name":"Kimitoshi Kato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimitoshi Kato","raw_affiliation_strings":["CURE: Gastroenteric Biology Center, University of California, Los Angeles 90073;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CURE: Gastroenteric Biology Center, University of California, Los Angeles 90073;","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091680206","display_name":"John Henry Walsh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John H. Walsh","raw_affiliation_strings":["CURE: Gastroenteric Biology Center, University of California, Los Angeles 90073;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CURE: Gastroenteric Biology Center, University of California, Los Angeles 90073;","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083325211","display_name":"Andrew H. Soll","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew H. Soll","raw_affiliation_strings":["CURE: Gastroenteric Biology Center, University of California, Los Angeles 90073;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CURE: Gastroenteric Biology Center, University of California, Los Angeles 90073;","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.3305,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.9256926,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"274","issue":"6","first_page":"G992","last_page":"G996"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/helicobacter-pylori","display_name":"Helicobacter pylori","score":0.9980000257492065},{"id":"https://openalex.org/keywords/gastrin-secretion","display_name":"gastrin secretion","score":0.9649999737739563},{"id":"https://openalex.org/keywords/g-cells","display_name":"G cells","score":0.8330000042915344},{"id":"https://openalex.org/keywords/gastric-antrum","display_name":"gastric antrum","score":0.8029999732971191},{"id":"https://openalex.org/keywords/hypergastrinemia","display_name":"hypergastrinemia","score":0.9539999961853027},{"id":"https://openalex.org/keywords/bacterial-extracts","display_name":"bacterial extracts","score":0.5979999899864197},{"id":"https://openalex.org/keywords/caga","display_name":"CagA","score":0.7620000243186951},{"id":"https://openalex.org/keywords/vaca","display_name":"VacA","score":0.9919999837875366},{"id":"https://openalex.org/keywords/peptic-ulcer","display_name":"peptic ulcer","score":0.7839999794960022},{"id":"https://openalex.org/keywords/canine","display_name":"canine","score":0.4519999921321869}],"concepts":[{"id":"https://openalex.org/C2776986829","wikidata":"https://www.wikidata.org/wiki/Q407181","display_name":"Gastrin","level":3,"score":0.9269541501998901},{"id":"https://openalex.org/C2778204961","wikidata":"https://www.wikidata.org/wiki/Q83146136","display_name":"CagA","level":4,"score":0.9118117094039917},{"id":"https://openalex.org/C2776409635","wikidata":"https://www.wikidata.org/wiki/Q180556","display_name":"Helicobacter pylori","level":2,"score":0.8105363249778748},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.8074588775634766},{"id":"https://openalex.org/C119811328","wikidata":"https://www.wikidata.org/wiki/Q2987004","display_name":"G cell","level":4,"score":0.7244719862937927},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.6635869741439819},{"id":"https://openalex.org/C131253125","wikidata":"https://www.wikidata.org/wiki/Q609361","display_name":"Antrum","level":3,"score":0.4922861158847809},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4844505786895752},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4176161289215088},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3798961043357849},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33697253465652466},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.32552915811538696},{"id":"https://openalex.org/C2779422922","wikidata":"https://www.wikidata.org/wiki/Q1029907","display_name":"Stomach","level":2,"score":0.21079900860786438},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20813900232315063},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13438057899475098},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.09555530548095703},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005755","descriptor_name":"Gastrins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011706","descriptor_name":"Pyloric Antrum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011706","descriptor_name":"Pyloric Antrum","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D013010","descriptor_name":"Sonication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016480","descriptor_name":"Helicobacter pylori","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpgi.1998.274.6.g992","doi":"https://doi.org/10.1152/ajpgi.1998.274.6.g992","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpgi.1998.274.6.g992","pdf_url":null,"source":{"id":"https://openalex.org/S34136372","display_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","issn_l":"0193-1857","issn":["0193-1857","1522-1547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","raw_type":"journal-article"},{"id":"pmid:9696722","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9696722","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W329946253","https://openalex.org/W1538891740","https://openalex.org/W1561069887","https://openalex.org/W1933982026","https://openalex.org/W1979273869","https://openalex.org/W1991076385","https://openalex.org/W1992209131","https://openalex.org/W1994527533","https://openalex.org/W2017643024","https://openalex.org/W2031423487","https://openalex.org/W2043247919","https://openalex.org/W2050282552","https://openalex.org/W2067464438","https://openalex.org/W2075638984","https://openalex.org/W2096370484","https://openalex.org/W2108661484","https://openalex.org/W2110407425","https://openalex.org/W2122606773","https://openalex.org/W2122821108","https://openalex.org/W2133329092","https://openalex.org/W2135972635","https://openalex.org/W2137125723","https://openalex.org/W2166785990","https://openalex.org/W2256438062","https://openalex.org/W2268141963","https://openalex.org/W2396076691","https://openalex.org/W2407353637","https://openalex.org/W2591775790"],"related_works":["https://openalex.org/W1976986405","https://openalex.org/W2407353637","https://openalex.org/W1989655056","https://openalex.org/W4244299874","https://openalex.org/W2096370484","https://openalex.org/W4252715867","https://openalex.org/W2283967385","https://openalex.org/W1495964018","https://openalex.org/W2108661484","https://openalex.org/W2112380189"],"abstract_inverted_index":{"Patients":[0],"chronically":[1],"infected":[2],"with":[3],"Helicobacter":[4],"pylori":[5,37,61,120],"are":[6],"known":[7],"to":[8,33,108],"have":[9,13],"hypergastrinemia.":[10],"Previous":[11],"studies":[12],"demonstrated":[14,97],"the":[15,102,146],"stimulation":[16,100],"of":[17,29,45,153],"gastrin":[18,41,46,94,99,129],"from":[19,47,67,83],"isolated":[20],"G":[21,49,114,134],"cells":[22,50],"by":[23,101],"monocytes":[24],"and":[25,75,89,150],"cytokines.":[26],"The":[27,43],"aim":[28],"this":[30],"study":[31],"was":[32,55,105],"determine":[34],"if":[35],"H.":[36,60,119,147],"can":[38,126],"directly":[39,127],"stimulate":[40,128],"secretion.":[42],"secretion":[44],"canine":[48,133],"in":[51,131,145],"48-h":[52],"primary":[53],"cultures":[54],"investigated":[56],"using":[57],"either":[58],"live":[59],"bacteria":[62],"or":[63],"various":[64],"bacterial":[65,72],"extracts":[66,74,104],"three":[68],"well-characterized":[69],"strains.":[70],"Whole":[71],"sonic":[73,103],"water-extracted":[76],"surface":[77],"proteins,":[78],"but":[79],"not":[80,106],"PBS":[81],"extracts,":[82],"strains":[84],"43579":[85],"(CagA+/VacA+),":[86,88],"60190":[87],"60190:v1":[90],"(CagA+/VacA-)":[91],"significantly":[92],"stimulated":[93],"release.":[95],"Controls":[96],"that":[98,118],"due":[107],"a":[109,122],"direct":[110],"toxic":[111],"effect":[112,139],"on":[113],"cells.":[115],"We":[116],"conclude":[117],"produces":[121],"soluble":[123],"factor(s),":[124],"which":[125],"release":[130],"enriched":[132],"cell":[135],"cultures.":[136],"This":[137],"stimulatory":[138],"may":[140],"play":[141],"an":[142],"important":[143],"role":[144],"pylori-associated":[148],"hypergastrinemia":[149],"subsequent":[151],"development":[152],"peptic":[154],"ulcer":[155],"disease.":[156]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
