{"id":"https://openalex.org/W22759652","doi":"https://doi.org/10.1093/ajcp/90.3.268","title":"Red Blood Cell Fragmentation: Improved Detection and Identification of Causes","display_name":"Red Blood Cell Fragmentation: Improved Detection and Identification of Causes","publication_year":1988,"publication_date":"1988-09-01","ids":{"openalex":"https://openalex.org/W22759652","doi":"https://doi.org/10.1093/ajcp/90.3.268","mag":"22759652","pmid":"https://pubmed.ncbi.nlm.nih.gov/2458032"},"language":"en","primary_location":{"id":"doi:10.1093/ajcp/90.3.268","doi":"https://doi.org/10.1093/ajcp/90.3.268","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ajcp/90.3.268","pdf_url":null,"source":{"id":"https://openalex.org/S15871148","display_name":"American Journal of Clinical Pathology","issn_l":"0002-9173","issn":["0002-9173","1943-7722"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Clinical Pathology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113664631","display_name":"Joel David Bessman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J. David Bessman","raw_affiliation_strings":["Department of Internal Medicine and the Pryce-Jones Memorial Laboratory, University of Texas Medical Branch at Galveston, Galveston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and the Pryce-Jones Memorial Laboratory, University of Texas Medical Branch at Galveston, Galveston, Texas","institution_ids":["https://openalex.org/I55302922"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5113664631"],"corresponding_institution_ids":["https://openalex.org/I55302922"],"apc_list":{"value":4660,"currency":"USD","value_usd":4660},"apc_paid":null,"fwci":0.2746,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.54155454,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"90","issue":"3","first_page":"268","last_page":"273"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":0.8720999956130981,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":0.8720999956130981,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.05990000069141388,"subfield":{"id":"https://openalex.org/subfields/3607","display_name":"Medical Laboratory Technology"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.03830000013113022,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/red-blood-cell-fragmentation","display_name":"red blood cell fragmentation","score":0.9779999852180481},{"id":"https://openalex.org/keywords/peripheral-blood-smear","display_name":"peripheral blood smear","score":0.9649999737739563},{"id":"https://openalex.org/keywords/conventional-chemotherapy","display_name":"cytotoxic chemotherapy","score":0.699999988079071},{"id":"https://openalex.org/keywords/iron-deficiency","display_name":"iron deficiency","score":0.7789999842643738},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.9350000023841858},{"id":"https://openalex.org/keywords/sensitivity-and-specificity","display_name":"sensitivity and specificity","score":0.8159999847412109}],"concepts":[{"id":"https://openalex.org/C2776557347","wikidata":"https://www.wikidata.org/wiki/Q37187","display_name":"Red blood cell","level":2,"score":0.7389780282974243},{"id":"https://openalex.org/C50244902","wikidata":"https://www.wikidata.org/wiki/Q420870","display_name":"Spectrin","level":4,"score":0.631517767906189},{"id":"https://openalex.org/C2910929737","wikidata":"https://www.wikidata.org/wiki/Q3296909","display_name":"Nucleated Red Blood Cell","level":4,"score":0.6173738241195679},{"id":"https://openalex.org/C50965678","wikidata":"https://www.wikidata.org/wiki/Q2724302","display_name":"Abnormality","level":2,"score":0.6144233345985413},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5634499788284302},{"id":"https://openalex.org/C191015642","wikidata":"https://www.wikidata.org/wiki/Q1132459","display_name":"Fragmentation (computing)","level":2,"score":0.5177189707756042},{"id":"https://openalex.org/C2779979121","wikidata":"https://www.wikidata.org/wiki/Q211709","display_name":"Blood cell","level":2,"score":0.5101768970489502},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4736051559448242},{"id":"https://openalex.org/C2777208419","wikidata":"https://www.wikidata.org/wiki/Q4347672","display_name":"Red Cell","level":2,"score":0.4200391471385956},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.41910573840141296},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32960009574890137},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.285854697227478},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28274691104888916},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11894232034683228},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.0},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.0},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000747","descriptor_name":"Anemia, Hypochromic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001772","descriptor_name":"Blood Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004909","descriptor_name":"Erythrocyte Indices","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D013049","descriptor_name":"Spectrin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013194","descriptor_name":"Staining and Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/ajcp/90.3.268","doi":"https://doi.org/10.1093/ajcp/90.3.268","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ajcp/90.3.268","pdf_url":null,"source":{"id":"https://openalex.org/S15871148","display_name":"American Journal of Clinical Pathology","issn_l":"0002-9173","issn":["0002-9173","1943-7722"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Clinical Pathology","raw_type":"journal-article"},{"id":"pmid:2458032","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2458032","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of clinical pathology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1993633011","display_name":null,"funder_award_id":"CA39182","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G453680820","display_name":null,"funder_award_id":"CA07701","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3217563696","https://openalex.org/W2039104000","https://openalex.org/W1913230203","https://openalex.org/W2014660782","https://openalex.org/W2076992379","https://openalex.org/W2410801834","https://openalex.org/W2160197189","https://openalex.org/W3114272425","https://openalex.org/W32382316","https://openalex.org/W4404385027"],"abstract_inverted_index":{"The":[0,63,107],"peripheral":[1,123],"blood":[2,7,18,36,44,85,101,114,124,131],"film":[3,45,125],"and":[4,49,60,75,134],"the":[5,43,55,90,112,122],"red":[6,17,35,84,113,130],"cell":[8,19,86,115,132],"size":[9],"distribution":[10],"histogram":[11,56,117,141],"were":[12,70],"examined":[13],"for":[14,126],"evidence":[15],"of":[16,42,54,67,129],"fragments":[20],"in":[21,96],"2,350":[22],"subjects.":[23],"To":[24],"distinguish":[25],"subjects":[26,97],"with":[27,72,98],"greater":[28],"than":[29,121],"or":[30],"equal":[31],"to":[32,92],"10":[33],"fragments/1,000":[34],"cells":[37],"(abnormal)":[38],"from":[39],"normal,":[40],"examination":[41,53],"was":[46,57,89],"0.83":[47],"sensitive":[48,59],"0.30":[50],"specific,":[51],"whereas":[52],"0.97":[58],"0.87":[61],"specific.":[62],"most":[64],"common":[65,146],"causes":[66],"abnormal":[68,83,140],"fragmentation":[69,87],"malignancy":[71],"cytotoxic":[73],"chemotherapy":[74],"severe":[76],"iron":[77],"deficiency.":[78],"In":[79],"two":[80,110],"subjects,":[81],"an":[82,99],"pattern":[88],"clue":[91],"a":[93,144],"spectrin":[94,136],"mutant":[95],"automated":[100],"count":[102],"previously":[103],"evaluated":[104],"as":[105],"normal.":[106],"data":[108],"suggest":[109],"conclusions:":[111],"volume":[116],"appears":[118],"more":[119],"accurate":[120],"routine":[127],"identification":[128],"fragments;":[133],"asymptomatic":[135],"abnormality":[137],"identifiable":[138],"by":[139],"may":[142],"be":[143],"relatively":[145],"disorder.":[147]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
