{"id":"https://openalex.org/W2275889193","doi":null,"title":"Lip and Perioral Enhancement: A 12-Month Prospective, Randomized, Controlled Study.","display_name":"Lip and Perioral Enhancement: A 12-Month Prospective, Randomized, Controlled Study.","publication_year":2015,"publication_date":"2015-12-01","ids":{"openalex":"https://openalex.org/W2275889193","mag":"2275889193","pmid":"https://pubmed.ncbi.nlm.nih.gov/26659938"},"language":"en","primary_location":{"id":"pmid:26659938","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26659938","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of drugs in dermatology : JDD","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043052154","display_name":"Herv\u00e9 Raspaldo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Herv\u00e9 Raspaldo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083823749","display_name":"Jonquille Chantrey","orcid":"https://orcid.org/0000-0002-0222-234X","observed_orcids":["https://orcid.org/0000-0002-0222-234X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonquille Chantrey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032246260","display_name":"Lakhdar Belhaouari","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lakhdar Belhaouari","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110313027","display_name":"David Eccleston","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Eccleston","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017208124","display_name":"Roy Saleh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roy Saleh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068412634","display_name":"Raj Acquilla","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raj Acquilla","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5047763542","display_name":"Diane K. Murphy","orcid":"https://orcid.org/0009-0003-9858-8227","observed_orcids":["https://orcid.org/0009-0003-9858-8227"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Diane K Murphy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8605,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.85731947,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"14","issue":"12","first_page":"1444","last_page":"52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11322","display_name":"Facial Rejuvenation and Surgery Techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11322","display_name":"Facial Rejuvenation and Surgery Techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11258","display_name":"Breast Implant and Reconstruction","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10356","display_name":"Orthodontics and Dentofacial Orthopedics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3505","display_name":"Orthodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lip-enhancement","display_name":"lip enhancement","score":0.8389999866485596},{"id":"https://openalex.org/keywords/hyaluronic-acid-fillers","display_name":"hyaluronic acid fillers","score":0.9190000295639038},{"id":"https://openalex.org/keywords/lidocaine","display_name":"lidocaine","score":0.8740000128746033},{"id":"https://openalex.org/keywords/non-inferiority","display_name":"non-inferiority","score":0.8080000281333923},{"id":"https://openalex.org/keywords/lip-fullness","display_name":"lip fullness","score":0.8640000224113464},{"id":"https://openalex.org/keywords/oral-commissure","display_name":"oral commissure","score":0.9900000095367432},{"id":"https://openalex.org/keywords/injection-site-reactions","display_name":"injection site reactions","score":0.6899999976158142},{"id":"https://openalex.org/keywords/repeated-treatment","display_name":"repeated treatment","score":0.6549999713897705}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9468673467636108},{"id":"https://openalex.org/C2780149897","wikidata":"https://www.wikidata.org/wiki/Q216935","display_name":"Lidocaine","level":2,"score":0.9436055421829224},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4873379170894623},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.40889161825180054},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.3455091118812561}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003357","descriptor_name":"Cosmetic Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008012","descriptor_name":"Lidocaine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008012","descriptor_name":"Lidocaine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008046","descriptor_name":"Lip","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":true},{"descriptor_ui":"D008046","descriptor_name":"Lip","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009055","descriptor_name":"Mouth","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":true},{"descriptor_ui":"D009055","descriptor_name":"Mouth","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012060","descriptor_name":"Rejuvenation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:26659938","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26659938","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of drugs in dermatology : JDD","raw_type":"Journal Article"},{"id":"mag:2275889193","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26659938","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6899999976158142}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2030428181","https://openalex.org/W4253611252","https://openalex.org/W2062687858","https://openalex.org/W2587697179","https://openalex.org/W7099700088","https://openalex.org/W2026767134","https://openalex.org/W4308632556","https://openalex.org/W2790189842","https://openalex.org/W4280606208","https://openalex.org/W4387611809"],"abstract_inverted_index":{"BACKGROUND:":[0],"Juv\u00e9derm\u00ae":[1],"Volbella\u00ae":[2],"with":[3,23,30,45,81,115,146,149,169,172,180,183,197,208],"Lidocaine":[4,24,46,82,116,150,184,198],"is":[5,199],"a":[6],"hyaluronic":[7,28],"acid":[8,29],"filler":[9],"suited":[10],"for":[11,203],"lip":[12,40,130,204],"enhancement.":[13],"OBJECTIVE:":[14],"Evaluate":[15],"the":[16],"safety":[17],"and":[18,62,108,140,163,175,201,205],"effectiveness":[19,176,209],"of":[20,78,90,177,191],"Juv\u00e9derm":[21,43,79,113,147,170,181,195],"Volbella":[22,44,80,114,148,171,182,196],"versus":[25,151],"non-animal":[26],"stabilized":[27],"lidocaine":[31],"(Restylane-L\u00ae).":[32],"METHODS:":[33],"This":[34],"study":[35],"randomized":[36],"280":[37],"subjects":[38],"desiring":[39],"enhancement":[41],"to":[42,83,105,119,156,187,212],"or":[47],"Restylane-L.":[48],"Investigators":[49],"rated":[50],"outcomes":[51],"using":[52,74],"Allergan's":[53],"Lip":[54],"Fullness":[55],"Scale":[56],"(LFS),":[57],"Perioral":[58],"Lines":[59],"Severity":[60,65],"Scale,":[61],"Oral":[63],"Commissures":[64],"Scale.":[66],"Independent":[67],"central":[68],"reviewers":[69],"(ICRs)":[70],"assessed":[71],"3-dimensional":[72],"photographs":[73],"these":[75],"scales.":[76],"Noninferiority":[77],"Restylane-L":[84,120,152],"was":[85,117,159,185],"based":[86],"on":[87],"ICR":[88],"assessment":[89],"LFS":[91],"responders":[92],"(\u2265":[93],"1-point":[94],"improvement":[95],"from":[96],"baseline)":[97],"at":[98,121,153],"month":[99],"3.":[100],"Subjects":[101],"were":[102],"evaluated":[103],"up":[104,211],"12":[106,213],"months":[107,154],"after":[109],"repeat":[110,178],"treatment.":[111],"RESULTS:":[112],"noninferior":[118],"3":[122],"months.":[123,214],"Investigator":[124],"assessments":[125],"showed":[126],"significant":[127],"improvements":[128],"in":[129],"fullness":[131],"(P":[132,137,143],"\u2264":[133,138,144],".03),":[134],"perioral":[135,206],"lines":[136],".04),":[139],"oral":[141],"commissures":[142],".03)":[145],"6":[155],"12.":[157],"There":[158],"less":[160],"acute":[161],"swelling":[162],"fewer":[164],"severe":[165],"injection":[166],"site":[167],"responses":[168],"Lidocaine.":[173],"Safety":[174],"treatment":[179],"comparable":[186],"initial":[188,192],"treatment,":[189],"regardless":[190],"filler.":[193],"CONCLUSIONS:":[194],"safe":[200],"effective":[202],"enhancement,":[207],"lasting":[210]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}