{"id":"https://openalex.org/W2275650581","doi":null,"title":"New radiopharmaceutical agents for the treatment of castration-resistant prostate cancer.","display_name":"New radiopharmaceutical agents for the treatment of castration-resistant prostate cancer.","publication_year":2015,"publication_date":"2015-12-01","ids":{"openalex":"https://openalex.org/W2275650581","mag":"2275650581","pmid":"https://pubmed.ncbi.nlm.nih.gov/26222274"},"language":"en","primary_location":{"id":"pmid:26222274","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26222274","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of...","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037618450","display_name":"Lorenzo Stefano Maffioli","orcid":"https://orcid.org/0000-0002-8867-2447","observed_orcids":["https://orcid.org/0000-0002-8867-2447"]},"institutions":[{"id":"https://openalex.org/I4210162221","display_name":"Azienda Ospedaliera Ospedale Civile di Legnano","ror":"https://ror.org/046w0kr18","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210162221"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"L Maffioli","raw_affiliation_strings":["U.O. Nuclear Medicine, Multi\u2011Hospital Department of Oncology, Civile Hospital of Legnano, Legnano, Milan, Italy - lorenzo.maffioli@ao-legnano.it","U.O. Nuclear Medicine, Multi\u2011Hospital Department of Oncology, Civile Hospital of Legnano, Legnano, Milan, Italy -"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U.O. Nuclear Medicine, Multi\u2011Hospital Department of Oncology, Civile Hospital of Legnano, Legnano, Milan, Italy - lorenzo.maffioli@ao-legnano.it","institution_ids":["https://openalex.org/I4210162221"]},{"raw_affiliation_string":"U.O. Nuclear Medicine, Multi\u2011Hospital Department of Oncology, Civile Hospital of Legnano, Legnano, Milan, Italy -","institution_ids":["https://openalex.org/I4210162221"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026888232","display_name":"Luigia Florimonte","orcid":"https://orcid.org/0000-0002-5254-6852","observed_orcids":["https://orcid.org/0000-0002-5254-6852"]},"institutions":[{"id":"https://openalex.org/I2803066834","display_name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","ror":"https://ror.org/016zn0y21","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I189158943","https://openalex.org/I2803066834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"L Florimonte","raw_affiliation_strings":["Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico;","institution_ids":["https://openalex.org/I2803066834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003076929","display_name":"Durval C. Costa","orcid":"https://orcid.org/0000-0001-8039-4924","observed_orcids":["https://orcid.org/0000-0001-8039-4924"]},"institutions":[{"id":"https://openalex.org/I113358080","display_name":"Champalimaud Foundation","ror":"https://ror.org/03g001n57","country_code":"PT","type":"facility","lineage":["https://openalex.org/I113358080"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"D C Costa","raw_affiliation_strings":["Unknown Champalimaud Foundation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unknown Champalimaud Foundation","institution_ids":["https://openalex.org/I113358080"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041692746","display_name":"Joana C. Castanheira","orcid":"https://orcid.org/0000-0001-7041-1516","observed_orcids":["https://orcid.org/0000-0001-7041-1516"]},"institutions":[{"id":"https://openalex.org/I113358080","display_name":"Champalimaud Foundation","ror":"https://ror.org/03g001n57","country_code":"PT","type":"facility","lineage":["https://openalex.org/I113358080"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"J Correia Castanheira","raw_affiliation_strings":["Unknown Champalimaud Foundation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unknown Champalimaud Foundation","institution_ids":["https://openalex.org/I113358080"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042452114","display_name":"Chiara Maria Grana","orcid":"https://orcid.org/0000-0002-3808-2174","observed_orcids":["https://orcid.org/0000-0002-3808-2174"]},"institutions":[{"id":"https://openalex.org/I6141010","display_name":"European Institute of Oncology","ror":"https://ror.org/02vr0ne26","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I6141010"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C Grana","raw_affiliation_strings":["Istituto Europeo di Oncologia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Europeo di Oncologia","institution_ids":["https://openalex.org/I6141010"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032324073","display_name":"Markus Luster","orcid":"https://orcid.org/0000-0003-4638-3679","observed_orcids":["https://orcid.org/0000-0003-4638-3679"]},"institutions":[{"id":"https://openalex.org/I268975460","display_name":"Universit\u00e4tsklinikum Gie\u00dfen und Marburg","ror":"https://ror.org/032nzv584","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I268975460"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M Luster","raw_affiliation_strings":["Universitatsklinikum Giessen und Marburg, Standort Marburg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universitatsklinikum Giessen und Marburg, Standort Marburg","institution_ids":["https://openalex.org/I268975460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020320888","display_name":"Lisa Bodei","orcid":"https://orcid.org/0000-0001-6930-7383","observed_orcids":["https://orcid.org/0000-0001-6930-7383"]},"institutions":[{"id":"https://openalex.org/I6141010","display_name":"European Institute of Oncology","ror":"https://ror.org/02vr0ne26","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I6141010"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"L Bodei","raw_affiliation_strings":["Istituto Europeo di Oncologia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Europeo di Oncologia","institution_ids":["https://openalex.org/I6141010"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091844302","display_name":"Marco Chinol","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I6141010","display_name":"European Institute of Oncology","ror":"https://ror.org/02vr0ne26","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I6141010"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M Chinol","raw_affiliation_strings":["Istituto Europeo di Oncologia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Europeo di Oncologia","institution_ids":["https://openalex.org/I6141010"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.487,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.88337752,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"59","issue":"4","first_page":"420","last_page":"38"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9419000148773193,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9419000148773193,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.04349999874830246,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/castration-resistant-prostate-cancer","display_name":"castration-resistant prostate cancer","score":0.9950000047683716},{"id":"https://openalex.org/keywords/radiopharmaceuticals","display_name":"radiopharmaceuticals","score":0.9399999976158142},{"id":"https://openalex.org/keywords/radium-223-dichloride","display_name":"radium-223 dichloride","score":0.9279999732971191},{"id":"https://openalex.org/keywords/bone-metastases","display_name":"bone metastasis","score":0.9200000166893005},{"id":"https://openalex.org/keywords/prostate-specific-membrane-antigen","display_name":"prostate-specific membrane antigen","score":0.7760000228881836},{"id":"https://openalex.org/keywords/gastrin-releasing-peptide-receptor","display_name":"gastrin-releasing peptide receptor","score":0.9850000143051147},{"id":"https://openalex.org/keywords/bombesin-analogues","display_name":"bombesin analogues","score":0.9589999914169312},{"id":"https://openalex.org/keywords/gallium-68","display_name":"gallium-68","score":0.8389999866485596},{"id":"https://openalex.org/keywords/pet-ct-imaging","display_name":"PET/CT imaging","score":0.7739999890327454}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9440717697143555},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.8249450325965881},{"id":"https://openalex.org/C151872237","wikidata":"https://www.wikidata.org/wiki/Q1410759","display_name":"Homing (biology)","level":2,"score":0.6278021335601807},{"id":"https://openalex.org/C2777783956","wikidata":"https://www.wikidata.org/wiki/Q848085","display_name":"Bone metastasis","level":4,"score":0.5736767649650574},{"id":"https://openalex.org/C2780737065","wikidata":"https://www.wikidata.org/wiki/Q18888805","display_name":"Radium-223","level":5,"score":0.5544431209564209},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49572455883026123},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4770630896091461},{"id":"https://openalex.org/C2777899217","wikidata":"https://www.wikidata.org/wiki/Q4759439","display_name":"Androgen deprivation therapy","level":4,"score":0.46807703375816345},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.46041184663772583},{"id":"https://openalex.org/C2778311097","wikidata":"https://www.wikidata.org/wiki/Q5903784","display_name":"Hormonal therapy","level":4,"score":0.45961540937423706},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.45014363527297974},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.4181903004646301},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010166","descriptor_name":"Palliative Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059408","descriptor_name":"Pain Management","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064129","descriptor_name":"Prostatic Neoplasms, Castration-Resistant","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D064129","descriptor_name":"Prostatic Neoplasms, Castration-Resistant","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D064129","descriptor_name":"Prostatic Neoplasms, Castration-Resistant","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:26222274","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26222274","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of...","raw_type":"Journal Article"},{"id":"mag:2275650581","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26222274","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2004538226","https://openalex.org/W2019289198","https://openalex.org/W1796050564","https://openalex.org/W2134463877","https://openalex.org/W322560825","https://openalex.org/W2981025721","https://openalex.org/W2502135520","https://openalex.org/W3032129223","https://openalex.org/W2138052510","https://openalex.org/W194201398"],"abstract_inverted_index":{"Prostate":[0,209],"cancer":[1,8,24],"(PCa)":[2],"is":[3,19,214],"the":[4,21,31,65,96,106,158,163,166,181,251,312],"fourth":[5],"most":[6,22,83],"common":[7,23,334],"worldwide":[9],"in":[10,25,117,150,246,283],"terms":[11],"of":[12,36,39,56,70,98,119,141,148,165,168,184,222,253,315],"incidence":[13],"and":[14,82,220,236,288,294,327,335],"third":[15],"among":[16],"male,":[17],"but":[18],"becoming":[20],"developed":[26],"countries.":[27],"In":[28,110,188],"many":[29],"patients":[30,48,57,193],"disease":[32],"will":[33],"progress":[34],"despite":[35],"castration":[37],"levels":[38,228],"testosterone,":[40],"to":[41,75,102,138,171,191,200,232,285],"become":[42],"castration-resistant":[43],"PCa":[44,224,296],"(CRPC).":[45],"Nearly":[46],"all":[47],"with":[49,58,125,160,194,258,276],"CRPC":[50],"show":[51],"bone":[52,107,121,131,151],"metastases.":[53],"The":[54],"treatment":[55,159,176],"bony":[59],"metastases":[60],"has":[61,320],"dramatically":[62],"changed":[63],"during":[64],"past":[66],"three":[67],"years":[68],"because":[69],"new":[71,146],"therapeutic":[72],"approaches":[73],"addressed":[74],"obtain":[76],"pain":[77],"control,":[78],"reduced":[79],"skeletal":[80],"morbidity,":[81],"importantly,":[84],"increased":[85],"survival":[86],"rate.":[87],"A":[88],"possible":[89],"therapy":[90,221,307],"can":[91],"be":[92],"based":[93],"also":[94,243],"on":[95],"use":[97],"radiopharmaceuticals":[99,113],"systemically":[100],"administered":[101],"slow":[103],"or":[104],"reverse":[105],"metastatic":[108],"progression.":[109,237],"facts":[111],"bone-homing":[112,186],"are":[114,229,242],"taken":[115],"up":[116],"areas":[118,124],"high":[120,126,255],"turnover,":[122],"including":[123],"osteoblastic":[127],"activity.":[128],"Recently,":[129],"a":[130,145,254,329],"targeting":[132,262],"radiopharmaceutical,":[133],"Radium-223":[134],"dichloride":[135],"was":[136],"added":[137],"this":[139,185,333],"group":[140],"drugs":[142],"clearly":[143],"representing":[144],"generation":[147],"radiopharmaceutical":[149],"therapy.":[152],"Clinical":[153],"trials":[154],"had":[155],"shown":[156],"that":[157],"Ra-223":[161],"allowed":[162],"reduction":[164],"risk":[167],"death":[169],"respect":[170],"placebo.":[172],"No":[173],"other":[174],"radiometabolic":[175],"achieved":[177],"such":[178,280],"result,":[179],"evidentiating":[180],"disease-modifying":[182],"properties":[183],"radiopharmaceutical.":[187],"an":[189],"effort":[190],"treat":[192],"disseminated":[195],"PCa,":[196],"who":[197],"became":[198],"resistant":[199],"hormonal":[201],"therapy,":[202],"molecular":[203,265,271],"targets":[204,272],"have":[205,273,309],"been":[206,274,322],"recently":[207],"identified.":[208],"specific":[210,318],"membrane":[211],"antigen":[212],"(PSMA)":[213],"one":[215],"attractive":[216],"target":[217],"for":[218,290],"diagnosis":[219],"metastasized":[223],"since":[225],"its":[226,324],"expression":[227],"directly":[230],"correlated":[231],"androgen":[233],"independence,":[234],"metastasis,":[235],"Gastrin-releasing":[238],"peptide":[239,304],"receptors":[240],"(GRPr)":[241],"highly":[244],"overexpressed":[245],"PCa.":[247],"Numerous":[248],"studies":[249,308],"suggest":[250],"possibility":[252],"PCa-specific":[256],"signal":[257],"radiolabeled":[259,275],"bombesin":[260],"analogs":[261],"GRPr.":[263],"Low":[264],"weight":[266],"peptides":[267],"directed":[268],"against":[269,332],"these":[270],"positron":[277],"emitting":[278],"radionuclides":[279],"as":[281],"68Ga":[282,316],"order":[284],"improve":[286],"sensitivity":[287],"specificity":[289],"detecting":[291],"primary,":[292],"metastatic,":[293],"recurrent":[295],"by":[297],"PET/CT":[298],"over":[299],"conventional":[300],"imaging":[301],"techniques.":[302],"Although":[303],"radionuclide":[305],"ligand":[306],"just":[310],"initiated,":[311],"diagnostic":[313],"relevance":[314],"labeled":[317],"tracers":[319],"already":[321],"established":[323],"clinical":[325],"utility":[326],"represents":[328],"valid":[330],"tool":[331],"deadly":[336],"cancer.":[337]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
