{"id":"https://openalex.org/W2275558208","doi":null,"title":"Estudio de la expresi\u00f3n del gen CISD1 mediada por la actividad del CFTR","display_name":"Estudio de la expresi\u00f3n del gen CISD1 mediada por la actividad del CFTR","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2275558208","mag":"2275558208"},"language":"es","primary_location":{"id":"pmh:oai:RDI UBA:aextesis:tesis_n4788_Taminelli_oai","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.12110/tesis_n4788_Taminelli","pdf_url":null,"source":{"id":"https://openalex.org/S4306402562","display_name":"Repositorio Digital Institucional de la Universidad de Buenos Aires (Universidad de Buenos Aires)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I24354313","host_organization_name":"Universidad de Buenos Aires","host_organization_lineage":["https://openalex.org/I24354313"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/20.500.12110/tesis_n4788_Taminelli","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066085386","display_name":"G. Taminelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR"],"is_corresponding":true,"raw_author_name":"G. Taminelli","raw_affiliation_strings":["University of Buenos Aires"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Buenos Aires","institution_ids":["https://openalex.org/I24354313"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5066085386"],"corresponding_institution_ids":["https://openalex.org/I24354313"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.01640000008046627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cisd1","display_name":"CISD1","score":0.8920000195503235},{"id":"https://openalex.org/keywords/cftr","display_name":"CFTR","score":0.9580000042915344},{"id":"https://openalex.org/keywords/cystic-fibrosis","display_name":"cystic fibrosis","score":1.0},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.8679999709129333},{"id":"https://openalex.org/keywords/mitochondrial-proteins","display_name":"mitochondrial proteins","score":0.5649999976158142},{"id":"https://openalex.org/keywords/2fe-2s-cluster","display_name":"[2Fe-2S] cluster","score":0.9129999876022339},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.5580000281333923},{"id":"https://openalex.org/keywords/oxidative-phosphorylation","display_name":"oxidative phosphorylation","score":0.6919999718666077},{"id":"https://openalex.org/keywords/cftr-inhibitors","display_name":"CFTR inhibitors","score":0.5270000100135803},{"id":"https://openalex.org/keywords/cftr-activators","display_name":"CFTR activators","score":0.8989999890327454},{"id":"https://openalex.org/keywords/cftr-rescue","display_name":"CFTR rescue","score":0.8019999861717224}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.7107787132263184},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.4971902668476105},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4610300660133362},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2931445837020874}],"mesh":[],"locations_count":6,"locations":[{"id":"pmh:oai:RDI UBA:aextesis:tesis_n4788_Taminelli_oai","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.12110/tesis_n4788_Taminelli","pdf_url":null,"source":{"id":"https://openalex.org/S4306402562","display_name":"Repositorio Digital Institucional de la Universidad de Buenos Aires (Universidad de Buenos Aires)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I24354313","host_organization_name":"Universidad de Buenos Aires","host_organization_lineage":["https://openalex.org/I24354313"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:americanae.aecid.es:3001042","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.12110/tesis_n4788_Taminelli","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Biblioteca Digital (UBA-FCEN)","raw_type":"http://purl.org/coar/resource_type/c_db06"},{"id":"pmh:snrd:Tesis_4788_Taminelli","doi":null,"is_oa":true,"landing_page_url":"http://digital.bl.fcen.uba.ar/gsdl-282/cgi-bin/library.cgi?a=d&c=tesis&d=Tesis_4788_Taminelli","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Biblioteca Digital (UBA-FCEN)","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:tesis:tesis_n4788_Taminelli","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.12110/tesis_n4788_Taminelli","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Biblioteca Digital (UBA-FCEN)","raw_type":"http://purl.org/coar/resource_type/c_db06"},{"id":"pmh:oai:RDI UBA:aextesis:Tesis_4788_Taminelli_oai","doi":null,"is_oa":false,"landing_page_url":"http://digital.bl.fcen.uba.ar/gsdl-282/cgi-bin/library.cgi?a=d&c=tesis&d=Tesis_4788_Taminelli","pdf_url":null,"source":{"id":"https://openalex.org/S4306402562","display_name":"Repositorio Digital Institucional de la Universidad de Buenos Aires (Universidad de Buenos Aires)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I24354313","host_organization_name":"Universidad de Buenos Aires","host_organization_lineage":["https://openalex.org/I24354313"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Tesis Doctoral"},{"id":"mag:2275558208","doi":null,"is_oa":false,"landing_page_url":"http://digital.bl.fcen.uba.ar/download/tesis/tesis_n4788_Taminelli.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:RDI UBA:aextesis:tesis_n4788_Taminelli_oai","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.12110/tesis_n4788_Taminelli","pdf_url":null,"source":{"id":"https://openalex.org/S4306402562","display_name":"Repositorio Digital Institucional de la Universidad de Buenos Aires (Universidad de Buenos Aires)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I24354313","host_organization_name":"Universidad de Buenos Aires","host_organization_lineage":["https://openalex.org/I24354313"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":259,"referenced_works":["https://openalex.org/W44803040","https://openalex.org/W46570322","https://openalex.org/W75328084","https://openalex.org/W84246939","https://openalex.org/W89071597","https://openalex.org/W119766675","https://openalex.org/W168788800","https://openalex.org/W196469802","https://openalex.org/W205807682","https://openalex.org/W217644409","https://openalex.org/W262255493","https://openalex.org/W1523858318","https://openalex.org/W1528658828","https://openalex.org/W1533844265","https://openalex.org/W1554250492","https://openalex.org/W1561484646","https://openalex.org/W1562020128","https://openalex.org/W1572230739","https://openalex.org/W1597544092","https://openalex.org/W1630678156","https://openalex.org/W1745204207","https://openalex.org/W1775749144","https://openalex.org/W1899670941","https://openalex.org/W1909128047","https://openalex.org/W1911225603","https://openalex.org/W1946951765","https://openalex.org/W1947785372","https://openalex.org/W1954895018","https://openalex.org/W1957129715","https://openalex.org/W1963761882","https://openalex.org/W1964767165","https://openalex.org/W1966532097","https://openalex.org/W1967867658","https://openalex.org/W1968973147","https://openalex.org/W1969697265","https://openalex.org/W1971184818","https://openalex.org/W1971736406","https://openalex.org/W1974160984","https://openalex.org/W1974951228","https://openalex.org/W1975971473","https://openalex.org/W1977373496","https://openalex.org/W1978105937","https://openalex.org/W1978368163","https://openalex.org/W1979541437","https://openalex.org/W1980017808","https://openalex.org/W1980775459","https://openalex.org/W1981772538","https://openalex.org/W1982071077","https://openalex.org/W1983239520","https://openalex.org/W1985629904","https://openalex.org/W1986449424","https://openalex.org/W1986682462","https://openalex.org/W1988312683","https://openalex.org/W1990637933","https://openalex.org/W1990670389","https://openalex.org/W1991271048","https://openalex.org/W1991878680","https://openalex.org/W1995459103","https://openalex.org/W1995698798","https://openalex.org/W1996027687","https://openalex.org/W1996302426","https://openalex.org/W1998195903","https://openalex.org/W1998338448","https://openalex.org/W2001083394","https://openalex.org/W2005150915","https://openalex.org/W2006211612","https://openalex.org/W2006860521","https://openalex.org/W2010691166","https://openalex.org/W2010786983","https://openalex.org/W2010986573","https://openalex.org/W2011374678","https://openalex.org/W2013912459","https://openalex.org/W2015357935","https://openalex.org/W2015473205","https://openalex.org/W2015531712","https://openalex.org/W2016743497","https://openalex.org/W2019042812","https://openalex.org/W2019099644","https://openalex.org/W2019410656","https://openalex.org/W2019959952","https://openalex.org/W2020887083","https://openalex.org/W2020924011","https://openalex.org/W2022395635","https://openalex.org/W2023243075","https://openalex.org/W2023681929","https://openalex.org/W2023775801","https://openalex.org/W2023995540","https://openalex.org/W2024147831","https://openalex.org/W2026771151","https://openalex.org/W2027085827","https://openalex.org/W2027768938","https://openalex.org/W2028171116","https://openalex.org/W2029299728","https://openalex.org/W2029742510","https://openalex.org/W2030074619","https://openalex.org/W2030423815","https://openalex.org/W2030686317","https://openalex.org/W2030819680","https://openalex.org/W2033335450","https://openalex.org/W2034282653","https://openalex.org/W2034685372","https://openalex.org/W2036134087","https://openalex.org/W2036559289","https://openalex.org/W2036774130","https://openalex.org/W2037459969","https://openalex.org/W2037598514","https://openalex.org/W2037922224","https://openalex.org/W2038701031","https://openalex.org/W2039599894","https://openalex.org/W2040527376","https://openalex.org/W2041850796","https://openalex.org/W2042843548","https://openalex.org/W2043218849","https://openalex.org/W2045302409","https://openalex.org/W2045465686","https://openalex.org/W2046353863","https://openalex.org/W2047233384","https://openalex.org/W2047703509","https://openalex.org/W2049635421","https://openalex.org/W2050573110","https://openalex.org/W2051475668","https://openalex.org/W2051962580","https://openalex.org/W2052347357","https://openalex.org/W2052588826","https://openalex.org/W2056934536","https://openalex.org/W2057119680","https://openalex.org/W2058530636","https://openalex.org/W2060351031","https://openalex.org/W2060811345","https://openalex.org/W2064209460","https://openalex.org/W2065712473","https://openalex.org/W2066235646","https://openalex.org/W2067370872","https://openalex.org/W2068233575","https://openalex.org/W2071936542","https://openalex.org/W2073095545","https://openalex.org/W2074444128","https://openalex.org/W2074624473","https://openalex.org/W2076964895","https://openalex.org/W2078282757","https://openalex.org/W2078765652","https://openalex.org/W2079031049","https://openalex.org/W2079351767","https://openalex.org/W2079750805","https://openalex.org/W2079770391","https://openalex.org/W2080443532","https://openalex.org/W2081804379","https://openalex.org/W2082968284","https://openalex.org/W2084098035","https://openalex.org/W2084600753","https://openalex.org/W2084796782","https://openalex.org/W2085101416","https://openalex.org/W2087885007","https://openalex.org/W2088020457","https://openalex.org/W2088043549","https://openalex.org/W2088769712","https://openalex.org/W2089006464","https://openalex.org/W2090943591","https://openalex.org/W2091485211","https://openalex.org/W2093925252","https://openalex.org/W2093935222","https://openalex.org/W2095408626","https://openalex.org/W2095770592","https://openalex.org/W2099663899","https://openalex.org/W2100427094","https://openalex.org/W2100619015","https://openalex.org/W2101273248","https://openalex.org/W2103037573","https://openalex.org/W2103539716","https://openalex.org/W2104934425","https://openalex.org/W2104999290","https://openalex.org/W2105292130","https://openalex.org/W2105815827","https://openalex.org/W2108222684","https://openalex.org/W2111439678","https://openalex.org/W2112998606","https://openalex.org/W2113074631","https://openalex.org/W2113227301","https://openalex.org/W2115617146","https://openalex.org/W2116048591","https://openalex.org/W2116506351","https://openalex.org/W2117961791","https://openalex.org/W2120193720","https://openalex.org/W2121493145","https://openalex.org/W2123302926","https://openalex.org/W2123397214","https://openalex.org/W2123779991","https://openalex.org/W2124073224","https://openalex.org/W2125391335","https://openalex.org/W2125399390","https://openalex.org/W2126458759","https://openalex.org/W2126532539","https://openalex.org/W2127402429","https://openalex.org/W2129980101","https://openalex.org/W2131806767","https://openalex.org/W2135556820","https://openalex.org/W2136291881","https://openalex.org/W2137424160","https://openalex.org/W2137450588","https://openalex.org/W2137999969","https://openalex.org/W2140107851","https://openalex.org/W2140455347","https://openalex.org/W2141020521","https://openalex.org/W2141885858","https://openalex.org/W2142188572","https://openalex.org/W2142535516","https://openalex.org/W2143046500","https://openalex.org/W2143173841","https://openalex.org/W2145498392","https://openalex.org/W2147103558","https://openalex.org/W2147551208","https://openalex.org/W2149054264","https://openalex.org/W2149986918","https://openalex.org/W2150399236","https://openalex.org/W2151631634","https://openalex.org/W2152033571","https://openalex.org/W2152896217","https://openalex.org/W2156041450","https://openalex.org/W2156847224","https://openalex.org/W2157393167","https://openalex.org/W2158120166","https://openalex.org/W2158714788","https://openalex.org/W2158947190","https://openalex.org/W2162716442","https://openalex.org/W2163301402","https://openalex.org/W2164174765","https://openalex.org/W2165627203","https://openalex.org/W2170294849","https://openalex.org/W2170370717","https://openalex.org/W2171315493","https://openalex.org/W2181803248","https://openalex.org/W2185014469","https://openalex.org/W2187603576","https://openalex.org/W2302670980","https://openalex.org/W2308269884","https://openalex.org/W2313829157","https://openalex.org/W2319884815","https://openalex.org/W2321094204","https://openalex.org/W2328538504","https://openalex.org/W2329750935","https://openalex.org/W2336714143","https://openalex.org/W2336764462","https://openalex.org/W2337925307","https://openalex.org/W2339425856","https://openalex.org/W2340233470","https://openalex.org/W2399303067","https://openalex.org/W2403578638","https://openalex.org/W2407952916","https://openalex.org/W2411584046","https://openalex.org/W2411699215","https://openalex.org/W2411855649","https://openalex.org/W2437546984","https://openalex.org/W2439958617","https://openalex.org/W2472535850","https://openalex.org/W2789633529","https://openalex.org/W3021661733","https://openalex.org/W3023243658","https://openalex.org/W3106798016","https://openalex.org/W7139930683"],"related_works":["https://openalex.org/W55067300","https://openalex.org/W2079770391","https://openalex.org/W6960014158","https://openalex.org/W7018993375","https://openalex.org/W2517672238","https://openalex.org/W6959937552","https://openalex.org/W1559792249","https://openalex.org/W6989117177","https://openalex.org/W7037964720","https://openalex.org/W6903599525"],"abstract_inverted_index":{"La":[0,194,227],"Fibrosis":[1],"Qu\u00edstica":[2],"(FQ)":[3],"es":[4,75,81,148,232],"una":[5,76,177,190],"enfermedad":[6],"autos\u00f3mica":[7],"recesivaproducida":[8],"por":[9,34,199,327,337,385,396,418,428],"mutaciones":[10],"en":[11,30,65,115,153,219,249,253,264,335,340,360,388,398,422,446],"el":[12,16,31,73,90,154,157],"gen":[13,54],"que":[14,51,72,134,146,187,205,277,305,394,409,434],"codifica":[15,189],"canal":[17,38],"de":[18,43,55,69,93,122,124,129,139,160,167,176,192,215,229,239,242,259,271,281,284,287,297,300,304,366,382,401,413,431,438],"cloruro":[19],"CFTR.":[20,39,144],"Muy":[21],"poco":[22],"se":[23,88,104,151,173,275,324],"sabe":[24],"sobre":[25],"los":[26,98,120],"mecanismos":[27],"moleculares":[28],"involucrados":[29],"da\u00f1ocelular":[32],"producido":[33],"la":[35,41,52,164,260,278,298,319,328,349,410,414,435,441],"falla":[36],"del":[37,100,143,211,353,416,444],"Mediante":[40],"metodolog\u00eda":[42],"\u201cDisplay":[44],"Diferencial\u201d":[45],"o":[46,131,141],"\u201cDifferential":[47],"Display\u201d":[48],"(DD)":[49],"observamos":[50,408],"expresi\u00f3ndel":[53],"origen":[56],"nuclear":[57],"CISD1":[58,125,147,188,206,331,383],"(CDGSH":[59],"Iron":[60],"Sulfur":[61],"Domain":[62],"1)":[63],"estabadisminu\u00edda":[64],"un":[66,149,208,220,243,254,268,379,399],"modelo":[67],"celular":[68],"FQ.":[70],"Dado":[71],"DD":[74],"t\u00e9cnica":[77],"queaporta":[78],"evidencias":[79],"pero":[80,234],"susceptible":[82],"a":[83,180,223],"falsos":[84],"positivos":[85],"y":[86,111,182,201,273,372,392,420],"negativos,":[87],"decidi\u00f3que":[89],"primer":[91],"enfoque":[92,159],"esta":[94,161,230],"Tesis":[95,162],"fuera":[96],"corroborar":[97],"resultados":[99],"DD.":[101],"Para":[102,345],"ello":[103],"utilizaron":[105],"t\u00e9cnicas":[106],"como":[107,217],"RT-PCR":[108],"semi":[109],"cuantitativas":[110],"RT":[112],"seguidade":[113],"PCR":[114],"tiempo":[116],"real":[117],"para":[118,403],"medir":[119],"niveles":[121],"expresi\u00f3n":[123,329,402],"endistintos":[126],"modelos":[127,364,424],"celulares":[128],"FQ":[130,336,368,425],"con":[132,291,370,378],"c\u00e9lulas":[133,240,367,373,447],"expresasen":[135],"CFTR":[136],"wt":[137],"enpresencia":[138],"inhibidores":[140],"activadores":[142],"Ya":[145],"genque":[150],"encuentra":[152],"genoma":[155],"nuclear,":[156],"siguiente":[158,314],"fuedeterminar":[163],"localizaci\u00f3n":[165,195,308],"subcelular":[166],"su":[168,224,307,341],"producto.":[169],"En":[170],"este":[171],"caso,":[172],"utiliz\u00f3":[174],"laexpresi\u00f3n":[175,429],"quimera":[178],"unida":[179],"EGFP":[181],"mediante":[183,310,355],"microscop\u00eda":[184],"confocalpudimos":[185],"demostrar":[186],"prote\u00edna":[191,231,279],"localizaci\u00f3nmitocondrial.":[193],"mitocondrial":[196,309,323],"fue":[197,316],"confirmada":[198],"Wiley":[200],"col.":[202,421],"Ellosadem\u00e1s":[203],"reportaron":[204],"posee":[207],"grupo":[209],"prost\u00e9tico":[210],"tipo":[212],"2Fe-2S":[213],"enlugar":[214],"Zinc,":[216],"postulamos":[218],"principio":[221],"debido":[222],"estructura":[225],"primaria.":[226],"funci\u00f3n":[228],"desconocida,":[233],"estudios":[235],"hechos":[236],"enmitocondrias":[237],"aisladas":[238],"card\u00edacas":[241],"rat\u00f3n":[244,282],"nulo":[245],"(-/-)":[246],"paramitoNEET":[247],"(CISD1":[248],"humanos)":[250],"presentaban":[251],"disminu\u00edda":[252],"30":[255],"%":[256],"lacapacidad":[257],"m\u00e1xima":[258],"fosforilaci\u00f3n":[261],"oxidativa":[262],"medida":[263],"estado":[265],"3.":[266],"Adem\u00e1s,en":[267],"trabajo":[269],"anterior":[270],"Colca":[272],"colaboradores,":[274],"report\u00f3":[276],"Minner-1":[280],"(producto":[283],"splicing":[285],"alternativo":[286],"CISD1)":[288],"co-inmuno":[289],"precipit\u00f3":[290],"prote\u00ednas":[292],"pertenecientes":[293],"al":[294],"complejo":[295,321],"l":[296],"cadena":[299],"transportede":[301],"electrones.":[302],"Luego":[303],"comprobamos":[306],"laquimera":[311],"GFP-CISD1,":[312],"nuestro":[313],"objetivo":[315],"determinar":[317],"si":[318],"actividaddel":[320],"I":[322],"encontraba":[325],"afectada":[326],"diferencialde":[330],"(un":[332],"efecto":[333],"observado":[334],"Grabriel":[338],"Valdivieso":[339,419],"Tesis,":[342],"a\u00fanno":[343],"publicado).":[344],"tal":[346],"fin":[347],"medimos":[348],"actividad":[350,415,442],"in":[351],"gel":[352],"CIm":[354],"lat\u00e9cnica":[356],"\u201cBlue":[357],"Native-PAGE\u201d":[358],"(BN-PAGE),":[359],"mitocondrias":[361],"extra\u00eddas":[362],"desdediferentes":[363],"experimentales":[365],"transfectadas":[369,377],"CISD1salvaje":[371],"Caco-2":[374,448],"(no":[375,449],"FQ)":[376],"variante":[380,436],"mutada":[381,437],"obtenida":[384],"mutag\u00e9nesis":[386],"dirigida":[387],"las":[389],"ciste\u00ednas":[390],"72":[391],"74":[393],"fueronreemplazadas":[395],"serinas":[397],"pl\u00e1smido":[400],"eucariotas":[404],"pcDNA":[405],"3.1(-).":[406],"As\u00ed,":[407],"disminuci\u00f3n":[411],"significativa":[412],"CImreportada":[417],"distintos":[423],"era":[426],"restaurada":[427],"ect\u00f3pica":[430],"CISD1,":[432],"mientras":[433],"CISD1modul\u00f3":[439],"negativamente":[440],"normal":[443],"Clm":[445],"FQ).":[450]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}