{"id":"https://openalex.org/W2275069080","doi":"https://doi.org/10.1186/s12979-016-0060-5","title":"Higher plasma levels of complement C3a, C4a and C5a increase the risk of subretinal fibrosis in neovascular age-related macular degeneration","display_name":"Higher plasma levels of complement C3a, C4a and C5a increase the risk of subretinal fibrosis in neovascular age-related macular degeneration","publication_year":2016,"publication_date":"2016-02-15","ids":{"openalex":"https://openalex.org/W2275069080","doi":"https://doi.org/10.1186/s12979-016-0060-5","mag":"2275069080","pmid":"https://pubmed.ncbi.nlm.nih.gov/26884800","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4754842"},"language":"en","primary_location":{"id":"doi:10.1186/s12979-016-0060-5","doi":"https://doi.org/10.1186/s12979-016-0060-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12979-016-0060-5","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12979-016-0060-5.pdf","source":{"id":"https://openalex.org/S183475463","display_name":"Immunity & Ageing","issn_l":"1742-4933","issn":["1742-4933"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunity &amp; Ageing","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1186/s12979-016-0060-5.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102925183","display_name":"Judith Lechner","orcid":"https://orcid.org/0000-0002-3315-5282","observed_orcids":["https://orcid.org/0000-0002-3315-5282"]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Judith Lechner","raw_affiliation_strings":["The Wellcome-Wolfson Institute of Experimental Medicine, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wellcome-Wolfson Institute of Experimental Medicine, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK","institution_ids":["https://openalex.org/I126231945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100360828","display_name":"Mei Chen","orcid":"https://orcid.org/0000-0001-5661-1386","observed_orcids":["https://orcid.org/0000-0001-5661-1386"]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mei Chen","raw_affiliation_strings":["The Wellcome-Wolfson Institute of Experimental Medicine, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wellcome-Wolfson Institute of Experimental Medicine, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK","institution_ids":["https://openalex.org/I126231945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048960834","display_name":"Ruth Esther Hogg","orcid":"https://orcid.org/0000-0001-9413-2669","observed_orcids":["https://orcid.org/0000-0001-9413-2669"]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ruth E. Hogg","raw_affiliation_strings":["The Wellcome-Wolfson Institute of Experimental Medicine, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wellcome-Wolfson Institute of Experimental Medicine, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK","institution_ids":["https://openalex.org/I126231945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025280592","display_name":"Levente T\u00f3th","orcid":"https://orcid.org/0000-0001-6763-2326","observed_orcids":["https://orcid.org/0000-0001-6763-2326"]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Levente Toth","raw_affiliation_strings":["The Wellcome-Wolfson Institute of Experimental Medicine, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wellcome-Wolfson Institute of Experimental Medicine, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK","institution_ids":["https://openalex.org/I126231945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101469581","display_name":"Giuliana Silvestri","orcid":"https://orcid.org/0000-0001-5662-5374","observed_orcids":["https://orcid.org/0000-0001-5662-5374"]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Giuliana Silvestri","raw_affiliation_strings":["The Wellcome-Wolfson Institute of Experimental Medicine, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wellcome-Wolfson Institute of Experimental Medicine, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK","institution_ids":["https://openalex.org/I126231945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019521414","display_name":"Usha Chakravarthy","orcid":"https://orcid.org/0000-0002-2606-3734","observed_orcids":["https://orcid.org/0000-0002-2606-3734"]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Usha Chakravarthy","raw_affiliation_strings":["The Wellcome-Wolfson Institute of Experimental Medicine, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wellcome-Wolfson Institute of Experimental Medicine, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK","institution_ids":["https://openalex.org/I126231945"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046784348","display_name":"Heping Xu","orcid":"https://orcid.org/0000-0003-4000-931X","observed_orcids":["https://orcid.org/0000-0003-4000-931X"]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Heping Xu","raw_affiliation_strings":["The Wellcome-Wolfson Institute of Experimental Medicine, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK"],"raw_orcid":"https://orcid.org/0000-0003-4000-931X","affiliations":[{"raw_affiliation_string":"The Wellcome-Wolfson Institute of Experimental Medicine, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK","institution_ids":["https://openalex.org/I126231945"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5046784348"],"corresponding_institution_ids":["https://openalex.org/I126231945"],"apc_list":{"value":3190,"currency":"USD","value_usd":3190},"apc_paid":{"value":1358,"currency":"EUR","value_usd":1464},"fwci":13.1,"has_fulltext":true,"cited_by_count":114,"citation_normalized_percentile":{"value":0.99046414,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"13","issue":"1","first_page":"4","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neovascular-age-related-macular-degeneration","display_name":"neovascular age-related macular degeneration","score":0.9769999980926514},{"id":"https://openalex.org/keywords/complement-c3a","display_name":"complement C3a","score":0.824999988079071},{"id":"https://openalex.org/keywords/complement-c4a","display_name":"complement C4A","score":0.9980000257492065},{"id":"https://openalex.org/keywords/c5a","display_name":"C5a","score":1.0},{"id":"https://openalex.org/keywords/subretinal-fibrosis","display_name":"subretinal fibrosis","score":0.9070000052452087},{"id":"https://openalex.org/keywords/choroidal-neovascularization","display_name":"choroidal neovascularization","score":0.9229999780654907},{"id":"https://openalex.org/keywords/retinal-angiomatous-proliferation","display_name":"retinal angiomatous proliferation","score":0.9629999995231628},{"id":"https://openalex.org/keywords/polypoidal-choroidal-vasculopathy","display_name":"polypoidal choroidal vasculopathy","score":1.0},{"id":"https://openalex.org/keywords/anti-vegf-therapy-response","display_name":"anti-VEGF therapy response","score":0.9039999842643738},{"id":"https://openalex.org/keywords/plasma-complement-levels","display_name":"plasma complement levels","score":0.7490000128746033}],"concepts":[{"id":"https://openalex.org/C2776403814","wikidata":"https://www.wikidata.org/wiki/Q27429789","display_name":"Macular degeneration","level":2,"score":0.9252021908760071},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8856525421142578},{"id":"https://openalex.org/C90630246","wikidata":"https://www.wikidata.org/wiki/Q17854107","display_name":"C4A","level":3,"score":0.7612088918685913},{"id":"https://openalex.org/C2781359195","wikidata":"https://www.wikidata.org/wiki/Q5105209","display_name":"Choroidal neovascularization","level":3,"score":0.6319581270217896},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.5402358174324036},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.5367302894592285},{"id":"https://openalex.org/C2781100027","wikidata":"https://www.wikidata.org/wiki/Q414270","display_name":"Ranibizumab","level":4,"score":0.5139036178588867},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5025503635406494},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4756621718406677},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.33864396810531616},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.19160214066505432},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.13433179259300232},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.12880688905715942},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.08554837107658386},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/s12979-016-0060-5","doi":"https://doi.org/10.1186/s12979-016-0060-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12979-016-0060-5","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12979-016-0060-5.pdf","source":{"id":"https://openalex.org/S183475463","display_name":"Immunity & Ageing","issn_l":"1742-4933","issn":["1742-4933"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunity &amp; Ageing","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4754842","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4754842","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immun Ageing","raw_type":"Text"},{"id":"pmid:26884800","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26884800","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunity & ageing : I & A","raw_type":"Journal Article"},{"id":"pmh:oai:pure.qub.ac.uk/portal:openaire/c31c7d11-3336-40ac-821e-a2431b9655f8","doi":null,"is_oa":true,"landing_page_url":"https://pure.qub.ac.uk/en/publications/c31c7d11-3336-40ac-821e-a2431b9655f8","pdf_url":null,"source":{"id":"https://openalex.org/S4306402319","display_name":"Research Portal (Queen's University Belfast)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I126231945","host_organization_name":"Queen's University Belfast","host_organization_lineage":["https://openalex.org/I126231945"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Lechner, J, Chen, M, Hogg, R, Toth, L, Silvestri, G, Chakravarthy, U & Xu, H 2016, 'Higher plasma levels of complement C3a, C4a and C5a increase the risk of subretinal fibrosis in neovascular age-related macular degeneration.', Immunity and Ageing, vol. 13, no. 4. https://doi.org/10.1186/s12979-016-0060-5","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/s12979-016-0060-5","doi":"https://doi.org/10.1186/s12979-016-0060-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12979-016-0060-5","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12979-016-0060-5.pdf","source":{"id":"https://openalex.org/S183475463","display_name":"Immunity & Ageing","issn_l":"1742-4933","issn":["1742-4933"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunity &amp; Ageing","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.7599999904632568,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G4109077845","display_name":null,"funder_award_id":"R188/0211","funder_id":"https://openalex.org/F4320320080","funder_display_name":"Dunhill Medical Trust"}],"funders":[{"id":"https://openalex.org/F4320320080","display_name":"Dunhill Medical Trust","ror":"https://ror.org/05ayqqv15"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2275069080.pdf","grobid_xml":"https://content.openalex.org/works/W2275069080.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W154709760","https://openalex.org/W1585939626","https://openalex.org/W1593071308","https://openalex.org/W1632120505","https://openalex.org/W1670632949","https://openalex.org/W1901360874","https://openalex.org/W1953417341","https://openalex.org/W1965404473","https://openalex.org/W1968327904","https://openalex.org/W1977327764","https://openalex.org/W1990057691","https://openalex.org/W1997288094","https://openalex.org/W2000156623","https://openalex.org/W2001661375","https://openalex.org/W2003101845","https://openalex.org/W2009256817","https://openalex.org/W2016584341","https://openalex.org/W2027707278","https://openalex.org/W2028283509","https://openalex.org/W2031331863","https://openalex.org/W2033493034","https://openalex.org/W2046953076","https://openalex.org/W2050217807","https://openalex.org/W2073924928","https://openalex.org/W2085174145","https://openalex.org/W2088551743","https://openalex.org/W2089481411","https://openalex.org/W2092638574","https://openalex.org/W2093621960","https://openalex.org/W2096547439","https://openalex.org/W2103941977","https://openalex.org/W2113784410","https://openalex.org/W2123156974","https://openalex.org/W2129537774","https://openalex.org/W2132154261","https://openalex.org/W2139373552","https://openalex.org/W2143613937","https://openalex.org/W2147322584","https://openalex.org/W2149003678","https://openalex.org/W2154334837","https://openalex.org/W2162946426","https://openalex.org/W2164796644","https://openalex.org/W2169958703","https://openalex.org/W2171338724","https://openalex.org/W2209285888","https://openalex.org/W3048476598","https://openalex.org/W4256107229"],"related_works":["https://openalex.org/W6939947048","https://openalex.org/W2582581571","https://openalex.org/W2949424847","https://openalex.org/W2043618519","https://openalex.org/W2982123947","https://openalex.org/W4393349303","https://openalex.org/W4285388774","https://openalex.org/W2955642130","https://openalex.org/W4403969552","https://openalex.org/W3110583921"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,122],"aim":[2],"of":[3,12,21,125,141,148,168,191,229,237],"this":[4,71],"study":[5],"was":[6,76,83,97],"to":[7,33,36,70,93,119,137,201],"investigate":[8],"the":[9,29,91,120,146,235],"plasma":[10,123],"levels":[11,30,124,147,167,190,228],"complement":[13,210,231],"C3a,":[14,126,149,169],"C4a,":[15],"and":[16,27,61,65,82,112,128,151,163,171,220],"C5a":[17,129,152,172],"in":[18,78,85,100,133,156,176,184,195,212,240],"different":[19],"types":[20],"neovascular":[22],"age-related":[23],"macular":[24],"degeneration":[25],"(nAMD)":[26],"whether":[28],"were":[31,68,105,109,130,153,173,193],"related":[32],"patients'":[34],"responsiveness":[35,92],"anti-VEGF":[37,94,202],"therapy.":[38,121,203],"RESULTS:":[39],"Ninety-six":[40],"nAMD":[41,80,87,101,134,142,177,196,213,241],"patients":[42,81,104,115,135,157,178,197,214],"(including":[43],"61":[44],"with":[45,50,56,158,179,215],"choroidal":[46,58],"neovascularisation":[47],"(CNV),":[48],"17":[49],"retinal":[51],"angiomatous":[52],"proliferation":[53],"(RAP),":[54],"14":[55],"polypoidal":[57],"vasculopathy":[59],"(PCV)":[60],"4":[62,114],"unclassified":[63],"patients)":[64],"43":[66],"controls":[67],"recruited":[69],"case-control":[72],"study.":[73],"Subretinal":[74],"fibrosis":[75,181,239],"observed":[77,175,194],"45":[79],"absent":[84],"51":[86],"patients.":[88,102,242],"In":[89],"addition,":[90],"(Lucentis)":[95],"therapy":[96],"also":[98,174,224],"evaluated":[99],"Forty-four":[103],"complete":[106],"responders,":[107,111],"48":[108],"partially":[110,200],"only":[113],"did":[116],"not":[117,161,183,218],"respond":[118],"C4a":[127,150,170],"significantly":[131,154],"higher":[132,227],"compared":[136],"controls.":[138],"Further":[139],"analysis":[140],"subgroups":[143],"showed":[144],"that":[145,226],"increased":[155,166,208],"CNV":[159,216],"but":[160,182,217],"RAP":[162,219],"PCV.":[164,221],"Significantly":[165],"subretinal":[180,187,238],"those":[185],"without":[186],"fibrosis.":[188],"Higher":[189],"C3a":[192],"who":[198],"responded":[199],"CONCLUSIONS:":[204],"Our":[205,222],"results":[206,223],"suggest":[207,225],"systemic":[209,230],"activation":[211,232],"may":[233],"increase":[234],"risk":[236]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":6}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
