{"id":"https://openalex.org/W2274792575","doi":"https://doi.org/10.1158/1557-3125.advbc-b035","title":"Abstract B035: Preneoplastic transformation of murine mammary stem cells by aging and inhibition by rapamycin","display_name":"Abstract B035: Preneoplastic transformation of murine mammary stem cells by aging and inhibition by rapamycin","publication_year":2013,"publication_date":"2013-10-01","ids":{"openalex":"https://openalex.org/W2274792575","doi":"https://doi.org/10.1158/1557-3125.advbc-b035","mag":"2274792575"},"language":"en","primary_location":{"id":"doi:10.1158/1557-3125.advbc-b035","doi":"https://doi.org/10.1158/1557-3125.advbc-b035","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1557-3125.advbc-b035","pdf_url":null,"source":{"id":"https://openalex.org/S192067876","display_name":"Molecular Cancer Research","issn_l":"1541-7786","issn":["1541-7786","1557-3125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056931880","display_name":"Lu\u2010Zhe Sun","orcid":"https://orcid.org/0000-0001-7117-4559","observed_orcids":["https://orcid.org/0000-0001-7117-4559"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lu-Zhe Sun","raw_affiliation_strings":["1University of Texas Health Science Center, San Antonio, TX,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Texas Health Science Center, San Antonio, TX,","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045793356","display_name":"Abhik M. Bandyopadhyay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abhik Bandyopadhyay","raw_affiliation_strings":["1University of Texas Health Science Center, San Antonio, TX,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Texas Health Science Center, San Antonio, TX,","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108047154","display_name":"Qiaoxiang Dong","orcid":"https://orcid.org/0000-0003-4003-7919","observed_orcids":["https://orcid.org/0000-0003-4003-7919"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qiaoxiang Dong","raw_affiliation_strings":["1University of Texas Health Science Center, San Antonio, TX,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Texas Health Science Center, San Antonio, TX,","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hui Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Gao","raw_affiliation_strings":["2Wenzhou Medical College, Wenzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Wenzhou Medical College, Wenzhou, China","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114269571","display_name":"Xiang Gu","orcid":"https://orcid.org/0000-0002-2245-7082","observed_orcids":["https://orcid.org/0000-0002-2245-7082"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiang Gu","raw_affiliation_strings":["1University of Texas Health Science Center, San Antonio, TX,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Texas Health Science Center, San Antonio, TX,","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103274171","display_name":"Danhan Wang","orcid":"https://orcid.org/0000-0001-9550-8939","observed_orcids":["https://orcid.org/0000-0001-9550-8939"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Danhan Wang","raw_affiliation_strings":["2Wenzhou Medical College, Wenzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Wenzhou Medical College, Wenzhou, China","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088121330","display_name":"Anqi Wu","orcid":"https://orcid.org/0000-0002-7483-7618","observed_orcids":["https://orcid.org/0000-0002-7483-7618"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Anqi Wu","raw_affiliation_strings":["2Wenzhou Medical College, Wenzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Wenzhou Medical College, Wenzhou, China","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021750559","display_name":"Changjiang Huang","orcid":"https://orcid.org/0000-0001-5137-2136","observed_orcids":["https://orcid.org/0000-0001-5137-2136"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Changjiang Huang","raw_affiliation_strings":["2Wenzhou Medical College, Wenzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Wenzhou Medical College, Wenzhou, China","institution_ids":["https://openalex.org/I27781120"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"11","issue":"10_Supplement","first_page":"B035","last_page":"B035"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.8939999938011169,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.8939999938011169,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.015699999406933784,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.01510000042617321,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mammary-stem-cells","display_name":"mammary stem cells","score":0.9909999966621399},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.9139999747276306},{"id":"https://openalex.org/keywords/rapamycin","display_name":"rapamycin","score":0.8080000281333923},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.6660000085830688},{"id":"https://openalex.org/keywords/mammary-carcinogenesis","display_name":"mammary carcinogenesis","score":0.7400000095367432},{"id":"https://openalex.org/keywords/mammosphere-formation","display_name":"mammosphere formation","score":0.8970000147819519},{"id":"https://openalex.org/keywords/mammary-fat-pad-transplantation","display_name":"mammary fat pad transplantation","score":0.7279999852180481},{"id":"https://openalex.org/keywords/atypical-ductal-hyperplasia","display_name":"atypical ductal hyperplasia","score":0.8980000019073486},{"id":"https://openalex.org/keywords/hyperplasia","display_name":"hyperplasia","score":0.574999988079071},{"id":"https://openalex.org/keywords/mtor-inhibition","display_name":"mTOR inhibition","score":0.6019999980926514},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.4950000047683716},{"id":"https://openalex.org/keywords/c57bl-6-mice","display_name":"C57BL/6 mice","score":0.7860000133514404},{"id":"https://openalex.org/keywords/mammary-gland-regeneration","display_name":"mammary gland regeneration","score":0.5490000247955322}],"concepts":[{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6998925805091858},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6687412261962891},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6352009773254395},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5844071507453918},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5709603428840637},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5291973352432251},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5056900978088379},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.48950040340423584},{"id":"https://openalex.org/C2993273003","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Neoplastic transformation","level":4,"score":0.4635315239429474},{"id":"https://openalex.org/C2778001805","wikidata":"https://www.wikidata.org/wiki/Q189961","display_name":"Mammary gland","level":4,"score":0.46327540278434753},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3794504702091217},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3452123999595642},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3384714126586914},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20459195971488953},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10891807079315186}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1557-3125.advbc-b035","doi":"https://doi.org/10.1158/1557-3125.advbc-b035","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1557-3125.advbc-b035","pdf_url":null,"source":{"id":"https://openalex.org/S192067876","display_name":"Molecular Cancer Research","issn_l":"1541-7786","issn":["1541-7786","1557-3125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2049274172","https://openalex.org/W2283911818","https://openalex.org/W3133186878","https://openalex.org/W3130123102","https://openalex.org/W2741461219","https://openalex.org/W2317868013","https://openalex.org/W2407279003","https://openalex.org/W2508699576","https://openalex.org/W2320466689","https://openalex.org/W2069637351"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"number":[2,47,185,258],"one":[3],"risk":[4],"fact":[5],"for":[6,23,65,212],"breast":[7,32,217],"cancer":[8,230],"is":[9],"aging.":[10],"Recent":[11],"research":[12],"implicated":[13],"that":[14,38,105,175,202,264,352,375],"adult":[15],"mammary":[16,40,90,159,281,418],"stem":[17,419],"cells":[18,347,350,420],"(MaSCs)":[19],"might":[20],"be":[21,43,355,391],"responsible":[22],"the":[24,36,66,106,114,176,208,253,327,356,362,431],"initiation":[25],"and":[26,48,71,80,85,113,169,189,259,292,307,341,348,366,383,423,443],"progression":[27],"of":[28,31,50,68,116,131,186,210,256,298,314,335,416,430],"certain":[29],"types":[30],"cancer.":[33],"We":[34,103],"tested":[35],"hypothesis":[37],"aging-associated":[39,254],"tumorigenesis":[41],"may":[42,354],"due":[44],"to":[45,225,246,361,379,384],"altered":[46,363],"function":[49,72],"MaSCs":[51,117,149,181,204,303],"using":[52,135],"mouse":[53],"models.":[54],"MaSC-enriched":[55],"basal":[56],"cells,":[57],"characterized":[58,286],"by":[59,75,86,111,141,287,301,368,393,421,425],"their":[60],"immunophenotype":[61],"(Lin-CD49fhighCD24med),":[62],"were":[63,284],"utilized":[64],"evaluation":[67],"MaSC":[69,257,294,364,378],"frequency":[70,115],"during":[73],"aging":[74,376,422],"in":[76,87,120,128,156,216,231,318,338,344,437],"vitro":[77,121],"mammosphere":[78],"formation":[79],"3D-ECM":[81,138],"sphere":[82],"differentiation":[83],"assays":[84,122],"vivo":[88,157],"cleared":[89],"fat":[91],"pad":[92],"transplantation":[93],"(IVT)":[94],"as":[95,207],"we":[96,173,234],"reported":[97],"recently":[98],"(Stem":[99],"Cell":[100],"Res.":[101],"2013).":[102],"found":[104,174],"basal-to-luminal":[107],"cell":[108,209,290],"ratios":[109],"analyzed":[110,118],"FACS":[112],"with":[119,125,239,279,326],"increased":[123,293],"steadily":[124],"increasing":[126],"age":[127],"various":[129],"strains":[130],"mice.":[132],"Subsequent":[133,321],"IVT":[134],"mammosphers":[136],"or":[137,145,243,268],"structures":[139],"formed":[140],"young":[142,168,197],"(4":[143],"months)":[144,148],"old":[146,170,180,236],"(28":[147],"derived":[150,304],"from":[151,179,196,305],"C57BL/6":[152,237],"mice":[153,238,309],"showed":[154,310],"similar":[155,164],"functional":[158],"gland":[160],"regenerative":[161],"capacity":[162],"indicating":[163],"self-renewal/differentiation":[165],"ability":[166],"between":[167],"MaSCs.":[171,198],"However,":[172],"regenerated":[177,299],"glands":[178,300],"had":[182],"significantly":[183],"higher":[184],"spontaneous":[187],"hyperplastic":[188,192],"atypical":[190],"ductal":[191],"lesions":[193,317],"than":[194],"those":[195],"These":[199],"findings":[200,262,373],"indicate":[201,263],"aged":[203,280,302],"can":[205,251,390],"serve":[206],"origin":[211],"early":[213,315,386],"neoplastic":[214,316,387],"transformation":[215,415],"tissue.":[218],"Because":[219],"rapamycin":[220,249,273,394],"treatment":[221,250,274],"has":[222],"been":[223],"shown":[224],"ameliorate":[226],"age-related":[227],"pathologies":[228],"including":[229],"murine":[232,417],"models,":[233],"fed":[235],"microencapsulated":[240],"rapamycin-containing":[241],"food":[242],"control":[244,306],"diet":[245],"determine":[247],"whether":[248],"inhibit":[252],"alteration":[255],"function.":[260],"Our":[261],"short-term":[265],"(5-10":[266],"days)":[267],"long-term":[269],"(>":[270],"2":[271],"year)":[272],"reversed":[275],"phenotypic":[276],"changes":[277],"associated":[278],"gland,":[282],"which":[283,389],"mainly":[285],"decreased":[288],"luminal-to-basal":[289],"ratio":[291],"frequency.":[295],"Histological":[296],"analysis":[297,325],"rapamycin-treated":[308,319],"a":[311],"significant":[312],"decrease":[313],"group.":[320],"whole":[322],"genome":[323],"transcriptome":[324],"second":[328],"generation":[329],"sequencing":[330],"revealed":[331],"age-associated":[332],"differential":[333],"expression":[334],"genes":[336],"involved":[337],"immune,":[339],"inflammatory,":[340],"wounding":[342],"responses":[343],"both":[345],"mammosphere-forming":[346],"stromal":[349],"suggesting":[351],"these":[353],"main":[357],"cellular":[358],"processes":[359],"contributing":[360],"phenotypes":[365],"inhibited":[367,392],"rapamycin.":[369,426],"In":[370],"conclusion,":[371],"our":[372],"suggest":[374],"causes":[377],"increase":[380],"its":[381],"pool":[382],"form":[385],"lesions,":[388],"treatment.":[395],"Citation":[396],"Format:":[397],"Lu-Zhe":[398],"Sun,":[399],"Abhik":[400],"Bandyopadhyay,":[401],"Qiaoxiang":[402],"Dong,":[403],"Hui":[404],"Gao,":[405],"Xiang":[406],"Gu,":[407],"Danhan":[408],"Wang,":[409],"Anqi":[410],"Wu,":[411],"Changjiang":[412],"Huang.":[413],"Preneoplastic":[414],"inhibition":[424],"[abstract].":[427],"In:":[428],"Proceedings":[429],"AACR":[432],"Special":[433],"Conference":[434],"on":[435],"Advances":[436],"Breast":[438],"Cancer":[439,456],"Research:":[440],"Genetics,":[441],"Biology,":[442],"Clinical":[444],"Applications;":[445],"Oct":[446],"3-6,":[447],"2013;":[448],"San":[449],"Diego,":[450],"CA.":[451],"Philadelphia":[452],"(PA):":[453],"AACR;":[454],"Mol":[455],"Res":[457],"2013;11(10":[458],"Suppl):Abstract":[459],"nr":[460],"B035.":[461]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
