{"id":"https://openalex.org/W2274747748","doi":null,"title":"SOX7 is downregulated and functions as a tumor suppressive transcription factor in breast cancer","display_name":"SOX7 is downregulated and functions as a tumor suppressive transcription factor in breast cancer","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2274747748","mag":"2274747748"},"language":"en","primary_location":{"id":"pmh:oai:wakespace.lib.wfu.edu:10339/39287","doi":null,"is_oa":false,"landing_page_url":"https://wakespace.lib.wfu.edu/handle/10339/39287","pdf_url":null,"source":{"id":"https://openalex.org/S4377196938","display_name":"WakeSpace Scholarship (Wake Forest University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I47251452","host_organization_name":"Wake Forest University","host_organization_lineage":["https://openalex.org/I47251452"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076510750","display_name":"Daniel B. Stovall","orcid":"https://orcid.org/0000-0001-5739-5080","observed_orcids":["https://orcid.org/0000-0001-5739-5080"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Stovall, Daniel B.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5076510750"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.6815999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.6815999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.14720000326633453,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.042899999767541885,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sox7","display_name":"SOX7","score":0.9990000128746033},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8949999809265137},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.7360000014305115},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.9810000061988831},{"id":"https://openalex.org/keywords/gene-downregulation","display_name":"gene downregulation","score":0.9120000004768372},{"id":"https://openalex.org/keywords/tumor-suppressor-loss","display_name":"tumor suppressor loss","score":0.8009999990463257},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.7639999985694885},{"id":"https://openalex.org/keywords/antiproliferative-therapy","display_name":"antiproliferative therapy","score":0.7059999704360962}],"concepts":[{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6517341732978821},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6441575288772583},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.47980836033821106},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.45088163018226624},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3818487524986267},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35954248905181885},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34866008162498474},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3129071593284607},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20164033770561218},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18649086356163025},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.11128467321395874},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:wakespace.lib.wfu.edu:10339/39287","doi":null,"is_oa":false,"landing_page_url":"https://wakespace.lib.wfu.edu/handle/10339/39287","pdf_url":null,"source":{"id":"https://openalex.org/S4377196938","display_name":"WakeSpace Scholarship (Wake Forest University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I47251452","host_organization_name":"Wake Forest University","host_organization_lineage":["https://openalex.org/I47251452"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":173,"referenced_works":["https://openalex.org/W26028518","https://openalex.org/W101268677","https://openalex.org/W1551940451","https://openalex.org/W1577377935","https://openalex.org/W1582366896","https://openalex.org/W1611419331","https://openalex.org/W1832431561","https://openalex.org/W1921728861","https://openalex.org/W1965581435","https://openalex.org/W1965719589","https://openalex.org/W1966498224","https://openalex.org/W1968204605","https://openalex.org/W1972371148","https://openalex.org/W1975613775","https://openalex.org/W1976149758","https://openalex.org/W1977396924","https://openalex.org/W1978967539","https://openalex.org/W1980039397","https://openalex.org/W1980858003","https://openalex.org/W1986375477","https://openalex.org/W1987459318","https://openalex.org/W1990895545","https://openalex.org/W1991529714","https://openalex.org/W1993889000","https://openalex.org/W1999463736","https://openalex.org/W1999746344","https://openalex.org/W1999851893","https://openalex.org/W2002263141","https://openalex.org/W2005204848","https://openalex.org/W2007149178","https://openalex.org/W2008674168","https://openalex.org/W2008812172","https://openalex.org/W2009584074","https://openalex.org/W2010059199","https://openalex.org/W2012020865","https://openalex.org/W2013008691","https://openalex.org/W2013246689","https://openalex.org/W2013912082","https://openalex.org/W2014665031","https://openalex.org/W2020486699","https://openalex.org/W2022584463","https://openalex.org/W2023002592","https://openalex.org/W2023671527","https://openalex.org/W2023694015","https://openalex.org/W2025203479","https://openalex.org/W2028236537","https://openalex.org/W2030406325","https://openalex.org/W2030613909","https://openalex.org/W2032968455","https://openalex.org/W2033355083","https://openalex.org/W2035315325","https://openalex.org/W2037631027","https://openalex.org/W2037950862","https://openalex.org/W2038783205","https://openalex.org/W2038831321","https://openalex.org/W2040102705","https://openalex.org/W2041509376","https://openalex.org/W2041541046","https://openalex.org/W2044303467","https://openalex.org/W2045245489","https://openalex.org/W2047333953","https://openalex.org/W2047529648","https://openalex.org/W2048142144","https://openalex.org/W2048162805","https://openalex.org/W2048353182","https://openalex.org/W2049526761","https://openalex.org/W2049774540","https://openalex.org/W2054307558","https://openalex.org/W2055751544","https://openalex.org/W2056302937","https://openalex.org/W2057559260","https://openalex.org/W2058443035","https://openalex.org/W2059359776","https://openalex.org/W2059706311","https://openalex.org/W2063519617","https://openalex.org/W2070777085","https://openalex.org/W2071271349","https://openalex.org/W2071517371","https://openalex.org/W2074189902","https://openalex.org/W2075439298","https://openalex.org/W2080154785","https://openalex.org/W2083381199","https://openalex.org/W2084400739","https://openalex.org/W2086415805","https://openalex.org/W2086831875","https://openalex.org/W2087377443","https://openalex.org/W2088017477","https://openalex.org/W2090757807","https://openalex.org/W2091161969","https://openalex.org/W2097255042","https://openalex.org/W2097627545","https://openalex.org/W2098285533","https://openalex.org/W2100192772","https://openalex.org/W2100841018","https://openalex.org/W2100927775","https://openalex.org/W2101039596","https://openalex.org/W2101410152","https://openalex.org/W2101427112","https://openalex.org/W2101722758","https://openalex.org/W2102304447","https://openalex.org/W2103211592","https://openalex.org/W2103619902","https://openalex.org/W2106292881","https://openalex.org/W2106554405","https://openalex.org/W2107277218","https://openalex.org/W2110510042","https://openalex.org/W2111181435","https://openalex.org/W2112001233","https://openalex.org/W2113209482","https://openalex.org/W2115367680","https://openalex.org/W2116044467","https://openalex.org/W2116236561","https://openalex.org/W2117357260","https://openalex.org/W2117480088","https://openalex.org/W2117692326","https://openalex.org/W2119284420","https://openalex.org/W2119507443","https://openalex.org/W2120433843","https://openalex.org/W2121245760","https://openalex.org/W2121665346","https://openalex.org/W2122431346","https://openalex.org/W2122890549","https://openalex.org/W2126504590","https://openalex.org/W2130445581","https://openalex.org/W2130733741","https://openalex.org/W2130979840","https://openalex.org/W2131515610","https://openalex.org/W2131596261","https://openalex.org/W2131994307","https://openalex.org/W2135548733","https://openalex.org/W2135810600","https://openalex.org/W2135836598","https://openalex.org/W2136725005","https://openalex.org/W2137986693","https://openalex.org/W2138125744","https://openalex.org/W2139444209","https://openalex.org/W2140047153","https://openalex.org/W2141393790","https://openalex.org/W2141831115","https://openalex.org/W2142735201","https://openalex.org/W2143188916","https://openalex.org/W2144510218","https://openalex.org/W2145802624","https://openalex.org/W2146573461","https://openalex.org/W2146900615","https://openalex.org/W2148629421","https://openalex.org/W2148929244","https://openalex.org/W2149162919","https://openalex.org/W2152278958","https://openalex.org/W2152746477","https://openalex.org/W2153206149","https://openalex.org/W2154918211","https://openalex.org/W2155127143","https://openalex.org/W2155735026","https://openalex.org/W2155979487","https://openalex.org/W2157132094","https://openalex.org/W2163287575","https://openalex.org/W2163363238","https://openalex.org/W2164457061","https://openalex.org/W2166810745","https://openalex.org/W2166967514","https://openalex.org/W2167198607","https://openalex.org/W2167281518","https://openalex.org/W2169344919","https://openalex.org/W2169666080","https://openalex.org/W2170602872","https://openalex.org/W2180507994","https://openalex.org/W2183350970","https://openalex.org/W2237040806","https://openalex.org/W2411906342","https://openalex.org/W2416393887","https://openalex.org/W4251640819","https://openalex.org/W4300131722"],"related_works":["https://openalex.org/W2330528678","https://openalex.org/W2122431346","https://openalex.org/W2563104755","https://openalex.org/W4239409080","https://openalex.org/W2802887171","https://openalex.org/W2910525070","https://openalex.org/W3031501279","https://openalex.org/W7071403181","https://openalex.org/W2329165505","https://openalex.org/W2789449468"],"abstract_inverted_index":{"Second":[0],"only":[1],"to":[2,34,68],"lung":[3],"cancer,":[4],"breast":[5,55],"cancer":[6,18,56],"is":[7,19],"the":[8,35,60,69],"leading":[9,33],"cause":[10],"of":[11,23,37,41,51,62,71],"cancer-related":[12],"deaths":[13],"in":[14,54],"American":[15],"women.":[16],"Breast":[17],"a":[20,49],"heterogeneous":[21],"set":[22],"diseases":[24],"characterized":[25],"by":[26],"aberrant":[27],"genetic":[28],"and":[29],"epigenetic":[30],"states,":[31],"often":[32],"ablation":[36],"tumor":[38,42,63,79],"suppressors.":[39],"Loss":[40],"suppressor":[43,64,80],"function":[44,81],"has":[45],"been":[46],"established":[47],"as":[48],"driver":[50],"disease":[52],"progression":[53],"patients.":[57],"Thus,":[58],"understanding":[59],"deregulation":[61],"activity":[65],"may":[66],"lead":[67],"identification":[70],"potential":[72],"therapeutic":[73],"targets":[74],"whose":[75],"inhibition":[76],"can":[77],"restore":[78],"and,":[82],"consequently,":[83],"an":[84],"anti-proliferative":[85],"cellular":[86],"state.":[87]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}
