{"id":"https://openalex.org/W2274148752","doi":null,"title":"The determination of tryptophan in plasma, liver, and urine.","display_name":"The determination of tryptophan in plasma, liver, and urine.","publication_year":1967,"publication_date":"1967-01-01","ids":{"openalex":"https://openalex.org/W2274148752","mag":"2274148752","pmid":"https://pubmed.ncbi.nlm.nih.gov/6018066"},"language":"en","primary_location":{"id":"pmid:6018066","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6018066","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of laboratory and clinical medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004623194","display_name":"W D Denckla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W D Denckla","raw_affiliation_strings":["From the Cancer Research Institute, New England Deaconess Hospital Boston, Mass. USA","From the Department of Biological Chemistry, Harvard Medical School, Boston, Mass. USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cancer Research Institute, New England Deaconess Hospital Boston, Mass. USA","institution_ids":[]},{"raw_affiliation_string":"From the Department of Biological Chemistry, Harvard Medical School, Boston, Mass. USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080750939","display_name":"Henry K. Dewey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H K Dewey","raw_affiliation_strings":["From the Cancer Research Institute, New England Deaconess Hospital Boston, Mass. USA","From the Department of Biological Chemistry, Harvard Medical School, Boston, Mass. USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cancer Research Institute, New England Deaconess Hospital Boston, Mass. USA","institution_ids":[]},{"raw_affiliation_string":"From the Department of Biological Chemistry, Harvard Medical School, Boston, Mass. USA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I136199984"],"apc_list":null,"apc_paid":null,"fwci":4.797,"has_fulltext":false,"cited_by_count":823,"citation_normalized_percentile":{"value":0.96039604,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"69","issue":"1","first_page":"160","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.6753000020980835,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.6753000020980835,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.23240000009536743,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.03500000014901161,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tryptophan","display_name":"tryptophan","score":0.9340000152587891},{"id":"https://openalex.org/keywords/norharmane","display_name":"norharman","score":0.7839999794960022},{"id":"https://openalex.org/keywords/fluorometric-assay","display_name":"fluorometric assay","score":0.953000009059906},{"id":"https://openalex.org/keywords/tryptamine","display_name":"tryptamine","score":0.7319999933242798},{"id":"https://openalex.org/keywords/plasma","display_name":"plasma","score":0.8489999771118164},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.9509999752044678},{"id":"https://openalex.org/keywords/urine","display_name":"urine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/amino-acid-analysis","display_name":"amino acid analysis","score":0.6779999732971191},{"id":"https://openalex.org/keywords/fluorescence","display_name":"fluorescence","score":0.5059999823570251}],"concepts":[{"id":"https://openalex.org/C2776706248","wikidata":"https://www.wikidata.org/wiki/Q181003","display_name":"Tryptophan","level":3,"score":0.9115305542945862},{"id":"https://openalex.org/C37160838","wikidata":"https://www.wikidata.org/wiki/Q427601","display_name":"Cuvette","level":2,"score":0.8929526805877686},{"id":"https://openalex.org/C2777135210","wikidata":"https://www.wikidata.org/wiki/Q409439","display_name":"Tryptamine","level":2,"score":0.8330270051956177},{"id":"https://openalex.org/C2778617687","wikidata":"https://www.wikidata.org/wiki/Q2448456","display_name":"Fluorophore","level":3,"score":0.7719550132751465},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7163935899734497},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.6756293773651123},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.6457613110542297},{"id":"https://openalex.org/C40875361","wikidata":"https://www.wikidata.org/wiki/Q2356542","display_name":"Reagent","level":2,"score":0.5551431775093079},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.4708896279335022},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2723081707954407},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.08672928810119629},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.06615811586380005},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005470","descriptor_name":"Fluorometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D014364","descriptor_name":"Tryptophan","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D014364","descriptor_name":"Tryptophan","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014364","descriptor_name":"Tryptophan","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:6018066","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6018066","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of laboratory and clinical medicine","raw_type":"Journal Article"},{"id":"mag:2274148752","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6018066","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W3736467","https://openalex.org/W35745114","https://openalex.org/W62964809","https://openalex.org/W96453855","https://openalex.org/W146927540","https://openalex.org/W158978002","https://openalex.org/W161524209","https://openalex.org/W346003294","https://openalex.org/W1480053029","https://openalex.org/W1532308271","https://openalex.org/W1547203551","https://openalex.org/W1993109186","https://openalex.org/W1995998413","https://openalex.org/W2001359999","https://openalex.org/W2001709584","https://openalex.org/W2008663663","https://openalex.org/W2071359038","https://openalex.org/W2091353341","https://openalex.org/W2106130994","https://openalex.org/W2147155062","https://openalex.org/W2254503714","https://openalex.org/W2338043748","https://openalex.org/W2946151597"],"related_works":["https://openalex.org/W1991069509","https://openalex.org/W1986054123","https://openalex.org/W2254503714","https://openalex.org/W2000645036","https://openalex.org/W1979216866","https://openalex.org/W1850297644","https://openalex.org/W2263271936","https://openalex.org/W1845518215","https://openalex.org/W2355701287","https://openalex.org/W2106077606"],"abstract_inverted_index":{"Abstract":[0],"A":[2],"fluorometric":[3],"method":[4,66],"for":[5,103,112],"the":[6,18,21,29,65,71,82,100],"measurement":[7,30,49],"of":[8,20,31,36,48,64,70,81,85],"tryptophan":[9,37,58],"in":[10,38,59,99],"biological":[11,60],"materials":[12],"has":[13],"been":[14],"developed":[15],"based":[16],"on":[17],"formation":[19],"fluorophore":[22,95],"norharman.":[23],"The":[24,45,62,87,94],"sensitivity":[25],"and":[26,106],"range":[27],"permit":[28],"0.04":[32],"to":[33],"20":[34],"nmoles":[35],"standard":[39,46],"1":[40,104],"cm.":[41],"2":[42,115],"cuvettes.":[44],"deviation":[47],"is":[50,67,97],"less":[51],"than":[52],"3":[53],"per":[54,92],"cent":[55],"when":[56],"determining":[57],"materials.":[61],"specificity":[63],"such":[68],"that,":[69],"compounds":[72],"tested,":[73],"only":[74],"tryptamine":[75],"produces":[76],"appreciable":[77],"fluorescence:":[78],"one":[79],"tenth":[80],"molar":[83],"fluorescence":[84],"tryptophan.":[86],"simplicity":[88],"permits":[89],"60":[90],"determinations":[91],"day.":[93],"produced":[96],"stable":[98,111],"assay":[101],"solution":[102],"week":[105],"all":[107],"reagents":[108],"used":[109],"are":[110],"at":[113],"least":[114],"months.":[116]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}