{"id":"https://openalex.org/W2274052111","doi":"https://doi.org/10.1096/fasebj.21.6.a841-c","title":"The Obese Diabetic Zucker fa/fa Rat has higher urinary nitric oxide levels compared to their lean littermates.","display_name":"The Obese Diabetic Zucker fa/fa Rat has higher urinary nitric oxide levels compared to their lean littermates.","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2274052111","doi":"https://doi.org/10.1096/fasebj.21.6.a841-c","mag":"2274052111"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.21.6.a841-c","doi":"https://doi.org/10.1096/fasebj.21.6.a841-c","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.6.a841-c","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012970497","display_name":"Sharon R. Inman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106879","display_name":"Ohio University","ror":"https://ror.org/01jr3y717","country_code":"US","type":"education","lineage":["https://openalex.org/I4210106879"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharon R Inman","raw_affiliation_strings":["Biomedical Sciences, Ohio University, 338 Irvine, Athens, OH, 45701"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Sciences, Ohio University, 338 Irvine, Athens, OH, 45701","institution_ids":["https://openalex.org/I4210106879"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051140861","display_name":"Mary Koloze","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106879","display_name":"Ohio University","ror":"https://ror.org/01jr3y717","country_code":"US","type":"education","lineage":["https://openalex.org/I4210106879"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary Koloze","raw_affiliation_strings":["Biomedical Sciences, Ohio University, 338 Irvine, Athens, OH, 45701"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Sciences, Ohio University, 338 Irvine, Athens, OH, 45701","institution_ids":["https://openalex.org/I4210106879"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Marcus Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106879","display_name":"Ohio University","ror":"https://ror.org/01jr3y717","country_code":"US","type":"education","lineage":["https://openalex.org/I4210106879"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcus Johnson","raw_affiliation_strings":["Biomedical Sciences, Ohio University, 338 Irvine, Athens, OH, 45701"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Sciences, Ohio University, 338 Irvine, Athens, OH, 45701","institution_ids":["https://openalex.org/I4210106879"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005780035","display_name":"Edwin Kerry Jackson","orcid":"https://orcid.org/0000-0002-8101-6009","observed_orcids":["https://orcid.org/0000-0002-8101-6009"]},"institutions":[{"id":"https://openalex.org/I4210106879","display_name":"Ohio University","ror":"https://ror.org/01jr3y717","country_code":"US","type":"education","lineage":["https://openalex.org/I4210106879"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edwin Jackson","raw_affiliation_strings":["Biomedical Sciences, Ohio University, 338 Irvine, Athens, OH, 45701"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Sciences, Ohio University, 338 Irvine, Athens, OH, 45701","institution_ids":["https://openalex.org/I4210106879"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060735154","display_name":"Felicia V. Nowak","orcid":"https://orcid.org/0000-0001-8601-3619","observed_orcids":["https://orcid.org/0000-0001-8601-3619"]},"institutions":[{"id":"https://openalex.org/I4210106879","display_name":"Ohio University","ror":"https://ror.org/01jr3y717","country_code":"US","type":"education","lineage":["https://openalex.org/I4210106879"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Felicia V Nowak","raw_affiliation_strings":["Biomedical Sciences, Ohio University, 338 Irvine, Athens, OH, 45701"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Sciences, Ohio University, 338 Irvine, Athens, OH, 45701","institution_ids":["https://openalex.org/I4210106879"]}]},{"author_position":"last","author":{"id":null,"display_name":"Jennifer Yee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106879","display_name":"Ohio University","ror":"https://ror.org/01jr3y717","country_code":"US","type":"education","lineage":["https://openalex.org/I4210106879"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Yee","raw_affiliation_strings":["Biomedical Sciences, Ohio University, 338 Irvine, Athens, OH, 45701"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Sciences, Ohio University, 338 Irvine, Athens, OH, 45701","institution_ids":["https://openalex.org/I4210106879"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210106879"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.27562855,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.8140000104904175,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.8140000104904175,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.16300000250339508,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9580000042915344},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.8790000081062317},{"id":"https://openalex.org/keywords/obese-zucker-rats","display_name":"Zucker fatty rats","score":0.609000027179718},{"id":"https://openalex.org/keywords/glomerular-filtration-rate","display_name":"glomerular filtration rate","score":0.8450000286102295},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.7279999852180481},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.7979999780654907},{"id":"https://openalex.org/keywords/blood-glucose","display_name":"blood glucose","score":0.7120000123977661},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7450000047683716},{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.5690000057220459},{"id":"https://openalex.org/keywords/nitric-oxide-synthase","display_name":"nitric oxide synthase","score":0.9380000233650208},{"id":"https://openalex.org/keywords/diabetic-nephropathy","display_name":"diabetic nephropathy","score":0.7149999737739563},{"id":"https://openalex.org/keywords/iohexol-clearance","display_name":"iohexol clearance","score":0.828000009059906}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7471598982810974},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.7301985621452332},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.7217801809310913},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7189188003540039},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.6888241767883301},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6853344440460205},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.643610417842865},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.5456891059875488},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.5020711421966553},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.47351789474487305},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.44000041484832764}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.21.6.a841-c","doi":"https://doi.org/10.1096/fasebj.21.6.a841-c","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.6.a841-c","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2060006528","https://openalex.org/W154197903","https://openalex.org/W2250443404","https://openalex.org/W2170131862","https://openalex.org/W2129347273","https://openalex.org/W2281464928","https://openalex.org/W2141990221","https://openalex.org/W2083067028","https://openalex.org/W2601450114","https://openalex.org/W2024735097"],"abstract_inverted_index":{"Diabetes":[0],"is":[1,21,36,198,230,243],"reaching":[2],"epidemic":[3],"proportions,":[4],"with":[5,17,73],"a":[6,30,37,66,231],"worldwide":[7],"prevalence":[8],"of":[9,25,46,104,157,166,179,186,203,214,240,258],"150":[10],"million":[11],"persons.":[12],"Renal":[13,75],"disease":[14],"in":[15,43,96,118,135,142,150,155,189,219],"patients":[16,191],"type":[18,47,69],"2":[19,48,70],"diabetes":[20,71],"the":[22,44,53,60,119,126,130,136,143,148,164,184,201,212,254],"leading":[23],"cause":[24],"terminal":[26],"renal":[27,209],"failure":[28],"and":[29,52,89,99,110,115,122,168,172,211,222],"major":[31],"health":[32],"care":[33],"problem.":[34],"There":[35],"need":[38],"to":[39,55,125,163,182,199,226,235,244,252],"explore":[40],"gender":[41,232],"differences":[42],"progression":[45],"diabetes,":[49],"its":[50],"complications,":[51],"response":[54,234],"therapy.":[56,236],"We":[57],"are":[58],"using":[59],"obese":[61,120,137,144],"Zucker":[62,224],"(fa/fa)":[63],"rat":[64],"as":[65,82],"model":[67],"for":[68],"associated":[72],"obesity.":[74],"function,":[76],"including":[77],"glomerular":[78],"filtration":[79],"rate":[80],"(GFR)":[81],"measured":[83,95],"by":[84],"iohexol":[85],"clearance,":[86],"plasma":[87],"glucose":[88,109,134],"urinary":[90],"nitric":[91,158,215],"oxide":[92,159,216],"levels":[93,156],"were":[94,113,147],"both":[97,151],"males":[98,121],"females":[100,123,138],"at":[101],"20":[102],"weeks":[103],"age.":[105],"Body":[106],"weight,":[107],"blood":[108,111,133],"pressure":[112],"increased,":[114],"GFRs":[116,146],"decreased,":[117],"compared":[124],"lean":[127],"controls.":[128],"Despite":[129],"fact":[131],"that":[132,141,248],"was":[139],"half":[140],"males,":[145],"same":[149],"these":[152,241],"groups.":[153],"Alterations":[154],"(NO)":[160],"can":[161],"lead":[162],"formation":[165],"peroxynitrites":[167],"potent":[169],"reactive":[170],"oxygen":[171],"nitrogen":[173],"species.":[174],"Therefore,":[175],"an":[176,204],"optimal":[177],"combination":[178],"antioxidant":[180,205],"nutrients":[181],"alleviate":[183],"burden":[185],"oxidative":[187],"stress":[188],"diabetic":[190,220],"would":[192],"be":[193],"beneficial.":[194],"Our":[195],"next":[196],"step":[197],"examine":[200],"effect":[202],"fortified":[206],"diet":[207],"on":[208],"function":[210],"expression":[213],"synthases":[217],"(NOSs)":[218],"male":[221],"female":[223],"rats,":[225],"determine":[227],"if":[228],"there":[229],"related":[233],"The":[237],"ultimate":[238],"goal":[239],"studies":[242],"establish":[245],"better":[246],"therapies":[247],"may":[249],"include":[250],"antioxidants,":[251],"prevent":[253],"long":[255],"term":[256],"complications":[257],"diabetes.":[259]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}