{"id":"https://openalex.org/W2274045923","doi":"https://doi.org/10.4172/2168-9296.1000e112","title":"Flying with Flies: Decoding Human Neurodegenerative Disorders in DrosophilaC","display_name":"Flying with Flies: Decoding Human Neurodegenerative Disorders in DrosophilaC","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2274045923","doi":"https://doi.org/10.4172/2168-9296.1000e112","mag":"2274045923"},"language":"en","primary_location":{"id":"doi:10.4172/2168-9296.1000e112","doi":"https://doi.org/10.4172/2168-9296.1000e112","is_oa":false,"landing_page_url":"https://doi.org/10.4172/2168-9296.1000e112","pdf_url":null,"source":{"id":"https://openalex.org/S2765057867","display_name":"Cell & Developmental Biology","issn_l":"2168-9296","issn":["2168-9296"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320466","host_organization_name":"OMICS Publishing Group","host_organization_lineage":["https://openalex.org/P4310320466"],"host_organization_lineage_names":["OMICS Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell & Developmental Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018968344","display_name":"Surajit Sarkar","orcid":"https://orcid.org/0000-0001-6861-2271","observed_orcids":["https://orcid.org/0000-0001-6861-2271"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Surajit Sarkar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5018968344"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4319,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.51687975,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"01","issue":"05","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.5791000127792358,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.5791000127792358,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.24619999527931213,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.03400000184774399,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.9449999928474426},{"id":"https://openalex.org/keywords/drosophila-melanogaster","display_name":"Drosophila melanogaster","score":0.8759999871253967},{"id":"https://openalex.org/keywords/model-organisms","display_name":"model organisms","score":0.4580000042915344},{"id":"https://openalex.org/keywords/huntington-s-disease","display_name":"Huntington's disease","score":0.972000002861023},{"id":"https://openalex.org/keywords/dentatorubral-pallidoluysian-atrophy","display_name":"dentatorubral-pallidoluysian atrophy","score":0.9559999704360962},{"id":"https://openalex.org/keywords/spinal-and-bulbar-muscular-atrophy","display_name":"spinal and bulbar muscular atrophy","score":0.972000002861023},{"id":"https://openalex.org/keywords/spinocerebellar-ataxia","display_name":"spinocerebellar ataxia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9950000047683716},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neuronal-loss","display_name":"neuronal loss","score":0.4519999921321869}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.535648763179779},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4562891125679016},{"id":"https://openalex.org/C57273362","wikidata":"https://www.wikidata.org/wiki/Q576722","display_name":"Decoding methods","level":2,"score":0.4145370423793793},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4088192284107208},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.35728365182876587},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.14225584268569946},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.4172/2168-9296.1000e112","doi":"https://doi.org/10.4172/2168-9296.1000e112","is_oa":false,"landing_page_url":"https://doi.org/10.4172/2168-9296.1000e112","pdf_url":null,"source":{"id":"https://openalex.org/S2765057867","display_name":"Cell & Developmental Biology","issn_l":"2168-9296","issn":["2168-9296"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320466","host_organization_name":"OMICS Publishing Group","host_organization_lineage":["https://openalex.org/P4310320466"],"host_organization_lineage_names":["OMICS Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell & Developmental Biology","raw_type":"journal-article"},{"id":"mag:2184188126","doi":null,"is_oa":false,"landing_page_url":"https://www.omicsgroup.org/journals/2168-9296/2168-9296-1-e112.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1533261981","https://openalex.org/W1592633314","https://openalex.org/W1969230606","https://openalex.org/W1971858157","https://openalex.org/W1980296810","https://openalex.org/W1988638938","https://openalex.org/W2007425620","https://openalex.org/W2015210211","https://openalex.org/W2015363763","https://openalex.org/W2035718469","https://openalex.org/W2047304481","https://openalex.org/W2054922779","https://openalex.org/W2061627162","https://openalex.org/W2084406437","https://openalex.org/W2106473141","https://openalex.org/W2110643873","https://openalex.org/W2131802378","https://openalex.org/W2141299299","https://openalex.org/W2142768713","https://openalex.org/W2145631524","https://openalex.org/W2152841877","https://openalex.org/W2160627717","https://openalex.org/W2166443571","https://openalex.org/W2169831780","https://openalex.org/W4301938208"],"related_works":["https://openalex.org/W2184188126","https://openalex.org/W1965909831","https://openalex.org/W4298444765","https://openalex.org/W2056238825","https://openalex.org/W2016729207","https://openalex.org/W1920415906","https://openalex.org/W2320295897","https://openalex.org/W2210338528","https://openalex.org/W7099874904","https://openalex.org/W2015210211"],"abstract_inverted_index":{"Human":[0],"neurodegenerative":[1,60,80,127],"diseases":[2,81,106,111,128,141],"are":[3,44,87,112,116,137,143],"traumatic":[4],"illnesses":[5],"characterized":[6],"by":[7],"progressive":[8],"loss":[9],"of":[10,15,33,39,42,54,58,68,78,85,109,125,150,171],"neurons":[11],"in":[12,27,139,148,155,160,166,169],"specific":[13,135],"areas":[14],"brain":[16,151],"resulting":[17],"locomotors":[18],"imbalance,":[19],"resting":[20],"tremor,":[21],"abnormal":[22],"gait,":[23],"dementia":[24],"and":[25,47,95,104,115,163],"defects":[26],"cognitive":[28],"thinking":[29],"[1].":[30],"This":[31],"group":[32],"disorders":[34,61],"exhibit":[35,129],"highly":[36],"comparable":[37],"manifestation":[38],"symptoms,":[40],"majority":[41,124],"which":[43,142],"adult":[45],"onset":[46],"do":[48],"not":[49],"manifest":[50],"during":[51],"early":[52],"stages":[53],"life.":[55],"Thus,":[56],"prevalence":[57],"most":[59],"increased":[62],"drastically":[63],"since":[64],"average":[65],"life":[66],"expectancy":[67],"world":[69],"population":[70,86],"extends":[71],"into":[72],"the":[73,79,126],"eight":[74],"decade":[75],"[2].":[76],"Some":[77],"affecting":[82],"large":[83],"number":[84],"Huntington\u2019s":[88,156],"disease":[89,162,173],"(HD),":[90],"Dentatorubral-Pallidoluysian":[91],"Atrophy":[92,98],"(DRPLA),":[93],"Spinal":[94],"Bulbar":[96],"Muscular":[97],"(SBMA),":[99],"Spinocerebellar":[100],"Ataxia":[101],"(SCA),":[102],"Alzheimer\u2019s":[103,161],"Parkinson\u2019s":[105,172],"etc.":[107],"[1].Most":[108],"these":[110],"dominantly":[113],"inherited":[114],"passed":[117],"from":[118],"generation":[119],"to":[120,146],"generation.":[121],"Interestingly,":[122],"although":[123],"overlapping":[130],"clinical":[131],"manifestations,":[132],"some":[133],"very":[134],"symptoms":[136],"prevalent":[138],"different":[140],"primarily":[144],"due":[145],"variances":[147],"part":[149],"affected;":[152],"basal":[153],"ganglia":[154],"disease,":[157],"cortical":[158],"region":[159],"dopaminergic":[164],"neuron":[165],"substantia":[167],"nigra":[168],"case":[170],"[3].":[174]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}