{"id":"https://openalex.org/W2273708684","doi":"https://doi.org/10.18632/oncotarget.7070","title":"The energy sensor AMPK regulates Hedgehog signaling in human cells through a unique Gli1 metabolic checkpoint","display_name":"The energy sensor AMPK regulates Hedgehog signaling in human cells through a unique Gli1 metabolic checkpoint","publication_year":2016,"publication_date":"2016-01-29","ids":{"openalex":"https://openalex.org/W2273708684","doi":"https://doi.org/10.18632/oncotarget.7070","mag":"2273708684","pmid":"https://pubmed.ncbi.nlm.nih.gov/26843621","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4891058"},"language":"en","primary_location":{"id":"doi:10.18632/oncotarget.7070","doi":"https://doi.org/10.18632/oncotarget.7070","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.7070","pdf_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=7070&path%5B%5D=20104","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=7070&path%5B%5D=20104","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000313152","display_name":"Laura Di Magno","orcid":"https://orcid.org/0000-0001-9446-8752","observed_orcids":["https://orcid.org/0000-0001-9446-8752"]},"institutions":[{"id":"https://openalex.org/I30771326","display_name":"Italian Institute of Technology","ror":"https://ror.org/042t93s57","country_code":"IT","type":"facility","lineage":["https://openalex.org/I30771326"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Laura Di Magno","raw_affiliation_strings":["Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, 00161 Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, 00161 Roma, Italy","institution_ids":["https://openalex.org/I30771326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020834202","display_name":"Alessio Basile","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessio Basile","raw_affiliation_strings":["Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012455396","display_name":"Sonia Coni","orcid":"https://orcid.org/0000-0002-0295-8904","observed_orcids":["https://orcid.org/0000-0002-0295-8904"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sonia Coni","raw_affiliation_strings":["Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071908701","display_name":"Simona Manni","orcid":"https://orcid.org/0000-0003-1845-6674","observed_orcids":["https://orcid.org/0000-0003-1845-6674"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Simona Manni","raw_affiliation_strings":["Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078286059","display_name":"Giulia Sdruscia","orcid":"https://orcid.org/0000-0001-9423-4286","observed_orcids":["https://orcid.org/0000-0001-9423-4286"]},"institutions":[{"id":"https://openalex.org/I30771326","display_name":"Italian Institute of Technology","ror":"https://ror.org/042t93s57","country_code":"IT","type":"facility","lineage":["https://openalex.org/I30771326"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giulia Sdruscia","raw_affiliation_strings":["Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, 00161 Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, 00161 Roma, Italy","institution_ids":["https://openalex.org/I30771326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011226747","display_name":"Davide Francesco D'Amico","orcid":"https://orcid.org/0000-0002-8499-9514","observed_orcids":["https://orcid.org/0000-0002-8499-9514"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Davide D\u2019Amico","raw_affiliation_strings":["Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001192190","display_name":"Laura Antonucci","orcid":"https://orcid.org/0000-0001-8965-2432","observed_orcids":["https://orcid.org/0000-0001-8965-2432"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Laura Antonucci","raw_affiliation_strings":["Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012691987","display_name":"Paola Infante","orcid":"https://orcid.org/0000-0003-0682-3916","observed_orcids":["https://orcid.org/0000-0003-0682-3916"]},"institutions":[{"id":"https://openalex.org/I30771326","display_name":"Italian Institute of Technology","ror":"https://ror.org/042t93s57","country_code":"IT","type":"facility","lineage":["https://openalex.org/I30771326"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paola Infante","raw_affiliation_strings":["Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, 00161 Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, 00161 Roma, Italy","institution_ids":["https://openalex.org/I30771326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004885916","display_name":"Enrico De Smaele","orcid":"https://orcid.org/0000-0003-4524-4423","observed_orcids":["https://orcid.org/0000-0003-4524-4423"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Enrico De Smaele","raw_affiliation_strings":["Department of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049174055","display_name":"Danilo Cucchi","orcid":"https://orcid.org/0000-0002-9934-510X","observed_orcids":["https://orcid.org/0000-0002-9934-510X"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Danilo Cucchi","raw_affiliation_strings":["Department of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037100565","display_name":"Elisabetta Ferretti","orcid":"https://orcid.org/0000-0001-7265-6429","observed_orcids":["https://orcid.org/0000-0001-7265-6429"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elisabetta Ferretti","raw_affiliation_strings":["Department of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044346256","display_name":"Lucia Di Marcotullio","orcid":"https://orcid.org/0000-0003-0274-7178","observed_orcids":["https://orcid.org/0000-0003-0274-7178"]},"institutions":[{"id":"https://openalex.org/I30771326","display_name":"Italian Institute of Technology","ror":"https://ror.org/042t93s57","country_code":"IT","type":"facility","lineage":["https://openalex.org/I30771326"]},{"id":"https://openalex.org/I4210153523","display_name":"Istituto Pasteur","ror":"https://ror.org/051v7w268","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210153523"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lucia Di Marcotullio","raw_affiliation_strings":["Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, 00161 Roma, Italy","Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy","Istituto Pasteur, Fondazione Cenci-Bolognetti, Sapienza University of Rome, 00161 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, 00161 Roma, Italy","institution_ids":["https://openalex.org/I30771326"]},{"raw_affiliation_string":"Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"Istituto Pasteur, Fondazione Cenci-Bolognetti, Sapienza University of Rome, 00161 Rome, Italy","institution_ids":["https://openalex.org/I4210153523","https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047735457","display_name":"Isabella Screpanti","orcid":"https://orcid.org/0000-0001-8071-9098","observed_orcids":["https://orcid.org/0000-0001-8071-9098"]},"institutions":[{"id":"https://openalex.org/I30771326","display_name":"Italian Institute of Technology","ror":"https://ror.org/042t93s57","country_code":"IT","type":"facility","lineage":["https://openalex.org/I30771326"]},{"id":"https://openalex.org/I4210153523","display_name":"Istituto Pasteur","ror":"https://ror.org/051v7w268","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210153523"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Isabella Screpanti","raw_affiliation_strings":["Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, 00161 Roma, Italy","Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy","Istituto Pasteur, Fondazione Cenci-Bolognetti, Sapienza University of Rome, 00161 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, 00161 Roma, Italy","institution_ids":["https://openalex.org/I30771326"]},{"raw_affiliation_string":"Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"Istituto Pasteur, Fondazione Cenci-Bolognetti, Sapienza University of Rome, 00161 Rome, Italy","institution_ids":["https://openalex.org/I4210153523","https://openalex.org/I861853513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052670103","display_name":"Gianluca Canettieri","orcid":"https://orcid.org/0000-0001-6694-2613","observed_orcids":["https://orcid.org/0000-0001-6694-2613"]},"institutions":[{"id":"https://openalex.org/I4210153523","display_name":"Istituto Pasteur","ror":"https://ror.org/051v7w268","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210153523"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Gianluca Canettieri","raw_affiliation_strings":["Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy","Istituto Pasteur, Fondazione Cenci-Bolognetti, Sapienza University of Rome, 00161 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"Istituto Pasteur, Fondazione Cenci-Bolognetti, Sapienza University of Rome, 00161 Rome, Italy","institution_ids":["https://openalex.org/I4210153523","https://openalex.org/I861853513"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5052670103"],"corresponding_institution_ids":["https://openalex.org/I4210153523","https://openalex.org/I861853513"],"apc_list":null,"apc_paid":null,"fwci":2.9447,"has_fulltext":true,"cited_by_count":47,"citation_normalized_percentile":{"value":0.9180586,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"7","issue":"8","first_page":"9538","last_page":"9549"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ampk","display_name":"AMPK","score":0.9739999771118164},{"id":"https://openalex.org/keywords/hedgehog-signaling","display_name":"Hedgehog signaling","score":0.9480000138282776},{"id":"https://openalex.org/keywords/gli1","display_name":"Gli1","score":0.9810000061988831},{"id":"https://openalex.org/keywords/proteasomal-degradation","display_name":"proteasomal degradation","score":0.8489999771118164},{"id":"https://openalex.org/keywords/medulloblastoma","display_name":"medulloblastoma","score":0.9070000052452087},{"id":"https://openalex.org/keywords/cerebellar-granule-cell-precursors","display_name":"cerebellar granule cell precursors","score":0.9750000238418579},{"id":"https://openalex.org/keywords/tumor-metabolism","display_name":"cancer metabolism","score":0.75},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.4729999899864197},{"id":"https://openalex.org/keywords/energy-sensing","display_name":"energy sensing","score":0.47999998927116394}],"concepts":[{"id":"https://openalex.org/C2779933373","wikidata":"https://www.wikidata.org/wiki/Q14886430","display_name":"GLI1","level":4,"score":0.950959324836731},{"id":"https://openalex.org/C2780124434","wikidata":"https://www.wikidata.org/wiki/Q12357464","display_name":"AMPK","level":4,"score":0.90189528465271},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6356633901596069},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6099405884742737},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.6066543459892273},{"id":"https://openalex.org/C88498014","wikidata":"https://www.wikidata.org/wiki/Q14859918","display_name":"Hedgehog signaling pathway","level":3,"score":0.6043599247932434},{"id":"https://openalex.org/C2778539099","wikidata":"https://www.wikidata.org/wiki/Q6120","display_name":"Hedgehog","level":3,"score":0.6042149066925049},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5294047594070435},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4943108558654785},{"id":"https://openalex.org/C2776637008","wikidata":"https://www.wikidata.org/wiki/Q14860072","display_name":"Sonic hedgehog","level":3,"score":0.45596829056739807},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3424190878868103},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.1987641453742981}],"mesh":[{"descriptor_ui":"D000071676","descriptor_name":"Zinc Finger Protein GLI1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002528","descriptor_name":"Cerebellar Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008527","descriptor_name":"Medulloblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016475","descriptor_name":"3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055372","descriptor_name":"AMP-Activated Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055372","descriptor_name":"AMP-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.18632/oncotarget.7070","doi":"https://doi.org/10.18632/oncotarget.7070","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.7070","pdf_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=7070&path%5B%5D=20104","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3877569","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4891058","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:26843621","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26843621","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4891058","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4891058/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Text"},{"id":"pmh:oai:iris.uniroma1.it:11573/863407","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11573/863407","pdf_url":"https://iris.uniroma1.it/bitstream/11573/863407/1/Di%20Magno_energy-sensor_2016.pdf","source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.18632/oncotarget.7070","doi":"https://doi.org/10.18632/oncotarget.7070","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.7070","pdf_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=7070&path%5B%5D=20104","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321873","display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","ror":"https://ror.org/0166hxq48"},{"id":"https://openalex.org/F4320322750","display_name":"Istituto Pasteur-Fondazione Cenci Bolognetti","ror":"https://ror.org/051v7w268"},{"id":"https://openalex.org/F4320323054","display_name":"Associazione Italiana per la Ricerca sul Cancro","ror":"https://ror.org/02g2x7380"},{"id":"https://openalex.org/F4320325847","display_name":"Istituto Italiano di Tecnologia","ror":"https://ror.org/042t93s57"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2273708684.pdf","grobid_xml":"https://content.openalex.org/works/W2273708684.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W597150531","https://openalex.org/W1523693806","https://openalex.org/W1658670721","https://openalex.org/W1855124090","https://openalex.org/W1964612733","https://openalex.org/W1972207998","https://openalex.org/W1979270142","https://openalex.org/W1986177147","https://openalex.org/W2004170579","https://openalex.org/W2004849589","https://openalex.org/W2011334551","https://openalex.org/W2013248580","https://openalex.org/W2013579158","https://openalex.org/W2016280793","https://openalex.org/W2016752484","https://openalex.org/W2018203300","https://openalex.org/W2028417396","https://openalex.org/W2038227076","https://openalex.org/W2043289157","https://openalex.org/W2044874695","https://openalex.org/W2057770213","https://openalex.org/W2059499603","https://openalex.org/W2079580613","https://openalex.org/W2081920342","https://openalex.org/W2085567056","https://openalex.org/W2087898777","https://openalex.org/W2088331553","https://openalex.org/W2088342479","https://openalex.org/W2088355036","https://openalex.org/W2090455515","https://openalex.org/W2090887468","https://openalex.org/W2111413580","https://openalex.org/W2122263758","https://openalex.org/W2122403976","https://openalex.org/W2137279272","https://openalex.org/W2140413719","https://openalex.org/W2148652623","https://openalex.org/W2154024784","https://openalex.org/W2474599166"],"related_works":["https://openalex.org/W1658670721","https://openalex.org/W2088331553","https://openalex.org/W2613509795","https://openalex.org/W2896324864","https://openalex.org/W2808524418","https://openalex.org/W1855124090","https://openalex.org/W2808356595","https://openalex.org/W2900618021","https://openalex.org/W2790445723","https://openalex.org/W1532997384"],"abstract_inverted_index":{"//":[0],"Laura":[1,26],"Di":[2,48],"Magno":[3],"3":[4,20,32,88],",":[5,9,13,17,21,25,29,33,38,42,46,53,59],"Alessio":[6],"Basile":[7],"1":[8,12,16,24,28,64],"Sonia":[10],"Coni":[11],"Simona":[14],"Manni":[15],"Giulia":[18],"Sdruscia":[19],"Davide":[22],"D\u2019Amico":[23],"Antonucci":[27],"Paola":[30],"Infante":[31],"Enrico":[34],"De":[35],"Smaele":[36],"2":[37,41,45,76],"Danilo":[39],"Cucchi":[40],"Elisabetta":[43],"Ferretti":[44],"Lucia":[47],"Marcotullio":[49],"1,":[50,56,62],"3,":[51,57],"4":[52,58,63,101],"Isabella":[54],"Screpanti":[55],"Gianluca":[60,115],"Canettieri":[61],"Department":[65,77],"of":[66,71,78,83,108,143,157,181,280,282,298],"Molecular":[67],"Medicine,":[68,80],"Sapienza":[69,81,106],"University":[70,82,107],"Rome,":[72,74,84,86,109,111],"00161":[73,85,98,110],"Italy":[75,87,100,112],"Experimental":[79],"Center":[89],"for":[90,242,270,288,295],"Life":[91],"Nano":[92],"Science@Sapienza,":[93],"Istituto":[94,102],"Italiano":[95],"di":[96],"Tecnologia,":[97],"Roma,":[99],"Pasteur,":[103],"Fondazione":[104],"Cenci-Bolognetti,":[105],"Correspondence":[113],"to:":[114],"Canettieri,":[116],"e-mail:":[117],"gianluca.canettieri@uniroma1.it":[118],"Keywords:":[119],"Hedgehog,":[120],"AMPK,":[121],"Gli1,":[122],"cancer":[123],"metabolism,":[124],"phosphorylation":[125],"Received:":[126],"August":[127],"18,":[128],"2015":[129],"Accepted:":[130],"January":[131,135],"12,":[132],"2016":[133,137],"Published:":[134],"29,":[136],"ABSTRACT":[138],"Hedgehog":[139],"signaling":[140,175,206],"controls":[141],"proliferation":[142,254],"cerebellar":[144],"granule":[145],"cell":[146],"precursors":[147],"(GCPs)":[148],"and":[149,195,255,291],"its":[150],"aberrant":[151],"activation":[152,202,251],"is":[153,185,227,240,259,286],"a":[154,178,266,277],"leading":[155],"cause":[156],"Medulloblastoma,":[158],"the":[159,169,222,296],"most":[160],"frequent":[161],"pediatric":[162],"brain":[163],"tumor.":[164],"We":[165],"show":[166,216,247],"here":[167],"that":[168,184,200,217,248,256],"energy":[170],"sensor":[171],"AMPK":[172,201,218,250],"inhibits":[173,203,252],"Hh":[174,205,271],"by":[176],"phosphorylating":[177],"single":[179],"residue":[180,224],"human":[182,289],"Gli1":[183,220,239,283,302],"not":[186,210,233],"conserved":[187,228],"in":[188,207,211,230,234],"other":[189,235,301],"species.":[190,236],"Studies":[191],"with":[192],"selective":[193,249],"agonists":[194],"genetic":[196],"deletion":[197],"have":[198],"revealed":[199],"canonical":[204],"human,":[208],"but":[209,232],"mouse":[212],"cells.":[213],"Indeed":[214],"we":[215,246],"phosphorylates":[219],"at":[221],"unique":[223],"Ser408,":[225],"which":[226,264,285],"only":[229],"primates":[231],"Once":[237],"phosphorylated,":[238],"targeted":[241],"proteasomal":[243],"degradation.":[244],"Notably,":[245],"Gli1-driven":[253],"this":[257,274],"effect":[258],"linked":[260],"to":[261],"Ser408":[262],"phosphorylation,":[263],"represents":[265],"key":[267],"metabolic":[268],"checkpoint":[269],"signaling.":[272],"Collectively,":[273],"data":[275],"unveil":[276],"novel":[278],"mechanism":[279],"inhibition":[281],"function,":[284],"exclusive":[287],"cells":[290],"may":[292],"be":[293],"exploited":[294],"treatment":[297],"Medulloblastoma":[299],"or":[300],"driven":[303],"tumors.":[304]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}