{"id":"https://openalex.org/W2273572579","doi":null,"title":"[Induction of CYP3A4 by 1alpha,25-dihydroxyvitamin D3 in HepG2 cells].","display_name":"[Induction of CYP3A4 by 1alpha,25-dihydroxyvitamin D3 in HepG2 cells].","publication_year":2008,"publication_date":"2008-03-01","ids":{"openalex":"https://openalex.org/W2273572579","mag":"2273572579","pmid":"https://pubmed.ncbi.nlm.nih.gov/18364084"},"language":"zh","primary_location":{"id":"pmid:18364084","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18364084","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014800434","display_name":"\u674e\u723d","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuang Li","raw_affiliation_strings":["Department of Infectious Diseases, First Affiliated Hospital of Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, First Affiliated Hospital of Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I4210152119"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081452433","display_name":"\u7f2a\u6653\u8f89","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiao-hui Miao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"16","issue":"3","first_page":"220","last_page":"3"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyp3a4-induction","display_name":"CYP3A4 induction","score":0.875},{"id":"https://openalex.org/keywords/1-25-dihydroxyvitamin-d3","display_name":"1,25-dihydroxyvitamin D3","score":0.9670000076293945},{"id":"https://openalex.org/keywords/hepg2-cells","display_name":"HepG2 cells","score":0.9470000267028809},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.6299999952316284},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.44999998807907104},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.5329999923706055},{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.5220000147819519},{"id":"https://openalex.org/keywords/cyp3a","display_name":"CYP3A","score":0.7400000095367432}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3039312958717346}],"mesh":[{"descriptor_ui":"D002117","descriptor_name":"Calcitriol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051544","descriptor_name":"Cytochrome P-450 CYP3A","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051544","descriptor_name":"Cytochrome P-450 CYP3A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051544","descriptor_name":"Cytochrome P-450 CYP3A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D056945","descriptor_name":"Hep G2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:18364084","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18364084","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology","raw_type":"Journal Article"},{"id":"mag:2273572579","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/90483A/200803/26740632.html","pdf_url":null,"source":{"id":"https://openalex.org/S3012915621","display_name":"Zhonghua ganzangbing zazhi","issn_l":"1007-3418","issn":["1007-3418"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["medline","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4320800525","host_organization_name":"Chinese Medical Association","host_organization_lineage":["https://openalex.org/P4320800525"],"host_organization_lineage_names":["Chinese Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e2d\u534e\u809d\u810f\u75c5\u6742\u5fd7","raw_type":null},{"id":"mag:2418947531","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18364084","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2418947531","https://openalex.org/W2075920649","https://openalex.org/W4212848111","https://openalex.org/W2165165683","https://openalex.org/W1174219435","https://openalex.org/W2946926455","https://openalex.org/W1748227957","https://openalex.org/W973262940","https://openalex.org/W2147791876","https://openalex.org/W338555346"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"establish":[2],"a":[3,243],"convenient":[4,244],"and":[5,14,47,55,72,91,137,164,172,187,193,199,216,220,245,254],"efficient":[6,246],"model":[7],"for":[8,250],"investigating":[9],"the":[10,43,106,108,147,155,184,229],"expression":[11,30,109,120,212,230],"of":[12,74,105,110,157,231,252],"CYP3A4":[13,29,65,75,111,118,158,177,232,237,253],"drug":[15,255],"metabolism":[16],"in":[17,31,85,154,180,183,239,247],"vitro.":[18],"METHODS:":[19],"1alpha,25-dihydroxyvitamin":[20,38,83,175,207,225],"D3":[21,39,84,208,226],"was":[22,60,68,113],"utilized":[23],"as":[24,234,236],"an":[25],"inducer":[26],"to":[27,42,99],"enhance":[28],"HepG2":[32,100],"cells.":[33,101],"0.1,":[34],"0.25,":[35],"0.35":[36,92,173],"micromol/L":[37,171,174,206],"were":[40,49,77,152],"added":[41],"cell":[44],"culture":[45],"media,":[46],"cells":[48],"harvested":[50],"after":[51,167,189,195,201],"24,":[52],"48,":[53,162],"72":[54,135,163,196,214],"96":[56,143,165,202,217],"hours.":[57],"Cell":[58],"proliferation":[59],"determined":[61],"with":[62,70,169],"MTT":[63],"assay.":[64],"mRNA":[66,112,119,233],"level":[67],"analyzed":[69],"RT-PCR":[71],"expressions":[73],"protein":[76,159,178,211,238],"measured":[78],"by":[79,123,130,138],"Western":[80],"blot.":[81],"RESULTS:":[82],"3":[86],"concentrations,":[87],"namely":[88],"0.10,":[89],"0.25":[90,170],"micromol/L,":[93],"did":[94],"not":[95,114],"show":[96],"obvious":[97],"toxicity":[98],"At":[102,161],"24":[103],"h":[104,215,218],"cultivation,":[107],"increased":[115,122,179],"significantly,":[116],"but":[117],"significantly":[121],"120%,":[124],"134%,":[125],"200%":[126],"at":[127,134,142,213],"48":[128,190],"h,":[129,136,144,191,197],"174%,":[131],"254%,":[132],"420%":[133],"258%,":[139],"450%,":[140],"370%":[141],"respectively":[145],"under":[146],"three":[148],"concentrations.":[149],"Similar":[150],"results":[151],"observed":[153],"induction":[156],"expression.":[160],"hours":[166],"treatment":[168],"D3,":[176],"various":[181],"folds":[182],"controls":[185],"(1.2":[186],"2.2":[188],"3.4":[192],"6.5":[194],"6.1":[198],"7.2":[200],"h),":[203],"while":[204],"0.10":[205],"only":[209],"induced":[210],"(1.8":[219],"4.1":[221],"folds,":[222],"respectively).":[223],"CONCLUSION:":[224],"could":[227],"induce":[228],"well":[235],"HepG2,":[240],"which":[241],"provides":[242],"vitro":[248],"system":[249],"investigation":[251],"interaction.":[256]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}