{"id":"https://openalex.org/W2273414653","doi":"https://doi.org/10.1038/srep11621","title":"Sox2-CreER mice are useful for fate mapping of mature, but not neonatal, cochlear supporting cells in hair cell regeneration studies","display_name":"Sox2-CreER mice are useful for fate mapping of mature, but not neonatal, cochlear supporting cells in hair cell regeneration studies","publication_year":2015,"publication_date":"2015-06-25","ids":{"openalex":"https://openalex.org/W2273414653","doi":"https://doi.org/10.1038/srep11621","mag":"2273414653","pmid":"https://pubmed.ncbi.nlm.nih.gov/26108463","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4479870"},"language":"en","primary_location":{"id":"doi:10.1038/srep11621","doi":"https://doi.org/10.1038/srep11621","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep11621","pdf_url":"https://www.nature.com/articles/srep11621.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/srep11621.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103411737","display_name":"Bradley J. Walters","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bradley J. Walters","raw_affiliation_strings":["Dept. of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA","Dept. of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, 38105, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Dept. of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, 38105, TN, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tetsuji Yamashita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tetsuji Yamashita","raw_affiliation_strings":["Dept. of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA","Dept. of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, 38105, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Dept. of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, 38105, TN, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100657071","display_name":"Jian Zuo","orcid":"https://orcid.org/0000-0002-1448-4507","observed_orcids":["https://orcid.org/0000-0002-1448-4507","https://orcid.org/0009-0007-6278-6335","https://orcid.org/0000-0002-5395-2887"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jian Zuo","raw_affiliation_strings":["Dept. of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA","Dept. of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, 38105, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Dept. of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, 38105, TN, USA","institution_ids":["https://openalex.org/I1313298211"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100657071"],"corresponding_institution_ids":["https://openalex.org/I1313298211"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":1.3007,"has_fulltext":true,"cited_by_count":26,"citation_normalized_percentile":{"value":0.77102623,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"5","issue":"1","first_page":"11621","last_page":"11621"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13738","display_name":"Congenital Ear and Nasal Anomalies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fate-mapping","display_name":"fate mapping","score":0.8149999976158142},{"id":"https://openalex.org/keywords/cochlear-supporting-cells","display_name":"cochlear supporting cells","score":0.9810000061988831},{"id":"https://openalex.org/keywords/hair-cell-regeneration","display_name":"hair cell regeneration","score":0.9440000057220459},{"id":"https://openalex.org/keywords/organ-of-corti","display_name":"organ of Corti","score":0.9580000042915344}],"concepts":[{"id":"https://openalex.org/C2777933648","wikidata":"https://www.wikidata.org/wiki/Q21114866","display_name":"SOX2","level":4,"score":0.932115912437439},{"id":"https://openalex.org/C2780659331","wikidata":"https://www.wikidata.org/wiki/Q1128309","display_name":"Organ of Corti","level":3,"score":0.749911904335022},{"id":"https://openalex.org/C2780130748","wikidata":"https://www.wikidata.org/wiki/Q317857","display_name":"Cochlea","level":2,"score":0.7008328437805176},{"id":"https://openalex.org/C2778585322","wikidata":"https://www.wikidata.org/wiki/Q1566641","display_name":"Hair cell","level":3,"score":0.6112160682678223},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5959723591804504},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.5427906513214111},{"id":"https://openalex.org/C63101894","wikidata":"https://www.wikidata.org/wiki/Q604095","display_name":"Fate mapping","level":4,"score":0.499406099319458},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.49169832468032837},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4626975655555725},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.4502134919166565},{"id":"https://openalex.org/C183074962","wikidata":"https://www.wikidata.org/wiki/Q213713","display_name":"Developmental biology","level":2,"score":0.43211114406585693},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.42811641097068787},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.3956993520259857},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3609858751296997},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.34546488523483276},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.26902395486831665},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18530580401420593},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.11128076910972595},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0679846704006195}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006198","descriptor_name":"Hair Cells, Auditory","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006198","descriptor_name":"Hair Cells, Auditory","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008164","descriptor_name":"Luminescent Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008164","descriptor_name":"Luminescent Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009925","descriptor_name":"Organ of Corti","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009925","descriptor_name":"Organ of Corti","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009925","descriptor_name":"Organ of Corti","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012038","descriptor_name":"Regeneration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019426","descriptor_name":"Integrases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019426","descriptor_name":"Integrases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054338","descriptor_name":"Cell Transdifferentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055748","descriptor_name":"SOXB1 Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055748","descriptor_name":"SOXB1 Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1038/srep11621","doi":"https://doi.org/10.1038/srep11621","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep11621","pdf_url":"https://www.nature.com/articles/srep11621.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3444343","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4479870","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4479870","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4479870","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:26108463","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26108463","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/srep11621","doi":"https://doi.org/10.1038/srep11621","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep11621","pdf_url":"https://www.nature.com/articles/srep11621.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46810001134872437}],"study_designs":[],"awards":[{"id":"https://openalex.org/G165480143","display_name":"Genetic analysis of mammalian hearing sensitivity","funder_award_id":"R01DC006471","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"},{"id":"https://openalex.org/G2474954790","display_name":null,"funder_award_id":"P30-CA21765","funder_id":"https://openalex.org/F4320310040","funder_display_name":"St. Jude Children's Research Hospital"},{"id":"https://openalex.org/G2649222700","display_name":null,"funder_award_id":"N000141210775","funder_id":"https://openalex.org/F4320337345","funder_display_name":"Office of Naval Research"},{"id":"https://openalex.org/G4856111422","display_name":null,"funder_award_id":"N000140911014","funder_id":"https://openalex.org/F4320337345","funder_display_name":"Office of Naval Research"},{"id":"https://openalex.org/G5383298809","display_name":null,"funder_award_id":"DC006471","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"},{"id":"https://openalex.org/G5998785214","display_name":null,"funder_award_id":"MR/N004299/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G7372847108","display_name":"Drug discovery for hair cell regeneration in adult mammalian cochleae","funder_award_id":"R21DC013879","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"},{"id":"https://openalex.org/G8281456828","display_name":null,"funder_award_id":"N000141210191","funder_id":"https://openalex.org/F4320337345","funder_display_name":"Office of Naval Research"},{"id":"https://openalex.org/G9000904664","display_name":"Cancer Center Support Grant (CCSG)","funder_award_id":"P30CA021765","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306926","display_name":"Hearing Health Foundation","ror":"https://ror.org/04ntvzq34"},{"id":"https://openalex.org/F4320307030","display_name":"National Organization for Hearing Research Foundation","ror":"https://ror.org/03mbtad86"},{"id":"https://openalex.org/F4320309331","display_name":"Hartwell Foundation","ror":"https://ror.org/038cgyc59"},{"id":"https://openalex.org/F4320310040","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967"},{"id":"https://openalex.org/F4320313598","display_name":"American Lebanese Syrian Associated Charities","ror":"https://ror.org/03rx10x31"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320337345","display_name":"Office of Naval Research","ror":"https://ror.org/00rk2pe57"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337352","display_name":"National Institute on Deafness and Other Communication Disorders","ror":"https://ror.org/04mhx6838"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2273414653.pdf","grobid_xml":"https://content.openalex.org/works/W2273414653.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W22367061","https://openalex.org/W1493367564","https://openalex.org/W1805838769","https://openalex.org/W1971757408","https://openalex.org/W1974373320","https://openalex.org/W1975149745","https://openalex.org/W1975700521","https://openalex.org/W1979509265","https://openalex.org/W1990811136","https://openalex.org/W1996822975","https://openalex.org/W1997470128","https://openalex.org/W2005143680","https://openalex.org/W2006723548","https://openalex.org/W2017022046","https://openalex.org/W2018647497","https://openalex.org/W2022151280","https://openalex.org/W2023914268","https://openalex.org/W2026120980","https://openalex.org/W2026715413","https://openalex.org/W2028913861","https://openalex.org/W2028916500","https://openalex.org/W2030091857","https://openalex.org/W2030415925","https://openalex.org/W2034193769","https://openalex.org/W2037011968","https://openalex.org/W2038440214","https://openalex.org/W2042111556","https://openalex.org/W2045653118","https://openalex.org/W2047170651","https://openalex.org/W2047855572","https://openalex.org/W2049365404","https://openalex.org/W2049903984","https://openalex.org/W2063464173","https://openalex.org/W2070308649","https://openalex.org/W2073603843","https://openalex.org/W2076110149","https://openalex.org/W2078829188","https://openalex.org/W2078891648","https://openalex.org/W2079144627","https://openalex.org/W2081584067","https://openalex.org/W2085550383","https://openalex.org/W2088357355","https://openalex.org/W2091640904","https://openalex.org/W2093298785","https://openalex.org/W2096821559","https://openalex.org/W2104010513","https://openalex.org/W2104135721","https://openalex.org/W2105493567","https://openalex.org/W2144773349","https://openalex.org/W2152953538","https://openalex.org/W2154294055","https://openalex.org/W2156041432","https://openalex.org/W2156310646","https://openalex.org/W2156396097","https://openalex.org/W2163241651","https://openalex.org/W2163755412","https://openalex.org/W2163857939"],"related_works":["https://openalex.org/W2156396097","https://openalex.org/W2991200150","https://openalex.org/W4323031077","https://openalex.org/W4313254981","https://openalex.org/W2119180916","https://openalex.org/W4243953569","https://openalex.org/W3102294944","https://openalex.org/W4308683401","https://openalex.org/W4296041595","https://openalex.org/W2550538297"],"abstract_inverted_index":{"Studies":[0],"of":[1,13,36,51,57,95,113],"hair":[2,97,115],"cell":[3,111],"regeneration":[4],"in":[5,49,93,128,143],"the":[6,55,144],"postnatal":[7,62],"cochlea":[8],"rely":[9],"on":[10],"fate":[11,77,107,134],"mapping":[12,78,135],"supporting":[14,52,71,110,158],"cells.":[15],"Here":[16],"we":[17],"characterized":[18],"a":[19,109],"Sox2-CreER":[20,66,88,101],"knock-in":[21],"mouse":[22,28],"line":[23],"with":[24,43],"two":[25],"independent":[26],"reporter":[27,39],"strains":[29],"at":[30,61,86,119,160],"neonatal":[31,120,164],"and":[32,137,169],"mature":[33,161],"ages.":[34,121],"Regardless":[35],"induction":[37],"age,":[38],"expression":[40],"was":[41,68,90],"robust,":[42],"CreER":[44,155],"activity":[45,67,89,156],"being":[46],"readily":[47],"detectable":[48],">85%":[50],"cells":[53,72,116,159],"within":[54],"organ":[56],"Corti.":[58],"When":[59],"induced":[60,85,118],"day":[63],"(P)":[64],"28,":[65],"exclusive":[69],"to":[70,106,157],"demonstrating":[73],"its":[74],"utility":[75],"for":[76,133,153],"studies":[79],"beyond":[80],"this":[81,124],"age.":[82],"However,":[83],"when":[84],"P1,":[87],"also":[91],"detected":[92],">50%":[94],"cochlear":[96],"cells,":[98],"suggesting":[99],"that":[100,123,148],"may":[102,138],"not":[103,163],"be":[104,139],"useful":[105],"map":[108],"origin":[112],"regenerated":[114],"if":[117],"Given":[122],"model":[125],"is":[126,166],"currently":[127],"use":[129],"by":[130,141],"several":[131],"investigators":[132],"purposes,":[136],"adopted":[140],"others":[142],"future,":[145],"our":[146],"finding":[147],"current":[149],"protocols":[150],"are":[151],"effective":[152],"restricting":[154],"but":[162],"ages":[165],"both":[167],"significant":[168],"timely.":[170]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}